Búsqueda de resultados para Maurizio Battino
| 41. | Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Artículos y libros Cerrado Inglés Strawberry represents the most important berry in the Mediterranean diet. It is the most consumed berry as both fresh and processed products, the most studied berry from the agronomic, genomic and nutritional point of view, and it is also a remarkable source of micronutrients and phytochemicals with a relevant biologically activity on human health. Although individual bioactive compounds present in strawberries have been studied for their biological activities, the mechanisms by which they are metabolized and exert their beneficial effects on human health are still unknown. For this reason, the first objective of this research is the development of an enzymatic in vitro system which simulates the gastrointestinal conditions that occur in vivo during the digestive process. Briefly, the method consists on an initial pepsin-HCl digestion for simulating gastric conditions (pH~1.7) followed by an intestinal digestion with pancreatin and bile salts through a dialysis membrane. The dialysates were concentrated under vacuum, resuspended in H2O2/glacial acetic acid and purified with a C-18 SepPaks Vac 6 cc cartridge. The strawberry cultivar chosen for the study is 'Romina', one of the most promising cultivars developed in the context of the European Euberry project. The total antioxidant capacity of both the fresh fruit and the digested fraction was tested through the DPPH, FRAP and TEAC assays. The results obtained have shown a significant variation in the antioxidant capacity of 'omina', before and after the enzymatic digestion process. Significant decreases were found in all the performed assay, highlighting how the antioxidant capacity present in fresh fruit is drastically reduced following digestion. Further studies are required to elucidate the mechanisms of transport and metabolism of these compounds, with the aim of providing predictive results on their bioavailability and thus their effect on human health. metadata Forbes-Hernández, Tamara Y.; Gasparrini, Massimiliano; Afrin, Sadia; Battino, Maurizio y Giampieri, Francesca mail tamara.forbes@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es, francesca.giampieri@uneatlantico.es (2017) The effect of an enzymatic digestion process on strawberry antioxidant capacity. Acta Horticulturae (1156). pp. 413-418. ISSN 2406-6168 ["page:item_not_available" not defined] | |
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Artículo
Materias > Biomedicina Materias > Alimentación Universidad Europea del Atlántico > Investigación > Artículos y libros Universidad Internacional Iberoamericana México > Investigación > Producción Científica Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica Cerrado Inglés In the last decade, specific dietary patterns, mainly characterized by high consumption of vegetables and fruits, have been proven beneficial for the prevention of both metabolic syndrome (MetS)-related dysfunctions and neurodegenerative disorders, such as Alzheimer’s disease (AD). Nowadays, neuroimaging readouts can be used to diagnose AD, investigate MetS effects on brain functionality and anatomy, and assess the effects of dietary supplementations and nutritional patterns in relation to neurodegeneration and AD-related features. Here we review scientific literature describing the use of the most recent neuroimaging techniques to detect AD- and MetS-related brain features, and also to investigate associations between consolidated dietary patterns or nutritional interventions and AD, specifically focusing on observational and intervention studies in humans. metadata Pistollato, Francesca; Sumalla Cano, Sandra; Elío Pascual, Iñaki; Masías Vergara, Manuel; Giampieri, Francesca y Battino, Maurizio mail francesca.pistollato@uneatlantico.es, sandra.sumalla@uneatlantico.es, inaki.elio@uneatlantico.es, manuel.masias@uneatlantico.es, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es (2015) The Use of Neuroimaging to Assess Associations Among Diet, Nutrients, Metabolic Syndrome, and Alzheimer’s Disease. Journal of Alzheimer's Disease, 48 (2). pp. 303-318. ISSN 13872877 ["page:item_not_available" not defined] |
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| 43. |
Artículo
Materias > Alimentación
