Búsqueda de resultados para Maurizio Battino
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| 21. | Artículo Materias > Biomedicina Universidad Europea del Atlántico > Investigación > Artículos y libros SIN ESPECIFICAR SIN ESPECIFICAR Honey is a natural product known to modulate several biological activities including cancer. The aim of the present study was to examine the phytochemical content and the antioxidant activity of Strawberry tree (Arbutus unedo) honey (STH) and its cytotoxic properties against human colon adenocarcinoma (HCT-116) and metastatic (LoVo) cell lines in comparison with Manuka (Leptospermum scoparium) honey (MH). Several unifloral STH and MH were analyzed for their phenolic, flavonoid, amino acid and protein contents, as well as their radical scavenging activities. STH from the Berchidda area showed the highest amount of phenolic, flavonoid, amino acid and protein content, and antioxidant capacity compared to MH. Both STH and MH induced cytotoxicity and cell death in a dose- and time-dependent manner in HCT-116 and LoVo cells, with less toxicity on non-cancer cells. Compared to MH, STH showed more effect at lower concentrations on HCT-116 and LoVo cells. In addition, both honeys increased intracellular reactive oxygen species (ROS) generation. In HCT-116 cells, STH and MH induced similar ROS production but in LoVo cells STH induced a higher percentage of ROS compared to MH. Our results indicate that STH and MH can induce cell growth inhibition and ROS generation in colon adenocarcinoma and metastatic cells, which could be due to the presence of phytochemicals with antioxidant properties. These preliminary results are interesting and suggest a potential chemopreventive action which could be useful for further studies in order to develop chemopreventive agents for colon cancer. metadata Afrin, Sadia; Forbes-Hernandez, Tamara Y.; Gasparrini, Massimiliano; Bompadre, Stefano; Quiles, José; Sanna, Gavino; Spano, Nadia; Giampieri, Francesca y Battino, Maurizio mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es (2017) Strawberry-Tree Honey Induces Growth Inhibition of Human Colon Cancer Cells and Increases ROS Generation: A Comparison with Manuka Honey. International Journal of Molecular Sciences, 18 (3). p. 613. ISSN 1422-0067 |
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| 22. | Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Artículos y libros SIN ESPECIFICAR SIN ESPECIFICAR Capuli cherry (Prunus serotina Ehr. subsp. capuli (Cav.) McVaugh) fruits from the inter-Andean region of Ecuador were analysed to determine their bioactive compounds content, total antioxidant capacity, radical scavenging activity and their anti-inflammatory and protective effects against the cytotoxic damage mediated by lipopolysaccharide (LPS) in RAW 264.7 macrophages. Capuli fruits proved to be a natural source of bioactive compounds such as anthocyanins, vitamin C and β-carotene as well as to present an important total antioxidant capacity and radical scavenging activities. RAW 264.7 macrophages were incubated with different concentration of Capuli crude extract and subsequently activated by LPS to determine the markers related to oxidative damage and the proinflammatory cytokine production. The markers of oxidative damage, nitrite levels, the interleukin 1β messenger RNA levels and the tumor necrosis factor α mRNA levels and secretion were significantly decreased after the pre-incubated with Capuli extract and subsequently stimulated with LPS. In summary, Capuli extract attenuated the LPS-induced damage in RAW 264.7 macrophages due to its antioxidant and anti-inflammatory properties, showing that Capuli fruits may represent a relevant source of bioactive compounds with promising benefits for human health. metadata Alvarez-Suarez, José M.; Carrillo-Perdomo, Estefanía; Aller, Angel; Giampieri, Francesca; Gasparrini, Massimiliano; González-Pérez, Lien; Beltrán-Ayala, Pablo y Battino, Maurizio mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es (2017) Anti-inflammatory effect of Capuli cherry against LPS-induced cytotoxic damage in RAW 264.7 macrophages. Food and Chemical Toxicology, 102. pp. 46-52. ISSN 0278-6915 ["page:item_not_available" not defined] | ||
