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2022

Article Subjects > Social Sciences Europe University of Atlantic > Research > Scientific Production
Fundación Universitaria Internacional de Colombia > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production
Abierto Inglés This article proposes a discussion on the form of coexistence of local Development Agencies in Uruguay, with local governments in the face of the new scenarios marked by the decentralization process, initiated in the country with the Constitutional Reform of 1996 and culminating in February 2009, with the Law of Political Decentralization and Citizen Participation. The discussion applies in particular to the local development agency of the city of Rivera (ADR), located in the northeast of the country. A descriptive, mixed, bibliographic, documentary investigation was carried out with primary data collection to internal and external references to ADR. The results show that the coexistence of both institutions has been difficult, without defining clear roles. Promoting dialogue to define the role of each seems to be the great challenge facing the sustainability of the agency metadata Garat de Marin, Mirtha Silvana and Soriano Flores, Emmanuel and Rodríguez Velasco, Carmen Lilí and Silva Alvarado, Eduardo and Calderón Iglesias, Rubén and Álvarez, Roberto Marcelo and Gracia Villar, Santos mail silvana.marin@uneatlantico.es, emmanuel.soriano@uneatlantico.es, carmen.rodriguez@uneatlantico.es, UNSPECIFIED, ruben.calderon@uneatlantico.es, roberto.alvarez@uneatlantico.es, santos.gracia@uneatlantico.es (2022) Development Agencies and Local Governments—Coexistence within the Same Territory. Social Sciences, 11 (9). p. 398. ISSN 2076-0760

Article Subjects > Engineering Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Cerrado Inglés Recently, the Internet of Medical Things (IoMT) could offload healthcare services to 5 G edge computing for low latency. However, some existing works assumed altruistic patients will sacrifice Quality of Service (QoS) for the global optimum. For priority-aware and deadline-sensitive healthcare, this sufficient and simplified assumption will undermine the engagement enthusiasm, i.e., unfairness. To address this issue, we propose a long-term proportional fairness-driven 5 G edge healthcare, i.e., FairHealth. First, we establish a long-term Nash bargaining game to model the service offloading, considering the stochastic demand and dynamic environment. We then design a Lyapunov-based proportional-fairness resource scheduling algorithm, which decouples the long-term fairness problem into single-slot sub-problems, realizing a trade-off between service stability and fairness. Moreover, we propose a block-coordinate descent method to iteratively solve non-convex fair sub-problems. Simulation results show that our scheme can improve 74.44% of the fairness index (i.e., Nash product), compared with the classic global time-optimal scheme. metadata Lin, Xi and Wu, Jun and Bashir, Ali Kashif and Yang, Wu and Singh, Aman and AlZubi, Ahmad Ali mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, aman.singh@uneatlantico.es, UNSPECIFIED (2022) FairHealth: Long-Term Proportional Fairness-Driven 5G Edge Healthcare in Internet of Medical Things. IEEE Transactions on Industrial Informatics. pp. 1-10. ISSN 1551-3203

Article Subjects > Engineering Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Abierto Inglés In Smart Cities’ applications, Multi-node cooperative spectrum sensing (CSS) can boost spectrum sensing efficiency in cognitive wireless networks (CWN), although there is a non-linear interaction among number of nodes and sensing efficiency. Cooperative sensing by nodes with low computational cost is not favorable to improving sensing reliability and diminishes spectrum sensing energy efficiency, which poses obstacles to the regular operation of CWN. To enhance the evaluation and interpretation of nodes and resolves the difficulty of sensor selection in cognitive sensor networks for energy-efficient spectrum sensing. We examined reducing energy usage in smart cities while substantially boosting spectrum detecting accuracy. In optimizing energy effectiveness in spectrum sensing while minimizing complexity, we use the energy detection for spectrum sensing and describe the challenge of sensor selection. This article proposed the algorithm for choosing the sensing nodes while reducing the energy utilization and improving the sensing efficiency. All the information regarding nodes is saved in the fusion center (FC) through which blockchain encrypts the information of nodes ensuring that a node’s trust value conforms to its own without any ambiguity, CWN-FC pick high-performance nodes to engage in CSS. The performance evaluation and computation results shows the comparison between various algorithms with the proposed approach which achieves 10% sensing efficiency in finding the solution for identification and triggering possibilities with the value of α=1.5 and γ=2.5 with the varying number of nodes. metadata Rani, Shalli and Babbar, Himanshi and Shah, Syed Hassan Ahmed and Singh, Aman mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, aman.singh@uneatlantico.es (2022) Improvement of energy conservation using blockchain-enabled cognitive wireless networks for smart cities. Scientific Reports, 12 (1). ISSN 2045-2322

