Search results for Maurizio Battino
41. |
Article
Subjects > Nutrition
Europe University of Atlantic > Research > Articles and books Ibero-american International University > Research > Scientific Production Cerrado Inglés Dietary polyphenols have been recently proposed as activators of the AMP-activated protein kinase (AMPK) signaling pathway and this fact might explain the relationship between the consumption of polyphenol-rich foods and the slowdown of the progression of aging. In the present work, the effects of strawberry consumption were evaluated on biomarkers of oxidative damage and on aging-associated reductions in mitochondrial function and biogenesis for 8weeks in old rats. Strawberry supplementation increased antioxidant enzyme activities, mitochondrial biomass and functionality, and decreased intracellular ROS levels and biomarkers of protein, lipid and DNA damage (P<0.05). Furthermore, a significant (P<0.05) increase in the expression of the AMPK cascade genes, involved in mitochondrial biogenesis and antioxidant defences, was also detected after strawberry intake. These in vivo results were then verified in vitro on HepG2 cells, confirming the involvement of AMPK in the beneficial effects exerted by strawberry against aging progression. metadata Giampieri, Francesca and Alvarez-Suarez, Josè M. and Cordero, Mario D. and Gasparrini, Massimiliano and Forbes-Hernandez, Tamara Y. and Afrin, Sadia and Santos-Buelga, Celestino and González-Paramás, Ana M. and Astolfi, Paola and Rubini, Corrado and Zizzi, Antonio and Tulipani, Sara and Quiles, Josè L. and Mezzetti, Bruno and Battino, Maurizio mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, tamara.forbes@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2017) Strawberry consumption improves aging-associated impairments, mitochondrial biogenesis and functionality through the AMP-activated protein kinase signaling cascade. Food Chemistry, 234. pp. 464-471. ISSN 03088146 Item not available from this repository. |
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42. | Article Subjects > Nutrition Europe University of Atlantic > Research > Articles and books Cerrado Inglés The aim of the present work was to evaluate the in vitro effect of Manuka honey and its combination with 5-Fu, the most common drug used in the treatment of colon cancer, on the morphological and physical parameters of colonspheres enriched with cancer stem-like cells deriving from HCT-116 colon adenocarcinoma cell line and on the apoptosis rate. Manuka honey, alone and more in combination with 5-Fu, reduced the weight, the diameter and mass density of the spheroids and induced apoptosis through the downregulation of many apoptosis inhibitors, including IAPs (Livin, Survivin, XIAP), IGFs (IGF-I, IGF-II and IGF-IR) and HSPs (HSP-27, HSP-60 and HSP-70). These results led to a reduction in the survival ability of cancer stem-like cells, as well as to a chemosensitizing effect of honey towards 5-Fu, considering that apoptosis resistance is one of the main causes of cancer stem-like cells chemoresistance. metadata Cianciosi, Danila and Forbes-Hernández, Tamara Y. and Regolo, Lucia and Alvarez-Suarez, José M. and Quinzi, Denise and Sargenti, Azzurra and Bai, Weibin and Tian, Lingmin and Giampieri, Francesca and Battino, Maurizio mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es (2022) Manuka honey in combination with 5-Fluorouracil decreases physical parameters of colonspheres enriched with cancer stem-like cells and reduces their resistance to apoptosis. Food Chemistry, 374. p. 131753. ISSN 03088146 Item not available from this repository. | |
43. | Article Subjects > Biomedicine Europe University of Atlantic > Research > Articles and books Cerrado Inglés Alzheimer’s disease (AD) is a progressive neurodegenerative pathology affecting milions of people worldwide associated with deposition of senile plaques. While the genetic and environmental risk factors associated with the onset and consolidation of late onset AD are heterogeneous and sporadic, growing evidence also suggests a potential link between some infectious diseases caused by oral microbiota and AD. Oral microbiota dysbiosis is purported to contribute either directly to amyloid protein production, or indirectly to neuroinflammation, occurring as a consequence of bacterial invasion. Over the last decade, the development of Human Oral Microbiome database (HOMD) has deepened our understanding of oral microbes and their different roles during the human lifetime. Oral pathogens mostly cause caries, periodontal disease, and edentulism in aged population, and, in particular, alterations of the oral microbiota causing chronic periodontal disease have been associated with the risk of AD. Here we describe how different alterations of the oral microbiota may be linked to AD, highlighting the importance of a good oral hygiene for the prevention of oral microbiota dysbiosis. metadata Sureda, Antoni and Daglia, Maria and Argüelles Castilla, Sandro and Sanadgol, Nima and Fazel Nabavi, Seyed and Khan, Haroon and Belwal, Tarun and Jeandet, Philippe and Marchese, Anna and Pistollato, Francesca and Forbes-Hernandez, Tamara and Battino, Maurizio and Berindan-Neagoe, Ioana and D’Onofrio, Grazia and Nabavi, Seyed Mohammad mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, francesca.pistollato@uneatlantico.es, UNSPECIFIED, maurizio.battino@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2020) Oral microbiota and Alzheimer’s disease: Do all roads lead to Rome? Pharmacological Research, 151. p. 104582. ISSN 10436618 Item not available from this repository. | |