Universidad Europea del Atlántico > Investigación > Artículos y libros Universidad Internacional Iberoamericana México > Investigación > Producción Científica Cerrado Inglés Dietary polyphenols have been recently proposed as activators of the AMP-activated protein kinase (AMPK) signaling pathway and this fact might explain the relationship between the consumption of polyphenol-rich foods and the slowdown of the progression of aging. In the present work, the effects of strawberry consumption were evaluated on biomarkers of oxidative damage and on aging-associated reductions in mitochondrial function and biogenesis for 8weeks in old rats. Strawberry supplementation increased antioxidant enzyme activities, mitochondrial biomass and functionality, and decreased intracellular ROS levels and biomarkers of protein, lipid and DNA damage (P<0.05). Furthermore, a significant (P<0.05) increase in the expression of the AMPK cascade genes, involved in mitochondrial biogenesis and antioxidant defences, was also detected after strawberry intake. These in vivo results were then verified in vitro on HepG2 cells, confirming the involvement of AMPK in the beneficial effects exerted by strawberry against aging progression. metadata Giampieri, Francesca; Alvarez-Suarez, Josè M.; Cordero, Mario D.; Gasparrini, Massimiliano; Forbes-Hernandez, Tamara Y.; Afrin, Sadia; Santos-Buelga, Celestino; González-Paramás, Ana M.; Astolfi, Paola; Rubini, Corrado; Zizzi, Antonio; Tulipani, Sara; Quiles, Josè L.; Mezzetti, Bruno y Battino, Maurizio mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, tamara.forbes@unini.edu.mx, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es (2017) Strawberry consumption improves aging-associated impairments, mitochondrial biogenesis and functionality through the AMP-activated protein kinase signaling cascade. Food Chemistry, 234. pp. 464-471. ISSN 03088146 ["page:item_not_available" not defined] |
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| 44. | Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Artículos y libros Cerrado Inglés The aim of the present work was to evaluate the in vitro effect of Manuka honey and its combination with 5-Fu, the most common drug used in the treatment of colon cancer, on the morphological and physical parameters of colonspheres enriched with cancer stem-like cells deriving from HCT-116 colon adenocarcinoma cell line and on the apoptosis rate. Manuka honey, alone and more in combination with 5-Fu, reduced the weight, the diameter and mass density of the spheroids and induced apoptosis through the downregulation of many apoptosis inhibitors, including IAPs (Livin, Survivin, XIAP), IGFs (IGF-I, IGF-II and IGF-IR) and HSPs (HSP-27, HSP-60 and HSP-70). These results led to a reduction in the survival ability of cancer stem-like cells, as well as to a chemosensitizing effect of honey towards 5-Fu, considering that apoptosis resistance is one of the main causes of cancer stem-like cells chemoresistance. metadata Cianciosi, Danila; Forbes-Hernández, Tamara Y.; Regolo, Lucia; Alvarez-Suarez, José M.; Quinzi, Denise; Sargenti, Azzurra; Bai, Weibin; Tian, Lingmin; Giampieri, Francesca y Battino, Maurizio mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es (2022) Manuka honey in combination with 5-Fluorouracil decreases physical parameters of colonspheres enriched with cancer stem-like cells and reduces their resistance to apoptosis. Food Chemistry, 374. p. 131753. ISSN 03088146 ["page:item_not_available" not defined] | |
| 45. | Artículo Materias > Biomedicina Universidad Europea del Atlántico > Investigación > Artículos y libros Cerrado Inglés Alzheimer’s disease (AD) is a progressive neurodegenerative pathology affecting milions of people worldwide associated with deposition of senile plaques. While the genetic and environmental risk factors associated with the onset and consolidation of late onset AD are heterogeneous and sporadic, growing evidence also suggests a potential link between some infectious diseases caused by oral microbiota and AD. Oral microbiota dysbiosis is purported to contribute either directly to amyloid protein production, or indirectly to neuroinflammation, occurring as a consequence of bacterial invasion. Over the last decade, the development of Human Oral Microbiome database (HOMD) has deepened our understanding of oral microbes and their different roles during the human lifetime. Oral pathogens mostly cause caries, periodontal disease, and edentulism in aged population, and, in particular, alterations of the oral microbiota causing chronic periodontal disease have been associated with the risk of AD. Here we describe how different alterations of the oral microbiota may be linked to AD, highlighting the importance of a good oral hygiene for the prevention of oral microbiota dysbiosis. metadata Sureda, Antoni; Daglia, Maria; Argüelles Castilla, Sandro; Sanadgol, Nima; Fazel Nabavi, Seyed; Khan, Haroon; Belwal, Tarun; Jeandet, Philippe; Marchese, Anna; Pistollato, Francesca; Forbes-Hernandez, Tamara; Battino, Maurizio; Berindan-Neagoe, Ioana; D’Onofrio, Grazia y Nabavi, Seyed Mohammad mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, francesca.pistollato@uneatlantico.es, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR (2020) Oral microbiota and Alzheimer’s disease: Do all roads lead to Rome? Pharmacological Research, 151. p. 104582. ISSN 10436618 ["page:item_not_available" not defined] | |