Article Subjects > Social Sciences Europe University of Atlantic > Research > Scientific Production
Fundación Universitaria Internacional de Colombia > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production
Abierto Inglés Angola, as with many countries on the African continent, has great inequalities or asymmetries between its provinces. At the economic, financial, and technological level, there is a great disparity between them, where it is observed that the province of Luanda is the largest financial business center to the detriment of others, such as Moxico, Zaire, and Cabinda. In the latter, despite the advantages of high oil production, from a regional point of view, they remain almost stagnant in time, in a social dysfunction where the population lives on extractivism and artisanal fishing. This article analyzes the most important events in contemporary regional history, the Portuguese occupation that was the Portuguese colonial rule over Angola (1890–1930) and the civil war that was a struggle between Angolans for control of the country (1975–2002), in the consolidation of the asymmetries between provinces. For this work, a theoretical-reflective study was conducted based on the reading of books, articles, and previous investigations on the phenomenon studied. Considering the interpretation and analysis of the theoretical content obtained through the bibliographic research conducted, this theoretical construction approaches the qualitative approach. We conclude that the deep inequalities between regions and within them, between the provinces studied, originated historically in the form of exploitation of the regions and from the consequences of the war. The asymmetries, observed through the variables studied show that the provinces historically explored and considered object regions present a lower growth compared to those that were considered subject regions in which the applied geopolitical strategy, as they are centers of primary production flows, was different. We also observe that, due to the conflicts of the civil war in the less developed regions, the inequalities have deepened, contributing seriously to a higher level of poverty and a lower development of the provinces where these conflicts took place. metadata Catoto Capitango, João Adolfo and Garat de Marin, Mirtha Silvana and Soriano Flores, Emmanuel and Rojo Gutiérrez, Marco Antonio and Gracia Villar, Mónica and Durántez Prados, Frigdiano Álvaro mail UNSPECIFIED, silvana.marin@uneatlantico.es, emmanuel.soriano@uneatlantico.es, marco.rojo@unini.edu.mx, monica.gracia@uneatlantico.es, durantez@uneatlantico.es (2022) Inequalities and Asymmetries in the Development of Angola’s Provinces: The Impact of Colonialism and Civil War. Social Sciences, 11 (8). p. 334. ISSN 2076-0760

Article Subjects > Engineering Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Abierto Inglés 5G has been launched in a few countries of the world, so now all focus shifted towards the development of future 6G networks. 5G has connected all aspects of society. Ubiquitous connectivity has opened the doors for more data sharing. Although 5G is providing low latency, higher data rates, and high-speed yet there are some security-related vulnerabilities. Those security issues need to be mitigated for securing 6G networks from existing challenges. Classical cryptography will not remain enough for securing the 6G network. As all classical cryptography can be disabled with the help of quantum mechanics. Therefore, in the place of traditional security solutions, in this article, we have reviewed all the existing quantum solutions of 5G existing security issues to mitigate them and secure 6G in a Future Quantum World. metadata Mangla, Cherry and Rani, Shalli and Faseeh Qureshi, Nawab Muhammad and Singh, Aman mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, aman.singh@uneatlantico.es (2022) Mitigating 5G security challenges for next-gen industry using quantum computing. Journal of King Saud University - Computer and Information Sciences. ISSN 13191578

Article Subjects > Engineering Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production
Abierto Inglés Thyroid disease prediction has emerged as an important task recently. Despite existing approaches for its diagnosis, often the target is binary classification, the used datasets are small-sized and results are not validated either. Predominantly, existing approaches focus on model optimization and the feature engineering part is less investigated. To overcome these limitations, this study presents an approach that investigates feature engineering for machine learning and deep learning models. Forward feature selection, backward feature elimination, bidirectional feature elimination, and machine learning-based feature selection using extra tree classifiers are adopted. The proposed approach can predict Hashimoto’s thyroiditis (primary hypothyroid), binding protein (increased binding protein), autoimmune thyroiditis (compensated hypothyroid), and non-thyroidal syndrome (NTIS) (concurrent non-thyroidal illness). Extensive experiments show that the extra tree classifier-based selected feature yields the best results with 0.99 accuracy and an F1 score when used with the random forest classifier. Results suggest that the machine learning models are a better choice for thyroid disease detection regarding the provided accuracy and the computational complexity. K-fold cross-validation and performance comparison with existing studies corroborate the superior performance of the proposed approach. metadata Chaganti, Rajasekhar and Rustam, Furqan and De La Torre Díez, Isabel and Vidal Mazón, Juan Luis and Rodríguez Velasco, Carmen Lilí and Ashraf, Imran mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, juanluis.vidal@uneatlantico.es, carmen.rodriguez@uneatlantico.es, UNSPECIFIED (2022) Thyroid Disease Prediction Using Selective Features and Machine Learning Techniques. Cancers, 14 (16). p. 3914. ISSN 2072-6694

