Strawberry-Based Cosmetic Formulations Protect Human Dermal Fibroblasts against UVA-Induced Damage
Article
Subjects > Biomedicine
Europe University of Atlantic > Research > Articles and books
Ibero-american International University > Research > Scientific Production
UNSPECIFIED
UNSPECIFIED
Extreme exposure of skin to Ultraviolet A (UVA)-radiation may induce a dysregulated production of reactive oxygen species (ROS) which can interact with cellular biomolecules leading to oxidative stress, inflammation, DNA damage, and alteration of cellular molecular pathways, responsible for skin photoaging, hyperplasia, erythema, and cancer. For these reasons, the use of dietary natural bioactive compounds with remarkable antioxidant activity could be a strategic tool to counteract these UVA-radiation-caused deleterious effects. Thus, the purpose of the present work was to test the efficacy of strawberry (50 μg/mL)-based formulations supplemented with Coenzyme Q10 (100 μg/mL) and sun protection factor 10 in human dermal fibroblasts irradiated with UVA-radiation. The apoptosis rate, the amount of intracellular reactive oxygen species (ROS) production, the expression of proteins involved in antioxidant and inflammatory response, and mitochondrial functionality were evaluated. The results showed that the synergic topical use of strawberry and Coenzyme Q10 provided a significant (p < 0.05) photoprotective effect, reducing cell death and ROS, increasing antioxidant defense, lowering inflammatory markers, and improving mitochondrial functionality. The obtained results suggest the use of strawberry-based formulations as an innovative, natural, and useful tool for the prevention of UVA exposure-induced skin diseases in order to decrease or substitute the amount of synthetic sunscreen agents.
metadata
Gasparrini, Massimiliano and Forbes-Hernandez, Tamara Y. and Afrin, Sadia and Reboredo-Rodriguez, Patricia and Cianciosi, Danila and Mezzetti, Bruno and Quiles, José L. and Bompadre, Stefano and Battino, Maurizio and Giampieri, Francesca
mail
UNSPECIFIED, tamara.forbes@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es, UNSPECIFIED
(2017)
Strawberry-Based Cosmetic Formulations Protect Human Dermal Fibroblasts against UVA-Induced Damage.
Nutrients, 9 (6).
p. 605.
ISSN 2072-6643
This is the latest version of this item.
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Abstract
Extreme exposure of skin to Ultraviolet A (UVA)-radiation may induce a dysregulated production of reactive oxygen species (ROS) which can interact with cellular biomolecules leading to oxidative stress, inflammation, DNA damage, and alteration of cellular molecular pathways, responsible for skin photoaging, hyperplasia, erythema, and cancer. For these reasons, the use of dietary natural bioactive compounds with remarkable antioxidant activity could be a strategic tool to counteract these UVA-radiation-caused deleterious effects. Thus, the purpose of the present work was to test the efficacy of strawberry (50 μg/mL)-based formulations supplemented with Coenzyme Q10 (100 μg/mL) and sun protection factor 10 in human dermal fibroblasts irradiated with UVA-radiation. The apoptosis rate, the amount of intracellular reactive oxygen species (ROS) production, the expression of proteins involved in antioxidant and inflammatory response, and mitochondrial functionality were evaluated. The results showed that the synergic topical use of strawberry and Coenzyme Q10 provided a significant (p < 0.05) photoprotective effect, reducing cell death and ROS, increasing antioxidant defense, lowering inflammatory markers, and improving mitochondrial functionality. The obtained results suggest the use of strawberry-based formulations as an innovative, natural, and useful tool for the prevention of UVA exposure-induced skin diseases in order to decrease or substitute the amount of synthetic sunscreen agents.
Item Type: | Article |
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Uncontrolled Keywords: | Skin damage; UVA-radiation; ROS; Apoptosis; Mitochondria functionality; Antioxidant defense; Inflammatory status; Strawberry polyphenols; Cosmetic formulation. |
Subjects: | Subjects > Biomedicine |
Divisions: | Europe University of Atlantic > Research > Articles and books Ibero-american International University > Research > Scientific Production |
SWORD Depositor: | Users 0 not found. |
Date Deposited: | 02 Jun 2021 23:55 |
Last Modified: | 03 May 2022 19:03 |
URI: | https://repositorio.uneatlantico.es/id/eprint/141 |
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- Gasparrini, Massimiliano and Forbes-Hernandez, Tamara Y. and Afrin, Sadia and Reboredo-Rodriguez, Patricia and Cianciosi, Danila and Mezzetti, Bruno and Quiles, José L. and Bompadre, Stefano and Battino, Maurizio and Giampieri, Francesca Strawberry-Based Cosmetic Formulations Protect Human Dermal Fibroblasts against UVA-Induced Damage. (deposited 02 Jun 2021 23:55) [Currently Displayed]
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