Items where Subject is "Subjects > Nutrition"

2023

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Fundación Universitaria Internacional de Colombia > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Cerrado Inglés Diets enriched in plant-based foods are associated with the maintenance of a good well-being and with the prevention of many non-communicable diseases. The health effects of fruits and vegetables consumption are mainly due to the presence of micronutrients, including vitamins and minerals, and polyphenols, plant secondary metabolites. One of the most important classes of phenolic compounds are anthocyanins, that confer the typical purple-red color to many foods, such as berries, peaches, plums, red onions, purple corn, eggplants, as well as purple carrots, sweet potatoes and red cabbages, among others. This commentary aims to briefly highlight the progress made by science in the last years, focusing on some unexpected aspects related with anthocyanins, such as their bioavailability, their health effects and their relationship with gut microbiota metadata Giampieri, Francesca and Cianciosi, Danila and Alvarez-Suarez, José M. and Quiles, José L. and Forbes-Hernández, Tamara Y. and Navarro-Hortal, María D. and Machì, Michele and Pali-Casanova, Ramón and Martínez Espinosa, Julio César and Chen, Xiumin and Zhang, Di and Bai, Weibin and Lingmin, Tian and Mezzetti, Bruno and Battino, Maurizio and Diaz, Yasmany Armas mail francesca.giampieri@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, jose.quiles@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, ramon.pali@unini.edu.mx, ulio.martinez@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es, UNSPECIFIED (2023) Anthocyanins: what do we know until now? Journal of Berry Research. pp. 1-6. ISSN 18785093

Article Subjects > Biomedicine
Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Abierto Inglés The genus Aeromonas has received constant attention in different areas, from aquaculture and veterinary medicine to food safety, where more and more frequent isolates are occurring with increased resistance to antibiotics. The present paper studied the interaction of Aeromonas strains isolated from fresh produce and water with different eukaryotic cell types with the aim of better understanding the cytotoxic capacity of these strains. To study host-cell pathogen interactions in Aeromonas, we used HT-29, Vero, J774A.1, and primary mouse embryonic fibroblasts. These interactions were analyzed by confocal microscopy to determine the cytotoxicity of the strains. We also used Galleria mellonella larvae to test their pathogenicity in this experimental model. Our results demonstrated that two strains showed high cytotoxicity in epithelial cells, fibroblasts, and macrophages. Furthermore, these strains showed high virulence using the G. mellonella model. All strains used in this paper generally showed low levels of resistance to the different families of the antibiotics being tested. These results indicated that some strains of Aeromonas present in vegetables and water pose a potential health hazard, displaying very high in vitro and in vivo virulence. This pathogenic potential, and some recent concerning findings on antimicrobial resistance in Aeromonas, encourage further efforts in examining the precise significance of Aeromonas strains isolated from foods for human consumption. metadata Pintor-Cora, Alberto and Tapia Martínez, Olga and Elexpuru Zabaleta, Maria and Ruiz de Alegría, Carlos and Rodríguez-Calleja, Jose M. and Santos, Jesús A. and Ramos Vivas, Jose mail UNSPECIFIED, olga.tapia@uneatlantico.es, maria.elexpuru@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, jose.ramos@uneatlantico.es (2023) Cytotoxicity and Antimicrobial Resistance of Aeromonas Strains Isolated from Fresh Produce and Irrigation Water. Antibiotics, 12 (3). p. 511. ISSN 2079-6382

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Inglés Ocimum is considered the largest genus in the Lamiacea family. The genus includes basil, a group of aromatic plants with a wide range of culinary uses that nowadays draws attention for its medicinal and pharmaceutical potential. This systematic review intends to explore the chemical composition of nonessential oils and their variation across different Ocimum species. Moreover, we aimed to identify the state of knowledge regarding the molecular space in this genus as well as the different methods of extraction/identification and geographical location. Seventy-nine eligible articles were selected for the final analysis, from which we extracted more than 300 molecules. We found that the countries with the highest number of studies into Ocimum species are India, Nigeria, Brazil, and Egypt. However, from all known species of Ocimum, only 12 were found to have an extensive chemical characterization, particularly Ocimum basilicum and Ocimum tenuiflorum. Our study focused especially on alcoholic, hydroalcoholic, and water extracts, in which the main techniques for compound identifications are GC-MS, LC-MS, and LC-UV. Across the compiled molecules, we found a wide variety of compounds, especially flavonoids, phenolic acids, and terpenoids, suggesting that this genus could be a very useful source of possible bioactive compounds. The information collected in this review also emphasizes the huge gap between the vast number of Ocimum species discovered and the number of studies in each of them that determined the chemical characterization. metadata Beltrán-Noboa, Andrea and Jordan-Álvarez, Alejandro and Guevara-Terán, Mabel and Gallo, Blanca and Berrueta, Luis A. and Giampieri, Francesca and Battino, Maurizio and Álvarez-Suarez, José M. and Tejera, Eduardo mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es, UNSPECIFIED, UNSPECIFIED (2023) Exploring the Chemistry of Ocimum Species under Specific Extractions and Chromatographic Methods: A Systematic Review. ACS Omega. ISSN 2470-1343

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production Abierto Inglés There is growing evidence that Alzheimer’s disease (AD) can be prevented by reducing risk factors involved in its pathophysiology. Food-derived bioactive molecules can help in the prevention and reduction of the progression of AD. Honey, a good source of antioxidants and bioactive molecules, has been tied to many health benefits, including those from neurological origin. Monofloral avocado honey (AH) has recently been characterized but its biomedical properties are still unknown. The aim of this study is to further its characterization, focusing on the phenolic profile. Moreover, its antioxidant capacity was assayed both in vitro and in vivo. Finally, a deep analysis on the pathophysiological features of AD such as oxidative stress, amyloid-β aggregation, and protein-tau-induced neurotoxicity were evaluated by using the experimental model C. elegans. AH exerted a high antioxidant capacity in vitro and in vivo. No toxicity was found in C. elegans at the dosages used. AH prevented ROS accumulation under AAPH-induced oxidative stress. Additionally, AH exerted a great anti-amyloidogenic capacity, which is relevant from the point of view of AD prevention. AH exacerbated the locomotive impairment in a C. elegans model of tauopathy, although the real contribution of AH remains unclear. The mechanisms under the observed effects might be attributed to an upregulation of daf-16 as well as to a strong ROS scavenging activity. These results increase the interest to study the biomedical applications of AH; however, more research is needed to deepen the mechanisms under the observed effects metadata Romero-Márquez, Jose M. and Navarro-Hortal, María D. and Orantes, Francisco J. and Esteban-Muñoz, Adelaida and Mazas Pérez-Oleaga, Cristina and Battino, Maurizio and Sánchez-González, Cristina and Rivas-García, Lorenzo and Giampieri, Francesca and Quiles, José L. and Forbes-Hernandez, Tamara Y. mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, cristina.mazas@uneatlantico.es, maurizio.battino@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, francesca.giampieri@uneatlantico.es, jose.quiles@uneatlantico.es, tamara.forbes@unini.edu.mx (2023) In Vivo Anti-Alzheimer and Antioxidant Properties of Avocado (Persea americana Mill.) Honey from Southern Spain. Antioxidants, 12 (2). p. 404. ISSN 2076-3921

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production Abierto Inglés Alzheimer’s Disease (AD) is the cause of around 60–70% of global cases of dementia and approximately 50 million people have been reported to suffer this disease worldwide. The leaves of olive trees (Olea europaea) are the most abundant by-products of the olive grove industry. These by-products have been highlighted due to the wide variety of bioactive compounds such as oleuropein (OLE) and hydroxytyrosol (HT) with demonstrated medicinal properties to fight AD. In particular, the olive leaf (OL), OLE, and HT reduced not only amyloid-β formation but also neurofibrillary tangles formation through amyloid protein precursor processing modulation. Although the isolated olive phytochemicals exerted lower cholinesterase inhibitory activity, OL demonstrated high inhibitory activity in the cholinergic tests evaluated. The mechanisms underlying these protective effects may be associated with decreased neuroinflammation and oxidative stress via NF-κB and Nrf2 modulation, respectively. Despite the limited research, evidence indicates that OL consumption promotes autophagy and restores loss of proteostasis, which was reflected in lower toxic protein aggregation in AD models. Therefore, olive phytochemicals may be a promising tool as an adjuvant in the treatment of AD. metadata Romero-Márquez, Jose M. and Forbes-Hernández, Tamara Y. and Navarro-Hortal, María D. and Quirantes-Piné, Rosa and Grosso, Giuseppe and Giampieri, Francesca and Lipari, Vivian and Sánchez-González, Cristina and Battino, Maurizio and Quiles, José L. mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, francesca.giampieri@uneatlantico.es, vivian.lipari@uneatlantico.es, UNSPECIFIED, maurizio.battino@uneatlantico.es, jose.quiles@uneatlantico.es (2023) Molecular Mechanisms of the Protective Effects of Olive Leaf Polyphenols against Alzheimer’s Disease. International Journal of Molecular Sciences, 24 (5). p. 4353. ISSN 1422-0067

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Inglés Olive-derived bioactive compound oleuropein was evaluated against damage induced by hydrogen peroxide in human trophoblast cells in vitro, by examining the changes in several markers implicated in oxidative stress interactions in the placenta. Trophoblast HTR-8/SVneo cells were preincubated with OLE at 10 and 100 µM and exposed to H2O2, as a model of oxidative stress. Protein and lipid peroxidation, as well as antioxidant enzymes’ activity, were determined spectrophotometrically, and DNA damage was evaluated by comet assay. iNOS protein expression was assessed by Western blot, while the mRNA expression of pro- and anti-apoptotic genes BAX and BCL2 and transcription factor NFE2L2, as well as cytokines IL-6 and TNF α were determined by qPCR. Oleuropein demonstrated cytoprotective effects against H2O2 in trophoblast cells by significantly improving the antioxidant status and preventing protein and lipid damage, as well as reducing the iNOS levels. OLE reduced the mRNA expression of IL-6 and TNF α, however, it did not influence the expression of NFE2L2 or the BAX/BCL2 ratio after H2O2 exposure. Oleuropein per se did not lead to any adverse effects in HTR-8/SVneo cells under the described conditions, confirming its safety in vitro. In conclusion, it significantly attenuated oxidative damage and restored antioxidant functioning, confirming its protective role in trophoblast metadata Pirković, Andrea and Vilotić, Aleksandra and Borozan, Sunčica and Nacka-Aleksić, Mirjana and Bojić-Trbojević, Žanka and Krivokuća, Milica Jovanović and Battino, Maurizio and Giampieri, Francesca and Dekanski, Dragana mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es, francesca.giampieri@uneatlantico.es, UNSPECIFIED (2023) Oleuropein Attenuates Oxidative Stress in Human Trophoblast Cells. Antioxidants, 12 (1). p. 197. ISSN 2076-3921

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production Cerrado Inglés Inflammatory bowel disease (IBD) patients are at substantially higher risk of colorectal cancer (CRC) and IBD-associated CRC accounts for roughly 10-15% of the annual mortality in IBD patients. IBD-related CRC also affects younger patients if compared with sporadic CRC, with a 5-year survival rate of 50%. Regardless of medical therapies, the persistent inflammation state characterizing IBD raises the risk for precancerous changes and CRC, with additional input from several elements including genetic and environmental risk factors, IBD-associated comorbidities, intestinal barrier disfunction, and gut microbiota modifications. It is well known that nutritional habits and dietary bioactive compounds can influence IBD-associated inflammation, microbiome abundance and composition, oxidative stress balance, and gut permeability. In addition, in the last years, results from broad epidemiological and experimental studies have associated certain foods or nutritional patterns with the risk of colorectal neoplasia. Here we review the possible role of nutrition in the prevention of IBD-related CRC, focusing specifically on human studies. In conclusion it emerges that nutritional interventions based on healthy, nutrient-dense dietary patterns characterized by a high intake of fiber, vegetables, fruit, Omega-3 PUFAs, and low amount of animal proteins, processed foods and alcohol, combined with probiotic supplementation have the potential of reducing IBD-activity and preventing the risk of IBD-related CRC through different mechanisms, suggesting that targeted nutritional interventions may represent a novel promising approach for the prevention and management of IBD-associated CRC. metadata Cassotta, Manuela and Cianciosi, Danila and De Giuseppe, Rachele and Navarro-Hortal, Maria Dolores and Diaz, Yasmany Armas and Forbes-Hernández, Tamara Yuliett and Tutusaus, Kilian and Pascual Barrera, Alina Eugenia and Grosso, Giuseppe and Xiao, Jianbo and Battino, Maurizio and Giampieri, Francesca mail manucassotta@gmail.com, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, kilian.tutusaus@uneatlantico.es, alina.pascual@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es, francesca.giampieri@uneatlantico.es (2023) Possible role of nutrition in the prevention of Inflammatory Bowel Disease-related colorectal cancer: a focus on human studies. Nutrition. p. 111980. ISSN 08999007

Article Subjects > Biomedicine
Subjects > Engineering
Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production Cerrado Inglés Obesity and overweight has increased in the last year and has become a pandemic disease, the result of sedentary lifestyles and unhealthy diets rich in sugars, refined starches, fats and calories. Machine learning (ML) has proven to be very useful in the scientific community, especially in the health sector. With the aim of providing useful tools to help nutritionists and dieticians, research focused on the development of ML and Deep Learning (DL) algorithms and models is searched in the literature. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol has been used, a very common technique applied to carry out revisions. In our proposal, 17 articles have been filtered in which ML and DL are applied in the prediction of diseases, in the delineation of treatment strategies, in the improvement of personalized nutrition and more. Despite expecting better results with the use of DL, according to the selected investigations, the traditional methods are still the most used and the yields in both cases fluctuate around positive values, conditioned by the databases (transformed in each case) to a greater extent than by the artificial intelligence paradigm used. Conclusions: An important compilation is provided for the literature in this area. ML models are time-consuming to clean data, but (like DL) they allow automatic modeling of large volumes of data which makes them superior to traditional statistics. metadata Ferreras, Antonio and Sumalla Cano, Sandra and Martínez-Licort, Rosmeri and Elío Pascual, Iñaki and Tutusaus, Kilian and Prola, Thomas and Vidal Mazón, Juan Luis and Sahelices, Benjamín and de la Torre Díez, Isabel mail UNSPECIFIED, sandra.sumalla@uneatlantico.es, UNSPECIFIED, inaki.elio@uneatlantico.es, kilian.tutusaus@uneatlantico.es, thomas.prola@uneatlantico.es, juanluis.vidal@uneatlantico.es, UNSPECIFIED, UNSPECIFIED (2023) Systematic Review of Machine Learning applied to the Prediction of Obesity and Overweight. Journal of Medical Systems, 47 (1). ISSN 1573-689X

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Cerrado Inglés Functional foods have emerged as an attractive option for many consumers, given their wide-ranging and long-term benefits. The functional food market size was valued at USD 177,770 Million in 2019 and is estimated to reach USD 267,924.4 Million by 2027, registering a CAGR of 6.7% from 2021 to 2027. Various natural products/compounds exert significant functional activity, and could also added value to food products alone or in combination, provided functional activity. The use of natural compounds in preparation of functional foods is important due to its higher safety, superior organoleptic properties, and functional attributes, resulted in wider consumer acceptance. Also, the use of advanced technologies in formulation of functional foods provides a better means of utilizing natural compounds for organoleptic and functional attributes. metadata Battino, Maurizio and Belwal, Tarun and Prieto, Miguel A. mail maurizio.battino@uneatlantico.es, UNSPECIFIED, UNSPECIFIED (2023) Valorization of food products using natural functional compounds for improving organoleptic and functional chemistry. Food Chemistry, 403. p. 134181. ISSN 03088146

2022

Article Subjects > Biomedicine
Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Abierto Inglés Background: The aim of this study was to relate adherence to the Mediterranean diet (MedDiet) to the prevalence of metabolic syndrome (MetS) in an elderly population from the north of Spain. Methods: We carried out an observational, descriptive, cross-sectional, and correlational study involving 556 non-institutionalised individuals aged 65 to 79 years. The MEDAS-14 questionnaire score was used to define the degree of adherence to the Mediterranean diet. The diagnosis of MetS was conducted using the International Diabetes Federation (IDF) criteria. Results: In 264 subjects with an average age of 71.9 (SD: ±4.2), 39% of whom were men, 36.4% had good adherence (score ≥ 9 in MEDAS-14), with no differences by gender or age. The prevalence of MetS was 40.2%, with 47.6% in men and 35.4% in women (p < 0.05). The prevalence of MetS was 2.4 times more frequent among individuals who consumed less than two servings (200 g) of vegetables daily compared with those who consumed two or more servings of vegetables daily (OR: 2.368, 95%CI: 1.141–4.916, p = 0.021). Low adherence to the MedDiet (MEDAS-14 score ≤ 8) was associated with an 82% higher prevalence of MetS (OR: 1.817, 95%CI: 1.072–3.081, p = 0.027). Conclusion: An inverse relationship was established between adherence to the MedDiet and the prevalence of MetS metadata Cubas-Basterrechea, Gloria and Elío Pascual, Iñaki and Alonso, Guzmán and Otero, Luis and Gutiérrez-Bardeci, Luis and Puente, Jesús and Muñoz-Cacho, Pedro mail UNSPECIFIED, inaki.elio@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2022) Adherence to the Mediterranean Diet Is Inversely Associated with the Prevalence of Metabolic Syndrome in Older People from the North of Spain. Nutrients, 14 (21). p. 4536. ISSN 2072-6643

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production Abierto Inglés Age-related macular degeneration (AMD) is a serious degenerative disease affecting the eyes, and is the main cause of severe vision loss among people >55 years of age in developed countries. Its onset and progression have been associated with several genetic and lifestyle factors, with diet appearing to play a pivotal role in the latter. In particular, dietary eating patterns rich in plant foods have been shown to lower the risk of developing the disease, and to decrease the odds of progressing to more advanced stages in individuals already burdened with early AMD. We systematically reviewed the literature to analyse the relationship between the adherence to a Mediterranean diet, a mainly plant-based dietary pattern, and the onset/progression of AMD. Eight human observational studies were analysed. Despite some differences, they consistently indicate that higher adherence to a Mediterranean eating pattern lowers the odds of developing AMD and decreases the risk of progression to more advanced stages of the disease, establishing the way for preventative measures emphasizing dietary patterns rich in plant-foods metadata Gastaldello, Annalisa and Giampieri, Francesca and Quiles, José L. and Navarro-Hortal, María D. and Aparicio Obregón, Silvia and García Villena, Eduardo and Tutusaus, Kilian and De Giuseppe, Rachele and Grosso, Giuseppe and Cianciosi, Danila and Forbes-Hernández, Tamara Y. and Nabavi, Seyed M. and Battino, Maurizio mail UNSPECIFIED, francesca.giampieri@uneatlantico.es, jose.quiles@uneatlantico.es, UNSPECIFIED, silvia.aparicio@uneatlantico.es, eduardo.garcia@uneatlantico.es, kilian.tutusaus@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2022) Adherence to the Mediterranean-Style Eating Pattern and Macular Degeneration: A Systematic Review of Observational Studies. Nutrients, 14 (10). p. 2028. ISSN 2072-6643

Article Subjects > Biomedicine
Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Abierto Inglés Alzheimer's is a chronic degenerative disease of the central nervous system considered the leading cause of dementia in the world. It is characterized by two etiopathological events related to oxidative stress: the aggregation of β-amyloid peptide and the formation of neurofibrillary tangles of hyperphosphorylated Tau protein in the brain. The incidence of this disease increases with age and has been associated with inadequate lifestyles. Some natural compounds have been shown to improve the hallmarks of the disease. However, despite its potential, there is no scientific evidence about Manuka honey (MH) in this regard. In the present work we evaluated the effect of MH on the toxicity induced by Aβ aggregation and Tau in a Caenorhabditis elegans model. Our results demonstrated that MH was able to improve indicators of oxidative stress and delayed Aβ-induced paralysis in the AD model CL4176 through HSP-16.2 and SKN-1/NRF2 pathways. Nevertheless, its sugar content impaired the indicators of locomotion (an indicator of tau neurotoxicity) in both the transgenic strain BR5706 and in the wild-type N2 worms. metadata Navarro-Hortal, María D. and Romero-Márquez, Jose M. and Muñoz-Ollero, Pedro and Jiménez-Trigo, Victoria and Esteban-Muñoz, Adelaida and Tutusaus, Kilian and Giampieri, Francesca and Battino, Maurizio and Sánchez-González, Cristina and Rivas-García, Lorenzo and Llopis, Juan and Forbes-Hernández, Tamara Y. and Quiles, José L. mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, kilian.tutusaus@uneatlantico.es, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, jose.quiles@uneatlantico.es (2022) Amyloid β-but not Tau-induced neurotoxicity is suppressed by Manuka honey via HSP-16.2 and SKN-1/Nrf2 pathways in an in vivo model of Alzheimer's disease. Food & Function. ISSN 2042-6496

Thesis Subjects > Nutrition Europe University of Atlantic > Teaching > Final Degree Projects Cerrado Español La alarmante incidencia del sobrepeso y la obesidad alienta a investigar dietas como el ayuno intermitente (AI) o la dieta cetogénica (DC) respecto a la conocida restricción calórica continua (RCC). El objetivo del presente trabajo fue revisar y comparar la información actual acerca del uso del AI, la DC y la RCC para la pérdida de peso en adultos con sobrepeso y obesidad. metadata Bermejo Palacio, Celia mail UNSPECIFIED (2022) Ayuno intermitente, dieta cetogénica y restricción calórica continua para la pérdida de peso en adultos con sobrepeso y obesidad. Diploma thesis, Universidad Europea del Atlántico.

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Inglés Beside honey, honeybees (Apis mellifera L.) are able to produce many byproducts, including bee pollen, propolis, bee bread, royal jelly, and beeswax. Even if the medicinal properties of these byproducts have been recognized for thousands of years by the ancient civilizations, in the modern era, they have a limited use, essentially as nutritional supplements or health products. However, these natural products are excellent sources of bioactive compounds, macro- and micronutrients, that, in a synergistic way, confer multiple biological activities to these byproducts, such as, for example, antimicrobial, antioxidant, and anti-inflammatory properties. This work aims to update the chemical and phytochemical composition of bee pollen, propolis, bee bread, royal jelly, and beeswax and to summarize the main effects exerted by these byproducts on human health, from the anticancer and immune-modulatory activities to the antidiabetic, hypolipidemic, hypotensive, and anti-allergic properties. metadata Giampieri, Francesca and Quiles, José L. and Cianciosi, Danila and Forbes-Hernández, Tamara Yuliett and Orantes-Bermejo, Francisco Josè and Alvarez-Suarez, José Miguel and Battino, Maurizio mail francesca.giampieri@uneatlantico.es, jose.quiles@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2022) Bee Products: An Emblematic Example of Underutilized Sources of Bioactive Compounds. Journal of Agricultural and Food Chemistry. ISSN 0021-8561

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Abierto Inglés The aim of this study was to evaluate the influence of the lockdown due to the COVID-19 pandemic, on eating and physical activity behavior, in a university population. A healthy diet such as the Mediterranean Diet (MD) pattern, rich in fruit and vegetables, can prevent degenerative diseases such as obesity, diabetes, cardiovascular diseases, etc. We conducted a cross-sectional study and data were collected by an anonymous online questionnaire. Participants completed a survey consisting of 3 sections: sociodemographic data; dietary behavior and physical activity; the Mediterranean Diet questionnaire (MEDAS-14) and the Emotional Eater Questionnaire (EEQ). A total of 168 participants completed the questionnaire: 66.7% were women, 79.2% were from Spain, 76.8% were students, 76.2% lived in their family home and 66.1% were of normal weight. During lockdown our population shopped for groceries 1 time or less per week (76.8%); maintained the same consumption of fruits (45.2%), vegetables (50.6%), dairy products (61.9%), pulses (64.9%), fish/seafood (57.7%), white meat (77.4%), red and processed meat (71.4%), pastries and snacks (48.2%), rice/pasta/potatoes (70.2%) and nuts (62.5%), spirits (98.8%) and sugary drinks (91.7%). Cooking time increased (73.2%) and the consumption decreased of low alcohol drinks (60.1%), spirits (75%) and sugary drinks (57.1%), and physical activity also diminished (49.4%). University Employees (UE) gained more weight (1.01 ± 0.02) than students (0.99 ± 0.03) (p < 0.05) during the confinement period. A total of 79.8% of the participants obtained a Medium/High Adherence to the MD during lockdown. Emotional and very emotional eaters were higher in the female group (p < 0.01). In the event of further confinement, strategies should be implemented to promote a balanced and healthy diet together with the practice of physical activity, taking special care of the female and UE groups. metadata Sumalla Cano, Sandra and Forbes-Hernández, Tamara and Aparicio-Obregón, Silvia and Crespo-Álvarez, Jorge and Elexpuru Zabaleta, Maria and Gracia Villar, Mónica and Giampieri, Francesca and Elío Pascual, Iñaki mail sandra.sumalla@uneatlantico.es, UNSPECIFIED, silvia.aparicio@uneatlantico.es, jorge.crespo@uneatlantico.es, maria.elexpuru@uneatlantico.es, monica.gracia@uneatlantico.es, francesca.giampieri@uneatlantico.es, inaki.elio@uneatlantico.es (2022) Changes in the Lifestyle of the Spanish University Population during Confinement for COVID-19. International Journal of Environmental Research and Public Health, 19 (4). p. 2210. ISSN 1660-4601

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Inglés This study reports a characterization of the nutritional quality of several vegetables belonging to Brassica genus and other species cultivated in the central Italy. The aim of this trial is to investigate the antioxidant capacity and phytochemical content of several vegetable products during two consecutive years. The sensorial quality is investigated with the measuring of soluble solid content (SSC), titratable acidity (TA) and pH; the nutritional quality is investigated by the measurement of the total antioxidant capacity (TAC), the total phenols content (TPH), the total anthocyanins content (ACY), and the vitamin C content. The results confirm the highest antioxidant capacity of Brassica genus, in particular, the red curly kale (13.68 and 11.97 mM Trolox/kg fw in the two locations tested); among other vegetables analyzed, the most interesting are chicory and borage (10.3 and 11.94 mM Trolox/kg fw in the first year of cultivation in Valdaso, respectively). A high intake of these vegetables may bring a lot of health benefits linked to their antioxidative capacity and the vitamin C metadata Biondi, Francesca and Balducci, Francesca and Capocasa, Franco and Mei, Elena and Vagnoni, Massimo and Visciglio, Marino and Mezzetti, Bruno and Mazzoni, Luca mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, bruno.mezzetti@uneatlantico.es, UNSPECIFIED (2022) Characterization and Comparison of Raw Brassica and Grass Field Sensorial and Nutritional Quality. Applied Sciences, 12 (17). p. 8783. ISSN 2076-3417

Thesis Subjects > Nutrition Europe University of Atlantic > Teaching > Final Degree Projects Cerrado Español Introducción: El trastorno depresivo mayor (TDM) es una patología de elevada prevalencia que incapacita a la persona que la sufre. Distintos modelos dietéticos saludables como la dieta mediterránea, la dieta DASH, la dieta MIND y la dieta vegetariana son estudiadas como estrategias preventivas de este trastorno. Objetivos: Comparar los efectos de la dieta mediterránea, la dieta DASH, la dieta MIND y la dieta vegetariana para determinar cuál es la mejor opción dietética preventiva en el TDM. Material y métodos: Se realizó una revisión bibliográfica, para la cual se seleccionaron y consultaron varios artículos científicos, documentos y libros. Se estudiaron con profundidad una totalidad de 10 artículos para llegar a la conclusión de la revisión. Discusión y conclusiones: Existe evidencia científica que afirma que el seguimiento de unos patrones dietéticos saludables se relacione con reducción de sintomatología depresiva y de prevención de la misma. Estos patrones confieren propiedades nutricionales que proporcionan buena salud. En lo que respecta al TDM, cabe destacar la dieta mediterránea como mejor opción preventiva debido a la elevada disponibilidad, rentabilidad local y valor sociocultural. metadata Rodríguez Salmón, Natalia mail UNSPECIFIED (2022) Comparación de distintos patrones dietéticos para la prevención del trastorno depresivo mayor. Diploma thesis, Universidad Europea del Atlántico.