44. | Article Subjects > Biomedicine Europe University of Atlantic > Research > Articles and books Cerrado Inglés Conventional cardiovascular risk factors (CVRFs) are accepted to identify asymptomatic individuals with high risk of acute myocardial infarction (AMI). However, AMI affects many patients previously classified at low risk. New biomarkers are needed to improve risk prediction. We propose to evaluate the NLRP3-inflammasome complex as a potential conventional cardiovascular risk (CVR) indicator in healthy males and post-AMI patients and compare both groups by known CVRFs. We included 109 men with no history of cardiovascular disease (controls) and 150 AMI patients attending a cardiac rehabilitation program. AMI patients had higher mean of body mass index (BMI) and waist circumference than the controls. However, high percentages of the controls had a high BMI and a waist circumference >95 cm. The controls also had higher systolic blood pressure (p > 0.001), total and low-density lipoprotein cholesterol, dietary nutrient, and calorific intake. Fuster BEWAT score (FBS) correlated more closely than Framingham risk score (FRS) with most CVRF, groups. However, only the FBS showed a correlation with inflammasome cytokine interleukin 1β (IL-1β). Several CVRFs were significantly better in AMI patients; however, this group also had higher mRNA expression of the inflammasome gene NLRP3 and lower expression of the autophagy gene MAP-LC3. The controls had high levels of CVRF, probably reflecting unhealthy lifestyle. FBS reflects the efficiency of strategies to induce lifestyle changes such as cardiac rehabilitation programs, and could provide a sensitive evaluation CVR. These results lead to the hypothesis that NLRP3-inflammasome and associated IL-1β release have potential as CVR biomarkers, particularly in post-AMI patients with otherwise low risk scores. Antioxid. Redox Signal. 27, 269-275. metadata Bullón, Pedro and Cano-García, Francisco J. and Alcocer-Gómez, Elísabet and Varela-López, Alfonso and Roman-Malo, Lourdes and Ruiz-Salmerón, Rafael J. and Quiles, José L. and Navarro-Pando, José M. and Battino, Maurizio and Ruiz-Cabello, Jesús and Jiménez-Borreguero, Luis J. and Cordero, Mario D. mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2017) Could NLRP3–Inflammasome Be a Cardiovascular Risk Biomarker in Acute Myocardial Infarction Patients? Antioxidants & Redox Signaling, 27 (5). pp. 269-275. ISSN 1523-0864 Item not available from this repository. | |
45. | Article Subjects > Nutrition Europe University of Atlantic > Research > Articles and books Cerrado Inglés Plant-based diets are known to preserve body tissues from oxidative stress and inflammation, both hallmarks of chronic-degenerative diseases. In particular, plant-derived foods, such as legumes, represent a natural source of bioactive nutrients known to contribute to the prevention and amelioration of insulin resistance, dyslipidemia, hypertension and impaired glucose metabolism, all factors implicated in metabolic syndrome (MetS), but also osteoporosis, neurodegeneration and some types of cancers. Here we revise recent literature on the role of plant-based diets, plant-foods and specific plant-nutrients in the prevention and regression of MetS and neurodegenerative diseases. We describe some of the molecular mechanisms underlying these protective effects, highlighting the role of diet in the control of hyper-homocysteinemia and insulin resistance, often implicated in the etiology of both metabolic and neurodegenerative syndromes. metadata Pistollato, Francesca and Battino, Maurizio mail UNSPECIFIED, maurizio.battino@uneatlantico.es (2014) Role of plant-based diets in the prevention and regression of metabolic syndrome and neurodegenerative diseases. Trends in Food Science & Technology, 40 (1). pp. 62-81. ISSN 09242244 Item not available from this repository. | |
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Article
Subjects > Biomedicine Subjects > Nutrition Europe University of Atlantic > Research > Articles and books Cerrado Inglés Ocimum basilicum and Ocimum tenuiflorum are two basil species widely used medicinally as an anti-inflammatory, antimicrobial and cardioprotective agent. This study focuses on the chemical characterization of the majoritarian compounds of both species and their anti-inflammatory potential. Up to 22 compounds such as various types of salvianolic acids, derivatives of rosmaniric acid and flavones were identified in both plants. The identified compounds were very similar between both plants and are consistent with previous finding in other studies in Portugal and Italy. Based on the identified molecules a consensus target prediction was carried out. Among the main predicted target proteins, we found a high representation of the carbonic anhydrase family (CA2, CA7 and CA12) and several key proteins from the arachidonic pathway (LOX5, PLA2, COX1 and COX2). Both pathways are well related to inflammation. The interaction between the compounds and these targets were explored through molecular docking and molecular dynamics simulation. Our results suggest that some molecules present in both plants can induce an anti-inflammatory response through a non-steroidal mechanism of action connected to the carbon dioxide metabolism. metadata Beltrán-Noboa, Andrea and Proaño-Ojeda, John and Guevara, Mabel and Gallo, Blanca and Berrueta, Luis A. and Giampieri, Francesca and Perez-Castillo, Yunierkis and Battino, Maurizio and Álvarez-Suarez, José M. and Tejera, Eduardo mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, francesca.giampieri@uneatlantico.es, UNSPECIFIED, maurizio.battino@uneatlantico.es, UNSPECIFIED, UNSPECIFIED (2022) Metabolomic profile and computational analysis for the identification of the potential anti-inflammatory mechanisms of action of the traditional medicinal plants Ocimum basilicum and Ocimum tenuiflorum. Food and Chemical Toxicology, 164. p. 113039. ISSN 02786915 Item not available from this repository. |