2021

Article Subjects > Psychology Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production
Cerrado Inglés Many earlier studies conducted on sports betting and addiction have examined sports betting in the context of gambling and have not taken into account the specific motivations of sports betting. Therefore, the effects of motivational elements of sports betting on sports betting addiction risk are unknown. The aim of the present study was to examine the effects of motivation factors specific to sports betting on sports betting addiction. Accordingly, three linked studies were conducted. Firstly, to determine sports betting motivations “Sports Betting Motivation Scale (SBMS)” developed and validated. Secondly, to determine the risks of sports betting addiction “Problem Sports Betting Severity Index (PSBSI)” was adapted from Problem Gambling Severity Index (PGSI). Finally, the third study examined effects of the sports betting motivations on sports betting addiction risk. Study one (n=281), study two comprised (n=230), and the final study comprised (n=643) sports fans who bet on sports regularly for 12 months with different motivations. The findings demonstrate that the SBMS appears to be a reliable and valid instrument for assessing sports betting motivations. Also, the findings provided PSBSI validity for the use of the Turkish and sports betting adapted version of PGSI. As a result of the main research, “make money,” “socialization,” and “being in the game” motivations were found to be positive predictors of sports betting addiction risk, while “fun” motivation was a negative predictor. The motivations “recreation/escape,” “knowledge of the game,” and “interest in sport” were found not to be significant predictors of the risk of sports betting addiction. metadata Gökce Yüce, Sevda and Yüce, Arif and Katırcı, Hakan and Nogueira-López, Abel and González-Hernández, Juan mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, abel.nogueira@uneatlantico.es, UNSPECIFIED (2021) Effects of Sports Betting Motivations on Sports Betting Addiction in a Turkish Sample. International Journal of Mental Health and Addiction. ISSN 1557-1874

Article Subjects > Teaching Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production
Abierto Inglés The purpose of this article was to evaluate the level of satisfaction of a sample of graduates in relation to different online postgraduate programs in the environmental area, as part of the process of continuous improvement in which the educational institution was immersed for the renewal of its accreditation before the corresponding official bodies. Based on the bibliographic review of a series of models and tools, a Likert scale measurement instrument was developed. This instrument, once applied and validated, showed a good level of reliability, with more than three quarters of the participants having a positive evaluation of satisfaction. Likewise, to facilitate the relational study, and after confirming the suitability of performing a factor analysis, four variable grouping factors were determined, which explained a good part of the variability of the instrument’s items. As a result of the analysis, it was found that there were significant values of low satisfaction in graduates from the Eurasian area, mainly in terms of organizational issues and academic expectations. On the other hand, it was observed that the methodological aspects of the “Auditing” and “Biodiversity” programs showed higher levels of dissatisfaction than the rest, with no statistically significant relationships between gender, entry profile or age groups. The methodology followed and the rigor in determining the validity and reliability of the instrument, as well as the subsequent analysis of the results, endorsed by the review of the documented information, suggest that the instrument can be applied to other multidisciplinary programs for decision making with guarantees in the educational field metadata García Villena, Eduardo and Pueyo Villa, Silvia and Delgado Noya, Irene and Tutusaus, Kilian and Ruiz Salces, Roberto and Pascual Barrera, Alina Eugenia mail eduardo.garcia@uneatlantico.es, silvia.pueyo@uneatlantico.es, irene.delgado@uneatlantico.es, kilian.tutusaus@uneatlantico.es, roberto.ruiz@uneatlantico.es, alina.pascual@unini.edu.mx (2021) Instrumentalization of a Model for the Evaluation of the Level of Satisfaction of Graduates under an E-Learning Methodology: A Case Analysis Oriented to Postgraduate Studies in the Environmental Field. Sustainability, 13 (9). p. 5112. ISSN 2071-1050