Article Subjects > Biomedicine
Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Español Ever since coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, was declared a pandemic on March 11, 2020, by the WHO, a concerted effort has been made to find compounds capable of acting on the virus and preventing its replication. In this context, researchers have refocused part of their attention on certain natural compounds that have shown promising effects on the virus. Considering the importance of this topic in the current context, this study aimed to present a critical review and analysis of the main reports of plant-derived compounds as possible inhibitors of the two SARS-CoV-2 proteases: main protease (Mpro) and Papain-like protease (PLpro). From the search in the PubMed database, a total of 165 published articles were found that met the search patterns. A total of 590 unique molecules were identified from a total of 122 articles as potential protease inhibitors. At the same time, 114 molecules reported as natural products and with annotation of theoretical support and antiviral effects were extracted from the COVID-19 Help database. After combining the molecules extracted from articles and those obtained from the database, we identified 648 unique molecules predicted as potential inhibitors of Mpro and/or PLpro. According to our results, several of the predicted compounds with higher theoretical confidence are present in many plants used in traditional medicine and even food, such as flavonoids, carboxylic acids, phenolic acids, triterpenes, terpenes phytosterols, and triterpenoids. These are potential inhibitors of Mpro and PLpro. Although the predictions of several molecules against SARS-CoV-2 are promising, little experimental information was found regarding certain families of compounds. Only 45 out of the 648 unique molecules have experimental data validating them as inhibitors of Mpro or PLpro, with the most frequent scaffold present in these 45 compounds being the flavone. The novelty of this work lies in the analysis of the structural diversity of the chemical space among the molecules predicted as inhibitors of SARS-CoV-2 Mpro and PLpro proteases and the comparison to those molecules experimentally validated. This work emphasizes the need for experimental validation of certain families of compounds, preferentially combining classical enzymatic assays with interaction-based methods. Furthermore, we recommend checking the presence of Pan-Assay Interference Compounds (PAINS) and the presence of molecules previously reported as inhibitors of Mpro or PLpro to optimize resources and time in the discovery of new SARS-CoV-2 antivirals from plant-derived molecules. metadata Guerra, Yasel and Celi, Diana and Cueva, Paul and Perez-Castillo, Yunierkis and Giampieri, Francesca and Alvarez-Suarez, José Miguel and Tejera, Eduardo mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, francesca.giampieri@uneatlantico.es, UNSPECIFIED, UNSPECIFIED (2022) Critical Review of Plant-Derived Compounds as Possible Inhibitors of SARS-CoV-2 Proteases: A Comparison with Experimentally Validated Molecules. ACS Omega. ISSN 2470-1343

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Inglés, Español Las alteraciones metabólicas suponen hoy en día una de las afecciones más padecidas en todo el mundo. Es por ello, que la indagación en el estudio sobre la influencia de la hora de la ingesta en el metabolismo de un nutriente, es de gran importancia para el desarrollo y aplicación de nuevos tratamientos en lo que a estas enfermedades respecta. Mediante esta revisión bibliográfica, a través de la búsqueda bibliográfica profunda en diferentes bases de datos, se han obtenido diversos archivos, documentos, artículos y estudios que han servido para el análisis, desarrollo y ejecución del vigente artículo. La molécula de la glucosa presenta niveles más acentuados en la tarde versus la mañana, debido a la disminución de la actividad de la insulina con el avance del día. La mayoría de los lípidos presentan sus niveles más altos en la mañana, a excepción de los triglicéridos mostrándolos en la tarde. En cuanto a las proteínas se necesita más estudio para su conocimiento en este aspecto. Se requiere de más investigación para poder obtener una conclusión más exacta. Aun así, se puede concluir en que la hora de la ingesta es un factor que afecta en la ritmicidad de los procesos metabólicos, interfiriendo y alterando la actividad y respuesta de los nutrientes. metadata Conde González, Sandra mail UNSPECIFIED (2022) Crononutrición: efecto de la hora de la ingesta en el metabolismo de los nutrientes. MLS Health & Nutrition Research, 1 (2).

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Inglés, Español En España se generan 1.726.000 toneladas anuales de lactosuero. En particular, en Cantabria se habla de una generación de lactosuero de 15.600 toneladas al año. El lactosuero se considera un residuo altamente contaminante si se vierte directamente al medioambiente dado su contenido elevado en materia orgánica. Con este proyecto se buscaba desarrollar nuevos métodos para el tratamiento y aprovechamiento de este residuo. La separación de la fracción sólida del lactosuero fermentado se puede conseguir de forma sostenible y efectiva con bentonita. Por su parte, en la composición de la fracción líquida acidificada, clarificada y esterilizada (LCE), no se observaron presencia de compuestos de interés económico para la industria láctea. En cambio, sí se detectaron oportunidades para convertirlo en subproductos de valor añadido para el sector agrícola y conservero. En el caso de la agricultura, se trabajó en la obtención de un nuevo bioestimulante capaz de aportar minerales, proteínas, regulación del pH, etc. Por otro lado, también se considera que el mercado de la industria alimentaria de conservas vegetales puede suponer un mercado objetivo que integre este subproducto como líquido de cobertura (conservador) pudiendo sustituir al vinagre metadata Rosas Staff, Jesús Emilio and Acebo Garfias, María José mail UNSPECIFIED (2022) Desarrollo de tecnologías para la reutilización sostenible del lactosuero. Environmental Sciences and Practices, 1 (1).

Article Subjects > Engineering
Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Inglés, Español El proyecto persigue el aprovechamiento de los residuos del sector alimentario cántabro (residuos cereales de la industria de bebidas espirituosas y el suero de leche), con el objeto de fabricar un sustrato plástico comestible, biodegradable y compostable, como alternativa a la producción de plásticos actual, aportando una solución a favor de la valorización de residuos industriales. Para el desarrollo del sustrato plástico comestible, se partió de los compuestos arabinoxilanos y kefirán, provenientes de residuos cereales y del suero lácteo respectivamente. Se desarrollaron varias formulaciones para crear un prototipo pre-industrial del biocompuesto para el sustrato plástico comestible, asimismo, se realizó una búsqueda sobre el uso del lactosuero para la obtención de biofilm. Se elaboró un plan de explotación que evidenció la necesidad de vender 1900 kg de pellets de bioplástico al mes para asegurar la viabilidad económica del proceso. Esta producción tendría un coste unitario de 15 €/kg, inferior al precio de venta estimado de 20€/kg. Aunque se estima que el margen de beneficio empresarial no sería muy alto, los impactos ambientales positivos son suficientemente buenos como para considerar la implantación de la solución desarrollada. metadata Balsa Núñez, María and Martínez de la Fuente, Jorge mail UNSPECIFIED (2022) Desarrollo de un bioplástico comestible y compostable a partir de residuos de la industria alimentaria. Environmental Sciences and Practices, 1 (1).

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Inglés Background: To develop and validate a questionnaire for the screening of Vitamin D in Italian adults (Evaluation Vitamin D dEficieNCy Questionnaire, EVIDENCe-Q). Methods: 150 participants, attending the 11Clinical Nutrition and Dietetics Operative Unit, Internal Medicine and Endocrinology, Istituti Clinici Scientifici Maugeri IRCCS, of Pavia were enrolled. Demographic variables and serum levels of vitamin D were recorded. The EVIDENCe-Q included information regarding factors affecting the production, intake, absorption and metabolism of Vitamin D. The EVIDENCe-Q score ranged from 0 (the best status) to 36 (the worst status). Results: Participants showed an inadequate status of Vitamin D, according to the current Italian reference values. A significant difference (p < 0.0001) in the EVIDENCe-Q score was found among the three classes of vitamin D status (severe deficiency, deficiency and adequate), being the mean score higher in severe deficiency and lower in the adequate one. A threshold value for EVIDENCe-Q score of 23 for severe deficiency, a threshold value of 21 for deficiency and a threshold value of 20 for insufficiency were identified. According to these thresholds, the prevalence of severe deficiency, deficiency and insufficiency was 22%, 35.3% and 43.3% of the study population, respectively. Finally, participants with EVIDENCe-Q scores <20 had adequate levels of vitamin D. Conclusions: EVIDENCe-Q can be a useful and easy screening tool for clinicians in their daily practice at a reasonable cost, to identify subjects potentially at risk of vitamin D deficiency and to avoid unwarranted supplementation and/or costly blood testing. metadata De Giuseppe, Rachele and Tomasinelli, Chiara Elena and Cena, Hellas and Braschi, Valentina and Giampieri, Francesca and Preatoni, Giorgia and Centofanti, Domenico and Princis, Maria Pilar and Bartoletti, Emanuele and Biino, Ginevra mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, francesca.giampieri@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2022) Development of a Short Questionnaire for the Screening for Vitamin D Deficiency in Italian Adults: The EVIDENCe-Q Project. Nutrients, 14 (9). p. 1772. ISSN 2072-6643

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Inglés The present study was designed to examine if dietary fat sources that have shown differences in lifespan and if some aging-related aspects can modulate the range of histopathologic changes in central nervous and endocrine systems that occur during the lifespan of Wistar rats. Moreover, it was attempted to gain insight into the relationship between longevity and the development of the different pathological changes, as well as possible interaction with diet. In order to achieve this, male Wistar rats were randomly assigned to three experimental groups fed semisynthetic and isoenergetic diets from weaning until death with different dietary fat sources, namely virgin olive, sunflower, or fish oil. An individual follow-up until death of each animal was performed. Incidence, severity, and burden of specific or group (i.e., neoplastic or non-neoplastic proliferative and non-proliferative) of lesions was calculated along with individual's disease and individual organ lesion burden. Most of the histopathological lesions found have been described in previous studies. Neoplasms, and in particular pituitary adenomas followed by brain tumors, were the most prevalent lesions found in the rats and the main cause of death involving both systems. Incidence of brain lesions was associated with age-at-death. Assayed dietary fats did not present differential effects on pathological changes occurring in endocrine and central nervous systems throughout rat lifespan. metadata Varela-López, Alfonso and Ramírez-Tortosa, César L. and Ramos-Pleguezuelos, Francisco M. and Márquez-Lobo, Bélgica and Battino, Maurizio and Quiles, José L. mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es, jose.quiles@uneatlantico.es (2022) Differences reported in the lifespan and aging of male Wistar rats maintained on diets containing fat with different fatty acid profiles (virgin olive, sunflower or fish oils) are not reflected by histopathological lesions found at death in central nervous and endocrine systems. Food and Chemical Toxicology, 168. p. 113357. ISSN 02786915

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Inglés In a world where 1 billion people suffer from hunger, lands and seas are overexploited and production systems are unsustainable, and there is an urgent need to find alternative foods. In this context, insects represent a good source of macro- and micronutrients and even bioactive compounds that could contribute to reducing nutritional deficiency and preventing some human diseases. However, some aspects related to their consumption, including health risks, need to be clarified. This communication aims to summarize the nutritional/phytochemical profile of common edible insects and the main safety concerns, highlighting the possible strategies to promote entomophagy in a more conscious way. metadata Giampieri, Francesca and Alvarez‐Suarez, José M. and Machì, Michele and Cianciosi, Danila and Navarro‐Hortal, Maria D. and Battino, Maurizio mail francesca.giampieri@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2022) Edible insects: A novel nutritious, functional, and safe food alternative. Food Frontiers. ISSN 2643-8429

Thesis Subjects > Nutrition Europe University of Atlantic > Teaching > Final Degree Projects Cerrado Español Introducción: El síndrome de ovario poliquístico es un problema muy extendido en la población de mujeres mundial. Genera muchas afecciones y problemas secundarios que podrían ser aminorados con una intervención nutricional adecuada. Actualmente, se están aplicando diversas intervenciones como la dieta mediterránea o la dieta cetogénica para tratar de mejorar la calidad de vida de las mujeres con este trastorno. Objetivo: Determinar la intervención nutricional más adecuada en mujeres con síndrome de ovario poliquístico. Material y métodos: Se realizó una revisión bibliográfica a través de diferentes bases de datos. Se priorizó la información de los estudios publicados en los últimos 5 años y de calidad científica y se compararon las conclusiones con las últimas revisiones sistemáticas publicadas. Se emplearon 35 estudios para el análisis científico. Discusión y conclusiones: Se ha demostrado que la dieta mediterránea, la dieta DASH, las dietas cetogénica y bajas en hidratos, la dieta basada en legumbres y el ayuno intermitente pueden generar mejoras positivas en las alteraciones producidas en mujeres con síndrome de ovario poliquístico. Cabe destacar que un patrón dietético saludable y sostenible en el tiempo generará de por sí beneficios en el organismo. metadata Becerril Martínez, Aída mail UNSPECIFIED (2022) Efectos de diferentes intervenciones dietéticas en el síndrome de ovario poliquístico. Diploma thesis, Universidad Europea del Atlántico.

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Inglés Tree nuts, including Brazil nuts, have been hypothesized to impact cardiovascular health through the modulation of oxidative stress and inflammation. Nonetheless, a quantitative analysis of these effects has not been performed. Therefore, the aim of this study was to systematically revise and quantify the effect of Brazil nut intervention on selenium status, blood lipids, and biomarkers of oxidative stress and inflammation using a meta-analytical approach. To meet the goals of this study, a systematic search of PubMed, EMBASE, and Web of Science databases of published randomised clinical trials reporting on dietary interventions with Brazil nuts and their effects on selenium status, blood lipids, and markers of oxidative stress and inflammation was performed. Eight articles were included for systematic review and meta-analysis. Based on the conducted analysis, a significant positive effect of Brazil nuts on selenium blood concentration (SMD = 6.93, 95% CI: 3.99; 9.87) was found. Additionally, a positive effect of Brazil nut intervention on glutathione peroxidase activity (SMD = 0.53, 95% CI: 0.07; 0.99) was observed. However, no significant results were found when considering blood lipid levels, including results for total cholesterol (SMD = −0.22, 95% CI: −0.57; 0.14), HDL cholesterol (SMD = −0.04, 95% CI: −0.28; 0.19) and LDL cholesterol (SMD = −0.15; 95% CI: −0.43; 0.13). In conclusion, the findings from this study suggest that Brazil nut consumption improves selenium status and exerts antioxidant effects, which could be considered a potential pathway for the prevention of metabolic disorders related to altered blood lipid profiles. However, further studies are needed to elucidate the effect of Brazil nuts toward blood lipid profile, also preferably controlling for other biomarkers. metadata Godos, Justyna and Giampieri, Francesca and Micek, Agnieszka and Battino, Maurizio and Forbes-Hernández, Tamara Y. and Quiles, José L. and Paladino, Nadia and Falzone, Luca and Grosso, Giuseppe mail UNSPECIFIED, francesca.giampieri@uneatlantico.es, UNSPECIFIED, maurizio.battino@uneatlantico.es, UNSPECIFIED, jose.quiles@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2022) Effect of Brazil Nuts on Selenium Status, Blood Lipids, and Biomarkers of Oxidative Stress and Inflammation: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Antioxidants, 11 (2). p. 403. ISSN 2076-3921

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Inglés The aim of this review was to explore existing evidence from studies conducted on humans and summarize the mechanisms of action of dietary polyphenols on vascular health, blood pressure and hypertension. There is evidence that some polyphenol-rich foods, including berry fruits rich in anthocyanins, cocoa and green tea rich in flavan-3-ols, almonds and pistachios rich in hydroxycinnamic acids, and soy products rich in isoflavones, are able to improve blood pressure levels. A variety of mechanisms can elucidate the observed effects. Some limitations of the evidence, including variability of polyphenol content in plant-derived foods and human absorption, difficulty disentangling the effects of polyphenols from other dietary compounds, and discrepancy of doses between animal and human studies should be taken into account. While no single food counteracts hypertension, adopting a plant-based dietary pattern including a variety of polyphenol-rich foods is an advisable practice to improve blood pressure metadata Grosso, Giuseppe and Godos, Justyna and Currenti, Walter and Micek, Agnieszka and Falzone, Luca and Libra, Massimo and Giampieri, Francesca and Forbes-Hernández, Tamara Y. and Quiles, José L. and Battino, Maurizio and La Vignera, Sandro and Galvano, Fabio mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, francesca.giampieri@uneatlantico.es, UNSPECIFIED, jose.quiles@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2022) The Effect of Dietary Polyphenols on Vascular Health and Hypertension: Current Evidence and Mechanisms of Action. Nutrients, 14 (3). p. 545. ISSN 2072-6643

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Inglés In order to improve the recovery process in combat sports disciplines, ergo-nutritional strategies could be an effective option in training and competition. Some of these ergo-nutritional aids could improve performance but literature references are scarce, with controversial results regarding actual recovery effects. This systematic review aimed to examine which ergo-nutritional methods are most effective for assisting in the recovery process in combat sports, and to determine the appropriate training stimuli. This systematic review was carried out following the Preferred Reporting Items for Systematic Review (PRISMA) guidelines. A computerized search was performed in PubMed, Web of Science, the Cochrane Collaboration Database, Evidence Database, Evidence Based Medicine Search review, National Guidelines, EM-BASE, Scopus and Google Scholar system (from 1995 to April 30, 2021). The PICOS model was used to define inclusion and exclusion criteria. Out of 123 studies initially found, 18 met the eligibility criteria and were included in the review. Data from 367 athletes from different disciplines were examined. The evidence was grouped in 4 areas: oxidative stress, muscle and energy recovery, muscle repair, and metabolic acidosis. Evidence showed that vitamins, minerals, and some natural ergo-nutritional products are effective as antioxidants. Carbohydrates and protein determine the recovery effect. Sodium bicarbonate has a role as primary acidosis metabolic delayer. Accordingly, ergo-nutritional aids can help in the recovery process. Considering the effects outlined in the literature, more studies are needed to provide firm evidence. metadata López Laval, Isaac and Marqués Giménez, Diego and Velarde-Sotres, Álvaro and Sitko, Sebastian and Calleja Gonzalez, Julio mail UNSPECIFIED, UNSPECIFIED, alvaro.velarde@uneatlantico.es, UNSPECIFIED, UNSPECIFIED (2022) Effects of ergo-nutritional strategies on recovery in combat sports disciplines. Nutrición Hospitalaria. ISSN 0212-1611

Other Subjects > Nutrition Europe University of Atlantic > Research > Projects I+D+I Cerrado Español El objetivo del proyecto es demostrar la especificidad de la "patata de Valderredible" metadata CITICAN-Universidad Europea del Atlántico, mail UNSPECIFIED (2022) Estudio técnico para mostrar la especificidad de la "patata de Valderredible". Repositorio de la Universidad. (Unpublished)

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Inglés, Español Niveles circulantes elevados de aminoácidos de cadena ramificada (BCAA) han sido descritos como un fuerte factor predictor de la diabetes mellitus tipo 2 (DM2) por su implicación en la resistencia a la insulina (RI). El principal objetivo es evaluar si una dieta rica en estos aminoácidos supone un riesgo para el desarrollo de DM2. Material y métodos: Esta revisión bibliográfica se ha sustentado en artículos científicos seleccionados de diferentes bases de datos, entre las que destaca PubMed. Un total de 23 artículos fueron estudiados en profundidad. Resultados y discusión: Una mayor ingesta de BCAA ha presentado una asociación positiva en el desarrollo de la DM2, principalmente si esta proviene de alimentos de origen animal. Asimismo, su restricción selectiva produce cierta mejora en la fisiopatología de la DM2 sin verse comprometida la ingesta de otros nutrientes esenciales. Por el contrario, no se ha observado que los protocolos de suplementación con BCAA presenten repercusiones negativas para la salud. La ingesta de BCAA si parece estar asociada a un mayor riesgo de padecer DM2; pero esta asociación no puede estudiarse de forma aislada, sino que debe considerarse parte de una interacción compleja de componentes dietéticos, en la cual, la calidad nutricional de los alimentos adquiere un importante papel. metadata Tejido Ruiz-Ogarrio, Carlota mail UNSPECIFIED (2022) Impacto del consumo de aminoácidos de cadena ramificada (BCAA) en la Diabetes Mellitus Tipo 2. MLS Health & Nutrition Research, 1 (2).

Article Subjects > Biomedicine
Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Inglés The chemical composition and biological capacities of berries depend on environmental parameters, maturity, and location. The Andean blueberry (Vaccinium floribundum Kunth), also known as mortiño, presents a unique combination of several phytochemicals, which play a synergistic role in its characterization as a functional food. We aimed to expose the possible variations that exist in the profile of the phenolic compounds as well as the antioxidant and antimicrobial capacity of the wild Andean blueberry with respect to three ripeness stages and two different altitudes. We found that polyphenols are the predominant compounds in the berry during the early ripeness stage and are the main bioactive compounds that give rise to the antioxidant capacity and inhibition effect on the growth of gram-positive and gram-negative bacteria. Moreover, the accumulation of ascorbic acid, free amino acids, and anthocyanins increases as the ripening process progresses, and they were the main bioactive compounds in the ripe berry. The latter compounds influence the production of the typical bluish or reddish coloration of ripe blueberries. In addition, it was determined that environmental conditions at high altitudes could have a positive influence in all cases. Overall, our data provide evidence regarding the high functional value of the wild Andean blueberry. metadata Guevara-Terán, Mabel and Padilla-Arias, Katherine and Beltrán-Novoa, Andrea and González-Paramás, Ana M. and Giampieri, Francesca and Battino, Maurizio and Vásquez-Castillo, Wilson and Fernandez-Soto, Paulina and Tejera, Eduardo and Alvarez-Suarez, José M. mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2022) Influence of Altitudes and Development Stages on the Chemical Composition, Antioxidant, and Antimicrobial Capacity of the Wild Andean Blueberry (Vaccinium floribundum Kunth). Molecules, 27 (21). p. 7525. ISSN 1420-3049

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Inglés Agro-foodindustries generate colossal amounts of non-edible waste and by-products, easily accessible as raw materials for up-cycling active phytochemicals. Phenolic compounds are particularly relevant in this field given their abundance in plant residues and the market interest of their functionalities (e.g. natural antioxidant activity) as part of nutraceutical, cosmetological and biomedical formulations. In “bench-to-bedside” achievements, sample extraction is essential because valorization benefits from matrix desorption and solubilization of targeted phytocompounds. Specifically, the composition and polarity of the extractant, the optimal sample particle size and sample:solvent ratio, as well as pH, pressure and temperature are strategic for the release and stability of mobilized species. On the other hand, current green chemistry environmental rules require extraction approaches that eliminate polluting consumables and reduce energy needs. Thus, the following pages provide an update on advanced technologies for the sustainable and efficient recovery of phenolics from plant matrices. metadata Gil-Martín, Emilio and Forbes-Hernández, Tamara and Romero, Alejandro and Cianciosi, Danila and Giampieri, Francesca and Battino, Maurizio mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2022) Influence of the extraction method on the recovery of bioactive phenolic compounds from food industry by-products. Food Chemistry, 378. p. 131918. ISSN 03088146

Revista Subjects > Nutrition Europe University of Atlantic > Research > Scientific Magazines Abierto Inglés La revista MLS Health and Nutrition Research nace como una publicación semestral con el objetivo de publicar artículos originales de investigación y de revisión tanto en áreas básicas como aplicadas y metodológicas que supongan una contribución científica al progreso de cualquier ámbito de la salud y nutrición como objetivo principal. Los artículos incluidos en esta revista se publican en español, portugués e inglés. La vocación internacional de esta revista promueve la difusión del conocimiento en sus diferentes áreas. metadata Multi-Lingual Scientific Journals, (MLS) mail mls@devnull.funiber.org (2022) MLS Health and Nutrition Research. [Revista] (Unpublished)

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Cerrado Inglés The aim of the present work was to evaluate the in vitro effect of Manuka honey and its combination with 5-Fu, the most common drug used in the treatment of colon cancer, on the morphological and physical parameters of colonspheres enriched with cancer stem-like cells deriving from HCT-116 colon adenocarcinoma cell line and on the apoptosis rate. Manuka honey, alone and more in combination with 5-Fu, reduced the weight, the diameter and mass density of the spheroids and induced apoptosis through the downregulation of many apoptosis inhibitors, including IAPs (Livin, Survivin, XIAP), IGFs (IGF-I, IGF-II and IGF-IR) and HSPs (HSP-27, HSP-60 and HSP-70). These results led to a reduction in the survival ability of cancer stem-like cells, as well as to a chemosensitizing effect of honey towards 5-Fu, considering that apoptosis resistance is one of the main causes of cancer stem-like cells chemoresistance. metadata Cianciosi, Danila and Forbes-Hernández, Tamara Y. and Regolo, Lucia and Alvarez-Suarez, José M. and Quinzi, Denise and Sargenti, Azzurra and Bai, Weibin and Tian, Lingmin and Giampieri, Francesca and Battino, Maurizio mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es (2022) Manuka honey in combination with 5-Fluorouracil decreases physical parameters of colonspheres enriched with cancer stem-like cells and reduces their resistance to apoptosis. Food Chemistry, 374. p. 131753. ISSN 03088146

Book Section Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Cerrado Inglés Obesity and metabolic syndrome, two of the major public health challenges worldwide, are characterized by a state of chronic inflammation, with the abnormal production of inflammatory cytokines and the prolonged activation of inflammatory pathways, responsible for the development and the complications of these pathologies. A fruitful strategy to decrease the chronic state of inflammation could be the adoption of a healthy diet, of which berries, enriched with well-known antioxidant and anti-inflammatory bioactive compounds, should be an important part. The aim of this chapter is to present the main results obtained from in vitro and animal studies, describing the effects of the main common consumed berries (blueberry, raspberry, strawberry, blackcurrant, and blackberry) on chronic inflammation related to obesity and metabolic syndrome, trying to elucidate the main molecular pathways involved in the beneficial effects of these berries. The human evidence is instead discussed in more detail in Chapter 11. metadata Giampieri, Francesca and Cianciosi, Danila and Ansary, J. and Forbes-Hernandez, T. Y. and Alvarez-Suarez, J. M. and Battino, M. mail francesca.giampieri@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2022) Mechanisms of Action of Berry Bioactives on Obesity-induced Inflammation (Chapter 12). In: Berries and Berry Bioactive Compounds in Promoting Health. Royal Society of Chemistry, pp. 335-365. ISBN 978-1-83916-216-9

