Régimen Alternativo en la Administración de Letrozol para Inducción Ovárica
Tesis Materias > Biomedicina Universidad Europea del Atlántico > Docencia > Trabajos finales de Máster Cerrado Español El letrozol es un fármaco comúnmente utilizado en tratamientos de baja complejidad en reproducción asistida, sin embargo, la posología convencional de 5mg/día durante 5 días puede ser causa de olvido y de que el tratamiento no dé el resultado esperado, es por esto que la posología propuesta de 12.5mg c/12hrs por 2 dosis puede resultar atractiva y con menor probabilidad de olvido por parte de las pacientes. Objetivo específico: Evaluar los resultados obstétricos en la inducción ovárica usando el esquema alternativo del letrozol y compararlo con los resultados del esquema convencional.Metodología utilizada: Es un estudio de tipo retrospectivo, transversal y observacional, se recolectaron los datos de los expedientes de pacientes de entre 20 y 35 años tratadas para inducción ovárica y clasificar las que usaron la posología convencional y las que usaron la posología alternativa en el periodo de diciembre 2020 a diciembre 2021. Se vaciaron los datos en base de datos excel y se realizó análisis estadístico utilizando Mann Whitney para comparar variables y se consideró una p<0.05 como valor significativo.Resultados: Se clsificaron los expedientes en dos grupos, el grupo con dosis convencional y el de dosis alternativa, se realizaron un máximo de 3 ciclos, obteniendo 30% vs 26% de embarazos, 0% vs 3% de embarazo gemelar y la presencia de aborto un 5% vs 3% para el grupo convencional y el alternativo respectivamente. Ambos grupos obtuvieron tasas similares de desarrollo folicular 33%,58% y 9% para 1, 2 y 3 folículos >18mmen el grupo convencional y 36%, 48% y 26% para el grupo alternativo, con la misma media de 8mm de grosor endometrial.Conclusiones: No se obtuvieron resultados estadísticamente significativos en ambos grupos, con lo que podemos concluir que la posología propuesta puede resultar tan efectiva como la convencional con una toma más sencilla y con menor probabilidad de olvido por parte de las pacientes. metadata Torres Sánchez, Adriana Carolina mail caro_sanz08@hotmail.com (2022) Régimen Alternativo en la Administración de Letrozol para Inducción Ovárica. Masters thesis, SIN ESPECIFICAR.
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El letrozol es un fármaco comúnmente utilizado en tratamientos de baja complejidad en reproducción asistida, sin embargo, la posología convencional de 5mg/día durante 5 días puede ser causa de olvido y de que el tratamiento no dé el resultado esperado, es por esto que la posología propuesta de 12.5mg c/12hrs por 2 dosis puede resultar atractiva y con menor probabilidad de olvido por parte de las pacientes. Objetivo específico: Evaluar los resultados obstétricos en la inducción ovárica usando el esquema alternativo del letrozol y compararlo con los resultados del esquema convencional.Metodología utilizada: Es un estudio de tipo retrospectivo, transversal y observacional, se recolectaron los datos de los expedientes de pacientes de entre 20 y 35 años tratadas para inducción ovárica y clasificar las que usaron la posología convencional y las que usaron la posología alternativa en el periodo de diciembre 2020 a diciembre 2021. Se vaciaron los datos en base de datos excel y se realizó análisis estadístico utilizando Mann Whitney para comparar variables y se consideró una p<0.05 como valor significativo.Resultados: Se clsificaron los expedientes en dos grupos, el grupo con dosis convencional y el de dosis alternativa, se realizaron un máximo de 3 ciclos, obteniendo 30% vs 26% de embarazos, 0% vs 3% de embarazo gemelar y la presencia de aborto un 5% vs 3% para el grupo convencional y el alternativo respectivamente. Ambos grupos obtuvieron tasas similares de desarrollo folicular 33%,58% y 9% para 1, 2 y 3 folículos >18mmen el grupo convencional y 36%, 48% y 26% para el grupo alternativo, con la misma media de 8mm de grosor endometrial.Conclusiones: No se obtuvieron resultados estadísticamente significativos en ambos grupos, con lo que podemos concluir que la posología propuesta puede resultar tan efectiva como la convencional con una toma más sencilla y con menor probabilidad de olvido por parte de las pacientes.
| Tipo de Documento: | Tesis (Masters) |
|---|---|
| Palabras Clave: | 1.Inhibidores de la aromatasa, 2.Inducción ovárica, 3.Letrozol, 4.Régimen alternativo, 5.Infertilidad. |
| Clasificación temática: | Materias > Biomedicina |
| Divisiones: | Universidad Europea del Atlántico > Docencia > Trabajos finales de Máster |
| Depositado: | 17 Nov 2023 23:30 |
| Ultima Modificación: | 17 Nov 2023 23:30 |
| URI: | https://repositorio.uneatlantico.es/id/eprint/2146 |
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