Blockade of the NLRP3 inflammasome improves metabolic health and lifespan in obese mice

Article Subjects > Biomedicine Europe University of Atlantic > Research > Articles and books Cerrado Inglés Aging is the major risk factor for many metabolic chronic diseases. Several metabolic pathways suffer a progressive impairment during aging including body composition and insulin resistance which are associated to autophagy dysfunction and increased inflammation. Many of these alterations are aggravated by non-healthy lifestyle such as obesity and hypercaloric diet which have been shown to accelerate aging. Here, we show that the deleterious effect of hypercaloric diets is reverted by the NLRP3 inflammasome inhibition. NLRP3 deficiency extends mean lifespan of adult mice fed a high-fat diet. This lifespan extension is accompanied by metabolic health benefits including reduced liver steatosis and cardiac damage, improved glucose and lipid metabolism, and improved protein expression profiles of SIRT-1, mTOR, autophagic flux, and apoptosis. These findings suggest that the suppression of NLRP3 prevented many age-associated changes in metabolism impaired by the effect of hypercaloric diets. metadata Cañadas-Lozano, Diego and Marín-Aguilar, Fabiola and Castejón-Vega, Beatriz and Ryffel, Bernhard and Navarro-Pando, José M. and Ruiz-Cabello, Jesús and Alcocer-Gómez, Elísabet and Bullón, Pedro and Cordero, Mario D. mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, jose.navarro@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, mario.cordero@uneatlantico.es (2020) Blockade of the NLRP3 inflammasome improves metabolic health and lifespan in obese mice. GeroScience, 42 (2). pp. 715-725. ISSN 2509-2715

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Abstract

Aging is the major risk factor for many metabolic chronic diseases. Several metabolic pathways suffer a progressive impairment during aging including body composition and insulin resistance which are associated to autophagy dysfunction and increased inflammation. Many of these alterations are aggravated by non-healthy lifestyle such as obesity and hypercaloric diet which have been shown to accelerate aging. Here, we show that the deleterious effect of hypercaloric diets is reverted by the NLRP3 inflammasome inhibition. NLRP3 deficiency extends mean lifespan of adult mice fed a high-fat diet. This lifespan extension is accompanied by metabolic health benefits including reduced liver steatosis and cardiac damage, improved glucose and lipid metabolism, and improved protein expression profiles of SIRT-1, mTOR, autophagic flux, and apoptosis. These findings suggest that the suppression of NLRP3 prevented many age-associated changes in metabolism impaired by the effect of hypercaloric diets.

Item Type: Article
Uncontrolled Keywords: NLRP3 inflammasome; High-fat diet; Aging; Autophagy; Longevity; Obesity.
Subjects: Subjects > Biomedicine
Divisions: Europe University of Atlantic > Research > Articles and books
SWORD Depositor: Users 0 not found.
Date Deposited: 01 Jun 2021 23:55
Last Modified: 15 Jun 2023 23:30
URI: https://repositorio.uneatlantico.es/id/eprint/115

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  • Blockade of the NLRP3 inflammasome improves metabolic health and lifespan in obese mice. (deposited 01 Jun 2021 23:55) [Currently Displayed]

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  • Cañadas-Lozano, Diego and Marín-Aguilar, Fabiola and Castejón-Vega, Beatriz and Ryffel, Bernhard and Navarro-Pando, José M. and Ruiz-Cabello, Jesús and Alcocer-Gómez, Elísabet and Bullón, Pedro and Cordero, Mario D. Blockade of the NLRP3 inflammasome improves metabolic health and lifespan in obese mice. (deposited 01 Jun 2021 23:55) [Currently Displayed]

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