Article Subjects > Biomedicine
Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Cerrado Inglés Ocimum basilicum and Ocimum tenuiflorum are two basil species widely used medicinally as an anti-inflammatory, antimicrobial and cardioprotective agent. This study focuses on the chemical characterization of the majoritarian compounds of both species and their anti-inflammatory potential. Up to 22 compounds such as various types of salvianolic acids, derivatives of rosmaniric acid and flavones were identified in both plants. The identified compounds were very similar between both plants and are consistent with previous finding in other studies in Portugal and Italy. Based on the identified molecules a consensus target prediction was carried out. Among the main predicted target proteins, we found a high representation of the carbonic anhydrase family (CA2, CA7 and CA12) and several key proteins from the arachidonic pathway (LOX5, PLA2, COX1 and COX2). Both pathways are well related to inflammation. The interaction between the compounds and these targets were explored through molecular docking and molecular dynamics simulation. Our results suggest that some molecules present in both plants can induce an anti-inflammatory response through a non-steroidal mechanism of action connected to the carbon dioxide metabolism. metadata Beltrán-Noboa, Andrea and Proaño-Ojeda, John and Guevara, Mabel and Gallo, Blanca and Berrueta, Luis A. and Giampieri, Francesca and Perez-Castillo, Yunierkis and Battino, Maurizio and Álvarez-Suarez, José M. and Tejera, Eduardo mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, francesca.giampieri@uneatlantico.es, UNSPECIFIED, maurizio.battino@uneatlantico.es, UNSPECIFIED, UNSPECIFIED (2022) Metabolomic profile and computational analysis for the identification of the potential anti-inflammatory mechanisms of action of the traditional medicinal plants Ocimum basilicum and Ocimum tenuiflorum. Food and Chemical Toxicology, 164. p. 113039. ISSN 02786915

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Cerrado Inglés As the number of older people has grown in recent decades, the search for new approaches to manage or delay aging is also growing. Among the modifiable factors, diet plays a crucial role in healthy aging and in the prevention of age-related diseases. Thus, the interest in the use of foods, which are rich in bioactive compounds such as functional foods with anti-aging effects is a growing market. This review summarizes the current knowledge about the molecular mechanisms of action of foods considered as functional foods in aging, namely berries, curcumin, and virgin olive oil. Moreover, honey is also analyzed as a food with well-known healthy benefits, but which has not been deeply evaluated from the point of view of aging. The effects of these foods on aging are analyzed from the point of view of molecular mechanisms including oxidative stress, mitochondrial dysfunction, inflammation, genomic stability, telomere attrition, cellular senescence, and deregulated nutrient-sensing. A comprehensive study of the scientific literature shows that the aforementioned foods have demonstrated positive effects on certain aspects of aging, which might justify their use as functional foods in elderly. However, more research is needed, especially in humans, designed to understand in depth the mechanisms of action through which they act. metadata Navarro-Hortal, María D. and Romero-Márquez, Jose M. and Jiménez-Trigo, Victoria and Xiao, Jianbo and Giampieri, Francesca and Forbes-Hernández, Tamara Y. and Grosso, Giuseppe and Battino, Maurizio and Sánchez-González, Cristina and Quiles, José L. mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, francesca.giampieri@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es, UNSPECIFIED, jose.quiles@uneatlantico.es (2022) Molecular bases for the use of functional foods in the management of healthy aging: Berries, curcumin, virgin olive oil and honey; three realities and a promise. Critical Reviews in Food Science and Nutrition. pp. 1-20. ISSN 1040-8398

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Inglés Context Obesity and mental health issues increasingly affect children and adolescents, but whether obesity is a risk factor for mental health issues is unclear. Objective To systematically review the association between obesity and mental health issues (ie, anxiety and/or depression) among Mexican children and adolescents. Data sourcing, extraction, and synthesis A literature search of 13 databases and 1 search engine was conducted. Population, exposure, comparison, outcomes, and study design data were extracted, analyzed, and narratively synthesized. The JBI critical appraisal tool was used to evaluate evidence quality. Results A total of 16 studies with 12 103 participants between 8 and 18 years old were included. Four studies focused on anxiety outcomes, 10 on depression, and 2 on both (ie, anxiety and depression). Evidence is unclear about the association of obesity with anxiety. However, most evidence shows that Mexican children and adolescents with overweight or obesity are more likely to have depression or report a higher number of depressive symptoms than normal-weight participants. Such likelihood is greater for females. Conclusion Health promotion interventions to treat or prevent obesity could also consider mental health outcomes. metadata Godina-Flores, Naara L and Gutierrez-Gómez, Yareni Yunuen and García-Botello, Marcela and López-Cruz, Lizet and Moreno-García, Carlos Francisco and Aceves-Martins, Magaly mail UNSPECIFIED (2022) Obesity and its association with mental health among Mexican children and adolescents: systematic review. Nutrition Reviews. ISSN 0029-6643

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Inglés Olive milling produces olive oil and different by-products, all of them very rich in different bioactive compounds like the phenolic alcohol hydroxytyrosol. The aim of the present study was to investigate the effects of an olive fruit extract 20% rich in hydroxytyrosol on the molecular mechanisms associated with Alzheimer disease features like Aβ- and tau- induced toxicity, as well as on oxidative stress in Caenorhabditis elegans. Moreover, characterization of the extracts, regarding the profile and content of phenolics, as well as total antioxidant ability, was investigated. The study of lethality, growth, pharyngeal pumping, and longevity in vivo demonstrated the lack of toxicity of the extract. One hundred μg/mL of extract treatment revealed prevention of oxidative stress and a delay in Aβ-induced paralysis related with a lower presence of Aβ aggregates. Indeed, the extract showed the ability to avoid a certain degree of proteotoxicity associated with aggregation of the tau protein. According to RNAi tests, SKN-1/NRF2 transcription factor and the overexpression of HSP-16.2 were mechanistically associated in the observed effects metadata Romero-Márquez, Jose M. and Navarro-Hortal, María D. and Jiménez-Trigo, Victoria and Muñoz-Ollero, Pedro and Forbes-Hernández, Tamara Y. and Esteban-Muñoz, Adelaida and Giampieri, Francesca and Delgado Noya, Irene and Bullón, Pedro and Vera-Ramírez, Laura and Battino, Maurizio and Sánchez-González, Cristina and Quiles, José L. mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, francesca.giampieri@uneatlantico.es, irene.delgado@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, jose.quiles@uneatlantico.es (2022) An Olive-Derived Extract 20% Rich in Hydroxytyrosol Prevents β-Amyloid Aggregation and Oxidative Stress, Two Features of Alzheimer Disease, via SKN-1/NRF2 and HSP-16.2 in Caenorhabditis elegans. Antioxidants, 11 (4). p. 629. ISSN 2076-3921

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Cerrado Inglés Organic farming is characterized by the prohibition of the use of chemical synthetic fertilizers, pesticides, feed additives and genetically modified organisms and by the application of sustainable agricultural technologies based on ecological principles and natural rules. Organic products are believed to be more nutritious and safer foods compared to the conventional alternatives by consumers, with the consequent increase of demand and price of these foodstuffs. However, in academic circles there is much debate on these issues, since there is not a clear scientific evidence of the difference on the environmental impact and on the nutritional quality, safety and health effects between conventional and organic foods. Therefore, this work aims to describe and update the most relevant data on organic foods, by describing the impact of this practice on environment, producers, consumers and society, as well as by comparing the physicochemical, nutritional and phytochemical quality of conventional and organic plant foods. metadata Giampieri, Francesca and Mazzoni, Luca and Cianciosi, Danila and Alvarez-Suarez, José M. and Regolo, Lucia and Sánchez-González, Cristina and Capocasa, Franco and Xiao, Jianbo and Mezzetti, Bruno and Battino, Maurizio mail francesca.giampieri@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2022) Organic vs conventional plant-based foods: A review. Food Chemistry, 383. p. 132352. ISSN 03088146

Article Subjects > Biomedicine
Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Fundación Universitaria Internacional de Colombia > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Universidad Internacional do Cuanza > Research > Scientific Production Cerrado Inglés Cactus has been used in traditional folk medicine because of its role in treating a number of diseases and conditions. Prickly pear fruit is an excellent source of secondary metabolites (i.e., betalains, flavonoids, and ascorbic acid) with health-promoting properties against many common human diseases, including diabetes, hypertension, hypercholesterolemia, rheumatic pain, gastric mucosa diseases and asthma. In addition, prickly pears are potential candidates for the development of low-cost functional foods because they grow with low water requirements in arid regions of the world. This review describes the main bioactive compounds found in this fruit and shows the in vitro and some clinical studies about the fruit of most important cactus (Opuntia ficus-indica) and its relationship with some chronic diseases. Even though a lot of effort have been done to study the relationship between this fruit and the human health, more studies on Opuntia ficus-indica could help better understand its pharmacological mechanism of action to provide clear scientific evidence to explain its traditional uses, and to identify its therapeutic potential in other diseases. metadata Armas Diaz, Yasmany and Machì, Michele and Salinari, Alessia and Mazas Pérez-Oleaga, Cristina and Martínez López, Nohora Milena and Briones Urbano, Mercedes and Cianciosi, Danila mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, cristina.mazas@uneatlantico.es, nohora.martinez@uneatlantico.es, mercedes.briones@uneatlantico.es, UNSPECIFIED (2022) Prickly pear fruits from "Opuntia ficus-indica" varieties as a source of potential bioactive compounds in the Mediterranean diet. Mediterranean Journal of Nutrition and Metabolism, 15 (4). pp. 581-592. ISSN 1973798X

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Inglés Food waste is a potential source to replace fresh materials for obtaining functional ingredients. Blueberry pomace contains considerable amounts of anthocyanins. In this study, we investigated ultrasonic-assisted extraction (UAE) of anthocyanins from blueberry pomace. We used a Box-Behnken design (BBD) to screen and optimize the important factors influencing yield. The optimum extraction conditions were a temperature of 40 °C, an ultrasonic power of 400 W and an extraction time of 40 min. The optimum yield was 108.23 mg/100 g DW. In addition, we used a cation column to separate anthocyanins, and optimized the chromatographic conditions of HPLC to analyze and identify the main anthocyanins. Thirteen anthocyanins were found in blueberry pomace, of which Malvidin-3-Galactoside (22.65 %) was the highest. These findings provide a theoretical basis and optimized process parameters for the recovery of high value-added anthocyanins from blueberry pomace with ultrasound-assisted extraction, thus facilitating the comprehensive utilization of blueberry pomace. metadata Zhang, Xuan and Wang, Songen and Wu, Qixia and Battino, Maurizio and Giampieri, Francesca and Bai, Weibin and Tian, Lingmin mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es, francesca.giampieri@uneatlantico.es, UNSPECIFIED, UNSPECIFIED (2022) Recovering high value-added anthocyanins from blueberry pomace with ultrasound-assisted extraction. Food Chemistry: X, 16. p. 100476. ISSN 25901575

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Inglés Anthocyanins are often targets in polyphenol analysis. However, it's hard to effectively separate anthocyanin from copigments such as phenolic acid and flavanols due to their similar structure. Thus, a cation exchange chromatography with 001 × 7 has been developed, which is available for anthocyanins isolation both on a small and large scale. The optimal process condition of anthocyanins isolation was determined. Compared to the macroporous adsorbent resins and Strong Cation Exchange resin (SCX), 001X7 shows greater economic advantages in large-scale purification of anthocyanins. More than 95% purity of the anthocyanin fraction can be achieved through this approach. This method shows a path to provide large quantities of copigments-free anthocyanins from mulberry polyphenols for the further study of its biological effects and may be extended to other analytical methods of polyphenol isolation from other plant materials. metadata Liao, Zhiwei and Zhang, Xuan and Chen, Xi and Battino, Maurizio and Giampieri, Francesca and Bai, Weibin and Tian, Lingmin mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es, francesca.giampieri@uneatlantico.es, UNSPECIFIED, UNSPECIFIED (2022) Recovery of value-added anthocyanins from mulberry by a cation exchange chromatography. Current Research in Food Science, 5. pp. 1445-1451. ISSN 26659271

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Abierto Inglés Background: The aim of this study was to relate the adherence to nut consumption (30 g) three or more days per week to the prevalence of abdominal obesity and metabolic syndrome (MetS) in an elderly population from the north of Spain. Methods: The study consists of an observational, descriptive, cross-sectional, and correlational study conducted in 556 non-institutionalised individuals between 65 and 79 years of age. To define the consumption recommendation of nuts the indication of the questionnaire MEDAS-14 was followed. The diagnosis of MetS was conducted using the International Diabetes Federation (IDF) criteria. Results: In 264 subjects aged 71.9 (SD: ±4.2) years old, 39% of whom were men, the adherence to nut consumption recommendations was 40.2%. Of these individuals, 79.5% had abdominal obesity. The prevalence of MetS was 40.2%, being 47.6% in men and 35.4% in women (p < 0.05). A nut consumption lower than recommended was associated with a 19% higher prevalence of abdominal obesity (Prevalence Ratio: 1.19; 95% CI: 1.03−1.37; p < 0.05) and a 61% higher prevalence of MetS (Prevalence Ratio: 1.61; 95% CI: 1.16−2.25; p = 0.005) compared to a consumption of ≥3 servings per week. Conclusion: An inverse relationship was established between nut consumption and the prevalence of abdominal obesity and metabolic syndrome. metadata Cubas-Basterrechea, Gloria and Elío Pascual, Iñaki and Sumalla Cano, Sandra and Aparicio Obregón, Silvia and González-Antón, Carolina Teresa and Muñoz-Cacho, Pedro mail UNSPECIFIED, inaki.elio@uneatlantico.es, sandra.sumalla@uneatlantico.es, silvia.aparicio@uneatlantico.es, UNSPECIFIED, UNSPECIFIED (2022) The Regular Consumption of Nuts Is Associated with a Lower Prevalence of Abdominal Obesity and Metabolic Syndrome in Older People from the North of Spain. International Journal of Environmental Research and Public Health, 19 (3). p. 1256. ISSN 1660-4601

Thesis Subjects > Nutrition Europe University of Atlantic > Teaching > Final Degree Projects Cerrado Español Objetivos: Conocer si existe relación entre el número y el horario de las comidas, la composición corporal y la pérdida de peso. Material y métodos: Se realizo una revisión bibliográfica, fueron seleccionados y consultados artículos científicos, tanto estudios como revisiones, webs oficiales y documentos relevantes. Se tuvieron en cuenta un total de 12 estudios publicados en los ultimos 5 anos pertenecientes a la base de datos Pubmed y Scielo, los cuales fueron analizados en profundidad. Discusión: Tanto el horario de las comidas como la frecuencia en la que estas se realizan o los macronutrientes que ingieren son estrategias dietetico-nutricionales efectivas para la modificación de la composición corporal y del peso. Conclusiones: Se necesitan un mayor número de investigaciones actuales, sobre todo en el ámbito de la frecuencia de las comidas para demostrar los efectos sobre la composición corporal, sin embargo, se puede concluir que tanto tener en cuenta los macronutrientes que se ingieren como el timing alimentario, son posibles estrategias de abordaje nutricional competentes para el cambio de composición y peso corporal. metadata Anaya Pérez, Carlota mail UNSPECIFIED (2022) Relación entre el horario de las comidas, la composición corporal y la pérdida de peso. Diploma thesis, Universidad Europea del Atlántico.

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Inglés Polyphenols are a group of phytochemicals with extensive biological functions and health-promoting potential. These compounds are present in most foods of plant origin and their increased widespread availability through the intake of nutritional supplements, fortified foods, and beverages, has also led to increased exposure throughout gestation. In this narrative review, we focus on the role of polyphenols in both healthy and pathological pregnancy. General information related to their classification and function is followed by an overview of their known effects in early-pregnancy events, including the current insights into molecular mechanisms involved. Further, we provide an overview of their involvement in some of the most common pregnancy-associated pathological conditions, such as preeclampsia and gestational diabetes mellitus. Additionally, we also discuss the estimated possible risk of polyphenol consumption on pregnancy outcomes. The consumption of dietary polyphenols during pregnancy needs particular attention considering the possible effects of polyphenols on the mechanisms involved in maternal adaptation and fetal development. Further studies are strongly needed to unravel the in vivo effects of polyphenol metabolites during pregnancy, as well as their role on advanced maternal age, prenatal nutrition, and metabolic risk of the offspring. metadata Nacka-Aleksić, Mirjana and Pirković, Andrea and Vilotić, Aleksandra and Bojić-Trbojević, Žanka and Jovanović Krivokuća, Milica and Giampieri, Francesca and Battino, Maurizio and Dekanski, Dragana mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es, UNSPECIFIED (2022) The Role of Dietary Polyphenols in Pregnancy and Pregnancy-Related Disorders. Nutrients, 14 (24). p. 5246. ISSN 2072-6643

Article Subjects > Biomedicine
Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Inglés Bioactive compounds from strawberries have been associated with multiple healthy benefits. The present study aimed to assess chemical characterization of a methanolic extract of the Romina strawberry variety in terms of antioxidant capacity, polyphenols profile and chemical elements content. Additionally, potential toxicity, the effect on amyloid-β production and oxidative stress of the extract was in vivo evaluated in the experimental model Caenorhabditis elegans. Results revealed an important content in phenolic compounds (mainly ellagic acid and pelargonidin-3-glucoside) and minerals (K, Mg, P and Ca). The treatment with 100, 500 or 1000 μg/mL of strawberry extract did not show toxicity. On the contrary, the extract was able to delay amyloid β-protein induced paralysis, reduced amyloid-β aggregation and prevented oxidative stress. The potential molecular mechanisms present behind the observed results explored by RNAi technology revealed that DAF-16/FOXO and SKN-1/NRF2 signaling pathways were, at least partially, involved. metadata Navarro-Hortal, María D. and Romero-Márquez, Jose M. and Esteban-Muñoz, Adelaida and Sánchez-González, Cristina and Rivas-García, Lorenzo and Llopis, Juan and Cianciosi, Danila and Giampieri, Francesca and Sumalla Cano, Sandra and Battino, Maurizio and Quiles, José L. mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, sandra.sumalla@uneatlantico.es, UNSPECIFIED, jose.quiles@uneatlantico.es (2022) Strawberry (Fragaria × ananassa cv. Romina) methanolic extract attenuates Alzheimer’s beta amyloid production and oxidative stress by SKN-1/NRF and DAF-16/FOXO mediated mechanisms in C. elegans. Food Chemistry, 372. p. 131272. ISSN 03088146

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Inglés, Español La enfermedad del hígado graso no alcohólico (EHGNA) cada vez es más prevalente y es la principal enfermedad hepática a nivel mundial. Se quiere comparar nuevas estrategias dietético-nutricionales, como la dieta mediterránea y los ácidos grasos poliinsaturados omega-3, para determinar cuál es más efectiva como tratamiento para esta enfermedad. Evaluar que manejo nutricional es más efectivo como tratamiento del hígado graso no alcohólico, si la suplementación con omega 3 o una dieta mediterránea. Se realizó una revisión bibliográfica, para la cual se consultaron y seleccionaron varios artículos científicos de diversas bases de datos, documentos y el servicio de información en línea provisto por la Biblioteca Nacional de Medicina de los Estados Unidos (MedlinePlus), obteniendo asi un total de 17 estudios pertenecientes a la base de datos Pubmed, los cuales fueron analizados en profundidad. Tanto la dieta mediterránea como la suplementación con ácidos grasos poliinsaturados omega-3 promueven beneficios sobre las características clínicas de los pacientes con hígado graso. La realización de una dieta mediterránea parece tener mayores beneficios en el tratamiento de la EHGNA al mejorar las características clínicas de la enfermedad como la esteatosis hepática, la inflamación, la fibrosis y la esteatohepatitis no alcohólica, además, del síndrome metabólico. metadata Celis Eguren, Andrea mail UNSPECIFIED (2022) Suplementación con ácidos grasos poliinsaturados omega 3 frente a una dieta mediterránea como tratamiento para la enfermedad del hígado graso no alcohólico. MLS Health & Nutrition Research, 1 (2).

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Inglés, Español El interés ambiental de la presente propuesta parte de la problemática para reducir los residuos no aprovechados de las plantaciones de eucalipto. así como también introducir en el sector de la alimentación un conservante “eco-friendly” natural y más eficiente energéticamente. En definitiva, el proyecto pretende convertir el residuo de las hojas de eucalipto en una materia prima de valor añadido que pueda ser empleado como conservante alimentario. Por un lado, se planteó la validación de un producto conservante basado en esencia de eucalipto para su uso en la industria alimentaria de frutos rojos. En particular, para el control del hongo Colletotrichum acutatum a nivel de postcosecha, en el que lamentablemente el extracto de eucalipto no mostró un efecto significativo dando valores de velocidad de crecimiento del hongo superiores al uso de ácidos orgánicos (láctico y cítrico). Por otro lado, se planteó una innovación tecnológica en el análisis del rendimiento de la extracción de esencia de Eucalyptus globulus de los bosques de Cantabria por diferentes métodos. El rendimiento promedio de extracción de aceite esencial demostró ser mayor por el método de destilación por arrastre de vapor. metadata Madrigal-Hoyos, Lorena and Sumalla Cano, Sandra and Elío Pascual, Iñaki mail lorena.madrigal@uneatlantico.es, sandra.sumalla@uneatlantico.es, inaki.elio@uneatlantico.es (2022) Tecnologías de conservación de frutos rojos basadas en residuos de Eucalyptus Globulus. Environmental Sciences and Practices, 1 (1).

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Inglés Ultra-processed food (UPF) consumption has been the focus of major attention due to their potential effects on human health. The aim of this study was to investigate the intake of UPFs in a sample of southern Italian individuals and assess its relationship with nutrient profile and dietary quality parameters. A cross-sectional study was conducted on 1936 individuals older than 18 years randomly selected from the general population. A total of 110 food times have been categorized based on the level of processing using the NOVA classification. The average daily energy intake of the sample was 2091.1 kcal, 38.7% of which were from the NOVA group of unprocessed/minimally processed foods, 5.7% from processed culinary ingredients, 38.3% from processed foods, and 17.9% from the UPFs group. UPFs were more consumed among young, unmarried individuals, with high cultural level, smokers, and often eating out of home. The mean energy share of UPFs varied from 6.3% of total daily energy intake for individuals in the lowest quintile of UPF consumption to 34.2% for those in the upper quintile. Within the UPF group, the highest energy contribution was provided by fast foods and sweets. Compared to the lowest quintile of UPF consumption, individuals in the highest quintile consumed, on average, additional 300 kcals per day and less fiber. Some plant-derived vitamins, such as vitamin A and vitamin C showed an inverse trend toward increasing shares of UPF consumption, while sodium intake increased. A significant higher intake of UPFs in individuals meeting the European and Italian dietary recommendations for carbohydrates, vitamin B12, vitamin D, and vitamin E was found, while UPFs were less consumed among those meeting the recommendations for total fats, fiber, sodium, potassium, and vitamin C. Finally, individuals displaying a “healthier” dietary profile, such as higher adherence to either the Mediterranean diet, the Dietary Approaches to Stop Hypertension, the Alternate Diet Quality Index, and the Diet Quality Index-International, consumed less UPFs and more unprocessed/minimally processed foods, with minor variation in the other NOVA food categories. In conclusion, consumption of UPF in southern Italy is in line with those reported in some other Mediterranean countries, although it negatively impacted the nutrient profile. It is important to monitor the consumption of UPFs before their availability and popularity put the grounds on younger generations’ dietary habits metadata Godos, Justyna and Giampieri, Francesca and Al-Qahtani, Wahidah H. and Scazzina, Francesca and Bonaccio, Marialaura and Grosso, Giuseppe mail UNSPECIFIED, francesca.giampieri@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2022) Ultra-Processed Food Consumption and Relation with Diet Quality and Mediterranean Diet in Southern Italy. International Journal of Environmental Research and Public Health, 19 (18). p. 11360. ISSN 1660-4601

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Cerrado Inglés Traditionally, edible flowers have been used as foods and for therapeutic purposes, today they have gained importance due to their bioactive compounds such as flavonols, anthocyanins or other phenolic compounds, which give them potential for biomedical applications. This work evaluated a methanolic extract of Tulbaghia violacea. Eleven individual phenolic compounds were found and quantified by mass spectrometry in the extract. Antioxidant activity tests (TEAC, FRAP and DPPH) and other characterization parameters were assayed (total phenolic content and total flavonoid content). In vitro studies showed antitumoral activity against ovarian tumoral cells mediated by the induction of non-dependent caspase cell death and by the activation of reactive oxygen species. The effect of the extract against features of Alzheimer disease was in vivo assayed in Caenorhabditis elegans. Tulbaghia extract led to a reduction in the 1–42 beta amyloid peptide formation and prevented oxidative stress. These results suggested that Tulbaghia violacea could be a new source of phenolic compounds for nutraceuticals and functional food development. metadata Rivas-García, Lorenzo and Romero-Márquez, Jose M. and Navarro-Hortal, M.D. and Esteban-Muñoz, Adelaida and Giampieri, Francesca and Sumalla Cano, Sandra and Battino, Maurizio and Quiles, José L. and Llopis, Juan and Sánchez-González, Cristina mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, sandra.sumalla@uneatlantico.es, UNSPECIFIED, jose.quiles@uneatlantico.es, UNSPECIFIED, UNSPECIFIED (2022) Unravelling potential biomedical applications of the edible flower Tulbaghia violacea. Food Chemistry, 381. p. 132096. ISSN 03088146

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Inglés The present manuscript describes the validation of a food knowledge questionnaire (FKQ) for Tanzanian childbearing age women. The FKQ was derived from the Ugandan version and was adapted according to Tanzanian culture and food habits, including 114 closed-ended questions, divided into five different sections. The FKQ was administered to 671 Tanzanian childbearing-age women who were eligible if they: (i) were aged between 14 and 49 years old, (ii) had not been diagnosed with any disease and (iii) lived in the urban or peri-urban area of the Arusha and Morogoro region. The validation process of the FKQ was conducted in Tanzania and the recruitment occurred between August and October 2020. The final version of the validated questionnaire was characterized by a total of 88 questions, divided into ten different sections; each section aimed to investigate a different aspect of food knowledge, except for section A, which collected information related to the social and demographic characteristics of the respondent. The food knowledge questionnaire showed good construct validity and content validity to assess knowledge and food practices in Tanzanian women of childbearing age and could be used in future studies to identify women at higher risk of unhealthy eating habits and food choices. metadata Conti, Maria Vittoria and Gnesi, Marco and De Giuseppe, Rachele and Giampieri, Francesca and Monti, Maria Cristina and Mshanga, Naelijwa and Kinabo, Joyce and Msuya, John and Cena, Hellas mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, francesca.giampieri@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2022) Validation of a Food Knowledge Questionnaire on Tanzanian Women of Childbearing Age. Nutrients, 14 (3). p. 691. ISSN 2072-6643