Article Subjects > Teaching Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Abierto Español La formación pedagógica del docente debe partir de las competencias que el profesor debe desarrollar para aplicar a las TIC de manera educativa a lo largo de su vida docente. Este estudio, que es parte del Proyecto Europeo Lovedistance – Learning Optmization and Academic Inclusion Via Equitative Distance Teaching and Learning 609949-EPP-1-2019-1-PTEPPKA2-CBHE-JP, tiene como objetivo medir los niveles y dimensiones de las competencias determinadas por la UNESCO (2016) en cuanto a la acción docente frente a la utilización de las TIC en escenarios educativos. Se destacan las posibilidades de llevar a cabo una planificación basada en las TIC; el diseño o la capacidad de organización y construcción de escenarios de aprendizaje con las TIC; y la evaluación o la posibilidad de medida de la efectividad de las TIC para la educación a lo largo de la vida, en los espacios educativos que se desarrollan como docentes (Coll, 2008). El presente estudio se basa en el diseño de encuesta y utiliza como instrumento el cuestionario, aplicando una complementariedad metodológica con unos resultados que indican a través de un análisis descriptivo que la formación del profesorado, la coordinación y cooperación docente, y la profundización en el manejo de las tecnologías, son factores de gran importancia y favorecedores del uso de las TIC en la comunidad educativa. metadata Sartor-Harada, Andresa mail andresa.sartor@uneatlantico.es (2021) La comunidad docente y las competencias digitales: la formación a lo largo de la vida. Revista Conhecimento Online, 1. p. 177. ISSN 2176-8501

2015

Article Subjects > Biomedicine
Subjects > Nutrition
Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Cerrado Inglés In the last decade, specific dietary patterns, mainly characterized by high consumption of vegetables and fruits, have been proven beneficial for the prevention of both metabolic syndrome (MetS)-related dysfunctions and neurodegenerative disorders, such as Alzheimer’s disease (AD). Nowadays, neuroimaging readouts can be used to diagnose AD, investigate MetS effects on brain functionality and anatomy, and assess the effects of dietary supplementations and nutritional patterns in relation to neurodegeneration and AD-related features. Here we review scientific literature describing the use of the most recent neuroimaging techniques to detect AD- and MetS-related brain features, and also to investigate associations between consolidated dietary patterns or nutritional interventions and AD, specifically focusing on observational and intervention studies in humans. metadata Pistollato, Francesca and Sumalla Cano, Sandra and Elío Pascual, Iñaki and Masías Vergara, Manuel and Giampieri, Francesca and Battino, Maurizio mail francesca.pistollato@uneatlantico.es, sandra.sumalla@uneatlantico.es, inaki.elio@uneatlantico.es, manuel.masias@uneatlantico.es, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es (2015) The Use of Neuroimaging to Assess Associations Among Diet, Nutrients, Metabolic Syndrome, and Alzheimer’s Disease. Journal of Alzheimer's Disease, 48 (2). pp. 303-318. ISSN 13872877

This list was generated on Tue Sep 27 23:40:56 2022 UTC.

<a href="/489/1/ijerph-19-00849.pdf" class="ep_document_link"><img class="ep_doc_icon" alt="[img]" src="/489/1.hassmallThumbnailVersion/ijerph-19-00849.pdf" border="0"/></a><a href="/489/1/ijerph-19-00849.pdf" class="ep_document_link"><img class="ep_doc_icon" alt="[img]" src="/489/1.hassmallThumbnailVersion/ijerph-19-00849.pdf" border="0"/></a>

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Detection of Upper Limb Asymmetries in Athletes According to the Stage of the Season—A Longitudinal Study

Abstract: Sports injuries can affect the performance of athletes. For this reason, functional tests are used for injury assessment and prevention, analyzing physical or physiological imbalances and detecting asymmetries. The main aim of this study was to detect the asymmetries in the upper limbs (right and left arms) in athletes, using the OctoBalance Test (OB), depending on the stage of the season. Two hundred and fifty-two participants (age: 23.33 ± 8.96 years old; height: 178.63 ± 11.12 cm; body mass: 80.28 ± 17.61 kg; body mass index: 24.88 ± 4.58; sports experience: 12.52 ± 6.28 years), practicing different sports (rugby, athletics, football, swimming, handball, triathlon, basketball, hockey, badminton and volleyball), assessed with the OB in medial, superolateral, and inferolateral directions in both arms, in four moments of the season (May 2017, September 2017, February 2018 and May 2018). ANOVA test was used with repeated measures with a p ≤ 0.05, for the analysis of the different studied variances. Significant differences were found (p = 0.021) in the medial direction of the left arm, between the first (May 2017) and fourth stages (May 2018), with values of 71.02 ± 7.15 cm and 65.03 ± 7.66 cm. From the detection of asymmetries, using the OB to measure, in the medial, superolateral and inferolateral directions, mobility and balance can be assessed. In addition, it is possible to observe functional imbalances, as a risk factor for injury, in each of the stages into which the season is divided, which will help in the prevention of injuries and in the individualization of training.

