The anti-metastatic effect of Manuka honey on colonspheres enriched with cancer stem cells: how does it influence the epithelial-mesenchymal transition process, angiogenesis, and telomere length?
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Subjects > Biomedicine
Subjects > Nutrition
Europe University of Atlantic > Research > Articles and books
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Colorectal cancer often leads to metastasis, with cancer stem cells (CSCs) playing a pivotal role in this process. Two closely linked mechanisms, epithelial-mesenchymal transition and angiogenesis, contribute to metastasis and recent research has also highlighted the impact of telomere replication on this harmful tumor progression. Standard chemotherapy alone can inadvertently promote drug-resistant CSCs, posing a challenge. Combining chemotherapy with other compounds, including natural ones, shows promise in enhancing effectiveness while minimizing side effects. This study investigated the anti-metastatic potential of Manuka honey, both alone and in combination with 5-Fluorouracil, using a 3D model of colon spheres enriched with CSCs-like cells. In summary, it was observed that the treatment reduced migration ability by increasing the expression of E-cadherin through the downregulation of transcription factors Slug, Snail, and Twist. Additionally, it downregulated pro-angiogenic factors and shortened CSC telomeres by downregulating c-Myc, demonstrating an effective anti-metastatic potential. This study suggests new research opportunities for studying the impact of natural compounds when combined with pharmaceuticals, with the potential to enhance effectiveness and reduce side effects.
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Cianciosi, Danila and Forbes-Hernández, Tamara Yuliett and Armas Diaz, Yasmany and Elexpuru Zabaleta, Maria and Quiles, José L. and Battino, Maurizio and Giampieri, Francesca
mail
UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maria.elexpuru@uneatlantico.es, jose.quiles@uneatlantico.es, maurizio.battino@uneatlantico.es, francesca.giampieri@uneatlantico.es
(2024)
The anti-metastatic effect of Manuka honey on colonspheres enriched with cancer stem cells: how does it influence the epithelial-mesenchymal transition process, angiogenesis, and telomere length?
Food & Function.
ISSN 2042-6496
Abstract
Colorectal cancer often leads to metastasis, with cancer stem cells (CSCs) playing a pivotal role in this process. Two closely linked mechanisms, epithelial-mesenchymal transition and angiogenesis, contribute to metastasis and recent research has also highlighted the impact of telomere replication on this harmful tumor progression. Standard chemotherapy alone can inadvertently promote drug-resistant CSCs, posing a challenge. Combining chemotherapy with other compounds, including natural ones, shows promise in enhancing effectiveness while minimizing side effects. This study investigated the anti-metastatic potential of Manuka honey, both alone and in combination with 5-Fluorouracil, using a 3D model of colon spheres enriched with CSCs-like cells. In summary, it was observed that the treatment reduced migration ability by increasing the expression of E-cadherin through the downregulation of transcription factors Slug, Snail, and Twist. Additionally, it downregulated pro-angiogenic factors and shortened CSC telomeres by downregulating c-Myc, demonstrating an effective anti-metastatic potential. This study suggests new research opportunities for studying the impact of natural compounds when combined with pharmaceuticals, with the potential to enhance effectiveness and reduce side effects.
Item Type: | Article |
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Subjects: | Subjects > Biomedicine Subjects > Nutrition |
Divisions: | Europe University of Atlantic > Research > Articles and books |
Date Deposited: | 17 Jun 2024 23:30 |
Last Modified: | 17 Jun 2024 23:30 |
URI: | https://repositorio.uneatlantico.es/id/eprint/12748 |
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