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Inglés Olive tree-derived products have been associated with numerous benefits for health. The aim of the present study was to characterize an olive leaf extract enriched in oleuropein (OLE) concerning phenolic content and profile as well as antioxidant capacity. Short-term and long-term toxicity, including oxidative stress, was in vivo evaluated in the experimental model Caenorhabditis elegans. Moreover, the potential therapeutic effect of the extract against Aβ induced- and tau protein induced-toxicity was also evaluated in C. elegans. OLE treatment did not exert toxicity. On the contrary, the extract was able to ameliorate oxidative stress and proteotoxicity related to Aβ and tau aggregation. The potential molecular mechanisms present behind the observed results explored by RNAi technology revealed that DAF-16/FOXO and SKN-1/NRF2, elements of the insulin insulin-like signalling pathway, as well as HSP-16.2 overexpression were involved. metadata Romero-Márquez, Jose M. and Navarro-Hortal, María D. and Jiménez-Trigo, Victoria and Vera-Ramírez, Laura and Forbes-Hernández, Tamara J. and Esteban-Muñoz, Adelaida and Giampieri, Francesca and Bullón, Pedro and Battino, Maurizio and Sánchez-González, Cristina and Quiles, José L. mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, francesca.giampieri@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, jose.quiles@uneatlantico.es (2022) An oleuropein rich-olive (Olea europaea L.) leaf extract reduces β-amyloid and tau proteotoxicity through regulation of oxidative- and heat shock-stress responses in Caenorhabditis elegans. Food and Chemical Toxicology, 162. p. 112914. ISSN 02786915

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Cerrado Inglés Polyphenols are plant secondary metabolites, whose biological activity has been widely demonstrated. However, the research in this field is a bit reductive, as very frequently the effect of individual compound is investigated in different experimental models, neglecting more complex, but common, relationships that are established in the diet. This review summarizes the data that highlighted the interaction between polyphenols and other food components, especially macro- (lipids, proteins, carbohydrates and fibers) and micronutrients (minerals, vitamins and organic pigments), paying particular attention on their bioavailability, antioxidant capacity and chemical, physical, organoleptic and nutritional characteristics. The topic of food interaction has yet to be extensively studied because a greater knowledge of the food chemistry behind these interactions and the variables that modify their effects, could offer innovations and improvements in various fields ranging from organoleptic, nutritional to health and economic field. metadata Cianciosi, Danila and Forbes-Hernández, Tamara Y. and Regolo, Lucia and Alvarez-Suarez, José M. and Navarro-Hortal, Maria Dolores and Xiao, Jianbo and Quiles, José L. and Battino, Maurizio and Giampieri, Francesca mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, jose.quiles@uneatlantico.es, UNSPECIFIED, francesca.giampieri@uneatlantico.es (2022) The reciprocal interaction between polyphenols and other dietary compounds: Impact on bioavailability, antioxidant capacity and other physico-chemical and nutritional parameters. Food Chemistry, 375. p. 131904. ISSN 03088146

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Cerrado Inglés Background The drive to reduce the negative impact of the global food system on the environment and human health, and to feed a growing global population, has led to the rapid development of meat alternatives, including plant-based and mycoprotein-based products such as burgers, cured meat and nuggets. These are generally food items manufactured with highly refined ingredients, so health professionals interested in promoting plant-based diets, or a reduction in meat consumption, need a deeper understanding about the potential health effects of these products in order to present them to the public in an objective and helpful manner. Scope and approaches In this narrative review, a search of the current available scientific literature was performed with the aim of exploring all these foods by delving into the way they are manufactured, their nutritional characteristics, their impact on health, as well as trying to understand their place in modern, diets. Key findings and conclusion Processed meat alternatives, despite being highly refined products, can be a good source of healthy food groups and nutrients often underrepresented in omnivores diets such as grains, legumes, plant protein and fibre, although attention must be paid to their salt and saturated fat content. For people wanting to move away from a meat-heavy diet, the consumption of these items can represent a stepping stone towards the adoption of more healthful dietary patterns centred on whole plant-foods. In addition, they might help to increase compliance with the new lifestyle as they tend to replicate some of the organoleptic properties of meat. metadata Gastaldello, Annalisa and Giampieri, Francesca and de Giuseppe, Rachele and Grosso, Giuseppe and Baroni, Luciana and Battino, Maurizio mail UNSPECIFIED, francesca.giampieri@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2022) The rise of processed meat alternatives: A narrative review of the manufacturing, composition, nutritional profile and health effects of newer sources of protein, and their place in healthier diets. Trends in Food Science & Technology. ISSN 09242244

2021

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Cerrado Inglés BACKGROUND:In Spain, there are several studies published on the relationship between eating habits and lifestyle among university students; but only a few of them are focused on online postgraduate students. OBJECTIVE:Herein we aimed to evaluate the degree of adherence to the Mediterranean diet pyramid (2010 edition), non-communicable diseases (NCDs), and lifestyle in online postgraduate students aged 20–65 years belonging to the food area of the Fundación Universitaria Iberoamericana (FUNIBER). METHODS:We performed a descriptive cross-sectional study including 100 online post-graduate students aged 20–65 years who were recruited by an accidental non-probabilistic sampling method consisting of a questionnaire on their sociodemographic characteristics, NCDs, lifestyle, and a 3-day food intake record (3-d). RESULTS:The profile of the students was 74% women, with a mean age of 36.6 (±10.5) years and body mass index (BMI) of 22.6 kg / m2 (±3.3). 71% of the volunteers presented normal weight, while 20% were overweight. Indeed, only a low percentage of the volunteers presented hypertension (1%), cardiovascular disease (0%), diabetes mellitus 1 (2%), diabetes mellitus 2 (3%), hypercholesterolemia (9%), and hyperuricemia (2%). Concerning lifestyle, (77%) of students were non-smokers, (78%) consumed beverages with caffeine, (51%) did not consume alcoholic beverages, and nearly all of them (84%) frequently (3 times /week) practiced physical activity. 68% of the recruited students exhibited adherence to “Medium diet quality diet (4–7)” followed by (26%) with a “Poor diet quality (<3)” and “Optimal diet quality” (6%). CONCLUSIONS:Spanish postgraduate students of the nutritional area, have good health and a healthy lifestyle but are moving away from the MD model, should be established campaigns for the improvement of eating habits of the postgraduate university population. metadata Elío Pascual, Iñaki and Jarrin, Sandra and Elexpuru Zabaleta, Maria and Crespo-Álvarez, Jorge and Dominguez Azpíroz, Irma and Tutusaus, Kilian and Ruiz Salces, Roberto and Calderón Iglesias, Rubén and Sumalla Cano, Sandra mail inaki.elio@uneatlantico.es, sandra.jarrin@uneatlantico.es, maria.elexpuru@uneatlantico.es, jorge.crespo@uneatlantico.es, irma.dominguez@uneatlantico.es, kilian.tutusaus@uneatlantico.es, roberto.ruiz@uneatlantico.es, ruben.calderon@uneatlantico.es, sandra.sumalla@uneatlantico.es (2021) Adherence to the pyramid of the Mediterranean diet (2010), non-communicable diseases and lifestyle in online postgraduate Spanish students in the food area. Mediterranean Journal of Nutrition and Metabolism, 14 (2). pp. 191-205. ISSN 1973798X

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Inglés The aim of this study was to evaluate for the first time the anti-inflammatory effects of chestnut (Castanea sativa) and Eucalyptus (Eucalyptus occidentalis) honeys collected in Italy on murine RAW 264.7 macrophages stressed with the bacterial endotoxin lipopolysaccharide (LPS). Pre-treatment with the two honeys markedly decreased apoptosis and stimulated wound healing in macrophages stressed with LPS, where they also reduced the intracellular levels of ROS and nitrite. Additionally, treatment with LPS decreased the levels of glutathione and suppressed the antioxidant enzyme activities, which were significantly (p < 0.05) increased in the presence of the two honeys, through the modulation of Nrf2 expression; in LPS-stressed macrophages, Chestnut or Eucalyptus honeys protected against inflammation by regulating the main inflammatory biomarkers, including TNF-α, IL-10 and iNOS, through the decrease of NF-кB expression. Finally, they improved mitochondrial respiration and the main related parameters. metadata Cianciosi, Danila and Forbes-Hernandez, Tamara Y. and Alvarez-Suarez, José M. and Ansary, Johura and Quinzi, Denise and Amici, Adolfo and Navarro-Hortal, María D. and Esteban-Muñoz, Adelaida and Quiles, José Luis and Battino, Maurizio and Giampieri, Francesca mail UNSPECIFIED (2021) Anti-inflammatory activities of Italian Chestnut and Eucalyptus honeys on murine RAW 264.7 macrophages. Journal of Functional Foods, 87. p. 104752. ISSN 17564646

Thesis Subjects > Nutrition Europe University of Atlantic > Teaching > Final Degree Projects Cerrado Español Introducción: La evolución del sobrepeso y la obesidad está influida por el ambiente en el que vivimos y el estilo de vida que incluye. Por ello son de gran importancia las estrategias nutricionales como el ayuno intermitente para prevenir y tratar dichas patologías mejorando el estado de salud de la población. Objetivo: Determinar si el ayuno intermitente contribuye a mejorar el estado de salud de los pacientes con sobrepeso y obesidad. Material y métodos: Se realizó una revisión bibliográfica, para la cual se analizaron y seleccionaron diversos artículos científicos. En total 11 estudios fueron examinados en profundidad; estos estudios han sido publicados en los últimos 6 años y encontrados en la base de datos Pubmed. Discusión y conclusiones: El ayuno intermitente es una técnica alternativa a la dieta hipocalórica convencional pero sus efectos sobre la pérdida de peso no son superiores. Es importante llevar a cabo un estilo de vida saludable que incluya ejercicio físico y dieta equilibrada. Evitar una ganancia de peso excesiva pudiendo llegar a desarrollar obesidad, resistencia a la insulina, diabetes, aumento de los triglicéridos, del colesterol o un estado de síndrome metabólico afectando gravemente a la salud. metadata Llamas Suárez, Cristina mail cristina.llamas@alumnos.uneatlantico.es (2021) Ayuno intermitente como coadyuvante para el tratamiento del sobrepeso y la obesidad. Diploma thesis, Universidad Europea del Atlántico.

Other Subjects > Engineering
Subjects > Nutrition Europe University of Atlantic > Research > Projects I+D+I Cerrado Español Tiene como objetivo estrechar las relaciones entre los Miembros del Grupo, a fin de aunar esfuerzos y establecer normas amplias de actuación que encaucen, incrementen y optimicen la capacidad de I+D que tiene cada uno de ellos por separado. Asimismo, tiene por objetivo la difusión y divulgación de las actividades de I+D desarrolladas por el Grupo. metadata CITICAN-Universidad Europea del Atlántico, mail UNSPECIFIED (2021) Creación de un Grupo Operativo orientado al sector de productos de la molinería. Repositorio de la Universidad. (Unpublished)

Thesis Subjects > Nutrition Europe University of Atlantic > Teaching > Final Degree Projects Cerrado Español Introducción: Las cremas de cacao y avellanas son un sucedáneo del chocolate de gran consumo compuesto en su mayor parte por azúcar y grasas saturadas, lo que lo convierte un alimento cuya ingesta frecuente en la dieta no es recomendable dentro de los patrones alimentarios saludables. Para solucionar ese problema, se propone el desarrollo teórico de una crema de caco y avellanas funcional, haciendo uso de los oleogeles al ser una herramienta prometedora para lograr la sustitución de las grasas saturadas y para actuar como matriz apta para su enriquecimiento con ácidos grasos omega-3. Materiales y métodos: Se realizó revisión sistemática haciendo uso de datos obtenidos a partir de artículos científicos y libros almacenados de bases de datos (Science Direct). Toda la información cumplió con el requisito de poseer un Factor de Impacto mayor a 1,5.Resultados: La información finalmente recopilada puede dividirse en 41 artículos que a su vez se reparten en tres áreas. La primera sobre ingredientes y tecnología de elaboración de cremas de chocolate y otros sucedáneos, la segunda acerca de los oleogeles y oleogeles de etilcelulosa como sustituto a las grasas saturadas. Finalmente, la tercera temática fueron los ingredientes y alimentos funcionales, así como su legislación a nivel europeo. Discusión: Dentro de la formulación de las cremas de cacao y avellanas, el cacao también parece ser un ingrediente funcional muy prometedor por su alto contenido en vitamina D2. Por otro lado, los monoglicéridos saturados y ceras de origen natural tienen potencial para actuar como oleogeladores alternativos a la etilcelulosa. Conclusiones: El desarrollo de una crema de cacao y avellanas funcional y baja en grasas saturadas haciendo uso de oleogeles enriquecidos con omega-3 de forma teórica es posible. Sin embargo, una experimentación a escala laboratorio y planta piloto es necesaria para poder validar los resultados. metadata León Mejia, Fabricio Samuel mail fabricio.leon@alumnos.uneatlantico.es (2021) Desarrollo Teórico de una Crema de Cacao y Avellanas Funcional Baja en Grasas Saturadas Utilizando Oleogeles Enriquecidos con Ácidos Grasos Omega-3. Diploma thesis, Universidad Europea del Atlántico.

Thesis Subjects > Nutrition Europe University of Atlantic > Teaching > Final Degree Projects Cerrado Español El Síndrome de Ovario Poliquístico (SOP) en un desorden endocrino y reproductivo que se presenta en mujeres en una prevalencia del 6 al 10%. Al síndrome se asocian la obesidad, resistencia a la insulina y el síndrome metabólico. Por ello, el objetivo del TFG es desarrollar unas pautas nutricionales para tratar estas alteraciones metabólicas. metadata Pazos Isabel, Carmen mail UNSPECIFIED (2021) Descripción del abordaje nutricional más adecuado para el tratamiento de las alteraciones metabólicas asociadas al Síndrome de Ovario Poliquístico. Diploma thesis, Universidad Europea del Atlántico.

Thesis Subjects > Biomedicine
Subjects > Nutrition Europe University of Atlantic > Teaching > Final Degree Projects Cerrado Español Estado de la cuestión: El trastorno del espectro autista (TEA) es un trastorno neurológico que afecta al comportamiento y la comunicación y que tiene múltiples etiologías. Actualmente no tiene cura, y por ello se están estudiando diferentes tratamientos sintomáticos, entre los cuáles se encuentra la dieta libre de gluten y caseína. Objetivo: Relacionar la dieta libre de gluten y caseína (GFCF) con la mejora de los síntomas en pacientes con trastorno del espectro autista (TEA).Material y métodos: Se realizó una revisión bibliográfica, y se seleccionaron y consultaron varios artículos científicos. Un total de 12 estudios publicados en los últimos 5 años fueron analizados en profundidad. Resultados y discusión: Existe gran controversia con la GFCF y si esta mejora los síntomas del TEA. En ocasiones, esta dieta ha mejorado tanto síntomas neurológicos como algunos gastrointestinales. Mientras que, en otros casos, no se ha observado mejora o incluso se han producido déficits en algunos nutrientes. Conclusiones: La GFCF no es un tratamiento nutricional recomendado en el TEA. Se necesitan más estudios a largo plazo que estudien el efecto de esta, así como sus posibles efectos secundarios. metadata Malo del Pozo, Leire mail leire.malo@alumnos.uneatlantico.es (2021) Dieta libre de gluten y caseína como tratamiento nutricional del trastorno del espectro autista (TEA). Diploma thesis, Universidad Europea del Atlántico.

Thesis Subjects > Nutrition Europe University of Atlantic > Teaching > Final Degree Projects Cerrado Español Introducción: La depresión es una enfermedad mental que padecen más de 300millones de habitantes en el mundo. Se valoran diferentes tipos de tratamiento entre los que destacan el psicológico y el farmacológico, pero entre los que no se encuentra el tratamiento nutricional pese a que esta enfermedad comparte numerosos factores de riesgo, como altos niveles inflamatorios, que pueden ser tratados mediante una dieta vegetariana o mediterránea. Objetivos: Comparar la efectividad de las dietas vegetariana y mediterránea en el tratamiento del trastorno depresivo para determinar la más indicada para combatirlo. Material y métodos: Revisión bibliográfica mediante el uso de Internet y bases de datos. De los resultados obtenidos se han estudiado en profundidad un total de 19 artículos. Resultados y discusión: El uso de las dietas mediterránea y vegetariana en el tratamiento de la depresión podría mejorar considerablemente los síntomas y reducir la gravedad de esta enfermedad. Esto se debe a sus características antiinflamatoria, su baja carga glucémica, ausencia de cereales refinados y su gran aporte de micronutrientes. Conclusiones: Las dietas mediterránea y vegetariana podrían usarse en un futuro como tratamiento complementario en la depresión. Sin embargo, es necesario realizar más estudios que determinen la duración del tratamiento y especifiquen la idoneidad de cada dieta en cada paciente. metadata Ramada Prieto, Nicolás mail nicolas.ramada@alumnos.uneatlantico.es (2021) Dieta mediterránea versus dieta vegetariana en el trastorno depresivo. Diploma thesis, Universidad Europea del Atlántico.

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Inglés Downy mildew caused by Plasmopara viticola is one of the most devastating diseases of grapevine, attacking all green parts of the plant. The damage is severe when the infection at flowering stage is left uncontrolled. P. viticola management consumes a significant amount of classical pesticides applied in vineyards, requiring efficient and environmentally safe disease management options. Spray-induced gene silencing (SIGS), through the application of exogenous double-stranded RNA (dsRNA), has shown promising results for the management of diseases in crops. Here, we developed and tested the potential of dsRNA targeting P. viticola Dicer-like (DCL) genes for SIGS-based crop protection strategy. The exogenous application of PvDCL1/2 dsRNA, a chimera of PvDCL1 and PvDCL2, highly affected the virulence of P. viticola. The reduced expression level of PvDCL1 and PvDCL2 transcripts in infected leaves, treated with PvDCL1/2 dsRNA, was an indication of an active RNA interference mechanism inside the pathogen to compromise its virulence. Besides the protective property, the PvDCL1/2 dsRNA also exhibited a curative role by reducing the disease progress rate of already established infection. Our data provide a promising future for PvDCL1/2 dsRNA as a new generation of RNA-based resistant plants or RNA-based agrochemical for the management of downy mildew disease in grapevine. metadata Haile, Zeraye Mehari and Gebremichael, Daniel Endale and Capriotti, Luca and Molesini, Barbara and Negrini, Francesca and Collina, Marina and Sabbadini, Silvia and Mezzetti, Bruno and Baraldi, Elena mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, bruno.mezzetti@uneatlantico.es, UNSPECIFIED (2021) Double-Stranded RNA Targeting Dicer-Like Genes Compromises the Pathogenicity of Plasmopara viticola on Grapevine. Frontiers in Plant Science, 12. ISSN 1664-462X

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Inglés Changes in eating behavior and eating disorders are especially common in young people, especially teenage and college women. The first year of college is a critical period, as students acquire freedoms that can lead to poor eating habits. During this first year, students usually gain weight. The aims of this project are to analyze the risk of developing eating disorders, the composition and dietary intake and the changes in the body composition of two groups of college students (independent from the family nucleus or still living within the family) in the first year of college. (2) Material and Methods: Multicentric prospective observational study protocol in which first-year students at the Universidad Europea del Atlántico and Universitat de Vic-Universitat Central de Catalunya voluntarily took part in the study. The students will be divided into two groups, independent and those residing in the family home, and the evolution of both groups will be compared at the beginning and at the end of the school year by performing anthropometric measurements, tests on lifestyle and eating habits (Test of Adherence to the Mediterranean Diet, MEDAS-14; Emotional Eater Questionnaire, EEQ), validated questionnaires on eating disorders (Eating Attitude Test, EAT26; Teen Figure Drawing Scales; SCOFF, Eating Behavior Test; Bulimia Investigatory Test Edinburgh, BITE) and their intake will be evaluated through 72 h dietary records. (3) Discussion: Determining the risk of suffering eating disorders of alimentary behavior, knowing eating consumption, perception of the corporal image and body composition through the first year of college will be decisive in establishing alimentary education strategies to prevent possible eating disorders in young students. metadata Vila-Martí, Anna and Elío Pascual, Iñaki and Sumalla Cano, Sandra mail UNSPECIFIED, inaki.elio@uneatlantico.es, sandra.sumalla@uneatlantico.es (2021) Eating Behavior during First-Year College Students, including Eating Disorders—RUVIC-RUNEAT-TCA Project. Protocol of an Observational Multicentric Study. International Journal of Environmental Research and Public Health, 18 (18). p. 9457. ISSN 1660-4601

Thesis Subjects > Nutrition Europe University of Atlantic > Teaching > Final Degree Projects Cerrado Español Introducción: la alimentación puede actuar como factor de riesgo o factor protector de las enfermedades cardiovasculares. Históricamente, las grasas saturadas se han relacionado con las patologías cardiovasculares y se recomienda reducir su consumo. El objetivo de esta revisión es determinar si existe una relación entre el consumo de grasas saturadas vegetales y la patología cardiovascular. Material y métodos: se realizó una revisión bibliográfica en la que se consultaron artículos y otros documentos científicos relacionados con las grasas saturadas vegetales y la salud cardiovascular de los últimos cinco años. La mayoría de los artículos se obtuvieron de PubMed.Discusión: la evidencia científica en los últimos cinco años sugiere que el consumo de diferentes grasas saturadas produce diferentes efectos en el colesterol sérico y la salud cardiovascular. Esto puede explicarse por la matriz alimentaria de cada grasa vegetal y los ácidos grasos que la componen. Conclusiones: no se puede establecer una clara relación entre el consumo de grasas saturadas vegetales y la enfermedad cardiovascular, se debe estudiar el efecto de cada grasa individualmente. Se debería considerar mejorar las recomendaciones sobre grasas saturadas de las guías alimentarias. metadata Lahera Rodríguez, Cristina mail cristina.lahera@alumnos.uneatlantico.es (2021) Efecto de las grasas saturadas de origen vegetal sobre la salud cardiovascular. Diploma thesis, Universidad Europea del Atlántico.

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production UNSPECIFIED UNSPECIFIED Antimony is a toxic element whose concentration in soil and water has been rising due to anthropogenic activities. This study focuses on its accumulation in leaves of Dittrichia viscosa growing in soils of an abandoned Sb mine, and the effect on oxidant/antioxidant systems and photosynthetic efficiency. The results showed leaves to have a high Sb accumulation capacity. The amount of total chlorophyll decreased depending on Sb concentration and of carotenoids increased slightly, with a consequent increase in carotenoid/chlorophyll ratio. Photosynthetic efficiency was unaffected. The amount of O .−2 rose, although there was no increase in cell membrane damage, with lipid peroxidation levels being similar to normal. This response may be due to considerable increases that were observed in total phenolics, PPO activity, and enzymatic antioxidant system. SOD, POX, and DHAR activities increased in response to increased Sb amounts in leaves. The ascorbate/glutathione cycle was also affected, with strong increases observed in all of its components, and consequent increases in total contents of the ascorbate and glutathione pools. However, the ratio between reduced and oxidized forms declined, reflecting an imbalance between the two, especially that between GSH and GSSG. Efficient detoxification of Sb may take place either through increases in phenolics, carotenoids, and components of the glutathione–ascorbate cycle or through the enzymatic antioxidant system. Since Dittrichia viscosa accumulates large amounts of Sb without suffering oxidative damage, it could be used for phytoremediation. metadata Garrido, Ignacio and Ortega, A. and Hernández Suárez, Marcos and Fernández-Pozo, L. and Cabezas, J. and Espinosa, F. mail UNSPECIFIED, UNSPECIFIED, marcos.hernandez@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2021) Effect of antimony in soils of an Sb mine on the photosynthetic pigments and antioxidant system of Dittrichia viscosa leaves. Environmental Geochemistry and Health, 43 (4). pp. 1367-1383. ISSN 0269-4042

Thesis Subjects > Nutrition Europe University of Atlantic > Teaching > Final Degree Projects Cerrado Español Introducción: El trabajo organizado mediante turnos rotativos supone un desajuste de los ritmos circadianos que puede derivar en obesidad. La crononutrición busca organizar las ingestas diarias teniendo en cuenta los tiempos que marca el reloj biológico. El uso de esta herramienta podría ser una manera efectiva de tratar la obesidad en aquellos trabajadores con una jornada laboral por turnos rotativos. Objetivos: Evaluar la eficacia del empleo de la crononutrición como herramienta complementaria a la dieta en trabajadores con turnos rotativos que padezcan obesidad. Material y métodos: Revisión bibliográfica de gran variedad de artículos científicos de actualidad obtenidos de revistas indexadas. Se analizaron 28 artículos publicados en los últimos 5 años, los cuales fueron obtenidos de la base de datos Pubmed. Discusión y conclusiones: La crononutrición podría ser un abordaje nutricional fundamental en el caso de personas obesas que trabajan por turnos rotativos. Son necesarios más estudios que relacionen los efectos de los turnos rotativos en la salud metabólica y observen la eficacia del empleo de la crononutrición. metadata López de Lerena de la Rica, Paloma mail paloma.lopez@alumnos.uneatlantico.es (2021) Empleo de la crononutrición en el abordaje de la obesidad en trabajadores con turnos rotativos. Diploma thesis, Universidad Europea del Atlántico.

Thesis Subjects > Nutrition Europe University of Atlantic > Teaching > Final Degree Projects Cerrado Español Objetivo: Evaluar la efectividad de una dieta hiperproteica y una suplementación específica como nuevas estrategias para el tratamiento de pacientes con sarcopenia. Material y métodos: Se realizó una revisión bibliográfica, para la cual se seleccionaron y consultaron varios artículos científicos, documentos y libros. Un total de 14 estudios publicados en los últimos 5 años pertenecientes principalmente a la base de datos Pubmed fueron analizados en profundidad. Resultados y discusión: Tanto la dieta hiperproteica como la suplementación específica son estrategias dietético-nutricionales tan efectivas y seguras como otros diferentes tipos de dietas, incluida la dieta Mediterránea, para el tratamiento de la sarcopenia. En cuanto a la dieta hiperproteica, es segura siempre y cuando no exista daño renal previo. Conclusiones: Se necesita un número mayor de estudios científicos para demostrar que ambas estrategias tienen efectos sobre la sarcopenia. metadata Murúa Foncea, Javier mail javier.murua@alumnos.uneatlantico.es (2021) Estrategias nutricionales para el tratamiento de la sarcopenia. Diploma thesis, Universidad Europea del Atlántico.

Thesis Subjects > Nutrition Europe University of Atlantic > Teaching > Final Degree Projects Cerrado Español Estado de la cuestión: En la actualidad existen numerosos problemas nutricionales y metabólicos derivados del trabajo por turnos. Dentro de estos problemas se encuentran enfermedades como la obesidad, la diabetes o el síndrome metabólico. Debido al momento de las comidas, el trabajo por turnos influye considerablemente en ello, provocando también que el descanso y las horas de sueño no sean las adecuadas, con lo que pueden producirse disrupciones que afecten a nuestro cuerpo. Metodología: La metodología consiste en todas las bases de datos utilizadas, así como las palabras clave, criterios de inclusión y exclusión aplicados para seleccionar los mejores estudios y llevar a cabo la revisión. Discusión y conclusiones: Los resultados de esta revisión fueron mayormente los esperados conforme a los objetivos propuestos, existe un vínculo entre la obesidad, la diabetes y los problemas metabólicos. A modo de conclusión cabe destacar que, pese a que existe una relación causal entre las diferentes variables analizadas (obesidad, diabetes, sueño, trabajo por turnos), aún no se puede llegar a una conclusión clara en muchos casos ya que existen más factores que influyen con lo que es recomendable seguir investigando esta área de la nutrición y la cronobiología. Recomendaciones: Es realmente recomendable ofrecer a los trabajadores una educación nutricional con la colaboración de diferentes profesionales de salud incluyendo a los familiares y compañeros de trabajo creando un clima favorable para desarrollar estrategias y prevenir este tipo de problemas. metadata Urtiaga Fernández, José María mail jose.urtiaga@alumnos.uneatlantico.es (2021) Estrategias nutricionales para la prevención de problemas nutricionales y metabólicos en trabajadores a turnos. Diploma thesis, Universidad Europea del Atlántico.

