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Effects of a 12-week multicomponent exercise programme on physical function in older adults with cancer: Study protocol for the ONKO-FRAIL randomised controlled trial
Introduction Cancer in older adults is often associated with functional limitations, geriatric syndromes, poor self-rated health, vulnerability, and frailty, and these conditions might worsen treatment-related side effects. Recent guidelines for patients with cancer during and after treatment have documented the beneficial effects of exercise to counteract certain side effects; however, little is known about the role of exercise during cancer treatment in older adults. Materials and Methods This is a multicentre randomised controlled trial in which 200 participants will be allocated to a control group or an intervention group (the sample size has been calculated to detect a clinical difference of 1 point in Short Physical Performance Battery (SPPB) score, assuming an α error of 0.05, a β error of 0.20, and a 10 % loss rate). Patients aged ≥70 years, diagnosed with any type of solid cancer and candidates for systemic treatment are eligible. Subjects in the intervention group are invited to participate in a 12-week supervised multicomponent exercise programme in addition to receiving usual care. Study assessments are conducted at baseline and three months. The primary outcome measure is physical function as assessed by the SPPB. Secondary outcome measures include comprehensive geriatric assessment scores (including social situation, basic and instrumental activities of daily living, cognitive function, depression, nutritional status, polypharmacy, geriatric syndromes, pain, and emotional distress), anthropometric characteristics, frailty status, physical fitness, physical activity, cognitive function, quality of life, fatigue, and nutritional status. Study assessments also include analysis of inflammatory, endocrine, and nutritional mediators in serum and plasma as potential frailty biomarkers at mRNA and protein levels and multiparametric flow cytometric analysis to measure immunosenescence markers on T and NK cells. Discussion This study seeks to extend our knowledge on exercise interventions during systemic anticancer treatment in patients over 70 years of age. Results from this research will guide the management of older adults during systemic treatment in hospitals seeking to enhance the standard of care.
Effectiveness Of Shoulder Ligamentoplasty And Its Relationship With Immobilization Time And Re-dislocation Rate.
PURPOSE: Shoulder ligamentoplasty (SL) is an arthroscopic technique for complex instabilities that uses an artificial ligament to generate a subscapular sling effect that reinforces tissue repair. The main objective of this study was to evaluate the efficacy of SL by analyzing its relationship with postoperative immobilization time and the incidence of re-dislocation.
Thermal degradation mechanism of myricetin in palmitic acid
Dietary polyphenols are susceptible to degradation during high-temperature cooking, yet their transformation behavior in lipid-rich frying systems remains poorly understood. The thermal stability and degradation of myricetin in a simplified palmitic acid model under frying-relevant conditions was investigated. Myricetin degraded rapidly at 180 °C but remained relatively stable at 120 °C. UPLC–QTOF–MS/MS, supported by density functional theory calculations, suggested that myricetin transformation is temperature-dependent but primarily governed by lipid oxidation–derived radical and carbonyl chemistry. Vitamin C markedly delayed myricetin degradation by suppressing radical initiation and limiting o-quinone–centered downstream reactions. These findings highlight lipid oxidation as a key determinant of polyphenol stability during frying and clarify the protective role of antioxidants in lipid-rich thermal processing systems.
Aprendizaje autónomo de lenguas: una experiencia comparativa con Duolingo y Busuu
Este estudio analiza una experiencia didáctica desarrollada en la asignatura Enseñanza y Aprendizaje de Lenguas (tercer curso) en la Universidad Europea del Atlántico. Participaron estudiantes de los grados en Traducción y Enseñanza de Lenguas y en Educación Primaria, quienes utilizaron las aplicaciones Duolingo y Busuu durante dos períodos consecutivos de 15 días con el fin de iniciarse en una nueva lengua extranjera en un contexto de aprendizaje autónomo. La investigación adopta un enfoque comparativo y se basa en un cuestionario posterior que evaluó la experiencia de uso, la percepción de utilidad pedagógica, la motivación, la retroalimentación recibida y la autorregulación del aprendizaje. Los resultados indican que ambas aplicaciones generan niveles similares de satisfacción global, pero responden a lógicas pedagógicas diferenciadas: Duolingo destaca por su capacidad motivacional y su diseño gamificado, que favorece la constancia y el hábito; Busuu, en cambio, es percibida como más estructurada y coherente desde el punto de vista gramatical, lo que refuerza la percepción de progreso cognitivo. Asimismo, la experiencia previa en el uso de herramientas digitales influye significativamente en la valoración de la autonomía y la eficacia percibida. Se concluye que Duolingo y Busuu no funcionan como herramientas sustitutivas, sino como recursos complementarios dentro del enfoque MALL. Finalmente, se discuten las implicaciones pedagógicas para la integración crítica y reflexiva de aplicaciones móviles en la formación universitaria de futuros docentes y mediadores lingüísticos.
Assessment Of Thermal Asymmetries In Professional Soccer Players According To Field Position
PURPOSE: Infrared Thermography is a valid and non-invasive tool to evaluate skin temperature. Analyzing changes in temperature in response to physiological processes is important to detect fatigue and risk factors for injury. The main aim of this study was to assess thermal asymmetries (TA) in the rectus femoris (RF) and biceps femoris (BF) in professional soccer players according to position.