| 46. | Artículo Materias > Biomedicina Universidad Europea del Atlántico > Investigación > Artículos y libros Cerrado Inglés Conventional cardiovascular risk factors (CVRFs) are accepted to identify asymptomatic individuals with high risk of acute myocardial infarction (AMI). However, AMI affects many patients previously classified at low risk. New biomarkers are needed to improve risk prediction. We propose to evaluate the NLRP3-inflammasome complex as a potential conventional cardiovascular risk (CVR) indicator in healthy males and post-AMI patients and compare both groups by known CVRFs. We included 109 men with no history of cardiovascular disease (controls) and 150 AMI patients attending a cardiac rehabilitation program. AMI patients had higher mean of body mass index (BMI) and waist circumference than the controls. However, high percentages of the controls had a high BMI and a waist circumference >95 cm. The controls also had higher systolic blood pressure (p > 0.001), total and low-density lipoprotein cholesterol, dietary nutrient, and calorific intake. Fuster BEWAT score (FBS) correlated more closely than Framingham risk score (FRS) with most CVRF, groups. However, only the FBS showed a correlation with inflammasome cytokine interleukin 1β (IL-1β). Several CVRFs were significantly better in AMI patients; however, this group also had higher mRNA expression of the inflammasome gene NLRP3 and lower expression of the autophagy gene MAP-LC3. The controls had high levels of CVRF, probably reflecting unhealthy lifestyle. FBS reflects the efficiency of strategies to induce lifestyle changes such as cardiac rehabilitation programs, and could provide a sensitive evaluation CVR. These results lead to the hypothesis that NLRP3-inflammasome and associated IL-1β release have potential as CVR biomarkers, particularly in post-AMI patients with otherwise low risk scores. Antioxid. Redox Signal. 27, 269-275. metadata Bullón, Pedro; Cano-García, Francisco J.; Alcocer-Gómez, Elísabet; Varela-López, Alfonso; Roman-Malo, Lourdes; Ruiz-Salmerón, Rafael J.; Quiles, José L.; Navarro-Pando, José M.; Battino, Maurizio; Ruiz-Cabello, Jesús; Jiménez-Borreguero, Luis J. y Cordero, Mario D. mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR (2017) Could NLRP3–Inflammasome Be a Cardiovascular Risk Biomarker in Acute Myocardial Infarction Patients? Antioxidants & Redox Signaling, 27 (5). pp. 269-275. ISSN 1523-0864 ["page:item_not_available" not defined] | |
| 47. | Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Artículos y libros Cerrado Inglés Plant-based diets are known to preserve body tissues from oxidative stress and inflammation, both hallmarks of chronic-degenerative diseases. In particular, plant-derived foods, such as legumes, represent a natural source of bioactive nutrients known to contribute to the prevention and amelioration of insulin resistance, dyslipidemia, hypertension and impaired glucose metabolism, all factors implicated in metabolic syndrome (MetS), but also osteoporosis, neurodegeneration and some types of cancers. Here we revise recent literature on the role of plant-based diets, plant-foods and specific plant-nutrients in the prevention and regression of MetS and neurodegenerative diseases. We describe some of the molecular mechanisms underlying these protective effects, highlighting the role of diet in the control of hyper-homocysteinemia and insulin resistance, often implicated in the etiology of both metabolic and neurodegenerative syndromes. metadata Pistollato, Francesca y Battino, Maurizio mail SIN ESPECIFICAR, maurizio.battino@uneatlantico.es (2014) Role of plant-based diets in the prevention and regression of metabolic syndrome and neurodegenerative diseases. Trends in Food Science & Technology, 40 (1). pp. 62-81. ISSN 09242244 ["page:item_not_available" not defined] | |
| 48. |
Artículo
Materias > Biomedicina Materias > Alimentación Universidad Europea del Atlántico > Investigación > Artículos y libros Cerrado Inglés Ocimum basilicum and Ocimum tenuiflorum are two basil species widely used medicinally as an anti-inflammatory, antimicrobial and cardioprotective agent. This study focuses on the chemical characterization of the majoritarian compounds of both species and their anti-inflammatory potential. Up to 22 compounds such as various types of salvianolic acids, derivatives of rosmaniric acid and flavones were identified in both plants. The identified compounds were very similar between both plants and are consistent with previous finding in other studies in Portugal and Italy. Based on the identified molecules a consensus target prediction was carried out. Among the main predicted target proteins, we found a high representation of the carbonic anhydrase family (CA2, CA7 and CA12) and several key proteins from the arachidonic pathway (LOX5, PLA2, COX1 and COX2). Both pathways are well related to inflammation. The interaction between the compounds and these targets were explored through molecular docking and molecular dynamics simulation. Our results suggest that some molecules present in both plants can induce an anti-inflammatory response through a non-steroidal mechanism of action connected to the carbon dioxide metabolism. metadata Beltrán-Noboa, Andrea; Proaño-Ojeda, John; Guevara, Mabel; Gallo, Blanca; Berrueta, Luis A.; Giampieri, Francesca; Perez-Castillo, Yunierkis; Battino, Maurizio; Álvarez-Suarez, José M. y Tejera, Eduardo mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, francesca.giampieri@uneatlantico.es, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR (2022) Metabolomic profile and computational analysis for the identification of the potential anti-inflammatory mechanisms of action of the traditional medicinal plants Ocimum basilicum and Ocimum tenuiflorum. Food and Chemical Toxicology, 164. p. 113039. ISSN 02786915 ["page:item_not_available" not defined] |