| 23. | Artículo Materias > Biomedicina Universidad Europea del Atlántico > Investigación > Artículos y libros Cerrado Inglés Acerola fruits (Malpighia emarginata DC.) from the central region of Cuba were analyzed to determine their chemical composition and protective capacity against oxidative damage using an in vitro human dermal fibroblast (HDFa) model. The chemical composition analyses showed a high content of vitamin C, total polyphenols, β-carotene and folates in the acerola fruit. From the HPLC-DAD/ESI-MSn analyses, two anthocyanins (cyanidin 3-O-rhamnoside and pelargonidin 3-O-rhamnoside), three hydroxycinnamoyl derivatives (caffeoyl hexoside, dihydrocaffeoylquinic acid and coumaroyl hexoside) and fifteen flavonols (mostly glycosylated forms of quercetin and kaempferol) were detected. HDFa were pre-incubated with an acerola crude extract (ACExt) and subsequently subjected to oxidative stress induced by AAPH. Apoptosis, intracellular ROS and the biomarkers of lipid and protein oxidation significantly increased after inducing stress, while the activities of the antioxidant enzyme catalase and superoxide dismutase and mitochondrial functionality were markedly affected. However, ACExt was able to protect against oxidative damage through decreasing apoptosis, intracellular ROS levels and lipid and protein damage, besides improving antioxidant enzyme activities and mitochondrial functionality. The obtained results support acerola fruits as relevant sources of functional compounds with promising effects on human health. metadata Alvarez-Suarez, José M.; Giampieri, Francesca; Gasparrini, Massimiliano; Mazzoni, Luca; Santos-Buelga, Celestino; González-Paramás, Ana M.; Forbes-Hernández, Tamara Y.; Afrin, Sadia; Páez-Watson, Timothy; Quiles, José L. y Battino, Maurizio mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, tamara.forbes@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es (2017) The protective effect of acerola (Malpighia emarginata) against oxidative damage in human dermal fibroblasts through the improvement of antioxidant enzyme activity and mitochondrial functionality. Food & Function, 8 (9). pp. 3250-3258. ISSN 2042-6496 ["page:item_not_available" not defined] | ||
| 24. |
Artículo
Materias > Biomedicina
Universidad Europea del Atlántico > Investigación > Artículos y libros Universidad Internacional Iberoamericana México > Investigación > Producción Científica SIN ESPECIFICAR SIN ESPECIFICAR Dyslipidemia and oxidation of low density lipoproteins (LDL) are recognized as critical factors in the development of atherosclerosis. Healthy dietary patterns, with abundant fruit and vegetable consumption, may prevent the onset of these risk factors due to the presence of phytochemical compounds. Strawberries are known for their high content of polyphenols; among them, flavonoids are the major constituents, and it is presumed that they are responsible for the biological activity of the fruit. Nevertheless, there are only a few studies that actually evaluate the effects of different fractions isolated from strawberries. In order to assess the effects of two different strawberry extracts (whole methanolic extract/anthocyanin-enriched fraction) on the lipid profile and antioxidant status in human hepatocellular carcinoma (HepG2) cells, the triglycerides and LDL-cholesterol content, lipid peroxidation, intracellular reactive oxygen species (ROS) content and antioxidant enzymes’ activity on cell lysates were determined. Results demonstrated that both strawberry extracts not only improved the lipid metabolism by decreasing triglycerides and LDL-cholesterol contents, but also improved the redox state of HepG2 cells by modulating thiobarbituric acid-reactive substances production, antioxidant enzyme activity and ROS generation. The observed effects were more pronounced for the anthocyanin-enriched fraction. metadata Forbes-Hernandez, Tamara Y.; Gasparrini, Massimiliano; Afrin, Sadia; Cianciosi, Danila; González-Paramás, Ana; Santos-Buelga, Celestino; Mezzetti, Bruno; Quiles, José L.; Battino, Maurizio; Giampieri, Francesca y Bompadre, Stefano mail tamara.forbes@unini.edu.mx, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR (2017) Strawberry (cv. Romina) Methanolic Extract and Anthocyanin-Enriched Fraction Improve Lipid Profile and Antioxidant Status in HepG2 Cells. International Journal of Molecular Sciences, 18 (6). p. 1149. ISSN 1422-0067 |
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| 25. |
Artículo
Materias > Biomedicina
Universidad Europea del Atlántico > Investigación > Artículos y libros Universidad Internacional Iberoamericana México > Investigación > Producción Científica SIN ESPECIFICAR SIN ESPECIFICAR Regulation of lipid metabolism is essential for treatment and prevention of several chronic diseases such as obesity, diabetes, and cardiovascular diseases, which are responsible for most deaths worldwide. It has been demonstrated that the AMP-activated protein kinase (AMPK) has a direct impact on lipid metabolism by modulating several downstream-signaling components. The main objective of the present work was to evaluate the in vitro effect of a methanolic strawberry extract on AMPK and its possible repercussion on lipid metabolism in human hepatocellular carcinoma cells (HepG2). For such purpose, the lipid profile and the expression of proteins metabolically related to AMPK were determined on cells lysates. The results demonstrated that strawberry methanolic extract decreased total cholesterol, low-density lipoprotein (LDL)-cholesterol, and triglycerides levels (up to 0.50-, 0.30-, and 0.40-fold, respectively) while it stimulated the p-AMPK/AMPK expression (up to 3.06-fold), compared to the control. AMPK stimulation led to the phosphorylation and consequent inactivation of acetyl coenzyme A carboxylase (ACC) and inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the major regulators of fatty acids and cholesterol synthesis, respectively. Strawberry treatment also entailed a 4.34-, 2.37-, and 2.47-fold overexpression of LDL receptor, sirtuin 1 (Sirt1), and the peroxisome proliferator activated receptor gamma coactivator 1-alpha (PGC-1α), respectively, compared to control. The observed results were counteracted by treatment with compound C, an AMPK pharmacological inhibitor, confirming that multiple effects of strawberries on lipid metabolism are mediated by the activation of this protein. metadata Forbes-Hernandez, Tamara Y.; Giampieri, Francesca; Gasparrini, Massimiliano; Afrin, Sadia; Mazzoni, Luca; Cordero, Mario; Mezzetti, Bruno; Quiles, José L. y Battino, Maurizio mail tamara.forbes@unini.edu.mx, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es (2017) Lipid Accumulation in HepG2 Cells Is Attenuated by Strawberry Extract through AMPK Activation. Nutrients, 9 (6). p. 621. ISSN 2072-6643 |
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| 26. |
Artículo
Materias > Biomedicina
Universidad Europea del Atlántico > Investigación > Artículos y libros Universidad Internacional Iberoamericana México > Investigación > Producción Científica SIN ESPECIFICAR SIN ESPECIFICAR Extreme exposure of skin to Ultraviolet A (UVA)-radiation may induce a dysregulated production of reactive oxygen species (ROS) which can interact with cellular biomolecules leading to oxidative stress, inflammation, DNA damage, and alteration of cellular molecular pathways, responsible for skin photoaging, hyperplasia, erythema, and cancer. For these reasons, the use of dietary natural bioactive compounds with remarkable antioxidant activity could be a strategic tool to counteract these UVA-radiation-caused deleterious effects. Thus, the purpose of the present work was to test the efficacy of strawberry (50 μg/mL)-based formulations supplemented with Coenzyme Q10 (100 μg/mL) and sun protection factor 10 in human dermal fibroblasts irradiated with UVA-radiation. The apoptosis rate, the amount of intracellular reactive oxygen species (ROS) production, the expression of proteins involved in antioxidant and inflammatory response, and mitochondrial functionality were evaluated. The results showed that the synergic topical use of strawberry and Coenzyme Q10 provided a significant (p < 0.05) photoprotective effect, reducing cell death and ROS, increasing antioxidant defense, lowering inflammatory markers, and improving mitochondrial functionality. The obtained results suggest the use of strawberry-based formulations as an innovative, natural, and useful tool for the prevention of UVA exposure-induced skin diseases in order to decrease or substitute the amount of synthetic sunscreen agents. metadata Gasparrini, Massimiliano; Forbes-Hernandez, Tamara Y.; Afrin, Sadia; Reboredo-Rodriguez, Patricia; Cianciosi, Danila; Mezzetti, Bruno; Quiles, José L.; Bompadre, Stefano; Battino, Maurizio y Giampieri, Francesca mail SIN ESPECIFICAR, tamara.forbes@unini.edu.mx, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es, SIN ESPECIFICAR (2017) Strawberry-Based Cosmetic Formulations Protect Human Dermal Fibroblasts against UVA-Induced Damage. Nutrients, 9 (6). p. 605. ISSN 2072-6643 |
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| 27. |
Artículo
Materias > Biomedicina
Universidad Europea del Atlántico > Investigación > Artículos y libros Universidad Internacional Iberoamericana México > Investigación > Producción Científica Cerrado Inglés A common denominator in the pathogenesis of most chronic inflammatory diseases is the involvement of oxidative stress, related to ROS production by all aerobic organisms. Dietary antioxidants from plant foods represent an efficient strategy to counteract this condition. The aim of the present study was to evaluate the protective effects of strawberry extracts on inflammatory status induced by E. Coli LPS on RAW 264.7 macrophages by measuring the main oxidative and inflammatory biomarkers and investigating the molecular pathways involved. Strawberry pre-treatment efficiently counteracted LPS-induced oxidative stress reducing the amount of ROS and nitrite production, stimulating endogenous antioxidant enzyme activities and enhancing protection against lipid, protein and DNA damage (P < 0.05). Strawberry pre-treatment exerted these protective effects primarily through the activation of the Nrf2 pathway, which is markedly AMPK-dependent and also by the modulation of the NF-kB signalling pathway. Finally, an improvement in mitochondria