Producción Científica

Álvaro Velarde-Sotres mail alvaro.velarde@uneatlantico.es, Antonio Bores-Cerezal mail antonio.bores@uneatlantico.es, Marcos Mecías-Calvo mail marcos.mecias@uneatlantico.es, Martín Barcala Furelos mail martin.barcala@uneatlantico.es, Silvia Aparicio Obregón mail silvia.aparicio@uneatlantico.es, Julio Calleja-González mail ,

Velarde-Sotres

<a href="/490/1/sustainability-14-00913-v2.pdf" class="ep_document_link"><img class="ep_doc_icon" alt="[img]" src="/490/1.hassmallThumbnailVersion/sustainability-14-00913-v2.pdf" border="0"/></a>

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Blockchain Interoperability: Towards a Sustainable Payment System

The highly fragmented blockchain and cryptocurrency ecosystem necessitates interoperability mechanisms as a requirement for blockchain-technology acceptance. The immediate implication of interchain interoperability is automatic swapping between cryptocurrencies. We performed a systematic review of the existing literature on Blockchain interoperability and atomic cross-chain transactions. We investigated different blockchain interoperability approaches, including industrial solutions, categorized them and identified the key mechanisms used, and list several example projects for each category. We focused on the atomic transactions between blockchain, a process also known as atomic swap. Furthermore, we studied recent implementations along with architectural approaches for atomic swap and deduced research issues and challenges in cross-chain interoperability and atomic swap. Atomic swap can instantly transfer tokens and significantly reduce the associated costs without using any centralized authority, and thus facilitates the development of a sustainable payment system for wider financial inclusion.

Producción Científica

Debasis Mohanty mail , Divya Anand mail , Hani Moaiteq Aljahdali mail , Santos Gracia Villar mail santos.gracia@uneatlantico.es,

Mohanty

<a href="/495/1/ijerph-19-01256.pdf" class="ep_document_link"><img class="ep_doc_icon" alt="[img]" src="/495/1.hassmallThumbnailVersion/ijerph-19-01256.pdf" border="0"/></a>

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The Regular Consumption of Nuts Is Associated with a Lower Prevalence of Abdominal Obesity and Metabolic Syndrome in Older People from the North of Spain

Background: The aim of this study was to relate the adherence to nut consumption (30 g) three or more days per week to the prevalence of abdominal obesity and metabolic syndrome (MetS) in an elderly population from the north of Spain. Methods: The study consists of an observational, descriptive, cross-sectional, and correlational study conducted in 556 non-institutionalised individuals between 65 and 79 years of age. To define the consumption recommendation of nuts the indication of the questionnaire MEDAS-14 was followed. The diagnosis of MetS was conducted using the International Diabetes Federation (IDF) criteria. Results: In 264 subjects aged 71.9 (SD: ±4.2) years old, 39% of whom were men, the adherence to nut consumption recommendations was 40.2%. Of these individuals, 79.5% had abdominal obesity. The prevalence of MetS was 40.2%, being 47.6% in men and 35.4% in women (p < 0.05). A nut consumption lower than recommended was associated with a 19% higher prevalence of abdominal obesity (Prevalence Ratio: 1.19; 95% CI: 1.03−1.37; p < 0.05) and a 61% higher prevalence of MetS (Prevalence Ratio: 1.61; 95% CI: 1.16−2.25; p = 0.005) compared to a consumption of ≥3 servings per week. Conclusion: An inverse relationship was established between nut consumption and the prevalence of abdominal obesity and metabolic syndrome.