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| 49. | Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Artículos y libros Cerrado Inglés As the number of older people has grown in recent decades, the search for new approaches to manage or delay aging is also growing. Among the modifiable factors, diet plays a crucial role in healthy aging and in the prevention of age-related diseases. Thus, the interest in the use of foods, which are rich in bioactive compounds such as functional foods with anti-aging effects is a growing market. This review summarizes the current knowledge about the molecular mechanisms of action of foods considered as functional foods in aging, namely berries, curcumin, and virgin olive oil. Moreover, honey is also analyzed as a food with well-known healthy benefits, but which has not been deeply evaluated from the point of view of aging. The effects of these foods on aging are analyzed from the point of view of molecular mechanisms including oxidative stress, mitochondrial dysfunction, inflammation, genomic stability, telomere attrition, cellular senescence, and deregulated nutrient-sensing. A comprehensive study of the scientific literature shows that the aforementioned foods have demonstrated positive effects on certain aspects of aging, which might justify their use as functional foods in elderly. However, more research is needed, especially in humans, designed to understand in depth the mechanisms of action through which they act. metadata Navarro-Hortal, María D.; Romero-Márquez, Jose M.; Jiménez-Trigo, Victoria; Xiao, Jianbo; Giampieri, Francesca; Forbes-Hernández, Tamara Y.; Grosso, Giuseppe; Battino, Maurizio; Sánchez-González, Cristina y Quiles, José L. mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, francesca.giampieri@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es, SIN ESPECIFICAR, jose.quiles@uneatlantico.es (2022) Molecular bases for the use of functional foods in the management of healthy aging: Berries, curcumin, virgin olive oil and honey; three realities and a promise. Critical Reviews in Food Science and Nutrition. pp. 1-20. ISSN 1040-8398 ["page:item_not_available" not defined] | |
| 50. | Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Artículos y libros Cerrado Inglés Functional foods have emerged as an attractive option for many consumers, given their wide-ranging and long-term benefits. The functional food market size was valued at USD 177,770 Million in 2019 and is estimated to reach USD 267,924.4 Million by 2027, registering a CAGR of 6.7% from 2021 to 2027. Various natural products/compounds exert significant functional activity, and could also added value to food products alone or in combination, provided functional activity. The use of natural compounds in preparation of functional foods is important due to its higher safety, superior organoleptic properties, and functional attributes, resulted in wider consumer acceptance. Also, the use of advanced technologies in formulation of functional foods provides a better means of utilizing natural compounds for organoleptic and functional attributes. metadata Battino, Maurizio; Belwal, Tarun y Prieto, Miguel A. mail maurizio.battino@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR (2023) Valorization of food products using natural functional compounds for improving organoleptic and functional chemistry. Food Chemistry, 403. p. 134181. ISSN 03088146 ["page:item_not_available" not defined] | |
| 51. |
Artículo
Materias > Alimentación
Universidad Europea del Atlántico > Investigación > Artículos y libros Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica Universidad Internacional Iberoamericana México > Investigación > Producción Científica Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica Cerrado Inglés Diets enriched in plant-based foods are associated with the maintenance of a good well-being and with the prevention of many non-communicable diseases. The health effects of fruits and vegetables consumption are mainly due to the presence of micronutrients, including vitamins and minerals, and polyphenols, plant secondary metabolites. One of the most important classes of phenolic compounds are anthocyanins, that confer the typical purple-red color to many foods, such as berries, peaches, plums, red onions, purple corn, eggplants, as well as purple carrots, sweet potatoes and red cabbages, among others. This commentary aims