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47. | Article Subjects > Nutrition Europe University of Atlantic > Research > Articles and books Cerrado Inglés As the number of older people has grown in recent decades, the search for new approaches to manage or delay aging is also growing. Among the modifiable factors, diet plays a crucial role in healthy aging and in the prevention of age-related diseases. Thus, the interest in the use of foods, which are rich in bioactive compounds such as functional foods with anti-aging effects is a growing market. This review summarizes the current knowledge about the molecular mechanisms of action of foods considered as functional foods in aging, namely berries, curcumin, and virgin olive oil. Moreover, honey is also analyzed as a food with well-known healthy benefits, but which has not been deeply evaluated from the point of view of aging. The effects of these foods on aging are analyzed from the point of view of molecular mechanisms including oxidative stress, mitochondrial dysfunction, inflammation, genomic stability, telomere attrition, cellular senescence, and deregulated nutrient-sensing. A comprehensive study of the scientific literature shows that the aforementioned foods have demonstrated positive effects on certain aspects of aging, which might justify their use as functional foods in elderly. However, more research is needed, especially in humans, designed to understand in depth the mechanisms of action through which they act. metadata Navarro-Hortal, María D. and Romero-Márquez, Jose M. and Jiménez-Trigo, Victoria and Xiao, Jianbo and Giampieri, Francesca and Forbes-Hernández, Tamara Y. and Grosso, Giuseppe and Battino, Maurizio and Sánchez-González, Cristina and Quiles, José L. mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, francesca.giampieri@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es, UNSPECIFIED, jose.quiles@uneatlantico.es (2022) Molecular bases for the use of functional foods in the management of healthy aging: Berries, curcumin, virgin olive oil and honey; three realities and a promise. Critical Reviews in Food Science and Nutrition. pp. 1-20. ISSN 1040-8398 Item not available from this repository. | |
48. | Article Subjects > Nutrition Europe University of Atlantic > Research > Articles and books Cerrado Inglés Functional foods have emerged as an attractive option for many consumers, given their wide-ranging and long-term benefits. The functional food market size was valued at USD 177,770 Million in 2019 and is estimated to reach USD 267,924.4 Million by 2027, registering a CAGR of 6.7% from 2021 to 2027. Various natural products/compounds exert significant functional activity, and could also added value to food products alone or in combination, provided functional activity. The use of natural compounds in preparation of functional foods is important due to its higher safety, superior organoleptic properties, and functional attributes, resulted in wider consumer acceptance. Also, the use of advanced technologies in formulation of functional foods provides a better means of utilizing natural compounds for organoleptic and functional attributes. metadata Battino, Maurizio and Belwal, Tarun and Prieto, Miguel A. mail maurizio.battino@uneatlantico.es, UNSPECIFIED, UNSPECIFIED (2023) Valorization of food products using natural functional compounds for improving organoleptic and functional chemistry. Food Chemistry, 403. p. 134181. ISSN 03088146 Item not available from this repository. | |
49. |
Article
Subjects > Nutrition
Europe University of Atlantic > Research > Articles and books Fundación Universitaria Internacional de Colombia > Research > Scientific Production Ibero-american International University > Research > Scientific Production Ibero-american International University > Research > Scientific Production Cerrado Inglés Diets enriched in plant-based foods are associated with the maintenance of a good well-being and with the prevention of many non-communicable diseases. The health effects of fruits and vegetables consumption are mainly due to the presence of micronutrients, including vitamins and minerals, and polyphenols, plant secondary metabolites. One of the most important classes of phenolic compounds are anthocyanins, that confer the typical purple-red color to many foods, such as berries, peaches, plums, red onions, purple corn, eggplants, as well as purple carrots, sweet potatoes and red cabbages, among others. This commentary aims to briefly highlight the progress made by science in the last years, focusing on some unexpected aspects related with anthocyanins, such as their bioavailability, their health effects and their relationship with gut microbiota metadata Giampieri, Francesca and Cianciosi, Danila and Alvarez-Suarez, José M. and Quiles, José L. and Forbes-Hernández, Tamara Y. and Navarro-Hortal, María D. and Machì, Michele and Pali-Casanova, Ramón and Martínez Espinosa, Julio César and Chen, Xiumin and Zhang, Di and Bai, Weibin and Lingmin, Tian and Mezzetti, Bruno and Battino, Maurizio and Diaz, Yasmany Armas mail francesca.giampieri@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, jose.quiles@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, ramon.pali@unini.edu.mx, ulio.martinez@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es, UNSPECIFIED (2023) Anthocyanins: what do we know until now? Journal of Berry Research. pp. 1-6. ISSN 18785093 Item not available from this repository. |
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Article
Subjects > Nutrition