Producción Científica

Gloria Cubas-Basterrechea mail , Iñaki Elío Pascual mail inaki.elio@uneatlantico.es, Sandra Sumalla Cano mail sandra.sumalla@uneatlantico.es, Silvia Aparicio Obregón mail silvia.aparicio@uneatlantico.es, Carolina Teresa González-Antón mail , Pedro Muñoz-Cacho mail ,

Cubas-Basterrechea

<a href="/496/1/CO-WM-03886-02.pdf" class="ep_document_link"><img class="ep_doc_icon" alt="[img]" src="/496/1.hassmallThumbnailVersion/CO-WM-03886-02.pdf" border="0"/></a><a href="/496/1/CO-WM-03886-02.pdf" class="ep_document_link"><img class="ep_doc_icon" alt="[img]" src="/496/1.hassmallThumbnailVersion/CO-WM-03886-02.pdf" border="0"/></a>

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Effects of ergo-nutritional strategies on recovery in combat sports disciplines

In order to improve the recovery process in combat sports disciplines, ergo-nutritional strategies could be an effective option in training and competition. Some of these ergo-nutritional aids could improve performance but literature references are scarce, with controversial results regarding actual recovery effects. This systematic review aimed to examine which ergo-nutritional methods are most effective for assisting in the recovery process in combat sports, and to determine the appropriate training stimuli. This systematic review was carried out following the Preferred Reporting Items for Systematic Review (PRISMA) guidelines. A computerized search was performed in PubMed, Web of Science, the Cochrane Collaboration Database, Evidence Database, Evidence Based Medicine Search review, National Guidelines, EM-BASE, Scopus and Google Scholar system (from 1995 to April 30, 2021). The PICOS model was used to define inclusion and exclusion criteria. Out of 123 studies initially found, 18 met the eligibility criteria and were included in the review. Data from 367 athletes from different disciplines were examined. The evidence was grouped in 4 areas: oxidative stress, muscle and energy recovery, muscle repair, and metabolic acidosis. Evidence showed that vitamins, minerals, and some natural ergo-nutritional products are effective as antioxidants. Carbohydrates and protein determine the recovery effect. Sodium bicarbonate has a role as primary acidosis metabolic delayer. Accordingly, ergo-nutritional aids can help in the recovery process. Considering the effects outlined in the literature, more studies are needed to provide firm evidence.

Producción Científica

Isaac López Laval mail , Diego Marqués Giménez mail , Álvaro Velarde-Sotres mail alvaro.velarde@uneatlantico.es, Sebastian Sitko mail , Julio Calleja Gonzalez mail ,

López Laval

<a class="ep_document_link" href="/499/1/s12645-021-00107-6.pdf"><img class="ep_doc_icon" alt="[img]" src="/499/1.hassmallThumbnailVersion/s12645-021-00107-6.pdf" border="0"/></a>

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Non-homogeneous dispersion of graphene in polyacrylonitrile substrates induces a migrastatic response and epithelial-like differentiation in MCF7 breast cancer cells

Background Recent advances from studies of graphene and graphene-based derivatives have highlighted the great potential of these nanomaterials as migrastatic agents with the ability to modulate tumor microenvironments. Nevertheless, the administration of graphene nanomaterials in suspensions in vivo is controversial. As an alternative approach, herein, we report the immobilization of high concentrations of graphene nanoplatelets in polyacrylonitrile film substrates (named PAN/G10) and evaluate their potential use as migrastatic agents on cancer cells. Results Breast cancer MCF7 cells cultured on PAN/G10 substrates presented features resembling mesenchymal-to-epithelial transition, e.g., (i) inhibition of migratory activity; (ii) activation of the expression of E-cadherin, cytokeratin 18, ZO-1 and EpCAM, four key molecular markers of epithelial differentiation; (iii) formation of adherens junctions with clustering and adhesion of cancer cells in aggregates or islets, and (iv) reorganization of the actin cytoskeleton resulting in a polygonal cell shape. Remarkably, assessment with Raman spectroscopy revealed that the above-mentioned events were produced when MCF7 cells were preferentially located on top of graphene-rich regions of the PAN/G10 substrates. Conclusions The present data demonstrate the capacity of these composite substrates to induce an epithelial-like differentiation in MCF7 breast cancer cells, resulting in a migrastatic effect without any chemical agent-mediated signaling. Future works will aim to thoroughly evaluate the mechanisms of how PAN/G10 substrates trigger these responses in cancer cells and their potential use as antimetastatics for the treatment of solid cancers.

Producción Científica

Nazely Diban mail , Marián Mantecón-Oria mail , María T. Berciano mail , Alba Puente-Bedia mail , María J. Rivero mail , Ane Urtiaga mail , Miguel Lafarga mail , Olga Tapia Martínez mail olga.tapia@uneatlantico.es,

Diban