Thesis Subjects > Engineering
Subjects > Nutrition Europe University of Atlantic > Teaching > Final Degree Projects Cerrado Español Introducción: Se estima que actualmente la industria vitivinícola produce 1.5 toneladas de residuos por hectáreas al año, para 2021 la superficie total de viñedo a nivel mundial es de aproximadamente 7.3 millones de hectáreas. La cantidad de residuos generados por esta industria, supone un problema social, por lo que se debe encontrar la manera adecuada de gestionarlos. Siendo la valorización de residuos una solución óptima, ya que a su vez contribuirá a una economía circular. Los principales residuos generados son las lías y el orujo, que son de sumo provecho debido a las altas concentraciones de compuesto bioactivos que pueden ser extraídos para su reincorporación al sector industrial.Objetivos: Describir que métodos pueden emplearse para la extracción de compuestos bioactivos de los residuos de la industria vitivinícola. Material y métodos: Revisión bibliográfica, en la cual los documentos e información fue obtenida a partir de distintas bases de datos, como ScienceDirect, Google Academic, Research Gate, PubMed y Scientific Research. Se emplearon criterios de inclusión para seleccionar artículos cuyas fechas de publicación fueran desde 2015 hasta 2020.Resultados y discusión: Se contrastaron distintos datos sobre los métodos que presentaban un mayor rendimiento en la extracción de fenoles, polifenoles y antocianinas de orujo de uva y lías de vino. Se logró comprobar que aunque la extracción sólido-líquido es la más empleada se pueden mejorar los rendimientos de extracción al complementarlo con otros métodos como pueden ser las microondas, el ultrasonido o el uso de líquidos iónicos. Conclusiones: Existen variedad de métodos para la extracción los fenoles y las antocianinas presentes en los residuos de la industria vitivinícola. Aunque hay métodos que funcionan adecuadamente como la extracción a través de solventes, también hay métodos emergentes sobre los cuales hacen falta más estudios para asegurar su fiabilidad, como la extracción por ultrasonido y líquido iónico. La disolución etanol: agua probó ser un el solvente que permite un mayor rendimiento de extracción. metadata Aglietti Arcia, Alissa mail alissa.aglietti@alumnos.uneatlantico.es (2021) Estrategias para el aprovechamiento de residuos en la industria vitivinícola. Diploma thesis, Universidad Europea del Atlántico.

Article Subjects > Biomedicine
Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Cerrado Inglés Inflammation is a key mechanism of the immune system that can be elicited by several factors, among them several chemical, physical and biological agents. Once stimulated, the inflammatory response activates a series of signaling pathways and a number of immune cells which promote, in a very coordinated manner, the neutralization of the infectious agent. However, if uncontrolled, the inflammatory status may become chronic leading, potentially, to tissue damage and disease onset. Several risk factors are associated with the development of chronic inflammation and, among these factors, diet plays an essential role. In this chapter the effects of some dietary bioactive compounds, including micronutrients, omega-3 fatty acids, nucleotides and polyphenols, on the immunoinflammatory responses in different cellular, animal and human studies have been summarized. metadata Giampieri, Francesca and Cianciosi, Danila and Ansary, Johura and Elexpuru Zabaleta, Maria and Forbes-Hernandez, Tamara Y. and Battino, Maurizio mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maria.elexpuru@uneatlantico.es, UNSPECIFIED, UNSPECIFIED (2021) Immunoinflammatory effects of dietary bioactive compounds. Advances in Food and Nutrition Research, 95. pp. 295-336. ISSN 10434526

Thesis Subjects > Nutrition Europe University of Atlantic > Teaching > Final Degree Projects Cerrado Español Estado de la cuestión: la exposición a la publicidad de alimentos no saludables es un factor de riesgo en el desarrollo de la obesidad. Por esto, una alimentación saludable, especialmente durante la infancia, es un importante objetivo social, ya que en esta etapa se crean hábitos y conductas alimentarias que se mantendrán durante la vida adulta. Objetivo: analizar detalladamente cómo es la relación de los niños en edad escolar, comprendida entre los 3 y 11 años, con la televisión y cómo esta influye en sus conductas alimentarias. Material y métodos: se han utilizado las bases de datos PubMed, Scielo, Dialnet y Google Scholar para buscar bibliografía sobre la influencia de la publicidad en las conductas alimentarias de los niños. Un total de 51 artículos fueron seleccionados para el desarrollo de este trabajo. Resultados y discusión: la literatura existente sobre la relación entre la publicidad alimentaria y la infancia, indica que los niños consumen alimentos insanos y que esto se relaciona directamente con la obesidad. Conclusiones: los espacios publicitarios que se emiten en horario infantil no son adecuados para el correcto desarrollo nutricional de los niños. metadata Abascal Rábago, Marta mail marta.abascal@alumnos.uneatlantico.es (2021) Influencia de los mensajes publicitarios en los hábitos alimenticios de la población infantil. Diploma thesis, Universidad Europea del Atlántico.

Thesis Subjects > Nutrition Europe University of Atlantic > Teaching > Final Degree Projects Cerrado Español Estado de la cuestión: el sobrepeso y la obesidad son afecciones cuya prevalencia está en aumento en todo el mundo, asociándose con muchas patologías secundarias que van a empeorar el estado de salud. Recientemente se han llevado a cabo estudios para determinar si el sobrepeso y la obesidad pueden limitar el rendimiento académico durante la infancia, por lo que el objetivo del presente trabajo es averiguar si afecta negativamente a este rendimiento. Materiales y métodos: se llevó a cabo una revisión bibliográfica en la que se analizaron los artículos procedentes de varias bases de datos con una fecha de publicación máxima de cinco años. Resultados y discusión: la mayoría de los artículos seleccionados sugieren que los niños con un exceso de peso van a tener un rendimiento académico disminuido en comparación con los niños con un peso adecuado. Sin embargo, también se han encontrado unos pocos artículos que se oponen a la afirmación anterior, declarando que no se encuentran diferencias entre unos y otros. Conclusiones: la presencia de sobrepeso y obesidad en la infancia parece tener un efecto negativo en su rendimiento académico, aunque es necesaria la elaboración de más estudios con la finalidad de lograr un consenso. metadata Albarellos Arnilla, Ana mail ana.albarellos@alumnos.uneatlantico.es (2021) Influencia del sobrepeso/obesidad en el rendimiento académico durante la infancia (3-12 años). Diploma thesis, Universidad Europea del Atlántico.

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Inglés The prevalence of overweight and obesity has been rising among Mexican children and adolescents in the last decades. To systematically review obesity prevention interventions delivered to Mexican children and adolescents. Thirteen databases and one search engine were searched for evidence from 1995 to 2021. Searches were done in English and Spanish to capture relevant information. Studies with experimental designs, delivered in any setting (e.g., schools or clinics) or digital domains (e.g., social media campaigns) targeting Mexican children or adolescents (≤ 18 years) and reporting weight outcomes, were included in this review. In addition, the risk of bias was appraised with the Effective Public Health Practice Project Quality Assessment Tool. Twenty-nine studies with 19,136 participants (3-17 years old) were included. The prevalence of overweight and obesity at baseline ranged from 21 to 69%. Most of the studies (89.6%) were delivered in school settings. The duration ranged from 2 days to 3 school years, and the number of sessions also varied from 2 to 200 sessions at different intensities. Overall, anthropometric changes varied across studies. Thus, the efficacy of the included studies is heterogeneous and inconclusive among studies. Current evidence is heterogeneous and inconclusive about the efficacy of interventions to prevent obesity in Mexican children and adolescents. Interventions should not be limited to educational activities and should include different components, such as multi-settings delivery, family inclusion, and longer-term implementations. Mixed-method evaluations (including robust quantitative and qualitative approaches) could provide a deeper understanding of the effectiveness and best practices. metadata Aceves-Martins, Magaly and López-Cruz, Lizet and García-Botello, Marcela and Gutierrez-Gómez, Yareni Yunuen and Moreno-García, Carlos Francisco mail UNSPECIFIED (2021) Interventions to Prevent Obesity in Mexican Children and Adolescents: Systematic Review. Prevention Science. ISSN 1389-4986

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Inglés Context Prevalence of overweight and obesity has been rising in the past 3 decades among Mexican children and adolescents. Objective To systematically review experimental studies evaluating interventions to treat obesity in Mexican children and adolescents (≤18 years old). Data Sources For this study, 13 databases and 1 search engine were searched. Data Analysis A total of 29 studies met the inclusion criteria. Overall, 2302 participants (age range, 8–16 years) from 11 states in Mexico were included. Most of the studies (n = 17 of 29) were provided in a clinical setting. A random-effect meta-analysis of 4 randomized controlled trials was conducted and a significant effect was found on body mass index reduction that favored the intervention group (−1.52; 95%CI, −2.15 to −0.89) for short-term (≤6 mo) interventions. Conclusions A multicomponent, multidisciplinary, and individualized intervention that includes dietary modifications, physical activity practice, behavioral strategies, and active parental involvement might help treat childhood obesity in Mexico. However, long-term results need to be produced to identify effectiveness pointers that might help establish an integrated, long-lasting care model to treat obesity. metadata Aceves-Martins, Magaly and López-Cruz, Lizet and García-Botello, Marcela and Gutierrez-Gómez, Yareni Yunuen and Moreno-García, Carlos Francisco mail UNSPECIFIED (2021) Interventions to Treat Obesity in Mexican Children and Adolescents: Systematic Review and Meta-Analysis. Nutrition Reviews, 80 (3). pp. 544-560. ISSN 0029-6643

Thesis Subjects > Nutrition Europe University of Atlantic > Teaching > Final Degree Projects Cerrado Español Objetivos: La depresión (trastorno depresivo mayor o TDM), depresión mayor (DM o depresión clínica) es una enfermedad crónica, generalizada, de etiología compleja que afecta los pensamientos y el estado de ánimo. Dicho trastorno exige necesidades terapéuticas que en la actualidad aún son escasas y sin satisfacer. Por ello, el objetivo de este TFG es determinar la influencia de una dieta rica en ácidos omega-3,probióticos y/o prebióticos que puedan ayudar en la reducción de síntomas del espectro depresivo. Material y métodos: mediante búsqueda bibliográfica, en diferentes bases de datos, revistas y webs especializadas, se examinaron los factores predeterminantes que influyen en el TDM para encontrar la relación entre el trastorno depresivo y los posibles tratamientos dietéticos coadyuvantes para la reducción de los síntomas depresivos. Resultados y discusión: una dieta rica en probióticos, ácidos omega-3 y/o prebióticos podría servir en un futuro como tratamiento coadyuvante para reducir los síntomas de la depresión. Conclusiones: son necesarios más estudios, con muestras más grandes de pacientes diagnosticados con TDM para confirmar los resultados hallados metadata Díaz Rodríguez, Gabriela Margarita mail gabriela.diaz@alumnos.uneatlantico.es (2021) Nutrición y Depresión: Papel de los Ácidos Omega-3, Probióticos y Prebióticos. Diploma thesis, Universidad Europea del Atlántico.

Article Subjects > Biomedicine
Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Inglés Modern high-throughput ‘omics’ science tools (including genomics, transcriptomics, proteomics, metabolomics and microbiomics) are currently being applied to nutritional sciences to unravel the fundamental processes of health effects ascribed to particular nutrients in humans and to contribute to more precise nutritional advice. Diet and food components are key environmental factors that interact with the genome, transcriptome, proteome, metabolome and the microbiota, and this life-long interplay defines health and diseases state of the individual. Rheumatoid arthritis (RA) is a chronic autoimmune disease featured by a systemic immune-inflammatory response, in genetically susceptible individuals exposed to environmental triggers, including diet. In recent years increasing evidences suggested that nutritional factors and gut microbiome have a central role in RA risk and progression. The aim of this review is to summarize the main and most recent applications of ‘omics’ technologies in human nutrition and in RA research, examining the possible influences of some nutrients and nutritional patterns on RA pathogenesis, following a nutrigenomics approach. The opportunities and challenges of novel ‘omics technologies’ in the exploration of new avenues in RA and nutritional research to prevent and manage RA will be also discussed. metadata Cassotta, Manuela and Forbes-Hernandez, Tamara Y. and Cianciosi, Danila and Elexpuru Zabaleta, Maria and Sumalla Cano, Sandra and Dominguez Azpíroz, Irma and Bullon, Beatriz and Regolo, Lucia and Alvarez-Suarez, Josè Miguel and Giampieri, Francesca and Battino, Maurizio mail manucassotta@gmail.com, UNSPECIFIED, UNSPECIFIED, maria.elexpuru@uneatlantico.es, sandra.sumalla@uneatlantico.es, irma.dominguez@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es (2021) Nutrition and Rheumatoid Arthritis in the ‘Omics’ Era. Nutrients, 13 (3). p. 763. ISSN 2072-6643

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production UNSPECIFIED UNSPECIFIED In recent times, scientific attention has been paid to different foods and their bioactive components for the ability to inhibit the onset and progress of different types of cancer. Nigella sativa extract, powder and seed oil and its main components, thymoquinone and α-hederin, have showed potent anticancer and chemosensitizing effects against various types of cancer, such as liver, colon, breast, renal, cervical, lung, ovarian, pancreatic, prostate and skin tumors, through the modulation of various molecular signaling pathways. Herein, the purpose of this review was to highlight the anticancer activity of Nigella sativa and it constitutes, focusing on different in vitro, in vivo and clinical studies and projects, in order to underline their antiproliferative, proapoptotic, cytotoxic and antimetastatic effects. Particular attention has been also given to the synergistic effect of Nigella sativa and it constitutes with chemotherapeutic drugs, and to the synthesized analogs of thymoquinone that seem to enhance the chemo-sensitizing potential. This review could be a useful step towards new research on N. sativa and cancer, to include this plant in the dietary treatments in support to conventional therapies, for the best achievement of therapeutic goals. metadata Ansary, Johura and Giampieri, Francesca and Forbes-Hernandez, Tamara Y. and Regolo, Lucia and Quinzi, Denise and Gracia Villar, Santos and Garcia Villena, Eduardo and Tutusaus, Kilian and Alvarez-Suarez, José M. and Battino, Maurizio and Cianciosi, Danila mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, santos.gracia@uneatlantico.es, eduardo.garcia@uneatlantico.es, kilian.tutusaus@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2021) Nutritional Value and Preventive Role of Nigella sativa L. and Its Main Component Thymoquinone in Cancer: An Evidenced-Based Review of Preclinical and Clinical Studies. Molecules, 26 (8). p. 2108. ISSN 1420-3049

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Abierto Inglés Presently, biopreservation through protective bacterial cultures and their antimicrobial products or using antibacterial compounds derived from plants are proposed as feasible strategies to maintain the long shelf-life of products. Another emerging category of food biopreservatives are bacteriophages or their antibacterial enzymes called “phage lysins” or “enzybiotics”, which can be used directly as antibacterial agents due to their ability to act on the membranes of bacteria and destroy them. Bacteriophages are an alternative to antimicrobials in the fight against bacteria, mainly because they have a practically unique host range that gives them great specificity. In addition to their potential ability to specifically control strains of pathogenic bacteria, their use does not generate a negative environmental impact as in the case of antibiotics. Both phages and their enzymes can favor a reduction in antibiotic use, which is desirable given the alarming increase in resistance to antibiotics used not only in human medicine but also in veterinary medicine, agriculture, and in general all processes of manufacturing, preservation, and distribution of food. We present here an overview of the scientific background of phages and enzybiotics in the food industry, as well as food applications of these biopreservatives. metadata Ramos Vivas, Jose and Elexpuru Zabaleta, Maria and Sámano Celorio, María Luisa and Pascual Barrera, Alina Eugenia and Forbes-Hernandez, Tamara Y. and Giampieri, Francesca and Battino, Maurizio mail jose.ramos@uneatlantico.es, maria.elexpuru@uneatlantico.es, marialuisa.samano@uneatlantico.es, alina.pascual@unini.edu.mx, tamara.forbes@unini.edu.mx, UNSPECIFIED, UNSPECIFIED (2021) Phages and Enzybiotics in Food Biopreservation. Molecules, 26 (17). p. 5138. ISSN 1420-3049

Thesis Subjects > Nutrition Europe University of Atlantic > Teaching > Final Degree Projects Cerrado Español Muchas mujeres en edad fértil padecen un dolor en la parte baja del abdomen durante la menstruación, este dolor es conocido como dismenorrea, y en muchas ocasiones obliga a las mujeres a cesar sus actividades cotidianas. La evidencia científica señala que ciertos alimentos pueden mejorar o empeorar esta condición. Esta investigación pretende determinar si algunos alimentos, y la frecuencia de su consumo, pueden ejercer un impacto positivo sobre la intensidad o duración de la dismenorrea. La evidencia señala que los alimentos ricos en omega 3, frutas, verduras y unos hábitos regulares en la ingesta de las comidas son beneficiosos para paliar los efectos de la dismenorrea. metadata Gutiérrez Bedia, Ángela mail angela.gutierrez@alumnos.uneatlantico.es (2021) Relación del dolor menstrual con la alimentación. Diploma thesis, Universidad Europea del Atlántico.

Other Subjects > Engineering
Subjects > Nutrition Europe University of Atlantic > Research > Projects I+D+I Cerrado Español A través del presente proyecto de transferencia se pretende aportar una innovación en relación a un marcador en plasma que se correlacione con el consumo de frutas y verduras por parte de la población. A partir de ello, se pretenden comercializar nuevos servicios basados en la tecnología y orientados a la mejora de la salud en la población general y en el deporte. metadata , Universidad de León mail UNSPECIFIED (2021) Servicios tecnológicos para la industria alimentaria y la salud en torno al consumo de frutas y verduras. Repositorio de la Universidad. (Unpublished)

Thesis Subjects > Nutrition Europe University of Atlantic > Teaching > Final Degree Projects Cerrado Español Introducción: la producción y el consumo de carne está aumentando como consecuencia del incremento poblacional. Sin embargo, este exceso se relaciona con un impacto negativo sobre la salud humana y el medio ambiente. Así, han surgido varias alternativas en el mercado como posible solución ante esta problemática. Una de estas opciones es la carne cultivada, una carne obtenida a partir de células madre del animal. Pero, ¿es esta opción realmente más sostenible? Objetivo: analizar la situación actual de la producción de carne in vitro como una técnica más sostenible. Material y métodos: se realizó una revisión de 41 artículos obtenidos de la base de datos PubMed. En esta búsqueda, se tuvieron en cuenta los años de publicación y las revistas indexadas como factores de inclusión. Discusión y conclusiones: la producción de carne cultivada es aún una tecnología novedosa que requiere mejoras y, aunque ofrece numerosos beneficios potenciales, por el momento es complicado obtener una respuesta sobre si esta carne será más sostenible que la convencional. metadata Castanedo Cubas, María mail maria.castanedo@alumnos.uneatlantico.es (2021) Situación actual de la producción de la carne cultivada como técnica más sostenible frente a la carne tradicional. Diploma thesis, Universidad Europea del Atlántico.

Thesis Subjects > Nutrition Europe University of Atlantic > Teaching > Final Degree Projects Cerrado Español Introducción: La esquizofrenia es una enfermedad mental de naturaleza grave que afecta a más de 21 millones de personas, por ello, actualmente se está investigando la posible suplementación con omega 3 como nueva estrategia complementaria de tratamiento. Objetivos: Realizar una revisión bibliográfica sobre los beneficios clínicos del suplemento de omega 3 en la esquizofrenia. Materiales y métodos: Mediante la realización de una revisión bibliográfica se seleccionaron y analizaron 7 artículos, relacionados con la suplementación con omega 3 en pacientes con esquizofrenia, con una antigüedad máxima de 5 años de publicación utilizando como fuente principal la base de datos Pubmed. Resultados y discusión: Tras analizar la información obtenida de los estudios seleccionados, los cuales sugieren una suplementación con omega 3 como terapia complementaria a un tratamiento farmacológico con antipsicóticos, se dedujo que este tratamiento combinado ejercería un efecto beneficioso tanto en la sintomatología como en el propio abandono del tratamiento farmacológico. Conclusiones: Una suplementación con omega 3 mezclando ácido docosahexaenoico (DHA) y ácido eicosapentaenoico (EPA) en cantidades de 1 a 4 g diarios en pacientes con esquizofrenia ayuda a mejorar los diferentes síntomas asociados. metadata Martínez López, Carmen mail carmen.martinez@alumnos.uneatlantico.es (2021) Suplementación de Omega 3 en la esquizofrenia. Diploma thesis, Universidad Europea del Atlántico.

Thesis Subjects > Nutrition Europe University of Atlantic > Teaching > Final Degree Projects Cerrado Español Introducción: La diabetes mellitus tipo 2 se ha relacionado con el estilo de vida del siglo XXI. Frente a la prevalencia e incidencia se han creado alternativas terapéuticas basadas en los hábitos de vida, principalmente los nutricionales, siendo la crononutrición, específicamente el timing y orden de ingesta de los alimentos, una nueva estrategia terapéutica efectiva en la regulación de los valores insulínicos. Objetivo: Realizar una revisión bibliográfica de alta evidencia científica que permita comprobar la eficacia del timing y orden de ingesta de alimentos como tratamiento en los pacientes con diabetes mellitus 2.Métodos: Se realizó una búsqueda bibliográfica en bases de datos como Pubmed, Scielo, Google académico y ScienceDirect, teniendo en cuenta los criterios de inclusión planteados. Se obtuvo un total de 60 estudios de los cuales 51 fueron consultados para el capítulo 1 (estado de la cuestión) y 9 para el capítulo 4(discusión).Discusión y Conclusión: El timing y orden de ingesta de los alimentos ha demostrado ser una intervención dietética nutricional efectiva en la diabetes mellitus tipo II, al regular y mejorar los niveles glucémicos y la sintomatología, respectivamente. Sin embargo, hacen falta investigaciones actualizadas que permitan a los profesionales de salud adoptar esta alternativa de manera segura y generalizada en el ámbito de consulta, siendo una opción para cualquier sector dela población con esta enfermedad. metadata Acero Cely, Juanita mail juanita.acero@alumnos.uneatlantico.es (2021) Timing y orden de ingesta de alimentos como tratamiento en la diabetes Tipos II. Diploma thesis, Universidad Europea del Atlántico.

Other Subjects > Engineering
Subjects > Nutrition Europe University of Atlantic > Research > Projects I+D+I Cerrado Español La Organización de las Naciones Unidas para la Alimentación y la Agricultura (FAO) estima que una de las vías para alimentar a los más de 9000 millones de personas y miles de millones de animales que previsiblemente habrá en la Tierra en 2050 será con insectos. Dicha alternativa se adelanta a la previsión de que este aumento demográfico coincidirá con una importante degradación del planeta como consecuencia del cambio climático y la sobreexplotación de los recursos. necesitaremos un aumento del 70% se proteína para alimentar el planeta y recomendaban el insecto como fuentes de alimentación. Un aspecto en el que la insectocultura aprueba con buena nota es que la cría industrializada de tenebrio genera menos residuos y emisiones de gases de efecto invernadero que la ganadería convencional. Desde ese momento comienzan a apoyar al máximo mediante leyes y subvenciones muy importantes, como la del 1 enero del 2017 y el uso y comercialización del Tenebrio Molitor como fuente sostenible y saludable de alimento. La Soja está deforestando gran parte del planeta y se tiende a eliminar la dependencia que tenemos de ella y las harinas de pescado se pretende restringir una media de una tonelada menos al año en pesca para no sobrecargar a nuestros océanos. Esto hace que ahora sea el momento prefecto para comenzar con este tipo de producción. Además, se sabe que es una opción saludable: actualmente la entomofagia está regulada en la Unión Europea, Asia, América Latina y África, donde unos 2000 millones de personas ya complementan su dieta con insectos comestibles que se pueden encontrar en supermercados o restaurantes. En este proyecto se pretende, por un lado, desarrollar una BAC (Barrita Alimentaria Concentrada) con harina de tenebrio molitor y, por otro lado, estudiar la aceptabilidad que tendría en potenciales consumidores. metadata , YNSECTO mail UNSPECIFIED (2021) YNSECTO: Desarrollo de un nuevo producto a partir de harinas de tenebrio molitor con fines de alimentación humana. Repositorio de la Universidad. (Unpublished)

2020

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production UNSPECIFIED UNSPECIFIED Introducción: el envejecimiento de la población española se ha incrementado en las últimas décadas; en Santander, el 24,73 % de la población son personas mayores. La adherencia a las recomendaciones de una alimentación saludable en este colectivo se ha relacionado con un mejor estado de salud y calidad de vida. Objetivos: evaluar el grado de adherencia a las recomendaciones de la Guía de Alimentación Saludable para Atención Primaria y Colectivos Ciudadanos de la SENC (2018) en un grupo de población de entre 65 y 79 años de edad, no institucionalizada, del municipio de Santander (España). Métodos: este fue un estudio transversal, observacional y descriptivo. Participaron 317 individuos de 71,8 (±4,1) años, correspondientes a tres Centros de Atención Primaria (CAP) del Servicio Cántabro de Salud (SCS). Se cumplimentó un cuestionario de elaboración propia, extraído de las recomendaciones de la Guía de la SENC (2018). Se analizó la relación entre dos variables cualitativas independientes mediante la prueba del chi cuadrado, considerando significativo un valor p < 0,05. Resultados: la adherencia a las recomendaciones de alimentos de consumo diario fue: agua (23 %), cereales y patatas (12,9 %), frutas (50,2 %), verduras y hortalizas (16,7 %), aceite de oliva (61,8 %) y lácteos (39,1 %). En los alimentos de consumo semanal fue: pescado (12 %), carnes blancas (17 %), huevos (19,9 %), legumbres (75,1 %) y frutos secos (36,9 %). Conclusiones: los resultados obtenidos muestran una baja adherencia a las recomendaciones de la SENC, excepto en las legumbres. Por este motivo se precisa incidir en este grupo de población para mejorar sus hábitos dietéticos. metadata Cubas de Basterrechea, Gloria and González Antón, Carolina and de la Vega-Hazas Pérez, Carmen and Elío Pascual, Iñaki and Muñoz Cacho, Pedro mail UNSPECIFIED, UNSPECIFIED, carmen.delavega@alumnos.uneatlantico.es, inaki.elio@uneatlantico.es, UNSPECIFIED (2020) Adherence to the healthy eating guide issued by the Sociedad Española de Nutrición Comunitaria (SENC) (2018) among non-institutionalized elderly in Santander, Spain. Nutrición Hospitalaria, 37 (5). pp. 933-943. ISSN 0212-1611