functionality was also detected. The results obtained in this work highlight the health benefit of strawberries against inflammatory and oxidative stress in LPS-stimulated RAW 264.7 macrophages, investigating for the first time the possible involved molecular mechanisms. metadata Gasparrini, Massimiliano; Forbes-Hernandez, Tamara Y.; Giampieri, Francesca; Afrin, Sadia; Alvarez-Suarez, Josè M.; Mazzoni, Luca; Mezzetti, Bruno; Quiles, Josè L. y Battino, Maurizio mail SIN ESPECIFICAR, tamara.forbes@unini.edu.mx, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es (2017) Anti-inflammatory effect of strawberry extract against LPS-induced stress in RAW 264.7 macrophages. Food and Chemical Toxicology, 102. pp. 1-10. ISSN 0278-6915 ["page:item_not_available" not defined] |
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| 28. |
Artículo
Materias > Biomedicina
Universidad Europea del Atlántico > Investigación > Artículos y libros Universidad Internacional Iberoamericana México > Investigación > Producción Científica SIN ESPECIFICAR SIN ESPECIFICAR A protracted pro-inflammatory state is a major contributing factor in the development, progression and complication of the most common chronic pathologies. Fruit and vegetables represent the main sources of dietary antioxidants and their consumption can be considered an efficient tool to counteract inflammatory states. In this context an evaluation of the protective effects of strawberry extracts on inflammatory stress induced by E. coli LPS on human dermal fibroblast cells was performed in terms of viability assays, ROS and nitrite production and biomarkers of oxidative damage of the main biological macromolecules. The results demonstrated that strawberry extracts exerted an anti-inflammatory effect on LPS-treated cells, through an increase in cell viability, and the reduction of ROS and nitrite levels, and lipid, protein and DNA damage. This work showed for the first time the potential health benefits of strawberry extract against inflammatory and oxidative stress in LPS-treated human dermal fibroblast cells. metadata Gasparrini, Massimiliano; Forbes-Hernandez, Tamara Y.; Giampieri, Francesca; Afrin, Sadia; Mezzetti, Bruno; Quiles, José L.; Bompadre, Stefano y Battino, Maurizio mail SIN ESPECIFICAR, tamara.forbes@unini.edu.mx, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es (2017) Protective Effect of Strawberry Extract against Inflammatory Stress Induced in Human Dermal Fibroblasts. Molecules, 22 (1). p. 164. ISSN 1420-3049 |
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| 29. | Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Artículos y libros SIN ESPECIFICAR SIN ESPECIFICAR Here, we present new original data on the effects of strawberry consumption on body weight and liver status of aged rats. Wistar rats aged 19–21 months were fed a strawberry enriched diet prepared by substituting 15% of the total calories with freeze-dried strawberry powder for two months. Body weight, plasma biomarkers of liver injury (alanine transferase, aspartate aminotransferase and alkaline phosphatase) and liver histological analysis were assessed. These data indicate that strawberry supplementation did not interfere with normal animal maintenance and with liver structure and functionality. For further details and experimental findings please refer to the article “Strawberry consumption improves aging-associated impairments, mitochondrial biogenesis and functionality through the AMP-Activated Protein Kinase signaling cascade” in FOOD CHEMISTRY metadata Giampieri, Francesca; Alvarez-Suarez, Josè M.; Gasparrini, Massimiliano; Forbes-Hernandez, Tamara Y.; Afrin, Sadia; Rubini, Corrado; Zizzi, Antonio; Quiles, Josè L.; Mezzetti, Bruno y Battino, Maurizio mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es (2017) Data on body weight and liver functionality in aged rats fed an enriched strawberry diet. Data in Brief, 13. pp. 432-436. ISSN 2352-3409 ["page:item_not_available" not defined] | ||
| 30. |
Artículo
Materias > Biomedicina
Universidad Europea del Atlántico > Investigación > Artículos y libros Universidad Internacional Iberoamericana México > Investigación > Producción Científica Cerrado Inglés It is generally accepted that a fruit and vegetable–enriched diet is favorable for human health. The consumption of strawberries, in particular, has been related to the maintenance of well-being and the prevention of several chronic diseases, owing to the high contents of antioxidants and phytochemicals present in the fruit. Several biological effects have been explained through the total antioxidant capacity exerted by these bioactive compounds, but recently more intricate mechanisms have begun to be examined. In this context, it has been reported that strawberry phenolics are able to exert anti-inflammatory, anticarcinogenic, antiproliferative, and antiatherosclerotic activities, acting