Europe University of Atlantic > Research > Articles and books Ibero-american International University > Research > Scientific Production Universidad Internacional do Cuanza > Research > Scientific Production Cerrado Inglés Inflammatory bowel disease (IBD) patients are at substantially higher risk of colorectal cancer (CRC) and IBD-associated CRC accounts for roughly 10-15% of the annual mortality in IBD patients. IBD-related CRC also affects younger patients if compared with sporadic CRC, with a 5-year survival rate of 50%. Regardless of medical therapies, the persistent inflammation state characterizing IBD raises the risk for precancerous changes and CRC, with additional input from several elements including genetic and environmental risk factors, IBD-associated comorbidities, intestinal barrier disfunction, and gut microbiota modifications. It is well known that nutritional habits and dietary bioactive compounds can influence IBD-associated inflammation, microbiome abundance and composition, oxidative stress balance, and gut permeability. In addition, in the last years, results from broad epidemiological and experimental studies have associated certain foods or nutritional patterns with the risk of colorectal neoplasia. Here we review the possible role of nutrition in the prevention of IBD-related CRC, focusing specifically on human studies. In conclusion it emerges that nutritional interventions based on healthy, nutrient-dense dietary patterns characterized by a high intake of fiber, vegetables, fruit, Omega-3 PUFAs, and low amount of animal proteins, processed foods and alcohol, combined with probiotic supplementation have the potential of reducing IBD-activity and preventing the risk of IBD-related CRC through different mechanisms, suggesting that targeted nutritional interventions may represent a novel promising approach for the prevention and management of IBD-associated CRC. metadata Cassotta, Manuela and Cianciosi, Danila and De Giuseppe, Rachele and Navarro-Hortal, Maria Dolores and Diaz, Yasmany Armas and Forbes-Hernández, Tamara Yuliett and Tutusaus, Kilian and Pascual Barrera, Alina Eugenia and Grosso, Giuseppe and Xiao, Jianbo and Battino, Maurizio and Giampieri, Francesca mail manucassotta@gmail.com, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, kilian.tutusaus@uneatlantico.es, alina.pascual@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es, francesca.giampieri@uneatlantico.es (2023) Possible role of nutrition in the prevention of Inflammatory Bowel Disease-related colorectal cancer: a focus on human studies. Nutrition. p. 111980. ISSN 08999007 Item not available from this repository. |
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51. | Article Subjects > Nutrition Europe University of Atlantic > Research > Articles and books Cerrado Inglés Wine is a highly complex mixture of components with different chemical natures. These components largely define wine’s appearance, aroma, taste, and mouthfeel properties. Among them, aroma is among the most important indicators of wine’s sensory characteristics. The essence of winemaking ecosystem is the process of metabolic activities of diverse microbes including yeasts, lactic acid bacteria, and molds, which result in wines with complicated and diversified aromas. A better understanding of how these microbes affect wine’s aroma is a crucial step to producing premium quality wine. This study illustrates existing knowledge on the diversity and classification of wine aroma compounds and their microbial origin. Their contributions to wine characteristics are discussed, as well. Furthermore, we review the relationship between these microbes and wine aroma characteristics. This review broadens the discussion of wine aroma compounds to include more modern microbiological concepts, and it provides relevant background and suggests new directions for future research. metadata Liu, Shuxun and Lou, Ying and Li, Yixian and Zhao, Yan and Laaksonen, Oskar and Li, Ping and Zhang, Jiaojiao and Battino, Maurizio and Yang, Baoru and Gu, Qing mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es, UNSPECIFIED, UNSPECIFIED (2023) Aroma characteristics of volatile compounds brought by variations in microbes in winemaking. Food Chemistry, 420. p. 136075. ISSN 03088146 Item not available from this repository. | |
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Article
Subjects > Biomedicine Subjects > Physical Education and Sport Subjects > Nutrition Europe University of Atlantic > Research > Articles and books Cerrado Inglés Background Structural, metabolic and functional signs of skeletal muscle damage have been identified in subjects affected by type 1 diabetes (T1D), but, to date, no guidelines for the diagnosis and treatment of muscle impairment exist and studies on T1D and muscle health are still limited. The aim of this cross-sectional study was to evaluate the prevalence of sarcopenia in a long-term T1D population and to assess the impact of some clinical parameters on muscle mass and function. Methods 39 patients affected by T1D were enrolled, and Body Mass Index (BMI), body composition (Appendicular Lean Mass Index-ALMI and Fat Mass-FM) and muscle strength were measured. Additionally, the relationship between Mediterranean Diet (MD) adherence and sarcopenia was assessed. Results In our sample (mean age 49.32±13.49 years, 41.1% women, mean duration of diabetes 30.13±12.28 years), the prevalence of sarcopenia was 7.7% (12.5 % in women and 4.35% in men), while the prevalence of low ALMI was 23.1% (25% in women and 21.74% in men). We found significant inverse correlations between ALMI and duration of diabetes and ALMI vs. FM; and significant positive correlations between ALMI and BMI, physical activity level and muscle strength. At the same time, significant inverse correlations were observed between muscle strength and duration of diabetes and muscle strength vs. FM. Conclusions We observed a high prevalence of low muscle mass, similar to those found in the older age groups of the general population (25 years in advance) and our findings suggest a possible pathogenetic role of T1D duration on muscle trophism and function. metadata Pollakova, Daniela and Tubili, Claudio and Folco, Ugo Di and De Giuseppe, Rachele and Battino, Maurizio and Giampieri, Francesca mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es, francesca.giampieri@uneatlantico.es (2023) Muscular involvement in long term type 1 diabetes: does it represent an underestimated complication? Nutrition. p. 112060. ISSN 08999007 Item not available from this repository. |
