Mitochondrial Adaptations in the Growing Heart

Article Subjects > Biomedicine Europe University of Atlantic > Research > Scientific Production Cerrado Inglés The heart pumps blood throughout the whole life of an organism, without rest periods during which to replenish energy or detoxify. Hence, cardiomyocytes, the working units of the heart, have mechanisms to ensure constitutive production of energy and detoxification to preserve fitness and function for decades. Even more challenging, the heart must adapt to the varying conditions of the organism from fetal life to adulthood, old age, and pathological stress. Mitochondria are at the nexus of these processes by producing not only energy but also metabolites and oxidative byproducts that can activate alarm signals and be toxic to the cell. We review basic concepts about cardiac mitochondria with a focus on their remarkable adaptations, including elimination, throughout the mammalian lifetime. metadata Sánchez-Díaz, María and Nicolás-Ávila, José Ángel and Cordero, Mario D. and Hidalgo, Andrés mail UNSPECIFIED, UNSPECIFIED, mario.cordero@uneatlantico.es, UNSPECIFIED (2020) Mitochondrial Adaptations in the Growing Heart. Trends in Endocrinology & Metabolism, 31 (4). pp. 308-319. ISSN 1043-2760

This is the latest version of this item.

Full text not available from this repository.

Abstract

The heart pumps blood throughout the whole life of an organism, without rest periods during which to replenish energy or detoxify. Hence, cardiomyocytes, the working units of the heart, have mechanisms to ensure constitutive production of energy and detoxification to preserve fitness and function for decades. Even more challenging, the heart must adapt to the varying conditions of the organism from fetal life to adulthood, old age, and pathological stress. Mitochondria are at the nexus of these processes by producing not only energy but also metabolites and oxidative byproducts that can activate alarm signals and be toxic to the cell. We review basic concepts about cardiac mitochondria with a focus on their remarkable adaptations, including elimination, throughout the mammalian lifetime.

Item Type: Article
Subjects: Subjects > Biomedicine
Divisions: Europe University of Atlantic > Research > Scientific Production
SWORD Depositor: Users 0 not found.
Date Deposited: 01 Jun 2021 23:55
Last Modified: 30 Jun 2023 23:30
URI: https://repositorio.uneatlantico.es/id/eprint/128

Available Versions of this Item

  • Mitochondrial Adaptations in the Growing Heart. (deposited 01 Jun 2021 23:55) [Currently Displayed]

Commentary/Response Threads

  • Sánchez-Díaz, María and Nicolás-Ávila, José Ángel and Cordero, Mario D. and Hidalgo, Andrés Mitochondrial Adaptations in the Growing Heart. (deposited 01 Jun 2021 23:55) [Currently Displayed]

Actions (login required)

View Item View Item

<a class="ep_document_link" href="/10290/1/Influence%20of%20E-learning%20training%20on%20the%20acquisition%20of%20competences%20in%20basketball%20coaches%20in%20Cantabria.pdf"><img class="ep_doc_icon" alt="[img]" src="/10290/1.hassmallThumbnailVersion/Influence%20of%20E-learning%20training%20on%20the%20acquisition%20of%20competences%20in%20basketball%20coaches%20in%20Cantabria.pdf" border="0"/></a>

en

open

Influence of E-learning training on the acquisition of competences in basketball coaches in Cantabria

The main aim of this study was to analyse the influence of e-learning training on the acquisition of competences in basketball coaches in Cantabria. The current landscape of basketball coach training shows an increasing demand for innovative training models and emerging pedagogies, including e-learning-based methodologies. The study sample consisted of fifty students from these courses, all above 16 years of age (36 males, 14 females). Among them, 16% resided outside the autonomous community of Cantabria, 10% resided more than 50 km from the city of Santander, 36% between 10 and 50 km, 14% less than 10 km, and 24% resided within Santander city. Data were collected through a Google Forms survey distributed by the Cantabrian Basketball Federation to training course students. Participation was voluntary and anonymous. The survey, consisting of 56 questions, was validated by two sports and health doctors and two senior basketball coaches. The collected data were processed and analysed using Microsoft® Excel version 16.74, and the results were expressed in percentages. The analysis revealed that 24.60% of the students trained through the e-learning methodology considered themselves fully qualified as basketball coaches, contrasting with 10.98% of those trained via traditional face-to-face methodology. The results of the study provide insights into important characteristics that can be adjusted and improved within the investigated educational process. Moreover, the study concludes that e-learning training effectively qualifies basketball coaches in Cantabria.