Other Subjects > Nutrition Europe University of Atlantic > Research > Projects I+D+I Cerrado Español La miel es y ha sido una de las fuentes naturales alimenticias de la humanidad. Su valor terapéutico ha sido conocido y explotado con éxito desde la antigüedad. Sin embargo, aunque muchos de los métodos tradicionales han pervivido hasta nuestros días, los procedimientos de recolección y procesado han evolucionado en favor de técnicas más modernas. El manejo de la apicultura a través de panales artificiales aumenta la cosecha, pero en detrimento de los valores nutricionales y medicinales de la miel y demás productos derivados. En Cantabria, la industria agroalimentaria ha sido y es un pilar fundamental. En concreto, la producción y tradición apícola ha pasado de generación en generación siendo un signo de identidad en muchas comarcas de la región donde ha impulsado el empleo rural y la conservación del ecosistema. En los últimos años, la cría de Apis mellifera en esta Comunidad ha visto aumentar la producción melífera gracias a la obtención de denominaciones de origen protegidas (Miel de Liébana) (Pliego de Condiciones de La Denominación de Origen Protegida “Miel de Liébana,” n.d.) y al incremento de la producción y venta de enjambres (Consejeria de Desarrollo Rural, Ganaderia, Pesca y Biodiversidad, n.d.). La apicultura tradicional cántabra se realiza a través del aprovechamiento de troncos vaciados de árboles (dujos o corchos) que permite la producción de miel y cera con alta concentración de componentes bioactivos debido a la propia composición y características de las especies arbóreas y arbustivas de la orografía lebaniega. En efecto, la rugosidad interior de los troncos provoca que las abejas produzcan más cantidad de propóleo, sustancia antiparasitaria que, junto al uso de algunas plantas autóctonas, evitan el uso de pesticidas dando lugar a un producto que se podría caracterizar como biológico para el mercado tanto nacional como internacional. La documentación etnográfica y el análisis nutricional de la miel derivada de la apicultura tradicional nos brinda en este caso una oportunidad única de fomento de un sistema de producción apícola sostenible que cumplirá una doble función: por un lado, la recuperación de la técnica del trasmocho y el consiguiente saneamiento y mantenimiento del ecosistema natural de las abejas. Y, por otro lado, el rescate de las propiedades biológicas naturales que confieren un gran valor añadido a este producto. metadata CITICAN-Universidad Europea del Atlántico, mail UNSPECIFIED (2020) Caracterización de las propiedades nutricionales de la miel cántabra obtenida mediante métodos de apicultura tradicionales. Repositorio de la Universidad. (Unpublished)

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Español Para combatir la mala nutrición en todas sus formas es necesario integrar acciones desde la sociedad en su conjunto. El interés superior de los actores involucrados en generar estas acciones debe ser la salud. No obstante, existen actores con conflictos de interés que interfieren en el diseño, planeación, implementación y monitoreo de las políticas derivadas de dichas acciones. A fin de mitigar el efecto adverso que generan estos conflictos desde la etapa de generación de evidencia hasta el diseño e implementación de las políticas, se propone este código. Se invita a la comunidad de nutrición y salud a adoptarlo, promoverlo y sumarse al mismo, para favorecer el avance de las acciones y políticas necesarias sin interferencia de la industria y resolver el problema de la mala nutrición. metadata Barquera, Simón and Balderas, Nydia and Rodríguez, Estefanía and Kaufer-Horwitz, Martha and Perichart, Otilia and Rivera-Dommarco, Juan A mail UNSPECIFIED (2020) Código Nutricia: nutrición y conflicto de interés en la academia. Salud Pública de México, 62 (3, may). p. 313. ISSN 0036-3634

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Inglés University students frequently develop unhealthy eating habits. However, it is unknown if students enrolled in academic programs related to nutrition and culinary arts have healthier eating habits. We evaluated the relationship of eating habits and nutritional status of students in academic programs with knowledge on nutrition, as well as cooking methods and techniques. A descriptive cross-sectional study was conducted in spring of 2019, while we completed a survey measuring eating habits and knowledge on nutrition, as well as cooking methods and techniques. Anthropometric measurements were collected for nutritional status estimation. The non-probabilistic convenience sample comprised 93 students pursuing degrees at Universidad Ana G. Mendez, Puerto Rico. Inadequate body mass index (BMI) was observed in 59% of the students. Eating habits, knowledge on nutrition, and knowledge on cooking methods and techniques were inadequate in 86%, 68%, and 41% of the population, respectively. Eating habits were associated with knowledge on nutrition and academic program, but not with knowledge on cooking methods and techniques. Most students reported having inadequate eating habits and BMI. Nutrition and dietetics students had the best knowledge on nutrition compared to culinary management students, a majority of whom had inadequate knowledge. We can conclude that there are other factors inherent to students’ life that may have a stronger influence on eating habits metadata Rivera Medina, Christian and Briones Urbano, Mercedes and de Jesús Espinosa, Aixa and Toledo López, Ángel mail UNSPECIFIED, mercedes.briones@uneatlantico.es, UNSPECIFIED, UNSPECIFIED (2020) Eating Habits Associated with Nutrition-Related Knowledge among University Students Enrolled in Academic Programs Related to Nutrition and Culinary Arts in Puerto Rico. Nutrients, 12 (5). p. 1408. ISSN 2072-6643

Thesis Subjects > Nutrition Europe University of Atlantic > Teaching > Final Degree Projects Cerrado Español Objetivos: Estudiar el efecto de una Dieta Libre de Gluten y Caseína (GFCFD, por sus siglas en inglés) en la sintomatología del Trastorno del Espectro Autista (ASD, por sus siglas en inglés). Material y métodos: Revisión bibliográfica en la que se realizaron diferentes búsquedas en bases de datos científicas (Pubmed, SciELO, Autism Research Wiley Online Library). Los estudios fueron obtenidos gracias a la búsqueda mediante términos MeSH y a la adición de diferentes filtros de búsqueda. Resultados y discusión: Se analizaron 17 estudios en esta sección, 5 estudios experimentales y 12 revisiones bibliográficas. De todos ellos, 3 estudios experimentales y 4 revisiones bibliográficas sí muestran una posible mejoría de estos síntomas por la acción del tratamiento con GFCFD, sin embargo, no realizan recomendaciones específicas más allá de la necesidad de realizar nuevos estudios con menos sesgos para sacar conclusiones seguras, claras y válidas. Conclusiones: Dada la evidencia actual existente sobre este tema, no se puede recomendar una GFCFD para el tratamiento de la mejora de los síntomas del autismo, y su uso se debe limitar actualmente a personas con algún tipo de intolerancia o alergia alimenticia que hagan necesario la eliminación de gluten y/o caseína de la dieta. metadata Pérez Arenal, Íñigo mail UNSPECIFIED (2020) Estudio de la mejora de la sintomatología del Trastorno del Espectro Autista mediante un tratamiento dietético libre de gluten y caseína. Diploma thesis, Universidad Europea del Atlántico.

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production UNSPECIFIED UNSPECIFIED The interaction between nutrition and human infectious diseases has always been recognized. With the emergence of molecular tools and post-genomics, high-resolution sequencing technologies, the gut microbiota has been emerging as a key moderator in the complex interplay between nutrients, human body, and infections. Much of the host–microbial and nutrition research is currently based on animals or simplistic in vitro models. Although traditional in vivo and in vitro models have helped to develop mechanistic hypotheses and assess the causality of the host–microbiota interactions, they often fail to faithfully recapitulate the complexity of the human nutrient–microbiome axis in gastrointestinal homeostasis and infections. Over the last decade, remarkable progress in tissue engineering, stem cell biology, microfluidics, sequencing technologies, and computing power has taken place, which has produced a new generation of human-focused, relevant, and predictive tools. These tools, which include patient-derived organoids, organs-on-a-chip, computational analyses, and models, together with multi-omics readouts, represent novel and exciting equipment to advance the research into microbiota, infectious diseases, and nutrition from a human-biology-based perspective. After considering some limitations of the conventional in vivo and in vitro approaches, in this review, we present the main novel available and emerging tools that are suitable for designing human-oriented research. metadata Cassotta, Manuela and Forbes-Hernández, Tamara Y. and Calderón Iglesias, Ruben and Ruiz, Roberto and Elexpuru Zabaleta, Maria and Giampieri, Francesca and Battino, Maurizio mail manucassotta@gmail.com, UNSPECIFIED, ruben.calderon@uneatlantico.es, roberto.ruiz@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2020) Links between Nutrition, Infectious Diseases, and Microbiota: Emerging Technologies and Opportunities for Human-Focused Research. Nutrients, 12 (6). p. 1827. ISSN 2072-6643

Other Subjects > Nutrition Europe University of Atlantic > Research > Projects I+D+I Cerrado Español Los bacteriófagos se pueden utilizar para mejorar la vida útil de los alimentos elaborados, y también para desinfectar equipos y superficies utilizadas en la industria alimentaria. El aislamiento de fagos con interés alimentario -porque producen lisis específica de bacterias altamente contaminantes y persistentes en las plantas de producción de alimentos (por ej. las que forman biopelículas) daría lugar a su posible utilización en la práctica industrial. El desarrollo de nuevas herramientas de bio-preservación orientadas a necesidades del sector alimentario, que sean alternativas a los agentes de preservación existentes para combatir las contaminaciones bacterianas, es una demanda actual. Esta demanda es más acuciante a medida que se va incrementando la predilección del consumidor por alimentos libres de productos químicos, los llamados alimentos BIO. Por lo tanto, se puede afirmar que existe una clara oportunidad en el mercado para el desarrollo de los productos de bio-preservación abordados en este proyecto. El objetivo principal de este proyecto es el aislamiento y caracterización de fagos con potencial de bio-conservación, así como también la posibilidad de utilizar sus enzimas líticas para el mismo proceso. El mercado potencial de los resultados del proyecto son todas las empresas de alimentación, primeramente en el ámbito de Cantabria, tanto públicas como privadas. metadata CITICAN-Universidad Europea del Atlántico, mail UNSPECIFIED (2020) Obtención y caracterización de fagos líticos para su utilización en industrias alimentarias (FAGOFOOD). Repositorio de la Universidad. (Unpublished)

2019

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production UNSPECIFIED UNSPECIFIED Significance: In eukaryotes, autophagy represents a highly evolutionary conserved process, through which macromolecules and cytoplasmic material are degraded into lysosomes and recycled for biosynthetic or energetic purposes. Dysfunction of the autophagic process has been associated with the onset and development of many human chronic pathologies, such as cardiovascular, metabolic, and neurodegenerative diseases as well as cancer. Recent Advances: Currently, comprehensive research is being carried out to discover new therapeutic agents that are able to modulate the autophagic process in vivo. Recent evidence has shown that a large number of natural bioactive compounds are involved in the regulation of autophagy by modulating several transcriptional factors and signaling pathways. Critical Issues: Critical issues that deserve particular attention are the inadequate understanding of the complex role of autophagy in disease pathogenesis, the limited availability of therapeutic drugs, and the lack of clinical trials. In this context, the effects that natural bioactive compounds exert on autophagic modulation should be clearly highlighted, since they depend on the type and stage of the pathological conditions of diseases. Future Directions: Research efforts should now focus on understanding the survival-supporting and death-promoting roles of autophagy, how natural compounds interact exactly with the autophagic targets so as to induce or inhibit autophagy and on the evaluation of their pharmacological effects in a more in-depth and mechanistic way. In addition, clinical studies on autophagy-inducing natural products are strongly encouraged, also to highlight some fundamental aspects, such as the dose, the duration, and the possible synergistic action of these compounds with conventional therapy. metadata Giampieri, Francesca and Afrin, Sadia and Forbes-Hernandez, Tamara Y. and Gasparrini, Massimiliano and Cianciosi, Danila and Reboredo-Rodriguez, Patricia and Varela-Lopez, Alfonso and Quiles, Jose L. and Battino, Maurizio mail UNSPECIFIED, UNSPECIFIED, tamara.forbes@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2019) Autophagy in Human Health and Disease: Novel Therapeutic Opportunities. Antioxidants & Redox Signaling, 30 (4). pp. 577-634. ISSN 1523-0864

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Inglés The phenolic composition and content of olive fruit are some of the attributes that determine oil quality. This composition depends on the olive variety, the cultivation system, and the fruit's ripeness. This study considered two olive varieties (Manzanilla and Morisca), under two water regimes (irrigated and rainfed), harvested at three stages of maturation (S1, S2, and S3), over three consecutive campaigns (2011, 2012, and 2013). The accumulation of phenols in the fruit was found to depend only on the stage of ripeness, while the flavonoid and phenylpropanoid contents depended also on the variety and the water regime. Superoxide dismutase (SOD) activity was linked to O2- production, which in turn depended on water regime, variety, and stage of maturation (this last being a process involving ROS). The peroxidase (POX) activity seemed only to depend on ripeness, while polyphenol oxidase (PPO) activity varied from year to year as well as presenting a strong ripeness dependence that was in clear coherence with the levels of phenolic compounds that the olives accumulate. All these relationships between the variables and the factors conform a dataset with the structure of a multidimensional array that is difficult to interpret using conventional techniques of statistical analysis. This work takes a novel approach (MultiDimensional Scaling associated with a Partial Triadic Analysis, MDS-PTA) to the analysis of this type of data structure which allows its correct interpretation. The analysis showed that the state of maturation of the olives is the most clearly discriminating factor, far more so than the cultivar, water regime, or year. Thus, the phenols and the total antioxidant activity (FRAP) showed strong clustering, being closely related in all three years studied. The oxidant and antioxidant activities showed a certain tendency to cluster, although in these cases the year also had an influence as a factor, indicating that these parameters depend more on external factors and less on ripeness metadata Šiler, Branislav T. and Sáinz, Juan Antonio and Garrido, Inmaculada and Hernández Suárez, Marcos and Montaño, Alfonso and Llerena, José Luis and Espinosa, Francisco mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, marcos.hernandez@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2019) Influence of cultivar, irrigation, ripening stage, and annual variability on the oxidant/antioxidant systems of olives as determined by MDS-PTA. PLOS ONE, 14 (4). e0215540. ISSN 1932-6203

Other Subjects > Nutrition Europe University of Atlantic > Research > Projects I+D+I Cerrado Español El planteamiento del proyecto se hace para prevenir una de las enfermedades crónicas más habituales entre la población juvenil, los trastornos de la conducta alimentaria (TCA) e influir positivamente sobre sus hábitos de salud. Los TCAs en su conjunto representan la tercera enfermedad crónica más común entre la población adolescente, contando que entre un 3-7% de los adolescentes sufre algún trastorno de la conducta alimentaria, y sabiendo que el retraso en la identificación de los afectados de TCA conlleva a una mayor morbilidad. Ante esta problemática globalizada, los profesionales sanitarios deben contar con herramientas más fiables que detecten a tiempo una situación proclive a un TCA y puedan capturar el día a día de cada persona, que aunque resulta clave para la detección, se hace imposible conocer con las soluciones actuales. La oportunidad técnica para este proyecto se relaciona con el desarrollo de servicios TIC de salud para la detección temprana de los TCAs, muy alineada a las grandes tendencias del sector TIC en aplicación a la salud y oportunidad comercial para el sector sanitario. Este proyecto se desarrolla en Cantabria, España y está financiado por la convocatoria SODERCAN EC. El período que comprende este proyecto: 2019-2020 metadata CITICAN-Universidad Europea del Atlántico, and UNEATLANTICO, mail UNSPECIFIED (2019) Tecnologías para la detección temprana de trastornos de la conducta alimentaria en población juvenil (pTCA). Repositorio de la Universidad. (Unpublished)

2018

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production UNSPECIFIED UNSPECIFIED Several polifloral honeys from the Apis mellifera and Melipona beecheii bee were analyzed to evaluate their pollen profile, physicochemical parameters, chemical composition and their antioxidant and antimicrobial activity. Flavonoids and other phenolic derivatives, 16 compounds in Apis mellifera honeys and 19 compounds in Melipona beecheii honeys, were identified using the HPLC-DAD-ESI-MS/MS analysis. The physicochemical parameters were within the ranges reported for these honeys, showing some of the distinctive characteristics of M. beecheii honeys compared to A. mellifera honeys, such as their high moisture and acidity. M. beecheii honey showed the highest values of total antioxidant capacity and total phenolic, flavonoid, carotenoids, ascorbic acid, free amino acid and protein contents compared to A. mellifera honey. M. beecheii honey also exhibited a higher antimicrobial activity. Our result shows that M. beecheii honeys is an important source of bioactive compounds with relevant biological properties compared to A. mellifera honey. metadata Alvarez-Suarez, José M. and Giampieri, Francesca and Brenciani, Andrea and Mazzoni, Luca and Gasparrini, Massimiliano and González-Paramás, Ana M. and Santos-Buelga, Celestino and Morroni, Gianluca and Simoni, Serena and Forbes-Hernández, Tamara Y. and Afrin, Sadia and Giovanetti, Eleonora and Battino, Maurizio mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, tamara.forbes@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2018) Apis mellifera vs Melipona beecheii Cuban polifloral honeys: A comparison based on their physicochemical parameters, chemical composition and biological properties. LWT, 87. pp. 272-279. ISSN 0023-6438

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production UNSPECIFIED UNSPECIFIED We analyzed guava fruits (Psidium guajava L. cv. Red Suprema) from Cuba to determine their chemical composition, total antioxidant capacity, as well as their protective effect against oxidative damage using an in vitro model of human dermal fibroblasts. The guava fruit is a natural source of bioactive compounds, such as polyphenols, vitamin C, folates and beta carotenes with proven health benefits. Human dermal fibroblasts were pre-incubated with different concentrations of guava crude extract and then subjected to oxidative stress using the AAPH stressor. The number of apoptotic and dead cells, as well as the markers of oxidative damage such as lipid and protein oxidation significantly decreased when cells were pre-incubated with guava crude extract and then exposed to the stressor. The activity of antioxidant enzymes also improved when cells were pre-incubated with guava crude extract in comparison to cells subjected to stress without prior pre-incubation with the guava extract. The results obtained in this study highlight the health benefits of guava regarding oxidative stress, proving it to be an important source of bioactive compounds associated with important biological properties. metadata Alvarez-Suarez, José M. and Giampieri, Francesca and Gasparrini, Massimiliano and Mazzoni, Luca and Forbes-Hernández, Tamara Y. and Afrin, Sadia and Battino, Maurizio mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, tamara.forbes@uneatlantico.es, UNSPECIFIED, maurizio.battino@uneatlantico.es (2018) Guava (Psidium guajava L. cv. Red Suprema) Crude Extract Protect Human Dermal Fibroblasts against Cytotoxic Damage Mediated by Oxidative Stress. Plant Foods for Human Nutrition, 73 (1). pp. 18-24. ISSN 0921-9668

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production UNSPECIFIED UNSPECIFIED Dietary flavonoids, which occur in many plant foods, are considered as the most active constituents among the plant-derived ones in vitro and in vivo. To date, many studies have addressed the anti-inflammatory activity of flavonoids. However, their considerable structural diversity and in vivo bioavailability make them able to modulate different signaling pathways. The present review attempted to summarize and highlight a broad range of inflammation-associated signaling pathways modulated by flavonoids. Finally, based on the current scientist's literature, structure-activity relationships were concluded. Dietary flavonoids have the ability to attenuate inflammation by targeting different intracellular signaling pathways triggered by NF-κB, AP-1, PPAR, Nrf2, and MAPKs. Identification of the main structural features required for the modulation of these inflammation-related pathways (hydroxylation pattern, C2=C3 double bond) have an important role to play in the development of new anti-inflammatory drugs. metadata Chen, Lei and Teng, Hui and Jia, Zhen and Battino, Maurizio and Miron, Anca and Yu, Zhiling and Cao, Hui and Xiao, Jianbo mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2018) Intracellular signaling pathways of inflammation modulated by dietary flavonoids: The most recent evidence. Critical Reviews in Food Science and Nutrition, 58 (17). pp. 2908-2924. ISSN 1040-8398

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Español El sobao pasiego es uno de los productos de panificación y bollería más representativos de Cantabria y está constituido, principalmente, por mantequilla, harina de trigo, azúcar y huevo. Aunque la legislación relativa a la Indicación Geográfica Protegida (IGP) contempla un pequeño margen para el uso de ingredientes minoritarios tales como miel, dextrosa, glucosa, sal o algunos aditivos y conservantes. El reconocimiento como IGP identifica al producto como originario de un lugar determinado y como poseedor de unas características y una calidad determinada. En este caso particular, debido a las amplias restricciones que plantea el reconocimiento de un sobao como IGP, las oportunidades de lograr una mejora a nivel organoléptico se centraron en cuatro aspectos fundamentales: apariencia externa del producto, color de la corteza, color interno y textura. Tras el análisis estadístico realizado es de suponer que los aspectos de identificación visual priman en la elección, por encima del sabor o del olor. No obstante, las mejoras abordadas con respecto a la textura permitieron incidir de forma notable en su calidad organoléptica, sobre todo, con el paso del tiempo de vida útil del producto. De acuerdo con el estudio de aceptabilidad temporal realizado, se estima que transcurrido un tiempo desde la fecha de producción, 7 de cada 10 consumidores preferirán el sobao reformulado. metadata Crespo Alvarez, Jorge and Montserrat Echeto, Mercedes and Aparicio Obregón, Silvia and Agudo Toyos, Pablo and Guillen Asín, S. and Dzul Lopez, Luis and Sámano Celorio, María Luisa mail jorge.crespo@uneatlantico.es, mercedes.montserrat@uneatlantico.es, silvia.aparicio@uneatlantico.es, pablo.agudo@uneatlantico.es, UNSPECIFIED, luis.dzul@unini.edu.mx, marialuisa.samano@uneatlantico.es (2018) Mejora de las propiedades organolépticas de un producto sometido a las exigencias de un marco regulatorio de Indicación Geográfica Protegida: El sobao pasiego. Afinidad, 75 (583). ISSN 2339-9686

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production UNSPECIFIED UNSPECIFIED Organisms are constantly exposed to a broad range of pathological and stress-inducing agents, allergens and environmental chemicals that can induce infections, toxicity or other undesirable reactions. Our immune system has evolved over time in order to efficiently respond to these exogenous insults and maintain homeostasis. In particular, the innate immune system acts as primary barrier to prevent the entrance of invasive agents or allergens. This system is comprised of a diversity of cell types that are rapidly activated by recognition of common structures present in many potential pathogens known as pathogen-associated molecular patterns (PAMPs). The nuclear factor erythroid 2 related factor 2 (Nrf2) is a relevant basic leucine zipper (bZIP) transcription factor that is essential in the regulation of cell cycle homeostasis, cytoprotection, and innate immunity when cells are under stressful conditions. Although the role of Nrf2 in activating the expression of protective genes – such as antioxidant or anti-inflammatory – is known, its role in innate immunity and immune-related gene expression remains not yet clear. The present review summarizes current knowledge on Nrf2 signaling pathway structure and activity under both physiological state and upon oxidative stress. In addition, the relation between Nrf2 signaling pathway and the innate immune system is discussed, highlighting the potential therapeutic effects of diverse natural and synthetic compounds as Nrf2 regulators. metadata Battino, Maurizio and Giampieri, Francesca and Pistollato, Francesca and Sureda, Antoni and de Oliveira, Marcos Roberto and Pittalà, Valeria and Fallarino, Francesca and Nabavi, Seyed Fazel and Atanasov, Atanas Georgiev and Nabavi, Seyed Mohammad mail UNSPECIFIED, UNSPECIFIED, francesca.pistollato@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2018) Nrf2 as regulator of innate immunity: A molecular Swiss army knife! Biotechnology Advances, 36 (2). pp. 358-370. ISSN 0734-9750

Article Subjects > Biomedicine
Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Cerrado Inglés Ample epidemiological evidence suggests a strong correlation among diet, lifestyle factors and the onset and consolidation of dementia and Alzheimer’s disease (AD). It has been demonstrated that AD, diabetes, obesity, insulin resistance, and cardiovascular disease are strongly interconnected pathologies. Preventive strategies and nutritional interventions seem to be promising approaches to delay neurocognitive decline and reduce the risk of AD and other non-psychiatric co-morbidities. In this regard, healthy dietary patterns, characterized by high intake of plant-based foods, probiotics, antioxidants, soy beans, nuts, and omega-3 polyunsaturated fatty acids, and a low intake of saturated fats, animal-derived proteins, and refined sugars, have been shown to decrease the risk of neurocognitive impairments and eventually the onset of AD. Here we review the role of some nutrients and, in particular, of healthy dietary patterns, such as the Mediterranean diet and other emerging healthy diets, DASH (Dietary Approach to Stop Hypertension) and MIND (Mediterranean-DASH dietIntervention for Neurodegenerative Delay), for the maintenance of cognitive performance, focusing specifically on human studies. The beneficial effects associated with overall diet composition, rather than single nutrient supplementations, for the prevention or the delay of AD and dementia are discussed. metadata Pistollato, Francesca and Calderón Iglesias, Rubén and Ruiz Salces, Roberto and Aparicio-Obregón, Silvia and Crespo-Álvarez, Jorge and Dzul Lopez, Luis Alonso and Manna, Piera Pia and Giampieri, Francesca and Battino, Maurizio mail francesca.pistollato@uneatlantico.es, ruben.calderon@uneatlantico.es, roberto.ruiz@uneatlantico.es, silvia.aparicio@uneatlantico.es, jorge.crespo@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2018) Nutritional patterns associated with the maintenance of neurocognitive functions and the risk of dementia and Alzheimer’s disease: A focus on human studies. Pharmacological Research, 131. pp. 32-43. ISSN 10436618

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production UNSPECIFIED UNSPECIFIED Food fortification through the increase and/or modulation of bioactive compounds has become a major goal for preventing several diseases, including cancer. Here, strawberry lines of cv. Calypso transformed with a construct containing an anthocyanidin synthase (ANS) gene were produced to study the effects on anthocyanin biosynthesis, metabolism, and transcriptome. Three strawberry ANS transgenic lines (ANS L5, ANS L15, and ANS L18) were analyzed for phytochemical composition and total antioxidant capacity (TAC), and their fruit extracts were assessed for cytotoxic effects on hepatocellular carcinoma. ANS L18 fruits had the highest levels of total phenolics and flavonoids, while those of ANS L15 had the highest anthocyanin concentration; TAC positively correlated with total polyphenol content. Fruit transcriptome was also specifically affected in the polyphenol biosynthesis and in other related metabolic pathways. Fruit extracts of all lines exerted cytotoxic effects in a dose/time-dependent manner, increasing cellular apoptosis and free radical levels and impairing mitochondrial functionality. metadata Giampieri, Francesca and Gasparrini, Massimiliano and Forbes-Hernandez, Tamara Y. and Mazzoni, Luca and Capocasa, Franco and Sabbadini, Silvia and Alvarez-Suarez, José M. and Afrin, Sadia and Rosati, Carlo and Pandolfini, Tiziana and Molesini, Barbara and Sánchez-Sevilla, José Federico and Amaya, Iraida and Mezzetti, Bruno and Battino, Maurizio mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2018) Overexpression of the Anthocyanidin Synthase Gene in Strawberry Enhances Antioxidant Capacity and Cytotoxic Effects on Human Hepatic Cancer Cells. Journal of Agricultural and Food Chemistry, 66 (3). pp. 581-592. ISSN 0021-8561