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53. | Article Subjects > Nutrition Europe University of Atlantic > Research > Articles and books Cerrado Inglés Saponins, consisting of sapogenins as their aglycones and carbohydrate chains, are widely found in plants and some marine organisms. Due to the complexity of the structure of saponins, involving different types of sapogenins and sugar moieties, investigation of their absorption and metabolism is limited, which further hinders the explanation of their bioactivities. Large molecular weight and complex structures limit the direct absorption of saponins rendering their low bioavailability. As such, their major modes of action may be due to interaction with the gastrointestinal environment, such as enzymes and nutrients, and interaction with the gut microbiota. Many studies have reported the interaction between saponins and gut microbiota, that is, the effects of saponins on changing the composition of gut microbiota, and gut microbiota playing an indispensable role in the biotransformation of saponins into sapogenins. However, the metabolic routes of saponins by gut microbiota and their mutual interactions are still sparse. Thus, this review summarizes the chemistry, absorption, and metabolic pathways of saponins, as well as their interactions with gut microbiota and impacts on gut health, to better understand how saponins exert their health-promoting functions. metadata Zhang, Yu and Hao, Ruojie and Chen, Junda and Li, Sen and Huang, Kai and Cao, Hongwei and Farag, Mohamed A. and Battino, Maurizio and Daglia, Maria and Capanoglu, Esra and Zhang, Fan and Sun, Qiqi and Xiao, Jianbo and Sun, Zhenliang and Guan, Xiao mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2023) Health benefits of saponins and its mechanisms: perspectives from absorption, metabolism, and interaction with gut. Critical Reviews in Food Science and Nutrition. pp. 1-22. ISSN 1040-8398 Item not available from this repository. | |
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Article
Subjects > Nutrition
Europe University of Atlantic > Research > Articles and books Fundación Universitaria Internacional de Colombia > Research > Scientific Production Ibero-american International University > Research > Scientific Production Ibero-american International University > Research > Scientific Production Cerrado Inglés Manuka honey, which is rich in pinocembrin, quercetin, naringenin, salicylic, p-coumaric, ferulic, syringic and 3,4-dihydroxybenzoic acids, has been shown to have pleiotropic effects against colon cancer cells. In this study, potential chemosensitizing effects of Manuka honey against 5-Fluorouracil were investigated in colonspheres enriched with cancer stem cells (CSCs), which are responsible for chemoresistance. Results showed that 5-Fluorouracil increased when it was combined with Manuka honey by downregulating the gene expression of both ATP-binding cassette sub-family G member 2, an efflux pump and thymidylate synthase, the main target of 5-Fluorouracil which regulates the ex novo DNA synthesis. Manuka honey was associated with decreased self-renewal ability by CSCs, regulating expression of several genes in Wnt/β-catenin, Hedgehog and Notch pathways. This preliminary study opens new areas of research into the effects of natural compounds in combination with pharmaceuticals and, potentially, increase efficacy or reduce adverse effects. metadata Cianciosi, Danila and Armas Diaz, Yasmany and Alvarez-Suarez, José M. and Chen, Xiumin and Zhang, Di and Martínez López, Nohora Milena and Briones Urbano, Mercedes and Quiles, José L. and Amici, Adolfo and Battino, Maurizio and Giampieri, Francesca mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, nohora.martinez@uneatlantico.es, mercedes.briones@uneatlantico.es, jose.quiles@uneatlantico.es, UNSPECIFIED, maurizio.battino@uneatlantico.es, francesca.giampieri@uneatlantico.es (2023) Can the phenolic compounds of Manuka honey chemosensitize colon cancer stem cells? A deep insight into the effect on chemoresistance and self-renewal. Food Chemistry, 427. p. 136684. ISSN 03088146 Item not available from this repository. |
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55. | Article Subjects > Nutrition Europe University of Atlantic > Research > Articles and books Cerrado Inglés Asparagus species is recognized as a perennial herb with several valuable functional ingredients, and has been widely used as medicine and food since ancient times. Among its main chemical constituents, saponins play a vital role in the health benefits and biological activities including anti-cancer, antioxidant, immunomodulatory, anti-microbial, anti-inflammatory, and hypoglycemic. This review summarizes the preparation methods, structure and classification, biological functions, as well as the food and non-food applications of asparagus saponins, with a special emphasis on its anti-cancer effects in vitro and in vivo. Further, the main challenges and limitations of the current research trends in asparagus saponins are highlighted after a detailed analysis of the recent research information. This review bridges the gap between bioactive components and human health and aids current research on functional and health-promoting foods and medicinal application of Asparagus saponins. metadata Zhang, Fan and Chen, Shengxiong and Zhang, Jianguo and Thakur, Kiran and Battino, Maurizio and Cao, Hui and Farag, Mohamed A. and Xiao, Jianbo and Wei, Zhaojun mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2023) Asparagus saponins: effective natural beneficial ingredient in functional foods, from preparation to applications. Critical Reviews in Food Science and Nutrition. pp. 1-19. ISSN 1040-8398 Item not available from this repository. | |