Producción Científica

Josep Alemany Iturriaga mail josep.alemany@uneatlantico.es, Álvaro Velarde-Sotres mail alvaro.velarde@uneatlantico.es, Javier Jorge mail , Kamil Giglio mail ,

Alemany Iturriaga

en

close

Do ICT firms manage R&D differently? Firm-level and macroeconomic effects on corporate R&D investment: Empirical evidence from a multi-countries context

Technological firms invest in R&D looking for innovative solutions but assuming high costs and great (technological) uncertainty regarding final results and returns. Additionally, they face other problems related to R&D management. This empirical study tries to determine which of the factors favour or constrain the decision of these firms to engage in R&D. The analysis uses financial data of 14,619 ICT listed companies of 22 countries from 2003 to 2018. Additionally, macroeconomic data specific for the countries and the sector were used. For the analysis of dynamic panel data, a System-GMM method is used. Among the findings, we highlight that cash flow, contrary to the known theoretical models and empirical evidences, negatively impacts on R&D investment. Debt is neither the right source for R&D funding, as the effect is also negative. This suggests that ICT companies are forced to manage their R&D activities differently, relying more on other funding sources, taking advantage of growth opportunities and benefiting from a favourable macroeconomic environment in terms of growth and increased business sector spending on R&D. These results are similar in both sub-sectors and in all countries, both bank- and market based. The exception is firms with few growth opportunities and little debt.

Producción Científica

Inna Alexeeva-Alexeev mail inna.alexeeva@uneatlantico.es, Cristina Mazas Pérez-Oleag mail cristina.mazas@uneatlantico.es,

Alexeeva-Alexeev

<a class="ep_document_link" href="/10845/1/pharmaceuticals-17-00236.pdf"><img class="ep_doc_icon" alt="[img]" src="/10845/1.hassmallThumbnailVersion/pharmaceuticals-17-00236.pdf" border="0"/></a>

en

open

Isoflavones Effects on Vascular and Endothelial Outcomes: How Is the Gut Microbiota Involved?

Isoflavones are a group of (poly)phenols, also defined as phytoestrogens, with chemical structures comparable with estrogen, that exert weak estrogenic effects. These phytochemical compounds have been targeted for their proven antioxidant and protective effects. Recognizing the increasing prevalence of cardiovascular diseases (CVD), there is a growing interest in understanding the potential cardiovascular benefits associated with these phytochemical compounds. Gut microbiota may play a key role in mediating the effects of isoflavones on vascular and endothelial functions, as it is directly implicated in isoflavones metabolism. The findings from randomized clinical trials indicate that isoflavone supplementation may exert putative effects on vascular biomarkers among healthy individuals, but not among patients affected by cardiometabolic disorders. These results might be explained by the enzymatic transformation to which isoflavones are subjected by the gut microbiota, suggesting that a diverse composition of the microbiota may determine the diverse bioavailability of these compounds. Specifically, the conversion of isoflavones in equol—a microbiota-derived metabolite—seems to differ between individuals. Further studies are needed to clarify the intricate molecular mechanisms behind these contrasting results.