on specific molecular pathways related to antioxidant defenses, metabolism, survival, and proliferation. The overall aim of this work is to discuss and update the cellular and molecular mechanisms recently proposed to clarify the effects of strawberry phenolics on human health, with particular attention to the most common chronic diseases, such as metabolic syndrome, cardiovascular disease, and cancer. metadata Giampieri, Francesca; Forbes-Hernandez, Tamara Y.; Gasparrini, Massimiliano; Afrin, Sadia; Cianciosi, Danila; Reboredo-Rodriguez, Patricia; Varela-Lopez, Alfonso; Quiles, Jose L.; Mezzetti, Bruno y Battino, Maurizio mail SIN ESPECIFICAR, tamara.forbes@unini.edu.mx, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es (2017) The healthy effects of strawberry bioactive compounds on molecular pathways related to chronic diseases. Annals of the New York Academy of Sciences, 1398 (1). pp. 62-71. ISSN 0077-8923 ["page:item_not_available" not defined] |
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| 31. |
Artículo
Materias > Biomedicina
Universidad Europea del Atlántico > Investigación > Artículos y libros Universidad Internacional Iberoamericana México > Investigación > Producción Científica Cerrado Inglés Among gynaecological cancers, ovarian cancer represents the leading cause of death in women. Current treatment for ovarian cancer entails surgery followed by combined chemotherapy with platinum and taxane, which are associated, particularly cisplatin, with severe side effects. While this treatment approach appears to be initially effective in a high number of patients, nearly 70% of them suffer a relapse within a few months after initial treatment. Therefore, more effective and better-tolerated treatment options are clearly needed. In recent years, several natural compounds (such as curcumin, epigallocatechin 3-gallate (EGCG), resveratrol, sulforaphane and Withaferin-A), characterized by long-term safety and negligible and/or inexistent side effects, have been proposed as possible adjuvants of traditional chemotherapy. Indeed, several in vitro and in vivo studies have shown that phytocompounds can effectively inhibit tumor cell proliferation, stimulate autophagy, induce apoptosis, and specifically target ovarian cancer stem cells (CSCs), which are generally considered to be responsible for tumor recurrence in several types of cancer. Here we review current literature on the role of natural products in ovarian cancer chemoprevention, highlighting their effects particularly on the regulation of inflammation, autophagy, proliferation and apoptosis, chemotherapy resistance, and ovarian CSC growth. metadata Pistollato, Francesca; Calderón Iglesias, Rubén; Ruiz Salces, Roberto; Aparicio Obregón, Silvia; Crespo Alvare, Jorge; Dzul Lopez, Luis; Giampieri, Francesca y Battino, Maurizio mail SIN ESPECIFICAR, ruben.calderon@uneatlantico.es, roberto.ruiz@uneatlantico.es, silvia.aparicio@uneatlantico.es, jorge.crespo@uneatlantico.es, luis.dzul@unini.edu.mx, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es (2017) The use of natural compounds for the targeting and chemoprevention of ovarian cancer. Cancer Letters, 411. pp. 191-200. ISSN 0304-3835 ["page:item_not_available" not defined] |
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| 32. | Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Artículos y libros SIN ESPECIFICAR SIN ESPECIFICAR Raspberry seed is a massive byproduct of raspberry juice and wine but usually discarded. The present study employed a microwave-assisted method for extraction of raspberry seed oil (RSO). The results revealed that omega-6 fatty acids (linoleic acid and γ-linolenic acid) were the major constituents in RSO. Cellular antioxidant enzyme activity such as superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) were investigated in HepG2 cells treated with RSO. Induction of the synthesis of several antioxidants in H2O2-exposed HepG2 cells was found. RSO increased the enzyme activity of SOD, CAT, and GPx in H2O2-exposed HepG2. Furthermore, RSO inhibited the phosphorylation of upstream mitogen-activated protein kinases (MAPK) such as c-Jun N-terminal kinase (c-JNK) and extracellular signal-regulated kinase (ERK). Taken together, the possible mechanisms to increase antioxidant enzyme activities in HepG2 may through the suppression of ERK and JNK phosphorylation. Raspberry seed oil exhibited good effects on the activities of the intracellular antioxidant enzymes and seems to protect the liver from oxidative stress through the inhibition of MAPKs. metadata Teng, Hui; Lin, Qiyang; Li, Kang; Yuan, Benyao; Song, Hongbo; Peng, Hongquan; Yi, Lunzhao; Wei, Ming-Chi; Yang, Yu-Chiao; Battino, Maurizio; Cespedes Acuña, Carlos L.; Chen, Lei y Xiao, Jianbo mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR (2017) Hepatoprotective effects of raspberry (Rubus coreanus Miq.) seed oil and its major constituents. Food and Chemical Toxicology, 110. pp. 418-424. ISSN 0278-6915 ["page:item_not_available" not defined] | ||
