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Effects of a 12-week multicomponent exercise programme on physical function in older adults with cancer: Study protocol for the ONKO-FRAIL randomised controlled trial
Introduction Cancer in older adults is often associated with functional limitations, geriatric syndromes, poor self-rated health, vulnerability, and frailty, and these conditions might worsen treatment-related side effects. Recent guidelines for patients with cancer during and after treatment have documented the beneficial effects of exercise to counteract certain side effects; however, little is known about the role of exercise during cancer treatment in older adults. Materials and Methods This is a multicentre randomised controlled trial in which 200 participants will be allocated to a control group or an intervention group (the sample size has been calculated to detect a clinical difference of 1 point in Short Physical Performance Battery (SPPB) score, assuming an α error of 0.05, a β error of 0.20, and a 10 % loss rate). Patients aged ≥70 years, diagnosed with any type of solid cancer and candidates for systemic treatment are eligible. Subjects in the intervention group are invited to participate in a 12-week supervised multicomponent exercise programme in addition to receiving usual care. Study assessments are conducted at baseline and three months. The primary outcome measure is physical function as assessed by the SPPB. Secondary outcome measures include comprehensive geriatric assessment scores (including social situation, basic and instrumental activities of daily living, cognitive function, depression, nutritional status, polypharmacy, geriatric syndromes, pain, and emotional distress), anthropometric characteristics, frailty status, physical fitness, physical activity, cognitive function, quality of life, fatigue, and nutritional status. Study assessments also include analysis of inflammatory, endocrine, and nutritional mediators in serum and plasma as potential frailty biomarkers at mRNA and protein levels and multiparametric flow cytometric analysis to measure immunosenescence markers on T and NK cells. Discussion This study seeks to extend our knowledge on exercise interventions during systemic anticancer treatment in patients over 70 years of age. Results from this research will guide the management of older adults during systemic treatment in hospitals seeking to enhance the standard of care.
Assessment Of Thermal Asymmetries In Professional Soccer Players According To Field Position
PURPOSE: Infrared Thermography is a valid and non-invasive tool to evaluate skin temperature. Analyzing changes in temperature in response to physiological processes is important to detect fatigue and risk factors for injury. The main aim of this study was to assess thermal asymmetries (TA) in the rectus femoris (RF) and biceps femoris (BF) in professional soccer players according to position.
Effectiveness Of Shoulder Ligamentoplasty And Its Relationship With Immobilization Time And Re-dislocation Rate.
PURPOSE: Shoulder ligamentoplasty (SL) is an arthroscopic technique for complex instabilities that uses an artificial ligament to generate a subscapular sling effect that reinforces tissue repair. The main objective of this study was to evaluate the efficacy of SL by analyzing its relationship with postoperative immobilization time and the incidence of re-dislocation.
Thermal degradation mechanism of myricetin in palmitic acid
Dietary polyphenols are susceptible to degradation during high-temperature cooking, yet their transformation behavior in lipid-rich frying systems remains poorly understood. The thermal stability and degradation of myricetin in a simplified palmitic acid model under frying-relevant conditions was investigated. Myricetin degraded rapidly at 180 °C but remained relatively stable at 120 °C. UPLC–QTOF–MS/MS, supported by density functional theory calculations, suggested that myricetin transformation is temperature-dependent but primarily governed by lipid oxidation–derived radical and carbonyl chemistry. Vitamin C markedly delayed myricetin degradation by suppressing radical initiation and limiting o-quinone–centered downstream reactions. These findings highlight lipid oxidation as a key determinant of polyphenol stability during frying and clarify the protective role of antioxidants in lipid-rich thermal processing systems.
Conservative management of a cervically fractured zygomatic implant using a novel titanium device: a technical report with biomechanical validation and 24-month follow-up
Fracture of a zygomatic implant is an uncommon but clinically challenging complication. Conventional management generally involves implant removal or alternative anchorage strategies, both of which may require extensive surgery, increase patient morbidity, and compromise an existing implant-supported rehabilitation. This technical report describes the development, biomechanical validation, and first clinical application of a novel prosthetic rescue device for the conservative management of cervical fractures of zygomatic implants while preserving the osseointegrated apical segment. A customized Grade V titanium device incorporating an internal threaded connection and supplementary self-tapping fixation screws was specifically designed to restore the fractured implant. Biomechanical performance was assessed by dynamic fatigue testing according to ISO 14801. The device was subsequently used in a 60-year-old woman presenting with a cervical fracture of a zygomatic implant. Placement was performed using a surgical guide, and the device was secured with an insertion torque of approximately 20 Ncm. Fatigue testing demonstrated mechanical resistance exceeding five million loading cycles under a maximum load of 129 N. At the 24-month follow-up, the patient remained free of mechanical or biological complications, with stable clinical and radiographic findings and successful maintenance of the implant-supported prosthetic rehabilitation. This case suggests that the proposed prosthetic rescue device may represent a minimally invasive alternative to implant removal in carefully selected cases of cervical fracture of zygomatic implants with a stable osseointegrated apical segment. Further clinical studies are required to confirm the reproducibility, long-term mechanical performance, and clinical predictability of this approach.