56. | Article Subjects > Nutrition Europe University of Atlantic > Research > Articles and books Cerrado Inglés The aim of this study was to investigate the effects of enzymatic treatments (pectinase, pectin lyase, and cellulase) on the in vitro digestion and fermentation characteristics of whole mulberry fruit juice. The analysis focused on changes in carbohydrate properties within the black mulberry fruit matrix during simulated digestion and fermentation. Human fecal microbiota were collected and introduced to the fruit matrix to monitor the fate of both soluble and insoluble polysaccharides during fermentation. The results revealed that enzymatic treatments enhanced the solubilization of carbohydrates from mulberry fruits, with pectinase showing the most significant effect. Throughout the process of in vitro digestion, there was a gradual increase in the percentage of solubilized carbohydrates from the mulberry juice substrate. The digested suspensions underwent dialysis to remove degradation fragments, and a lower quantity of carbohydrate in the enzyme-treated groups compared to the control. Polysaccharide populations with varying molecular weights (Mw) were obtained from the soluble fractions of mulberry residues for subsequent fermentation. An increase in Mw of soluble polysaccharides was detected by HPSEC during fermentation in certain cases. The gut microbiota demonstrated the ability to convert specific insoluble fractions into soluble components, which were subsequently subjected to microbial utilization. Enzymatic treatments during mulberry juice preparation can potentially positively impact health by influencing gut microbiota and short-chain fatty acid (SCFA) modulations. Enzymes could serve as valuable tools for producing functional fruit and vegetable juices, with the need to specify processing conditions for specific raw materials remaining a subject of further investigation. metadata Luo, Peihuan and Ai, Jian and Wang, Yuxin and Wang, Songen and Schols, Henk A. and Smidt, Hauke and Battino, Maurizio and Bai, Weibin and Tian, Lingmin mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es, UNSPECIFIED, UNSPECIFIED (2024) Effects of enzymatic treatment on the in vitro digestion and fermentation patterns of mulberry fruit juice: A focus on carbohydrates. Food Hydrocolloids, 146. p. 109223. ISSN 0268005X Item not available from this repository. | |
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Subjects > Biomedicine Subjects > Nutrition Europe University of Atlantic > Research > Articles and books Cerrado Inglés Malvidin is an O-methylated anthocyanidin, the 3′,5′-methoxy derivative of delphinidin responsible for the blue-red color found in flowers and fruits. Its distribution covers a wide group of sources, such as flowers (edible and nonedible), medicinal plants, and fruits. It is the main substance responsible for the color of red grapes and red wine, being Vitis vinifera one of its main sources. Its consumption is important as it has been associated with important biological effects, such as anti-inflammatory activity, powerful antioxidant activity, and anticancer activity. Against this background, this chapter presents a general overview of malvidin’s main sources, biosynthesis pathway and biotransformation properties, physicochemical properties and stability, and aspects of its absorption, metabolism, and excretion. Additionally, we summarize recent studies using in vitro and in vivo models related to its various biological properties. In conclusion, this chapter aims to provide as detailed a picture as possible of the potential of malvidin in human health, as well as its main sources, chemical characteristics, and biotransformation. metadata Alvarez-Suarez, José M. and Giampieri, Francesca and Tejera, Eduardo and Battino, Maurizio mail UNSPECIFIED, francesca.giampieri@uneatlantico.es, UNSPECIFIED, maurizio.battino@uneatlantico.es (2023) Malvidin: Advances in the Resources, Biosynthesis Pathway, Bioavailability, Bioactivity, and Pharmacology. Handbook of Dietary Flavonoids. pp. 1-35. Item not available from this repository. |
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58. | Article Subjects > Nutrition Europe University of Atlantic > Research > Articles and books Abierto Inglés Noncommunicable chronic diseases (NCDs) are among the leading causes of death and disability worldwide. The most common NCDs are cancer, obesity, cardiovascular diseases, and diabetes. Nowadays, they represent one of the greatest challenges health systems face worldwide. The increase in the consumption of polyphenol-rich foods could contribute to the reduction of these pathologies, due to their antioxidant, anti-inflammatory, anticancer, immunomodulatory, and cardiovascular protective properties, among others. This review aims to highlight some studies carried out in recent years to enhance the possible benefits of a diet rich in polyphenols in the prevention or treatment of NCDs. metadata Armas Díaz, Yasmany and Ferreiro Cotorruelo, Maria Soledad and Battino, Maurizio mail UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2023) The role of dietary polyphenols in the control of chronic noncommunicable diseases. Food Safety and Health, 1 (1). pp. 13-21. ISSN 2835-1096 Item not available from this repository. | |