| 33. | Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Artículos y libros SIN ESPECIFICAR SIN ESPECIFICAR The potential health benefits associated with dietary intake of fruits have attracted increasing interest. Among berries, the strawberry is a rich source of several nutritive and non-nutritive bioactive compounds, which are implicated in various health-promoting and disease preventive effects. A plethora of studies have examined the benefits of strawberry consumption, such as prevention of inflammation disorders and oxidative stress, reduction of obesity related disorders and heart disease risk, and protection against various types of cancer. This review provides an overview of their nutritional and non-nutritional bioactive compounds and which factors affect their content in strawberries. In addition, the bioavailability and metabolism of major strawberry phytochemicals as well as their actions in combating many pathologies, including cancer, metabolic syndrome, cardiovascular disease, obesity, diabetes, neurodegeneration, along with microbial pathogenesis have been reviewed, with a particular attention to human studies. metadata Afrin, Sadia; Gasparrini, Massimiliano; Forbes-Hernandez, Tamara Y.; Reboredo-Rodriguez, Patricia; Mezzetti, Bruno; Varela-López, Alfonso; Giampieri, Francesca y Battino, Maurizio mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es (2016) Promising Health Benefits of the Strawberry: A Focus on Clinical Studies. Journal of Agricultural and Food Chemistry, 64 (22). pp. 4435-4449. ISSN 0021-8561 ["page:item_not_available" not defined] | ||
| 34. | Artículo Materias > Biomedicina Universidad Europea del Atlántico > Investigación > Artículos y libros SIN ESPECIFICAR SIN ESPECIFICAR Colon cancer is one of the most prevalent diseases across the world. Numerous epidemiological studies indicate that diets rich in fruit, such as berries, provide significant health benefits against several types of cancer, including colon cancer. The anticancer activities of berries are attributed to their high content of phytochemicals and to their relevant antioxidant properties. In vitro and in vivo studies have demonstrated that berries and their bioactive components exert therapeutic and preventive effects against colon cancer by the suppression of inflammation, oxidative stress, proliferation and angiogenesis, through the modulation of multiple signaling pathways such as NF-κB, Wnt/β-catenin, PI3K/AKT/PKB/mTOR, and ERK/MAPK. Based on the exciting outcomes of preclinical studies, a few berries have advanced to the clinical phase. A limited number of human studies have shown that consumption of berries can prevent colorectal cancer, especially in patients at high risk (familial adenopolyposis or aberrant crypt foci, and inflammatory bowel diseases). In this review, we aim to highlight the findings of berries and their bioactive compounds in colon cancer from in vitro and in vivo studies, both on animals and humans. Thus, this review could be a useful step towards the next phase of berry research in colon cancer. metadata Afrin, Sadia; Giampieri, Francesca; Gasparrini, Massimiliano; Forbes-Hernandez, Tamara; Varela-López, Alfonso; Quiles, José; Mezzetti, Bruno y Battino, Maurizio mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es (2016) Chemopreventive and Therapeutic Effects of Edible Berries: A Focus on Colon Cancer Prevention and Treatment. Molecules, 21 (2). p. 169. ISSN 1420-3049 |
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| 35. | Artículo Materias > Biomedicina Universidad Europea del Atlántico > Investigación > Artículos y libros Cerrado Inglés Excessive amounts of free radicals are deleterious for cells, resulting in cell damage, affecting the wound healing process and causing premature ageing or even neoplastic transformation. Here the capacity of Manuka honey (MH) to protect against oxidative damage and improve the process of skin wound healing was investigated. Up to 16 compounds were identified in MH, with leptosin derivatives and methyl syringate as the major ones. MH protected against apoptosis, intracellular ROS production, and lipid and protein oxidative damage. MH also protected mitochondrial functionality, promoted cell proliferation and activated the AMPK/Nrf2/ARE signalling pathway, as well as the expression of the antioxidant enzymes such as SOD and CAT. Here we describe for the first time that one of the possible mechanisms by which MH exhibits its ability to promote wound healing could be due to its capacity to improve the antioxidant response by activating AMPK phosphorylation and the ARE response. metadata Alvarez-Suarez, José Miguel; Giampieri, Francesca; Cordero, Mario; Gasparrini, Massimiliano; Forbes-Hernandez, Tamara Yuliet; Mazzoni, Luca; Afrin, Sadia; Beltrán-Ayala, Pablo; González-Paramás, Ana María; Santos-Buelga, Celestino; Varela-Lopez, Alfonso; Quiles, José Luis y Battino, Maurizio mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, tamara.forbes@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es (2016) Activation of AMPK/Nrf2 signalling by Manuka honey protects human dermal fibroblasts against oxidative damage by improving antioxidant response and mitochondrial function promoting wound healing. Journal of Functional Foods, 25. pp. 38-49. ISSN 1756-4646 ["page:item_not_available" not defined] |
