Autophagy in Human Health and Disease: Novel Therapeutic Opportunities
Article
Subjects > Nutrition
Europe University of Atlantic > Research > Scientific Production
Ibero-american International University > Research > Scientific Production
UNSPECIFIED
UNSPECIFIED
Significance: In eukaryotes, autophagy represents a highly evolutionary conserved process, through which macromolecules and cytoplasmic material are degraded into lysosomes and recycled for biosynthetic or energetic purposes. Dysfunction of the autophagic process has been associated with the onset and development of many human chronic pathologies, such as cardiovascular, metabolic, and neurodegenerative diseases as well as cancer.
Recent Advances: Currently, comprehensive research is being carried out to discover new therapeutic agents that are able to modulate the autophagic process in vivo. Recent evidence has shown that a large number of natural bioactive compounds are involved in the regulation of autophagy by modulating several transcriptional factors and signaling pathways.
Critical Issues: Critical issues that deserve particular attention are the inadequate understanding of the complex role of autophagy in disease pathogenesis, the limited availability of therapeutic drugs, and the lack of clinical trials. In this context, the effects that natural bioactive compounds exert on autophagic modulation should be clearly highlighted, since they depend on the type and stage of the pathological conditions of diseases.
Future Directions: Research efforts should now focus on understanding the survival-supporting and death-promoting roles of autophagy, how natural compounds interact exactly with the autophagic targets so as to induce or inhibit autophagy and on the evaluation of their pharmacological effects in a more in-depth and mechanistic way. In addition, clinical studies on autophagy-inducing natural products are strongly encouraged, also to highlight some fundamental aspects, such as the dose, the duration, and the possible synergistic action of these compounds with conventional therapy.
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Giampieri, Francesca and Afrin, Sadia and Forbes-Hernandez, Tamara Y. and Gasparrini, Massimiliano and Cianciosi, Danila and Reboredo-Rodriguez, Patricia and Varela-Lopez, Alfonso and Quiles, Jose L. and Battino, Maurizio
mail
UNSPECIFIED, UNSPECIFIED, tamara.forbes@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es
(2019)
Autophagy in Human Health and Disease: Novel Therapeutic Opportunities.
Antioxidants & Redox Signaling, 30 (4).
pp. 577-634.
ISSN 1523-0864
This is the latest version of this item.
Abstract
Significance: In eukaryotes, autophagy represents a highly evolutionary conserved process, through which macromolecules and cytoplasmic material are degraded into lysosomes and recycled for biosynthetic or energetic purposes. Dysfunction of the autophagic process has been associated with the onset and development of many human chronic pathologies, such as cardiovascular, metabolic, and neurodegenerative diseases as well as cancer. Recent Advances: Currently, comprehensive research is being carried out to discover new therapeutic agents that are able to modulate the autophagic process in vivo. Recent evidence has shown that a large number of natural bioactive compounds are involved in the regulation of autophagy by modulating several transcriptional factors and signaling pathways. Critical Issues: Critical issues that deserve particular attention are the inadequate understanding of the complex role of autophagy in disease pathogenesis, the limited availability of therapeutic drugs, and the lack of clinical trials. In this context, the effects that natural bioactive compounds exert on autophagic modulation should be clearly highlighted, since they depend on the type and stage of the pathological conditions of diseases. Future Directions: Research efforts should now focus on understanding the survival-supporting and death-promoting roles of autophagy, how natural compounds interact exactly with the autophagic targets so as to induce or inhibit autophagy and on the evaluation of their pharmacological effects in a more in-depth and mechanistic way. In addition, clinical studies on autophagy-inducing natural products are strongly encouraged, also to highlight some fundamental aspects, such as the dose, the duration, and the possible synergistic action of these compounds with conventional therapy.
Item Type: | Article |
---|---|
Uncontrolled Keywords: | Autophagy; Natural bioactive compounds; Disease prevention; Molecular target; Epignetic modifcation. |
Subjects: | Subjects > Nutrition |
Divisions: | Europe University of Atlantic > Research > Scientific Production Ibero-american International University > Research > Scientific Production |
SWORD Depositor: | Users 0 not found. |
Date Deposited: | 31 May 2021 14:00 |
Last Modified: | 30 Jun 2021 15:38 |
URI: | https://repositorio.uneatlantico.es/id/eprint/81 |
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- Autophagy in Human Health and Disease: Novel Therapeutic Opportunities. (deposited 31 May 2021 14:00) [Currently Displayed]
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- Giampieri, Francesca and Afrin, Sadia and Forbes-Hernandez, Tamara Y. and Gasparrini, Massimiliano and Cianciosi, Danila and Reboredo-Rodriguez, Patricia and Varela-Lopez, Alfonso and Quiles, Jose L. and Battino, Maurizio Autophagy in Human Health and Disease: Novel Therapeutic Opportunities. (deposited 31 May 2021 14:00) [Currently Displayed]
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The aim of this study was to investigate the effects of enzymatic treatments (pectinase, pectin lyase, and cellulase) on the in vitro digestion and fermentation characteristics of whole mulberry fruit juice. The analysis focused on changes in carbohydrate properties within the black mulberry fruit matrix during simulated digestion and fermentation. Human fecal microbiota were collected and introduced to the fruit matrix to monitor the fate of both soluble and insoluble polysaccharides during fermentation. The results revealed that enzymatic treatments enhanced the solubilization of carbohydrates from mulberry fruits, with pectinase showing the most significant effect. Throughout the process of in vitro digestion, there was a gradual increase in the percentage of solubilized carbohydrates from the mulberry juice substrate. The digested suspensions underwent dialysis to remove degradation fragments, and a lower quantity of carbohydrate in the enzyme-treated groups compared to the control. Polysaccharide populations with varying molecular weights (Mw) were obtained from the soluble fractions of mulberry residues for subsequent fermentation. An increase in Mw of soluble polysaccharides was detected by HPSEC during fermentation in certain cases. The gut microbiota demonstrated the ability to convert specific insoluble fractions into soluble components, which were subsequently subjected to microbial utilization. Enzymatic treatments during mulberry juice preparation can potentially positively impact health by influencing gut microbiota and short-chain fatty acid (SCFA) modulations. Enzymes could serve as valuable tools for producing functional fruit and vegetable juices, with the need to specify processing conditions for specific raw materials remaining a subject of further investigation.
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