59. | Article Subjects > Nutrition Europe University of Atlantic > Research > Articles and books Cerrado Inglés Diabetes is a metabolic disease due to impaired or defective insulin secretion and is considered one of the most serious chronic diseases worldwide. Gamma-aminobutyric acid (GABA) is a naturally occurring non-protein amino acid commonly present in a wide range of foods. A number of studies documented that GABA has good anti-diabetic potential. This review summarized the available dietary sources of GABA as well as animal and human studies on the anti-diabetic properties of GABA, while also discussing the underlying mechanisms. GABA may modulate diabetes through various pathways such as inhibiting the activities of α-amylase and α-glucosidase, promoting β-cell proliferation, stimulating insulin secretion from β-cells, inhibiting glucagon secretion from α-cells, improving insulin resistance and glucose tolerance, and increasing antioxidant and anti-inflammatory activities. However, further mechanistic studies on animals and human are needed to confirm the therapeutic effects of GABA against diabetes. metadata Sun, Yu and Mehmood, Arshad and Giampieri, Francesca and Battino, Maurizio and Chen, Xiumin mail UNSPECIFIED, UNSPECIFIED, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es, UNSPECIFIED (2023) Insights into the cellular, molecular, and epigenetic targets of gamma-aminobutyric acid against diabetes: a comprehensive review on its mechanisms. Critical Reviews in Food Science and Nutrition. pp. 1-18. ISSN 1040-8398 Item not available from this repository. | |
60. | Article Subjects > Nutrition Europe University of Atlantic > Research > Articles and books Cerrado Inglés Background The house cricket (A. domesticus) is one of the edible insects that are gaining attention as a new source of protein and nutrients with potential use in the food industry as a safe and environmentally sustainable option with high biological value. Scope and approach Here, we review the published literature on studies of chemical composition, nutritional value, and potential risks that the consumption of house crickets entails. We discuss the benefits of consuming A. domesticus from a nutritional point of view, as well as information concerning the properties of its components for use in the food industry. metadata Pilco-Romero, Gabriela and Chisaguano-Tonato, Aida M. and Herrera-Fontana, María E. and Chimbo-Gándara, Luis F. and Sharifi-Rad, Majid and Giampieri, Francesca and Battino, Maurizio and Vernaza, María Gabriela and Álvarez-Suárez, José M. mail UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es, UNSPECIFIED, UNSPECIFIED (2023) House cricket (Acheta domesticus): A review based on its nutritional composition, quality, and potential uses in the food industry. Trends in Food Science & Technology, 142. p. 104226. ISSN 09242244 Item not available from this repository. |
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Enzymatic treatment shapes in vitro digestion pattern of phenolic compounds in mulberry juice
The health benefits of mulberry fruit are closely associated with its phenolic compounds. However, the effects of enzymatic treatments on the digestion patterns of these compounds in mulberry juice remain largely unknown. This study investigated the impact of pectinase (PE), pectin lyase (PL), and cellulase (CE) on the release of phenolic compounds in whole mulberry juice. The digestion patterns were further evaluated using an in vitro simulated digestion model. The results revealed that PE significantly increased chlorogenic acid content by 77.8 %, PL enhanced cyanidin-3-O-glucoside by 20.5 %, and CE boosted quercetin by 44.5 %. Following in vitro digestion, the phenolic compound levels decreased differently depending on the treatment, while cyanidin-3-O-rutinoside content increased across all groups. In conclusion, the selected enzymes effectively promoted the release of phenolic compounds in mulberry juice. However, during gastrointestinal digestion, the degradation of phenolic compounds surpassed their enhanced release, with effects varying based on the compound's structure.
Peihuan Luo mail , Jian Ai mail , Qiongyao Wang mail , Yihang Lou mail , Zhiwei Liao mail , Francesca Giampieri mail francesca.giampieri@uneatlantico.es, Maurizio Battino mail maurizio.battino@uneatlantico.es, Elwira Sieniawska mail , Weibin Bai mail , Lingmin Tian mail ,
Luo
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A novel machine learning-based proposal for early prediction of endometriosis disease
Background Endometriosis is one of the causes of female infertility, with some studies estimating its prevalence at around 10 % of reproductive-age women worldwide and between 30 and 50 % in symptomatic women. However, its diagnosis is complex and often delayed, highlighting the need for more accessible and accurate diagnostic methods. The difficulty lies in its diverse etiology and the variability of symptoms among those affected. Methods This study proposes a predictive model based on supervised machine learning for the early identification of endometriosis, providing support for decision-making by healthcare professionals. For this purpose, an anonymised dataset of 5,143 female patients diagnosed with endometriosis at the private fertility clinic Inebir was used. The model integrates clinical records and genetic analysis through supervised machine learning algorithms, focusing on clinical variables and pathogenic and potentially pathogenic genetic variants. Results The developed predictive model achieves high accuracy in identifying the presence of endometriosis, highlighting the importance of combining clinical and genetic data in diagnosis. The integration of this data into the DELFOS platform, a clinical decision support system, demonstrates the utility of machine learning in improving the diagnosis of endometriosis. Conclusions The findings underscore the potential of clinical and genetic factors in the early diagnosis of endometriosis using supervised machine learning algorithms. This study contributes to the classification of clinical variables that influence endometriosis, offering a valuable tool for clinicians in making therapeutic and management decisions for their female patients.