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The main aim of this study was to analyse the influence of e-learning training on the acquisition of competences in basketball coaches in Cantabria. The current landscape of basketball coach training shows an increasing demand for innovative training models and emerging pedagogies, including e-learning-based methodologies. The study sample consisted of fifty students from these courses, all above 16 years of age (36 males, 14 females). Among them, 16% resided outside the autonomous community of Cantabria, 10% resided more than 50 km from the city of Santander, 36% between 10 and 50 km, 14% less than 10 km, and 24% resided within Santander city. Data were collected through a Google Forms survey distributed by the Cantabrian Basketball Federation to training course students. Participation was voluntary and anonymous. The survey, consisting of 56 questions, was validated by two sports and health doctors and two senior basketball coaches. The collected data were processed and analysed using Microsoft® Excel version 16.74, and the results were expressed in percentages. The analysis revealed that 24.60% of the students trained through the e-learning methodology considered themselves fully qualified as basketball coaches, contrasting with 10.98% of those trained via traditional face-to-face methodology. The results of the study provide insights into important characteristics that can be adjusted and improved within the investigated educational process. Moreover, the study concludes that e-learning training effectively qualifies basketball coaches in Cantabria.
Josep Alemany Iturriaga mail josep.alemany@uneatlantico.es, Álvaro Velarde-Sotres mail alvaro.velarde@uneatlantico.es, Javier Jorge mail , Kamil Giglio mail ,
Alemany Iturriaga
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Technological firms invest in R&D looking for innovative solutions but assuming high costs and great (technological) uncertainty regarding final results and returns. Additionally, they face other problems related to R&D management. This empirical study tries to determine which of the factors favour or constrain the decision of these firms to engage in R&D. The analysis uses financial data of 14,619 ICT listed companies of 22 countries from 2003 to 2018. Additionally, macroeconomic data specific for the countries and the sector were used. For the analysis of dynamic panel data, a System-GMM method is used. Among the findings, we highlight that cash flow, contrary to the known theoretical models and empirical evidences, negatively impacts on R&D investment. Debt is neither the right source for R&D funding, as the effect is also negative. This suggests that ICT companies are forced to manage their R&D activities differently, relying more on other funding sources, taking advantage of growth opportunities and benefiting from a favourable macroeconomic environment in terms of growth and increased business sector spending on R&D. These results are similar in both sub-sectors and in all countries, both bank- and market based. The exception is firms with few growth opportunities and little debt.
Inna Alexeeva-Alexeev mail inna.alexeeva@uneatlantico.es, Cristina Mazas Pérez-Oleag mail cristina.mazas@uneatlantico.es,
Alexeeva-Alexeev
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Introduction Aggressive behaviour on the road is still one of the most studied constructs within human factor due to its strong relationship with crash-related events. Objective The aim of the current research was to analyse the relationship among vital stress, emotion dysregulation, and aggressive behaviour in this specific context. Method A sample composed of 410 Spanish drivers (62.8% female, Mage = 36.12, SDage = 12.99) taken from the general population was tested. Results The results showed positive and significant bivariate correlations among almost all of the variables. The multiple mediation model showed a partial mediation effect of emotion dysregulation, with a significant effect on the whole model, and more specifically, on both the lack of control and life interference. Conclusion The relevance of developing clinical interventions to improve emotion regulation abilities in aggressive drivers is discussed.