Producción Científica

Samuele Laudani mail , Justyna Godos mail , Giovanni Luca Romano mail , Lucia Gozzo mail , Federica Martina Di Domenico mail , Irma Dominguez Azpíroz mail irma.dominguez@unini.edu.mx, Raquel Martínez Díaz mail raquel.martinez@uneatlantico.es, Francesca Giampieri mail francesca.giampieri@uneatlantico.es, José L. Quiles mail jose.quiles@uneatlantico.es, Maurizio Battino mail maurizio.battino@uneatlantico.es, Filippo Drago mail , Fabio Galvano mail , Giuseppe Grosso mail ,

Laudani

<a class="ep_document_link" href="/11044/1/A_Detectability_Analysis_of_Retinitis_Pigmetosa_Using_Novel_SE-ResNet_Based_Deep_Learning_Model_and_Color_Fundus_Images.pdf"><img class="ep_doc_icon" alt="[img]" src="/style/images/fileicons/text.png" border="0"/></a>

en

open

A Detectability Analysis of Retinitis Pigmetosa Using Novel SE-ResNet Based Deep Learning Model and Color Fundus Images

Retinitis pigmentosa (RP) is a group of genetic retinal disorders characterized by progressive vision loss, culminating in blindness. Identifying pigment signs (PS) linked with RP is crucial for monitoring and possibly slowing the disease’s degenerative course. However, the segmentation and detection of PS are challenging due to the difficulty of distinguishing between PS and blood vessels and the variability in size, shape, and color of PS. Recently, advances in deep learning techniques have shown impressive results in medical image analysis, especially in ophthalmology. This study presents an approach for classifying pigment marks in color fundus images of RP using a modified squeeze-and-excitation ResNet (SE-ResNet) architecture. This variant synergizes the efficiency of residual skip connections with the robust attention mechanism of the SE block to amplify feature representation. The SE-ResNet model was fine-tuned to determine the optimal layer configuration that balances performance metrics and computational costs. We trained the proposed model on the RIPS dataset, which comprises images from patients diagnosed at various RP stages. Experimental results confirm the efficacy of the proposed model in classifying different types of pigment signs associated with RP. The model yielded performance metrics, such as accuracy, sensitivity, specificity, and f-measure of 99.16%, 97.70%, 96.93%, 90.47%, 99.37%, 97.80%, 97.44%, and 90.60% on the testing set, based on GT1 & GT2 respectively. Given its performance, this model is an excellent candidate for integration into computer-aided diagnostic systems for RP, aiming to enhance patient care and vision-related healthcare services.

Producción Científica

Rubina Rashid mail , Waqar Aslam mail , Arif Mehmood mail , Debora L. Ramírez-Vargas mail debora.ramirez@unini.edu.mx, Isabel De La Torre Diez mail , Imran Ashraf mail ,

Rashid

en

close

Could Celiac Disease and Overweight/Obesity Coexist in School-Aged Children and Adolescents? A Systematic Review

Background: Celiac disease (CD) is a multifactorial, immune-mediated enteropathic disorder that may occur at any age with heterogeneous clinical presentation. In the last years, unusual manifestations have become very frequent, and currently, it is not so uncommon to diagnose CD in subjects with overweight or obesity, especially in adults; however, little is known in the pediatric population. This systematic review aims to evaluate the literature regarding the association between CD and overweight/obesity in school-age children. Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. An electronic database search of articles published in the last 20 years in English was carried out in Web of Sciences, PubMed, and Medline. The quality of the included studies was assessed by using the STrengthening the Reporting of OBservational studies in Epidemiology statement. Results: Of the 1396 articles identified, 9 articles, investigating overweight/obesity in children/adolescents affected by CD or screening CD in children/adolescents with overweight/obesity, met the inclusion criteria. Overall, the results showed that the prevalence of overweight or obesity in school-age children (6–17 years) affected by CD ranged between 3.5% and 20%, highlighting that the coexistence of CD with overweight/obesity in children is not uncommon as previously thought. Conclusion: Although CD has been historically correlated with being underweight due to malabsorption, it should be evaluated also in children with overweight and obesity, especially those who have a familiar predisposition to other autoimmune diseases and/or manifest unusual symptoms of CD.

Producción Científica

Rachele De Giuseppe mail , Francesca Bergomas mail , Federica Loperfido mail , Francesca Giampieri mail francesca.giampieri@uneatlantico.es, Giorgia Preatoni mail , Valeria Calcaterra mail , Hellas Cena mail ,

De Giuseppe