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production UNSPECIFIED UNSPECIFIED Honey is a natural substance appreciated for its therapeutic abilities since ancient times. Its content in flavonoids and phenolic acids plays a key role on human health, thanks to the high antioxidant and anti-inflammatory properties that they exert. Honey possesses antimicrobial capacity and anticancer activity against different types of tumors, acting on different molecular pathways that are involved on cellular proliferation. In addition, an antidiabetic activity has also been highlighted, with the reduction of glucose, fructosamine, and glycosylated hemoglobin serum concentration. Honey exerts also a protective effect in the cardiovascular system, where it mainly prevents the oxidation of low-density lipoproteins, in the nervous system, in the respiratory system against asthma and bacterial infections, and in the gastrointestinal system. A beneficial effect of honey can also be demonstrated in athletes. The purpose of this review is to summarize and update the current information regarding the role of honey in health and diseases. metadata Cianciosi, Danila and Forbes-Hernández, Tamara Y. and Afrin, Sadia and Gasparrini, Massimiliano and Reboredo-Rodriguez, Patricia and Manna, Piera and Zhang, Jiaojiao and Bravo Lamas, Leire and Martínez Flórez, Susana and Agudo Toyos, Pablo and Quiles, José and Giampieri, Francesca and Battino, Maurizio mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, leire.bravo@uneatlantico.es, susana.martínez@uneatlantico.es, pablo.agudo@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2018) Phenolic Compounds in Honey and Their Associated Health Benefits: A Review. Molecules, 23 (9). p. 2322. ISSN 1420-3049

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Abierto Español Introducción: el exceso de peso infantil se ha asociado con obesidad en la etapa adulta y, por consecuencia, mayor riesgo de muerte por factores cardiometabólicos. Objetivo: identificar si el índice de masa corporal (IMC) refleja cambios en el contenido y la distribución del tejido graso/adiposo y el riesgo cardiometabólico en niños y niñas de seis a nueve años. Material y métodos: participaron 537 niños (59,8% mujeres) seleccionados aleatoriamente. Las variables estudiadas correspondieron al IMC, perímetro de cintura (PC), índice cintura-estatura (ICE), composición corporal, estado nutricional y riesgo cardiometabólico. Se utilizó la prueba de correlación de Pearson y Chi-cuadrado para la relación de las variables junto con la aplicación de un test de proporciones. Se aplicaron las pruebas t de Student para muestras no pareadas, ANOVA una vía y concordancia diagnóstica en la comparación entre grupos. Se consideró un alfa ≤ 0,05 para todos los casos. Resultados: se exhiben correlaciones directas y significativas entre el estado nutricional con los parámetros antropométricos estudiados, excepto el porcentaje de adiposidad. Se aprecian variaciones significativas (p < 0,05) en el porcentaje de grasa y adiposidad según estado nutricional de la muestra. Además, existe consistencia entre la variación del estado nutricional con el riesgo cardiometabólico evaluado a través del PC e ICE. Conclusión: el IMC identifica las diferencias en la cantidad de tejido graso/adiposo en niños y niñas situados entre los seis y los nueve años al ser categorizados según estado nutricional. Además, refleja asociación directa con el riesgo cardiometabólico. metadata López-fuenzalida, Antonio and Illanes Aguilar, Lucia and Rodríguez Canales, Carolina and Contreras-briceño, Felipe and Durán Agüero, Samuel and Herrera-valenzuela, Tomás and Valdés-badilla, Pablo Antonio mail UNSPECIFIED, UNSPECIFIED, carolina.rodriguez@unini.org, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2018) Riesgo cardiometabólico y variación en el contenido graso/adiposo según el índice de masa corporal en niños de seis a nueve años. Nutrición Hospitalaria. ISSN 0212-1611

Other Subjects > Nutrition Europe University of Atlantic > Research > Projects I+D+I Cerrado Español El proyecto está orientado a generar un conocimiento de interés industrial para el aprovechamiento de la fracción líquida del lactosuero residual de la industria quesera. El conocimiento que pretendemos generar debe servir para crear dos subproductos a partir del lactosuero como son: bioestimulantes para cultivos agrícolas y líquido de cobertura para conservas vegetales. El proyecto contempla el cuidado del medioambiente a la par de una mejor gestión económica de los recursos, proponiendo una línea de procesado industrial para separar la fracción sólida y líquida del lactosuero de quesería (lo que reduce la contaminación ambiental), y caracterizando la fracción líquida del lactosuero enriquecido en ácido láctico para su utilización como bioestimulante para cultivos agrícolas, favoreciendo una producción agrícola sostenible, con menos fertilizantes de síntesis y menor huella hídrica. Con este proyecto, también se apunta a caracterizar la fracción líquida del lactosuero enriquecido en ácido láctico para su utilización en la industria conservera como líquido de cobertura de conservas vegetales que incremente la vida útil de las conservas y reduzca, además, la temperatura de los tratamientos térmicos, consiguiendo de esta manera, conservas vegetales de mayor calidad nutricional. metadata CITICAN-Universidad Europea del Atlántico, mail UNSPECIFIED (2018) SUERO: Desarrollo de tecnologías para la reutilización sostenible del lactosuero. Repositorio de la Universidad. (Unpublished)

Other Subjects > Nutrition Europe University of Atlantic > Research > Projects I+D+I Cerrado Español El proyecto EUCALIPTO pretende generar un conocimiento aplicable a la industria alimentaria para el aprovechamiento de los residuos del Eucalyptus Globulus. En la investigación, primeramente se evalúan las diferentes alternativas de captación de residuos forestales que genera la industria maderera de Cantabria en la tala de eucalipto. A continuación se evalúa y optimiza el proceso industrial de la extracción de aceites esenciales provenientes del residuo forestal. Seguidamente, se caracteriza y valida el producto obtenido para su utilización como conservante en la industria alimentaria relativa a frutos rojos. A partir de los resultados de la investigación, el subproducto a obtener a partir de los residuos de hojas de Eucalyptus Globulus puede ser una esencia de eucalipto que se aplica como un spray sobre la fruta, una bolsita generadora de atmósfera protectora que se ubica en el envase de los frutos rojos, o una cobertura de film protectora basada en quitosano y esencia de eucalipto. Finalmente, se define un plan de explotación y de negocio para la creación de una nueva empresa start-up que comercialice el nuevo subproducto. Este proyecto tiene un fuerte interés medioambiental: parte del uso de las hojas, residuos generados por la industria maderera que procesa las plantaciones de eucalipto, reduciendo de este modo el impacto por incendios forestales, así como también introducir en el sector de la alimentación un conservante “eco-friendly” natural y más eficiente energéticamente. metadata CITICAN-Universidad Europea del Atlántico, mail UNSPECIFIED (2018) Tecnologías de conservación de frutos rojos basadas en residuos de Eucalyptus Globulus. Repositorio de la Universidad. (Unpublished)

Other Subjects > Nutrition Europe University of Atlantic > Research > Projects I+D+I Cerrado Español Los objetivos del proyecto de investigación industrial son: 1- Reducir la cantidad de azúcar e incorporar ingredientes que reduzcan la velocidad de absorción del azúcar, y de esta manera evitar los picos de glucemia e insulina asociados tradicionalmente a estos productos y los efectos perjudiciales a largo plazo que pueden suponer. 2- Modificar la grasa añadida al sobao por otras de mayor calidad nutricional. 3- Mejorar la calidad del cacao añadido, para incluir los beneficios de los polifenoles y antioxidantes del cacao, así como para mejorar las características organolépticas del producto final. 4- Conseguir un producto con gran palatabilidad y aceptación entre el público objetivo del producto: población infanto-juvenil. Los objetivos de las tareas para el estudio de viabilidad son: 1- Analizar el potencial de este nuevo producto y evaluar su perspectiva de éxito y oportunidad comercial. 2- Determinar un plan de explotación que haga viable este nuevo plan empresarial, y facilite la toma de decisiones sobre futuras inversiones a realizar vinculadas con el nuevo producto. Además de las inversiones relativas a nuevos medios productivos relacionados con el nuevo producto, será necesario diseñar un formato atractivo para el consumidor, una nueva estrategia de comunicación, etc. La oportunidad que supone para la empresa JOSELIN es la de realizar un salto cualitativo hacia un nuevo mercado de potencial exportador creando un producto que se comercializaría en porciones de dos sobaos de tamaño reducido para meriendas y desayunos habituales para colectivos infanto-juveniles. La mejora respecto de la situación actual en la que nunca antes se ha producido para este mercado “saludable” es sustancial: formato de solo 2 unidades de consumo habitual y “saludable” e incorporando el chocolate. metadata JOSELIN, mail UNSPECIFIED (2018) Tecnologías para la creación de un sobao de chocolate saludable. Repositorio de la Universidad. (Unpublished)

2017

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production UNSPECIFIED UNSPECIFIED Capuli cherry (Prunus serotina Ehr. subsp. capuli (Cav.) McVaugh) fruits from the inter-Andean region of Ecuador were analysed to determine their bioactive compounds content, total antioxidant capacity, radical scavenging activity and their anti-inflammatory and protective effects against the cytotoxic damage mediated by lipopolysaccharide (LPS) in RAW 264.7 macrophages. Capuli fruits proved to be a natural source of bioactive compounds such as anthocyanins, vitamin C and β-carotene as well as to present an important total antioxidant capacity and radical scavenging activities. RAW 264.7 macrophages were incubated with different concentration of Capuli crude extract and subsequently activated by LPS to determine the markers related to oxidative damage and the proinflammatory cytokine production. The markers of oxidative damage, nitrite levels, the interleukin 1β messenger RNA levels and the tumor necrosis factor α mRNA levels and secretion were significantly decreased after the pre-incubated with Capuli extract and subsequently stimulated with LPS. In summary, Capuli extract attenuated the LPS-induced damage in RAW 264.7 macrophages due to its antioxidant and anti-inflammatory properties, showing that Capuli fruits may represent a relevant source of bioactive compounds with promising benefits for human health. metadata Alvarez-Suarez, José M. and Carrillo-Perdomo, Estefanía and Aller, Angel and Giampieri, Francesca and Gasparrini, Massimiliano and González-Pérez, Lien and Beltrán-Ayala, Pablo and Battino, Maurizio mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2017) Anti-inflammatory effect of Capuli cherry against LPS-induced cytotoxic damage in RAW 264.7 macrophages. Food and Chemical Toxicology, 102. pp. 46-52. ISSN 0278-6915

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production UNSPECIFIED UNSPECIFIED Here, we present new original data on the effects of strawberry consumption on body weight and liver status of aged rats. Wistar rats aged 19–21 months were fed a strawberry enriched diet prepared by substituting 15% of the total calories with freeze-dried strawberry powder for two months. Body weight, plasma biomarkers of liver injury (alanine transferase, aspartate aminotransferase and alkaline phosphatase) and liver histological analysis were assessed. These data indicate that strawberry supplementation did not interfere with normal animal maintenance and with liver structure and functionality. For further details and experimental findings please refer to the article “Strawberry consumption improves aging-associated impairments, mitochondrial biogenesis and functionality through the AMP-Activated Protein Kinase signaling cascade” in FOOD CHEMISTRY metadata Giampieri, Francesca and Alvarez-Suarez, Josè M. and Gasparrini, Massimiliano and Forbes-Hernandez, Tamara Y. and Afrin, Sadia and Rubini, Corrado and Zizzi, Antonio and Quiles, Josè L. and Mezzetti, Bruno and Battino, Maurizio mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2017) Data on body weight and liver functionality in aged rats fed an enriched strawberry diet. Data in Brief, 13. pp. 432-436. ISSN 2352-3409

Other Subjects > Biomedicine
Subjects > Nutrition Europe University of Atlantic > Research > Projects I+D+I Cerrado Español Se trata del diseño de un marcador en plasma de carotenoides que permita establecer el consumo de frutas y verduras en la población Universitaria de Cantabria y así poder asociarlo a su estado nutricional. Se utilizan herramientas nutricionales en combinación con herramientas TIC y estadísticas. Se correlacionan los resultados obtenidos en un Cuestionario de Frecuencia de Consumo Alimentario (CFCA) online y un registro de 24 horas de 3 días (R24-3). La biotecnología tiene grandes aplicaciones en la atención de la salud, siendo considerada biotecnología roja aquella que es aplicada a los procesos médicos. El estudio NUTRINOIDS, resulta innovador al aportar un método rápido, sensible y preciso para la establecer un método de correlación entre el consumo de frutas y verduras mediante un Cuestionario de Frecuencia de Consumo Alimentario (CFCA) y los niveles de carotenoides en plasma. Objetivo del Proyecto: Diseñar un marcador en plasma de carotenoides que permita establecer una relación significativa con el consumo de frutas y verduras a fin de asociarlo con el estado nutricional. Financiación: Este proyecto ha sido cofinanciado dentro del Programa INNOVA 2017 por el Fondo Europeo de Desarrollo Regional. Programa Operativo FEDER de Cantabria 2014-2020. “Una manera de hacer Europa”. Inicio: 30/06/2017 Fin: 31/08/2019 Código externo: 2017/INN/22 metadata CITICAN-Universidad Europea del Atlántico, and UNEATLANTICO, mail UNSPECIFIED (2017) Diseño de un marcador en plasma de carotenoides que permita establecer el consumo de frutas y verduras en la población Universitaria de Cantabria - NUTRINOIDS. Repositorio de la Universidad. (Unpublished)

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production UNSPECIFIED UNSPECIFIED Raspberry seed is a massive byproduct of raspberry juice and wine but usually discarded. The present study employed a microwave-assisted method for extraction of raspberry seed oil (RSO). The results revealed that omega-6 fatty acids (linoleic acid and γ-linolenic acid) were the major constituents in RSO. Cellular antioxidant enzyme activity such as superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) were investigated in HepG2 cells treated with RSO. Induction of the synthesis of several antioxidants in H2O2-exposed HepG2 cells was found. RSO increased the enzyme activity of SOD, CAT, and GPx in H2O2-exposed HepG2. Furthermore, RSO inhibited the phosphorylation of upstream mitogen-activated protein kinases (MAPK) such as c-Jun N-terminal kinase (c-JNK) and extracellular signal-regulated kinase (ERK). Taken together, the possible mechanisms to increase antioxidant enzyme activities in HepG2 may through the suppression of ERK and JNK phosphorylation. Raspberry seed oil exhibited good effects on the activities of the intracellular antioxidant enzymes and seems to protect the liver from oxidative stress through the inhibition of MAPKs. metadata Teng, Hui and Lin, Qiyang and Li, Kang and Yuan, Benyao and Song, Hongbo and Peng, Hongquan and Yi, Lunzhao and Wei, Ming-Chi and Yang, Yu-Chiao and Battino, Maurizio and Cespedes Acuña, Carlos L. and Chen, Lei and Xiao, Jianbo mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2017) Hepatoprotective effects of raspberry (Rubus coreanus Miq.) seed oil and its major constituents. Food and Chemical Toxicology, 110. pp. 418-424. ISSN 0278-6915

Other Subjects > Engineering
Subjects > Nutrition Europe University of Atlantic > Research > Projects I+D+I Cerrado Español El objetivo del proyecto es diseñar una metodología para la realización de estudios epidemiológicos en nutrición basada en la gamificación y en el uso de nuevos sensores físicos. La tecnología resultante permite obtener el patrón de consumo nutricional del usuario que utiliza el sistema de una forma atractiva e integrada en sus hábitos de consumo y que requiere poco esfuerzo para el mismo con el objeto de obtener una información fiable y simplificada de la realización de registros dietéticos. De esta forma se obtienen datos útiles para realizar estudios epidemiológicos a nivel nutricional de los usuarios que utilicen el sistema. Los datos obtenidos serán de gran utilidad para poder aplicarlos en numerosos estudios epidemiológicos que se pueden realizar al tener acceso continuo a información nutricional. La idea es poder dirigir los estudios epidemiológicos hacia la obtención de datos concretos sobre un determinado colectivo de la sociedad o patrón de consumo según la información que se crea de interés tanto para fines de investigación como para fines de salud o comerciales según cada caso. De esta forma, la aplicación de la herramienta se puede extender a numerosos entornos y mercados tanto nacionales como internacionales. Objetivo del Proyecto Diseñar una metodología para la realización de estudios epidemiológicos en nutrición basada en la gamificación. Financiación Este proyecto ha sido cofinanciado dentro del Programa INNOVA 2016 por el Fondo Europeo de Desarrollo Regional. Programa Operativo FEDER de Cantabria 2014-2020. “Una manera de hacer Europa”. Objetivo del Proyecto Diseñar una metodología para la realización de estudios epidemiológicos en nutrición basada en la gamificación. Financiación Este proyecto ha sido cofinanciado dentro del Programa INNOVA 2016 por el Fondo Europeo de Desarrollo Regional. Programa Operativo FEDER de Cantabria 2014-2020. “Una manera de hacer Europa”. Inicio: 01/01/2017 Fin: 30/11/2018 Código Externo: 2016/INN/62 metadata CITICAN-Universidad Europea del Atlántico, and UNEATLANTICO, mail UNSPECIFIED (2017) Metodología de captura de información dietética para investigaciones epidemiológicas - DIETEPID. Repositorio de la Universidad. (Unpublished)

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Cerrado Inglés Dietary polyphenols have been recently proposed as activators of the AMP-activated protein kinase (AMPK) signaling pathway and this fact might explain the relationship between the consumption of polyphenol-rich foods and the slowdown of the progression of aging. In the present work, the effects of strawberry consumption were evaluated on biomarkers of oxidative damage and on aging-associated reductions in mitochondrial function and biogenesis for 8weeks in old rats. Strawberry supplementation increased antioxidant enzyme activities, mitochondrial biomass and functionality, and decreased intracellular ROS levels and biomarkers of protein, lipid and DNA damage (P<0.05). Furthermore, a significant (P<0.05) increase in the expression of the AMPK cascade genes, involved in mitochondrial biogenesis and antioxidant defences, was also detected after strawberry intake. These in vivo results were then verified in vitro on HepG2 cells, confirming the involvement of AMPK in the beneficial effects exerted by strawberry against aging progression. metadata Giampieri, Francesca and Alvarez-Suarez, Josè M. and Cordero, Mario D. and Gasparrini, Massimiliano and Forbes-Hernandez, Tamara Y. and Afrin, Sadia and Santos-Buelga, Celestino and González-Paramás, Ana M. and Astolfi, Paola and Rubini, Corrado and Zizzi, Antonio and Tulipani, Sara and Quiles, Josè L. and Mezzetti, Bruno and Battino, Maurizio mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, tamara.forbes@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2017) Strawberry consumption improves aging-associated impairments, mitochondrial biogenesis and functionality through the AMP-activated protein kinase signaling cascade. Food Chemistry, 234. pp. 464-471. ISSN 03088146

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Cerrado Inglés Strawberry represents the most important berry in the Mediterranean diet. It is the most consumed berry as both fresh and processed products, the most studied berry from the agronomic, genomic and nutritional point of view, and it is also a remarkable source of micronutrients and phytochemicals with a relevant biologically activity on human health. Although individual bioactive compounds present in strawberries have been studied for their biological activities, the mechanisms by which they are metabolized and exert their beneficial effects on human health are still unknown. For this reason, the first objective of this research is the development of an enzymatic in vitro system which simulates the gastrointestinal conditions that occur in vivo during the digestive process. Briefly, the method consists on an initial pepsin-HCl digestion for simulating gastric conditions (pH~1.7) followed by an intestinal digestion with pancreatin and bile salts through a dialysis membrane. The dialysates were concentrated under vacuum, resuspended in H2O2/glacial acetic acid and purified with a C-18 SepPaks Vac 6 cc cartridge. The strawberry cultivar chosen for the study is 'Romina', one of the most promising cultivars developed in the context of the European Euberry project. The total antioxidant capacity of both the fresh fruit and the digested fraction was tested through the DPPH, FRAP and TEAC assays. The results obtained have shown a significant variation in the antioxidant capacity of 'omina', before and after the enzymatic digestion process. Significant decreases were found in all the performed assay, highlighting how the antioxidant capacity present in fresh fruit is drastically reduced following digestion. Further studies are required to elucidate the mechanisms of transport and metabolism of these compounds, with the aim of providing predictive results on their bioavailability and thus their effect on human health. metadata Forbes-Hernández, Tamara Y. and Gasparrini, Massimiliano and Afrin, Sadia and Battino, Maurizio and Giampieri, Francesca mail tamara.forbes@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es, francesca.giampieri@uneatlantico.es (2017) The effect of an enzymatic digestion process on strawberry antioxidant capacity. Acta Horticulturae (1156). pp. 413-418. ISSN 2406-6168

2016

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production UNSPECIFIED UNSPECIFIED Accumulation of proteinaceous amyloid β plaques and tau oligomers may occur several years before the onset of Alzheimer disease (AD). Under normal circumstances, misfolded proteins get cleared by proteasome degradation, autophagy, and the recently discovered brain glymphatic system, an astroglial-mediated interstitial fluid bulk flow. It has been shown that the activity of the glymphatic system is higher during sleep and disengaged or low during wakefulness. As a consequence, poor sleep quality, which is associated with dementia, might negatively affect glymphatic system activity, thus contributing to amyloid accumulation. The diet is another important factor to consider in the regulation of this complex network. Diets characterized by high intakes of refined sugars, salt, animal-derived proteins and fats and by low intakes of fruit and vegetables are associated with a higher risk of AD and can perturb the circadian modulation of cortisol secretion, which is associated with poor sleep quality. For this reason, diets and nutritional interventions aimed at restoring cortisol concentrations may ease sleep disorders and may facilitate brain clearance, consequentially reducing the risk of cognitive impairment and dementia. Here, we describe the associations that exist between sleep, cortisol regulation, and diet and their possible implications for the risk of cognitive impairment and AD. metadata Pistollato, Francesca and Sumalla Cano, Sandra and Elío Pascual, Iñaki and Masias Vergara, Manuel and Giampieri, Francesca and Battino, Maurizio mail francesca.pistollato@uneatlantico.es, sandra.sumalla@uneatlantico.es, inaki.elio@uneatlantico.es, manuel.masias@uneatlantico.es, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es (2016) Associations between Sleep, Cortisol Regulation, and Diet: Possible Implications for the Risk of Alzheimer Disease. Advances in Nutrition: An International Review Journal, 7 (4). pp. 679-689. ISSN 2156-5376

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Cerrado Inglés Current evidence indicates that the consumption of strawberries, a natural source of a wide range of nutritive and bioactive compounds, is associated with the prevention and improvement of chronic-degenerative diseases.. Studies involving cells and animals provide evidence on the anti-inflammatory, anticarcinogenic and antiproliferative activity of the strawberry. Epidemiological and clinical studies demonstrate that its acute consumption increases plasma antioxidant capacity, improves circulating inflammatory markers and ameliorates postprandial glycemic response. At the same time, a protracted intake reduces chronic inflammation and improves plasma lipid profile, supporting cardiovascular health, especially in individuals with increased risk for metabolic syndrome. To explain these beneficial effects, much attention has been paid in the past to the antioxidant properties of strawberry polyphenols. However, recent research has shown that their biological and functional activities are related not only to the antioxidant capacity but also to the modulation of many cellular pathways involved in metabolism, survival, proliferation, and antioxidant defenses. The aim of this review is to update and discuss the molecular and cellular mechanisms proposed in recent studies to elucidate the healthy effects of strawberry polyphenols against the most common chronic diseases, such as cancer, cardiovascular diseases, metabolic syndrome, and inflammation. metadata Forbes-Hernandez, Tamara Y. and Gasparrini, Massimiliano and Afrin, Sadia and Bompadre, Stefano and Mezzetti, Bruno and Quiles, Josè L. and Giampieri, Francesca and Battino, Maurizio mail tamara.forbes@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es (2016) The Healthy Effects of Strawberry Polyphenols: Which Strategy behind Antioxidant Capacity? Critical Reviews in Food Science and Nutrition, 56 (sup1). S46-S59. ISSN 1040-8398

Other Subjects > Engineering
Subjects > Nutrition Europe University of Atlantic > Research > Projects I+D+I Cerrado Español Realización de una cartografía de algas comestibles que aporten un beneficio nutricional en humanos. El desarrollo de este trabajo es de carácter meramente documental no siendo necesario en este punto ningún tipo de trabajo experimental, análisis sensorial, catas, etc. En concreto, la realización de la cartografía se basará en los siguientes aspectos: 1. Estudio de la cartografía de algas de Noja 2. Identificación de las algas comestibles capaces de proveer un aporte nutricional adecuado en humanos 3. Establecimiento de recomendaciones de consumo de las algas previamente identificadas 4. Recetario Objetivo del Proyecto: Estudio preliminar de la variedad de algas comestibles presentes en la franja costera de Noja, así como sus posibles usos en preparaciones culinarias. Financiación: Investigación contractual realizada por empresa privada Inicio: 11/05/2016 Fin 08/06/2016 metadata CITICAN-Universidad Europea del Atlántico, mail UNSPECIFIED (2016) Identificación de algas comestibles presentes en la franja costera de Noja. Repositorio de la Universidad. (Unpublished)

Other Subjects > Biomedicine
Subjects > Engineering
Subjects > Nutrition Europe University of Atlantic > Research > Projects I+D+I Cerrado Español En el mundo, algunas de las principales enfermedades no transmisibles se producen principalmente por hipertensión arterial, sobrepeso/obesidad e hiperglucemia. El proyecto pretende desarrollar la tecnología digital necesaria para mejorar sensiblemente el seguimiento de los tratamientos dietéticos analizando, comparando y clasificando perfiles de individuos obtenidos a partir de datos digitales correspondientes a personas que incluyen rasgos de la personalidad e informaciones que evolucionan en el tiempo. La tecnología clave a desarrollar debe permitir obtener perfiles característicos de los individuos (pacientes), analizarlos comparativamente y visualmente, y clasificarlos con objeto a poder lanzar actuaciones personalizadas, principalmente por mensajería, y realizar una evaluación posterior sobre la eficacia de las actuaciones promovidas por el sistema hacia dichos individuos. Estratégicamente, CITICAN pretende contar con tecnologías propias de análisis de perfiles de individuos que tienen aplicación potencial en otros campos como la formación online o el desarrollo de servicios digitales personalizados. Objetivo del Proyecto: Desarrollar la tecnología digital necesaria para mejorar sensiblemente el seguimiento de los tratamientos dietéticos analizando, comparando y clasificando perfiles de individuos obtenidos a partir de datos digitales correspondientes a personas que incluyen rasgos de la personalidad e informaciones que evolucionan en el tiempo. Financiación Este proyecto ha sido cofinanciado por la Sociedad de Desarrollo Regional de Cantabria (SODERCAN) y el el Programa Operativo FEDER de Cantabria en el marco del programa denominado I+C= +C 2016 (Investigación + Conocimiento= +Cantabria) que tiene por objetivo el fortalecimiento del tejido industrial de la región. Inicio: 01/09/2016 Fin: 31/08/2018 Código Externo: BI16-IN-005 metadata CITICAN-Universidad Europea del Atlántico, and UNEATLANTICO, mail UNSPECIFIED (2016) NUTRIX: Desarrollo de tecnologías para el análisis de pacientes en tratamientos dietéticos mediante sistemas expertos y redes neuronales. Repositorio de la Universidad. (Unpublished)