Elena Enamorado-Díaz mail , Leticia Morales-Trujillo mail , Julián-Alberto García-García mail , Ana Teresa Marcos Rodríguez mail anateresa.marcos@uneatlantico.es, José Manuel Navarro-Pando mail jose.navarro@uneatlantico.es, María-José Escalona-Cuaresma mail ,
Enamorado-Díaz
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Background The aging process leads to negative changes in various bodily systems, including the neuromuscular system. Strength training, is considered the best strategy to counteract these neuromuscular changes, preventing sarcopenia and frailty in older adults. Objective To compare the effects of strength training with elastic resistance and free weights on the muscle strength of knee extensors and flexors and functional performance in the older adults. Methods This was a randomised clinical study. Thirty-one participants of both sexes were allocated randomly into two groups: Training Group Free Weight (TGFW, n = 15) and Training Group with Elastic Resistance (TGER, n = 16). Two individuals were excluded and so, twenty-nine individuals were evaluated before and after eight weeks training protocol, which was performed three times a week. The determination of the training load was obtained using a protocol of 10 repetitions maximum. Results No significant differences were found in either the intra- or the inter-group comparisons, on functional performance and peak muscle strength. In the intra-groups (pre- and post-strength training), it was observed that both groups significantly increased the training load (10 RM) for the extensors (TGFW p = 0.0002; TGER p = 0.0001) and the knee flexors (TGFW p = 0.006; TGER p = 0.0001). Conclusion Both training protocols similarly were effective in increasing the training load observed by the 10 RM test of the extension and flexion movements of the knee.
Rafaela Zanin Ferreira mail , Antonio Felipe Souza Gomes mail , Marco Antonio Ferreira Baldim mail , Ricardo Silva Alves mail , Leonardo César Carvalho mail , Adriano Prado Simão mail ,
Ferreira
<a href="/15983/1/Food%20Science%20%20%20Nutrition%20-%202025%20-%20Tanveer%20-%20Novel%20Transfer%20Learning%20Approach%20for%20Detecting%20Infected%20and%20Healthy%20Maize%20Crop.pdf" class="ep_document_link"><img class="ep_doc_icon" alt="[img]" src="/style/images/fileicons/text.png" border="0"/></a>
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Novel Transfer Learning Approach for Detecting Infected and Healthy Maize Crop Using Leaf Images
Maize is a staple crop worldwide, essential for food security, livestock feed, and industrial uses. Its health directly impacts agricultural productivity and economic stability. Effective detection of maize crop health is crucial for preventing disease spread and ensuring high yields. This study presents VG-GNBNet, an innovative transfer learning model that accurately detects healthy and infected maize crops through a two-step feature extraction process. The proposed model begins by leveraging the visual geometry group (VGG-16) network to extract initial pixel-based spatial features from the crop images. These features are then further refined using the Gaussian Naive Bayes (GNB) model and feature decomposition-based matrix factorization mechanism, which generates more informative features for classification purposes. This study incorporates machine learning models to ensure a comprehensive evaluation. By comparing VG-GNBNet's performance against these models, we validate its robustness and accuracy. Integrating deep learning and machine learning techniques allows VG-GNBNet to capitalize on the strengths of both approaches, leading to superior performance. Extensive experiments demonstrate that the proposed VG-GNBNet+GNB model significantly outperforms other models, achieving an impressive accuracy score of 99.85%. This high accuracy highlights the model's potential for practical application in the agricultural sector, where the precise detection of crop health is crucial for effective disease management and yield optimization.
Muhammad Usama Tanveer mail , Kashif Munir mail , Ali Raza mail , Laith Abualigah mail , Helena Garay mail helena.garay@uneatlantico.es, Luis Eduardo Prado González mail uis.prado@uneatlantico.es, Imran Ashraf mail ,
Tanveer
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A novel and efficient digital image steganography technique using least significant bit substitution
Steganography is used to hide sensitive types of data including images, audio, text, and videos in an invisible way so that no one can detect it. Image-based steganography is a technique that uses images as a cover media for hiding and transmitting sensitive information over the internet. However, image-based steganography is a challenging task due to transparency, security, computational efficiency, tamper protection, payload, etc. Recently, different image steganography methods have been proposed but most of them have reliability issues. Therefore, to solve this issue, we propose an efficient technique based on the Least Significant Bit (LSB). The LSB substitution method minimizes the error rate in the embedding process and is used to achieve greater reliability. Our proposed image-based steganography algorithm incorporates LSB substitution with Magic Matrix, Multi-Level Encryption Algorithm (MLEA), Secret Key (SK), and transposition, flipping. We performed several experiments and the results show that our proposed technique is efficient and achieves efficient results. We tested a total of 165 different RGB images of various dimensions and sizes of hidden information, using various Quality Assessment Metrics (QAMs); A name of few are; Normalized Cross Correlation (NCC), Image Fidelity (IF), Peak Signal Noise Ratio (PSNR), Root Mean Square Error (RMSE), Quality Index (QI), Correlation Coefficient (CC), Structural Similarity Index (SSIM), Mean Square Error (MSE), Entropy, Contrast, and Homogeneity, Image Histogram (IH). We also conducted a comparative analysis with some existing methods as well as security analysis which showed better results. The achieved result demonstrates significant improvements over the current state-of-the-art methods.
Shahid Rahman mail , Jamal uddin mail , Hameed Hussain mail , Sabir Shah mail , Abdu Salam mail , Farhan Amin mail , Isabel de la Torre Díez mail , Debora L. Ramírez-Vargas mail debora.ramirez@unini.edu.mx, Julio César Martínez Espinosa mail ulio.martinez@unini.edu.mx,
Rahman