David Herrero-Fernández mail david.herrero@uneatlantico.es, Pamela Parada-Fernández mail pamela.parada@uneatlantico.es, Irene Rodríguez-Arcos mail , Julién Brito Ballester mail julien.brito@uneatlantico.es, Carmen Lilí Rodríguez Velasco mail carmen.rodriguez@uneatlantico.es,
Herrero-Fernández
<a href="/12706/1/remotesensing-16-02099.pdf" class="ep_document_link"><img class="ep_doc_icon" alt="[img]" src="/12706/1.hassmallThumbnailVersion/remotesensing-16-02099.pdf" border="0"/></a>
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The conservation of Cultural Heritage in cave environments, especially those hosting cave art, requires comprehensive conservation strategies to mitigate degradation risks derived from climatic influences and human activities. This study, focused on the Polychrome Hall of the Cave of Altamira, highlights the importance of integrating remote sensing methodologies to carry out effective conservation actions. By coupling a georeferenced Ground Penetrating Radar (GPR) with a 1.6 GHz central-frequency antenna along with photogrammetry, we conducted non-invasive and high-resolution 3D studies to map preferential moisture pathways from the surface of the ceiling to the first 50 cm internally of the limestone structure. In parallel, we monitored the dynamics of surface water on the Ceiling and its correlation with pigment and other substance migrations. By standardizing our methodology, we aim to increase knowledge about the dynamics of infiltration water, which will enhance our understanding of the deterioration processes affecting cave paintings related to infiltration water. This will enable us to improve conservation strategies, suggesting possible indirect measures to reverse active deterioration processes. Integrating remote sensing techniques with geospatial analysis will aid in the validation and calibration of collected data, allowing for stronger interpretations of subsurface structures and conditions. All of this puts us in a position to contribute to the development of effective conservation methodologies, reduce alteration risks, and promote sustainable development practices, thus emphasizing the importance of remote sensing in safeguarding Cultural Heritage.
Vicente Bayarri Cayón mail vicente.bayarri@uneatlantico.es, Alfredo Prada mail , Francisco García mail , Carmen De Las Heras mail , Pilar Fatás mail ,
Bayarri Cayón
<a href="/12747/1/sensors-24-03754%20%281%29.pdf" class="ep_document_link"><img class="ep_doc_icon" alt="[img]" src="/12747/1.hassmallThumbnailVersion/sensors-24-03754%20%281%29.pdf" border="0"/></a>
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Driving while drowsy poses significant risks, including reduced cognitive function and the potential for accidents, which can lead to severe consequences such as trauma, economic losses, injuries, or death. The use of artificial intelligence can enable effective detection of driver drowsiness, helping to prevent accidents and enhance driver performance. This research aims to address the crucial need for real-time and accurate drowsiness detection to mitigate the impact of fatigue-related accidents. Leveraging ultra-wideband radar data collected over five minutes, the dataset was segmented into one-minute chunks and transformed into grayscale images. Spatial features are retrieved from the images using a two-dimensional Convolutional Neural Network. Following that, these features were used to train and test multiple machine learning classifiers. The ensemble classifier RF-XGB-SVM, which combines Random Forest, XGBoost, and Support Vector Machine using a hard voting criterion, performed admirably with an accuracy of 96.6%. Additionally, the proposed approach was validated with a robust k-fold score of 97% and a standard deviation of 0.018, demonstrating significant results. The dataset is augmented using Generative Adversarial Networks, resulting in improved accuracies for all models. Among them, the RF-XGB-SVM model outperformed the rest with an accuracy score of 99.58%.
Hafeez Ur Rehman Siddiqui mail , Ambreen Akmal mail , Muhammad Iqbal mail , Adil Ali Saleem mail , Muhammad Amjad Raza mail , Kainat Zafar mail , Aqsa Zaib mail , Sandra Dudley mail , Jon Arambarri mail jon.arambarri@uneatlantico.es, Ángel Gabriel Kuc Castilla mail , Furqan Rustam mail ,
Siddiqui