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production UNSPECIFIED UNSPECIFIED We describe the biological effects of a polyphenol-rich strawberry extract (PRSE), obtained from the “Alba” variety, on the highly aggressive and invasive basal-like breast cancer cell line A17. Dose-response and time-course experiments showed that PRSE is able to decrease the cellular viability of A17 cells in a time- and dose-dependent manner. PRSE effect on cell survival was investigated in other tumor and normal cell lines of both mouse and human origin, demonstrating that PRSE is more active against breast cancer cells. Cytofluorimetric analysis of A17 cells demonstrated that sub-lethal doses of PRSE reduce the number of cells in S phase, inducing the accumulation of cells in G1 phase of cell cycle. In addition, the migration of A17 cells was studied monitoring the ability of PRSE to inhibit cellular mobility. Gene expression analysis revealed the modulation of 12 genes playing different roles in the cellular migration, adhesion and invasion processes. Finally, in vivo experiments showed the growth inhibition of A17 cells orthotopically transplanted into FVB syngeneic mice fed with PRSE. Overall, we demonstrated that PRSE exerts important biological activities against a highly invasive breast cancer cell line both in vitro and in vivo suggesting the strawberry extracts as preventive/curative food strategy. metadata Amatori, Stefano and Mazzoni, Luca and Alvarez-Suarez, José M. and Giampieri, Francesca and Gasparrini, Massimiliano and Forbes-Hernandez, Tamara Y. and Afrin, Sadia and Errico Provenzano, Alfredo and Persico, Giuseppe and Mezzetti, Bruno and Amici, Augusto and Fanelli, Mirco and Battino, Maurizio mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, tamara.forbes@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2016) Polyphenol-rich strawberry extract (PRSE) shows in vitro and in vivo biological activity against invasive breast cancer cells. Scientific Reports, 6 (1). ISSN 2045-2322

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production UNSPECIFIED UNSPECIFIED The potential health benefits associated with dietary intake of fruits have attracted increasing interest. Among berries, the strawberry is a rich source of several nutritive and non-nutritive bioactive compounds, which are implicated in various health-promoting and disease preventive effects. A plethora of studies have examined the benefits of strawberry consumption, such as prevention of inflammation disorders and oxidative stress, reduction of obesity related disorders and heart disease risk, and protection against various types of cancer. This review provides an overview of their nutritional and non-nutritional bioactive compounds and which factors affect their content in strawberries. In addition, the bioavailability and metabolism of major strawberry phytochemicals as well as their actions in combating many pathologies, including cancer, metabolic syndrome, cardiovascular disease, obesity, diabetes, neurodegeneration, along with microbial pathogenesis have been reviewed, with a particular attention to human studies. metadata Afrin, Sadia and Gasparrini, Massimiliano and Forbes-Hernandez, Tamara Y. and Reboredo-Rodriguez, Patricia and Mezzetti, Bruno and Varela-López, Alfonso and Giampieri, Francesca and Battino, Maurizio mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2016) Promising Health Benefits of the Strawberry: A Focus on Clinical Studies. Journal of Agricultural and Food Chemistry, 64 (22). pp. 4435-4449. ISSN 0021-8561

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Abierto Inglés It has been hypothesized that alterations in the composition of the gut microbiota might be associated with the onset of certain human pathologies, such as Alzheimer disease, a neurodegenerative syndrome associated with cerebral accumulation of amyloid-β fibrils. It has been shown that bacteria populating the gut microbiota can release significant amounts of amyloids and lipopolysaccharides, which might play a role in the modulation of signaling pathways and the production of proinflammatory cytokines related to the pathogenesis of Alzheimer disease. Additionally, nutrients have been shown to affect the composition of the gut microbiota as well as the formation and aggregation of cerebral amyloid-β. This suggests that modulating the gut microbiome and amyloidogenesis through specific nutritional interventions might prove to be an effective strategy to prevent or reduce the risk of Alzheimer disease. This review examines the possible role of the gut in the dissemination of amyloids, the role of the gut microbiota in the regulation of the gut–brain axis, the potential amyloidogenic properties of gut bacteria, and the possible impact of nutrients on modulation of microbiota composition and amyloid formation in relation to the pathogenesis of Alzheimer disease. metadata Pistollato, Francesca and Sumalla Cano, Sandra and Elío Pascual, Iñaki and Masias Vergara, Manuel and Giampieri, Francesca and Battino, Maurizio mail francesca.pistollato@uneatlantico.es, sandra.sumalla@uneatlantico.es, inaki.elio@uneatlantico.es, manuel.masias@uneatlantico.es, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es (2016) Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease. Nutrition Reviews, 74 (10). pp. 624-634. ISSN 0029-6643

Other Subjects > Engineering
Subjects > Nutrition Europe University of Atlantic > Research > Projects I+D+I Cerrado Español El Sobao Pasiego es un producto típico de la comarca pasiega. Los factores humanos son los que han contribuido a lo largo de los años a dar notoriedad al producto, una reputación que se ha ido generando y transmitiendo de generación en generación, un saber hacer que, por tanto, pertenece al patrimonio de la comarca pasiega y de ahí que el producto lleve y se reconozca por su nombre. En este sentido, Joselín Sobaos Pasiegos y Quesadas - como una empresa que apuesta por la innovación, pero manteniendo la tradición que les ha mantenido como referencia en el mercado de productos regionales de Cantabria desde 1948 - quiere fundir su filosofía de mantener la misma pureza de los ingredientes y la misma fórmula tradicional de fabricación de sus productos con las mejoras que puedan provenir de la transferencia de tecnología y de conocimientos de especialistas conocedores de los procesos que implica la elaboración de un sobao, pero desde una perspectiva científica a fin de lograr una mejora en un producto que, en sí mismo, ya ha demostrado tener una calidad excelente. Para ello, se pretende estudiar la viabilidad de generar un auténtico sobao pasiego de calidad suprema (“sobao premium”) respetando, tanto el modo de elaboración, como la receta tradicional. Objetivo del Proyecto: Estudiar la viabilidad de generar un auténtico sobao pasiego de calidad suprema (“sobao premium”) respetando, tanto el modo de elaboración, como la receta tradicional. Financiación: Este proyecto ha sido cofinanciado por la Sociedad de Desarrollo Regional de Cantabria (SODERCAN) y el el Programa Operativo FEDER de Cantabria en el marco del programa denominado I+C= +C 2016 (Investigación + Conocimiento= +Cantabria) que tiene por objetivo el fortalecimiento del tejido industrial de la región. Inicio: 11/11/2016 Fin: 10/11/2017 Código Externo: TF16-XX-006 metadata UNEATLANTICO, and CITICAN-Universidad Europea del Atlántico, and Sobaos Joselín, mail UNSPECIFIED (2016) SOBAO PREMIUM: Estudio de viabilidad para el desarrollo de un auténtico sobao pasiego de calidad suprema con base en la receta y el modo de elaboración tradicionales. Repositorio de la Universidad. (Unpublished)

Other Subjects > Engineering
Subjects > Nutrition Europe University of Atlantic > Research > Projects I+D+I Cerrado Español El objetivo de PEPANPI es el de poder ofrecer el primer servicio de mejora avanzada de productos alimentarios a partir del cual se puedan mejorar cuatro aspectos fundamentales del alimento: calidad nutricional, organoléptica, sanitaria y comercial. En particular, se aborda el desarrollo de alimentos de segunda generación en el ámbito de harinas y derivados. Para ello la empresa solicita la colaboración de la Universidad Europea del Atlántico dada su especialización en los ámbitos de la agroalimentación y de la nutrición humana. Objetivo del Proyecto: Desarrollo de alimentos de segunda generación en el ámbito de harinas y derivados. Financiación: Este proyecto ha sido cofinanciado por la Sociedad de Desarrollo Regional de Cantabria (SODERCAN) y el el Programa Operativo FEDER de Cantabria en el marco del programa denominado I+C= +C 2016 (Investigación + Conocimiento= +Cantabria) que tiene por objetivo el fortalecimiento del tejido industrial de la región. Inicio: 18/11/2016 Fin: 17/11/2018 metadata CITICAN-Universidad Europea del Atlántico, mail UNSPECIFIED (2016) Servicio para el diseño de alimentos funcionales de segunda generación: aplicaciones a la industria agroalimentaria - ALIMENT2.0. Repositorio de la Universidad. (Unpublished)

Other Subjects > Engineering
Subjects > Nutrition Europe University of Atlantic > Research > Projects I+D+I Cerrado Español Objetivo del Proyecto: Desarrollar un nuevo negocio y plan de explotación del suero de queso Picón en Cantabria a través de la comercialización de nuevos productos elaborados a partir de éste. Financiación: Este proyecto ha sido cofinanciado por la Sociedad de Desarrollo Regional de Cantabria (SODERCAN) y el el Programa Operativo FEDER de Cantabria en el marco del programa denominado I+C= +C 2016 (Investigación + Conocimiento= +Cantabria) que tiene por objetivo el fortalecimiento del tejido industrial de la región. Inicio 01/09/2016 Fin 31/08/2018 Código Externo BI16-IN-010 Categoría Alimentación Entidad Financiadora Sociedad para el Desarrollo de Cantabria metadata Probocado S.L., and CITICAN-Universidad Europea del Atlántico, mail UNSPECIFIED (2016) Valorización del subproducto lácteo suero de queso Picón para la producción de productos de valor añadido. Repositorio de la Universidad. (Unpublished)

2015

Other Subjects > Biomedicine
Subjects > Physical Education and Sport
Subjects > Nutrition Europe University of Atlantic > Research > Projects I+D+I Cerrado Español El objetivo del presente proyecto es la ampliación de la capacidad de la unidad de investigación experimental del Centro de Investigación y Tecnología Industrial de Cantabria (CITICAN). Para ello se contempla la contratación de personal investigador y la adquisición de equipamiento científico para dotar un laboratorio de ergogenia que permitirá la detección, cuantificación, verificación y diseño de suplementos nutricionales con capacidad ergogénica así como su posterior estudio en individuos, pertenecientes a diferentes segmentos poblacionales, en los que poder valorar la mejora de su rendimiento deportivo, prevención de lesiones y estado de salud. Financiación: Este proyecto ha sido cofinanciado dentro del Programa INNPULSA Cantabria 2015 – Línea INVIERTE por el Fondo Europeo de Desarrollo Regional. Programa Operativo FEDER de Cantabria 2014-2020. “Una manera de hacer Europa”. Inicio: 30/03/2015 Fin: 31/03/2016 Código Externo: 2015/INV/015 metadata CITICAN-Universidad Europea del Atlántico, mail UNSPECIFIED (2015) ERGOCITICan: Creación de un laboratorio de ergogénica para el desarrollo de suplementos nutricionales innovadores que incrementen la competitividad de la industria alimentaria de Cantabria. Repositorio de la Universidad. (Unpublished)

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production UNSPECIFIED UNSPECIFIED Oxidative stress is implicated in several infectious diseases. In this regard, lipopolysaccharide (LPS), an endotoxic component, induces mitochondrial dysfunction and oxidative stress in several pathological events such as periodontal disease or sepsis. In our experiments, LPS-treated fibroblasts provoked increased oxidative stress, mitochondrial dysfunction, reduced oxygen consumption and mitochondrial biogenesis. After comparing coenzyme Q10 (CoQ10) and N-acetylcysteine (NAC), we observed a more significant protection of CoQ10 than of NAC, which was comparable with other lipophilic and hydrophilic antioxidants such as vitamin E or BHA respectively. CoQ10 improved mitochondrial biogenesis by activating PGC-1α and TFAM. This lipophilic antioxidant protection was observed in mice after LPS injection. These results show that mitochondria-targeted lipophilic antioxidants could be a possible specific therapeutic strategy in pharmacology in the treatment of infectious diseases and their complications. metadata Bullón, Pedro and Román-Malo, Lourdes and Marín-Aguilar, Fabiola and Alvarez-Suarez, José Miguel and Giampieri, Francesca and Battino, Maurizio and Cordero, Mario D. mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, josemanuel.alvarez@unini.edu.mx, UNSPECIFIED, maurizio.battino@uneatlantico.es, UNSPECIFIED (2015) Lipophilic antioxidants prevent lipopolysaccharide-induced mitochondrial dysfunction through mitochondrial biogenesis improvement. Pharmacological Research, 91. pp. 1-8. ISSN 10436618

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production UNSPECIFIED UNSPECIFIED Impaired AMPK is associated with a wide spectrum of clinical and pathological conditions, ranging from obesity, altered responses to exercise or metabolic syndrome, to inflammation, disturbed mitochondrial biogenesis and defective response to energy stress. Fibromyalgia (FM) is a world-wide diffused musculoskeletal chronic pain condition that affects up to 5% of the general population and comprises all the above mentioned pathophysiological states. Here, we tested the involvement of AMPK activation in fibroblasts derived from FM patients. AMPK was not phosphorylated in fibroblasts from FM patients and was associated with decreased mitochondrial biogenesis, reduced oxygen consumption, decreased antioxidant enzymes expression levels and mitochondrial dysfunction. However, mtDNA sequencing analysis did not show any important alterations which could justify the mitochondrial defects. AMPK activation in FM fibroblast was impaired in response to moderate oxidative stress. In contrast, AMPK activation by metformin or incubation with serum from caloric restricted mice improved the response to moderate oxidative stress and mitochondrial metabolism in FM fibroblasts. These results suggest that AMPK plays an essential role in FM pathophysiology and could represent the basis for a valuable new therapeutic target/strategy. Furthermore, both metformin and caloric restriction could be an interesting therapeutic approach in FM. metadata Alcocer-Gómez, Elísabet and Garrido-Maraver, Juan and Bullón, Pedro and Marín-Aguilar, Fabiola and Cotán, David and Carrión, Angel M. and Alvarez-Suarez, José M. and Giampieri, Francesca and Sánchez-Alcazar, José Antonio and Battino, Maurizio and Cordero, Mario D. mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, jose.alvarez@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es, UNSPECIFIED (2015) Metformin and caloric restriction induce an AMPK-dependent restoration of mitochondrial dysfunction in fibroblasts from Fibromyalgia patients. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1852 (7). pp. 1257-1267. ISSN 0925-4439

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production UNSPECIFIED UNSPECIFIED Environmental and lifestyle factors are known to play an important role during gestation, determining newborns' health status and influencing their risk of being subject to certain noncommunicable diseases later in life. In particular, maternal nutritional patterns characterized by a low intake of plant-derived foods could increase the risk of gestation-related issues, such as preeclampsia and pregravid obesity, increase genotoxicant susceptibility, and contribute to the onset of pediatric diseases. In particular, the risk of pediatric wheeze, diabetes, neural tube defects, orofacial clefts, and some pediatric tumors seems to be reduced by maternal intake of adequate amounts of vegetables, fruits, and selected antioxidants. Nevertheless, plant-based diets, like any other diet, if improperly balanced, could be deficient in some specific nutrients that are particularly relevant during gestation, such as n–3 (ω-3) fatty acids, vitamin B-12, iron, zinc, and iodine, possibly affecting the offspring's health state. Here we review the scientific literature in this field, focusing specifically on observational studies in humans, and highlight protective effects elicited by maternal diets enriched in plant-derived foods and possible issues related to maternal plant-based diets. metadata Pistollato, Francesca and Sumalla Cano, Sandra and Elio Pascual, Iñaki and Masias Vergara, Manuel and Giampieri, Francesca and Battino, Maurizio mail francesca.pistollato@uneatlantico.es, sandra.sumalla@uneatlantico.es, inaki.elio@uneatlantico.es, manuel.masias@uneatlantico.es, UNSPECIFIED, maurizio.battino@uneatlantico.es (2015) Plant-Based and Plant-Rich Diet Patterns during Gestation: Beneficial Effects and Possible Shortcomings. Advances in Nutrition, 6 (5). pp. 581-591. ISSN 2161-8313

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production UNSPECIFIED UNSPECIFIED In recent years it has been hypothesized that cancer stem cells (CSCs) are the actual driving force of tumor formation, highlighting the need to specifically target CSCs to successfully eradicate cancer growth and recurrence. Particularly, the deregulation of physiological signaling pathways controlling stem cell proliferation, self-renewal, differentiation, and metabolism is currently considered as one of the leading determinants of cancer formation. Given their peculiar, slow-dividing phenotype and their ability to respond to multiple microenvironmental stimuli, stem cells appear to be more susceptible to genetic and epigenetic carcinogens, possibly undergoing mutations resulting in tumor formation. In particular, some animal-derived bioactive nutrients and metabolites known to affect the hormonal milieu, and also chemicals derived from food processing and cooking, have been described as possible carcinogenic factors. Here, we review most recent literature in this field, highlighting how some environmental toxicants, some specific nutrients and their secondary products can induce carcinogenesis, possibly impacting stem cells and their niches, thus causing tumor growth. metadata Persano, Luca and Zagoura, Dimitra and Louisse, Jochem and Pistollato, Francesca mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, francesca.pistollato@uneatlantico.es (2015) Role of Environmental Chemicals, Processed Food Derivatives, and Nutrients in the Induction of Carcinogenesis. Stem Cells and Development, 24 (20). pp. 2337-2352. ISSN 1547-3287

Article Subjects > Biomedicine
Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Cerrado Inglés In the last decade, specific dietary patterns, mainly characterized by high consumption of vegetables and fruits, have been proven beneficial for the prevention of both metabolic syndrome (MetS)-related dysfunctions and neurodegenerative disorders, such as Alzheimer’s disease (AD). Nowadays, neuroimaging readouts can be used to diagnose AD, investigate MetS effects on brain functionality and anatomy, and assess the effects of dietary supplementations and nutritional patterns in relation to neurodegeneration and AD-related features. Here we review scientific literature describing the use of the most recent neuroimaging techniques to detect AD- and MetS-related brain features, and also to investigate associations between consolidated dietary patterns or nutritional interventions and AD, specifically focusing on observational and intervention studies in humans. metadata Pistollato, Francesca and Sumalla Cano, Sandra and Elío Pascual, Iñaki and Masías Vergara, Manuel and Giampieri, Francesca and Battino, Maurizio mail francesca.pistollato@uneatlantico.es, sandra.sumalla@uneatlantico.es, inaki.elio@uneatlantico.es, manuel.masias@uneatlantico.es, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es (2015) The Use of Neuroimaging to Assess Associations Among Diet, Nutrients, Metabolic Syndrome, and Alzheimer’s Disease. Journal of Alzheimer's Disease, 48 (2). pp. 303-318. ISSN 13872877

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production UNSPECIFIED UNSPECIFIED Berries are a relevant source of micronutrients and nonessential phytochemicals, such as polyphenol compounds, that play a synergistic and cumulative role in human health promotion. Several systematic analyses showed that berry phenolics are able to detoxify reactive oxygen and nitrogen species, blocking their production, to intervene in the cell cycle, participating in the transduction and expression of genes involved in apoptosis, and to repair oxidative DNA damage. As a consequence, the improvement of the nutritional quality of berries has become a new quality target of breeding and biotechnological strategies, to control or to increase the content of specific health-related compounds in fruits. This work reviews, on the basis of the in vitro and in vivo evidence, the main berries' phytochemical compounds and their possible mechanisms of action on pathways involved in several type of diseases, with particular attention to cancer, inflammation, neurodegeneration, diabetes and cardiovascular diseases. © 2015 Society of Chemical Industry metadata Mazzoni, Luca and Perez-Lopez, Patricia and Giampieri, Francesca and Alvarez-Suarez, José M. and Gasparrini, Massimiliano and Forbes-Hernandez, Tamara Y. and Quiles, José L. and Mezzetti, Bruno and Battino, Maurizio mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, tamara.forbes@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2015) The genetic aspects of berries: from field to health. Journal of the Science of Food and Agriculture, 96 (2). pp. 365-371. ISSN 00225142

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Cerrado Inglés In the last decades cancer has been considered as an epigenetic dysfunction, given the profound role of diet and lifestyle in cancer prevention and the determination of cancer risk. A plethora of recent publications have addressed the specific role of several environmental factors, such as nutritional habits, behavior, stress and toxins in the regulation of the physiological and cancer epigenome. In particular, plant-derived bioactive nutrients have been seen to positively affect normal cell growth, proliferation and differentiation and also to revert cancer related epigenetic dysfunctions, reducing tumorigenesis, preventing metastasis and/or increasing chemo and radiotherapy efficacy. Moreover, virtually all cancer types are characterized by the presence of cancer stem cell (CSC) subpopulations, residing in specific hypoxic and acidic microenvironments, or niches, and these cells are currently considered responsible for tumor resistance to therapy and tumor relapse. Modern anti-cancer strategies should be designed to selectively target CSCs and modulate the hypoxic and acidic tumor microenvironment, and, to this end, natural bioactive components seem to play a role. This review aims to discuss the effects elicited by plant-derived bioactive nutrients in the regulation of CSC self-renewal, cancer metabolism and tumor microenvironment. metadata Pistollato, Francesca and Giampieri, Francesca and Battino, Maurizio mail francesca.pistollato@uneatlantico.es, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es (2015) The use of plant-derived bioactive compounds to target cancer stem cells and modulate tumor microenvironment. Food and Chemical Toxicology, 75. pp. 58-70. ISSN 02786915

2014

Other Subjects > Engineering
Subjects > Nutrition Europe University of Atlantic > Research > Projects I+D+I Cerrado Español El objetivo de este proyecto es la creación de una nueva unidad de investigación en tecnologías alimentarias y nutrición en el centro privado de I+D CITICAN. Para alcanzar este objetivo general, la actuación contempla la contratación de personal investigador y la adquisición de equipamiento científico para dotar dos laboratorios, uno de bromatología y otro de microbiología. Estas instalaciones se ubican en el Parque Científico-Tecnológico de Cantabria en las instalaciones de la Universidad Europea del Atlántico (entidad promotora y patrona de la Fundación CITICAN). Estos recursos permitirán a CITICAN posicionarse como una entidad de referencia en el campo de la investigación alimentaria y el apoyo a las industrias productoras de alimentos. En concreto: Dotar a CITICAN de un laboratorio de última generación para la realización de actividades de I+D relacionadas con las tecnologías de la alimentación y la nutrición humana. Contar con un equipo humano capaz de generar conocimiento así como de aplicarlo y transferirlo al sector industrial y a los consumidores. Posibilitar el desarrollo de líneas de investigación de interés para las industrias alimentarias y para el consumidor. Ofrecer servicios de investigación contractual en materia de investigación, desarrollo y análisis de alimentos y sus procesos de producción. Objetivo del Proyecto: Crear una nueva unidad de investigación en tecnologías alimentarias y nutrición en CITICAN. Para alcanzar este objetivo general, la actuación contempló la contratación de personal investigador y la adquisición de equipamiento científico para dotar dos laboratorios, uno de bromatología y otro de microbiología. Financiación: Este proyecto ha sido cofinanciado dentro del Programa INNPULSA Cantabria 2014 – Línea INNOVA por el Fondo Europeo de Desarrollo Regional. Programa Operativo FEDER de Cantabria 2014-2020. “Una manera de hacer Europa”. Inicio: 01/09/2014 Fin: 16/06/2016 Código Externo: 2014/INN/037 metadata CITICAN-Universidad Europea del Atlántico, mail UNSPECIFIED (2014) Creación de la unidad de investigación en tecnologías alimentarias y nutrición en el Centro de Investigación y Tecnología Industrial de Cantabria - CITICAN. Repositorio de la Universidad. (Unpublished)

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production Abierto Inglés Strawberry bioactive compounds are widely known to be powerful antioxidants. In this study, the antioxidant and anti-aging activities of a polyphenol-rich strawberry extract were evaluated using human dermal fibroblasts exposed to H2O2. Firstly, the phenol and flavonoid contents of strawberry extract were studied, as well as the antioxidant capacity. HPLC-DAD analysis was performed to determine the vitamin C and β-carotene concentration, while HPLC-DAD/ESI-MS analysis was used for anthocyanin identification. Strawberry extract presented a high antioxidant capacity, and a relevant concentration of vitamins and phenolics. Pelargonidin- and cyanidin-glycosides were the most representative anthocyanin components of the fruits. Fibroblasts incubated with strawberry extract and stressed with H2O2 showed an increase in cell viability, a smaller intracellular amount of ROS, and a reduction of membrane lipid peroxidation and DNA damage. Strawberry extract was also able to improve mitochondrial functionality, increasing the basal respiration of mitochondria and to promote a regenerative capacity of cells after exposure to pro-oxidant stimuli. These findings confirm that strawberries possess antioxidant properties and provide new insights into the beneficial role of strawberry bioactive compounds on protecting skin from oxidative stress and aging. metadata Giampieri, Francesca and Alvarez-Suarez, José and Mazzoni, Luca and Forbes-Hernandez, Tamara Y. and Gasparrini, Massimiliano and Gonzàlez-Paramàs, Ana and Santos-Buelga, Celestino and Quiles, José and Bompadre, Stefano and Mezzetti, Bruno and Battino, Maurizio mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, tamara.forbes@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2014) Polyphenol-Rich Strawberry Extract Protects Human Dermal Fibroblasts against Hydrogen Peroxide Oxidative Damage and Improves Mitochondrial Functionality. Molecules, 19 (6). pp. 7798-7816. ISSN 1420-3049

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production Cerrado Inglés Plant-based diets are known to preserve body tissues from oxidative stress and inflammation, both hallmarks of chronic-degenerative diseases. In particular, plant-derived foods, such as legumes, represent a natural source of bioactive nutrients known to contribute to the prevention and amelioration of insulin resistance, dyslipidemia, hypertension and impaired glucose metabolism, all factors implicated in metabolic syndrome (MetS), but also osteoporosis, neurodegeneration and some types of cancers. Here we revise recent literature on the role of plant-based diets, plant-foods and specific plant-nutrients in the prevention and regression of MetS and neurodegenerative diseases. We describe some of the molecular mechanisms underlying these protective effects, highlighting the role of diet in the control of hyper-homocysteinemia and insulin resistance, often implicated in the etiology of both metabolic and neurodegenerative syndromes. metadata Pistollato, Francesca and Battino, Maurizio mail UNSPECIFIED, maurizio.battino@uneatlantico.es (2014) Role of plant-based diets in the prevention and regression of metabolic syndrome and neurodegenerative diseases. Trends in Food Science & Technology, 40 (1). pp. 62-81. ISSN 09242244

2013

Article Subjects > Nutrition Europe University of Atlantic > Research > Scientific Production UNSPECIFIED UNSPECIFIED UNSPECIFIED metadata Elío Pascual, Iñaki and Sumalla Cano, Sandra and Dominguez Azpíroz, Irma and Jarrin, Sandra and Montejo, Marylin and Battino, Maurizio mail inaki.elio@uneatlantico.es, sandra.sumalla@uneatlantico.es, irma.dominguez@uneatlantico.es, sandra.jarrin@uneatlantico.es, UNSPECIFIED, maurizio.battino@uneatlantico.es (2013) PP194-MON assessing the nutritional intake and the profile of a latin american group of nutrition postgraduate students. Clinical Nutrition, 32. S194. ISSN 0261-5614