Autophagy in Human Health and Disease: Novel Therapeutic Opportunities

Article Subjects > Nutrition Europe University of Atlantic > Research > Articles and books
Ibero-american International University > Research > Scientific Production
UNSPECIFIED UNSPECIFIED Significance: In eukaryotes, autophagy represents a highly evolutionary conserved process, through which macromolecules and cytoplasmic material are degraded into lysosomes and recycled for biosynthetic or energetic purposes. Dysfunction of the autophagic process has been associated with the onset and development of many human chronic pathologies, such as cardiovascular, metabolic, and neurodegenerative diseases as well as cancer. Recent Advances: Currently, comprehensive research is being carried out to discover new therapeutic agents that are able to modulate the autophagic process in vivo. Recent evidence has shown that a large number of natural bioactive compounds are involved in the regulation of autophagy by modulating several transcriptional factors and signaling pathways. Critical Issues: Critical issues that deserve particular attention are the inadequate understanding of the complex role of autophagy in disease pathogenesis, the limited availability of therapeutic drugs, and the lack of clinical trials. In this context, the effects that natural bioactive compounds exert on autophagic modulation should be clearly highlighted, since they depend on the type and stage of the pathological conditions of diseases. Future Directions: Research efforts should now focus on understanding the survival-supporting and death-promoting roles of autophagy, how natural compounds interact exactly with the autophagic targets so as to induce or inhibit autophagy and on the evaluation of their pharmacological effects in a more in-depth and mechanistic way. In addition, clinical studies on autophagy-inducing natural products are strongly encouraged, also to highlight some fundamental aspects, such as the dose, the duration, and the possible synergistic action of these compounds with conventional therapy. metadata Giampieri, Francesca and Afrin, Sadia and Forbes-Hernandez, Tamara Y. and Gasparrini, Massimiliano and Cianciosi, Danila and Reboredo-Rodriguez, Patricia and Varela-Lopez, Alfonso and Quiles, Jose L. and Battino, Maurizio mail UNSPECIFIED, UNSPECIFIED, tamara.forbes@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2019) Autophagy in Human Health and Disease: Novel Therapeutic Opportunities. Antioxidants & Redox Signaling, 30 (4). pp. 577-634. ISSN 1523-0864

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Abstract

Significance: In eukaryotes, autophagy represents a highly evolutionary conserved process, through which macromolecules and cytoplasmic material are degraded into lysosomes and recycled for biosynthetic or energetic purposes. Dysfunction of the autophagic process has been associated with the onset and development of many human chronic pathologies, such as cardiovascular, metabolic, and neurodegenerative diseases as well as cancer. Recent Advances: Currently, comprehensive research is being carried out to discover new therapeutic agents that are able to modulate the autophagic process in vivo. Recent evidence has shown that a large number of natural bioactive compounds are involved in the regulation of autophagy by modulating several transcriptional factors and signaling pathways. Critical Issues: Critical issues that deserve particular attention are the inadequate understanding of the complex role of autophagy in disease pathogenesis, the limited availability of therapeutic drugs, and the lack of clinical trials. In this context, the effects that natural bioactive compounds exert on autophagic modulation should be clearly highlighted, since they depend on the type and stage of the pathological conditions of diseases. Future Directions: Research efforts should now focus on understanding the survival-supporting and death-promoting roles of autophagy, how natural compounds interact exactly with the autophagic targets so as to induce or inhibit autophagy and on the evaluation of their pharmacological effects in a more in-depth and mechanistic way. In addition, clinical studies on autophagy-inducing natural products are strongly encouraged, also to highlight some fundamental aspects, such as the dose, the duration, and the possible synergistic action of these compounds with conventional therapy.

Item Type: Article
Uncontrolled Keywords: Autophagy; Natural bioactive compounds; Disease prevention; Molecular target; Epignetic modifcation.
Subjects: Subjects > Nutrition
Divisions: Europe University of Atlantic > Research > Articles and books
Ibero-american International University > Research > Scientific Production
SWORD Depositor: Users 0 not found.
Date Deposited: 31 May 2021 14:00
Last Modified: 30 Jun 2021 15:38
URI: https://repositorio.uneatlantico.es/id/eprint/81

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  • Autophagy in Human Health and Disease: Novel Therapeutic Opportunities. (deposited 31 May 2021 14:00) [Currently Displayed]

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  • Giampieri, Francesca and Afrin, Sadia and Forbes-Hernandez, Tamara Y. and Gasparrini, Massimiliano and Cianciosi, Danila and Reboredo-Rodriguez, Patricia and Varela-Lopez, Alfonso and Quiles, Jose L. and Battino, Maurizio Autophagy in Human Health and Disease: Novel Therapeutic Opportunities. (deposited 31 May 2021 14:00) [Currently Displayed]

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Influence of E-learning training on the acquisition of competences in basketball coaches in Cantabria

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Josep Alemany Iturriaga mail josep.alemany@uneatlantico.es, Álvaro Velarde-Sotres mail alvaro.velarde@uneatlantico.es, Javier Jorge mail , Kamil Giglio mail ,

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