to briefly highlight the progress made by science in the last years, focusing on some unexpected aspects related with anthocyanins, such as their bioavailability, their health effects and their relationship with gut microbiota metadata Giampieri, Francesca; Cianciosi, Danila; Alvarez-Suarez, José M.; Quiles, José L.; Forbes-Hernández, Tamara Y.; Navarro-Hortal, María D.; Machì, Michele; Pali-Casanova, Ramón; Martínez Espinosa, Julio César; Chen, Xiumin; Zhang, Di; Bai, Weibin; Lingmin, Tian; Mezzetti, Bruno; Battino, Maurizio y Diaz, Yasmany Armas mail francesca.giampieri@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, jose.quiles@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, ramon.pali@unini.edu.mx, ulio.martinez@unini.edu.mx, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es, SIN ESPECIFICAR (2023) Anthocyanins: what do we know until now? Journal of Berry Research. pp. 1-6. ISSN 18785093 ["page:item_not_available" not defined] |
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| 52. |
Artículo
Materias > Alimentación
Universidad Europea del Atlántico > Investigación > Artículos y libros Universidad Internacional Iberoamericana México > Investigación > Producción Científica Universidad Internacional do Cuanza > Investigación > Producción Científica Cerrado Inglés Inflammatory bowel disease (IBD) patients are at substantially higher risk of colorectal cancer (CRC) and IBD-associated CRC accounts for roughly 10-15% of the annual mortality in IBD patients. IBD-related CRC also affects younger patients if compared with sporadic CRC, with a 5-year survival rate of 50%. Regardless of medical therapies, the persistent inflammation state characterizing IBD raises the risk for precancerous changes and CRC, with additional input from several elements including genetic and environmental risk factors, IBD-associated comorbidities, intestinal barrier disfunction, and gut microbiota modifications. It is well known that nutritional habits and dietary bioactive compounds can influence IBD-associated inflammation, microbiome abundance and composition, oxidative stress balance, and gut permeability. In addition, in the last years, results from broad epidemiological and experimental studies have associated certain foods or nutritional patterns with the risk of colorectal neoplasia. Here we review the possible role of nutrition in the prevention of IBD-related CRC, focusing specifically on human studies. In conclusion it emerges that nutritional interventions based on healthy, nutrient-dense dietary patterns characterized by a high intake of fiber, vegetables, fruit, Omega-3 PUFAs, and low amount of animal proteins, processed foods and alcohol, combined with probiotic supplementation have the potential of reducing IBD-activity and preventing the risk of IBD-related CRC through different mechanisms, suggesting that targeted nutritional interventions may represent a novel promising approach for the prevention and management of IBD-associated CRC. metadata Cassotta, Manuela; Cianciosi, Danila; De Giuseppe, Rachele; Navarro-Hortal, Maria Dolores; Diaz, Yasmany Armas; Forbes-Hernández, Tamara Yuliett; Tutusaus, Kilian; Pascual Barrera, Alina Eugenia; Grosso, Giuseppe; Xiao, Jianbo; Battino, Maurizio y Giampieri, Francesca mail manucassotta@gmail.com, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, kilian.tutusaus@uneatlantico.es, alina.pascual@unini.edu.mx, SIN ESPECIFICAR, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es, francesca.giampieri@uneatlantico.es (2023) Possible role of nutrition in the prevention of Inflammatory Bowel Disease-related colorectal cancer: a focus on human studies. Nutrition. p. 111980. ISSN 08999007 ["page:item_not_available" not defined] |
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| 53. | Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Artículos y libros Cerrado Inglés Wine is a highly complex mixture of components with different chemical natures. These components largely define wine’s appearance, aroma, taste, and mouthfeel properties. Among them, aroma is among the most important indicators of wine’s sensory characteristics. The essence of winemaking ecosystem is the process of metabolic activities of diverse microbes including yeasts, lactic acid bacteria, and molds, which result in wines with complicated and diversified aromas. A better understanding of how these microbes affect wine’s aroma is a crucial step to producing premium quality wine. This study illustrates existing knowledge on the diversity and classification of wine aroma compounds and their microbial origin. Their contributions to wine characteristics are discussed, as well. Furthermore, we review the relationship between these microbes and wine aroma characteristics. This review broadens the discussion of wine aroma compounds to include more modern microbiological concepts, and it provides relevant background and suggests new directions for future research. metadata Liu, Shuxun; Lou, Ying; Li, Yixian; Zhao, Yan; Laaksonen, Oskar; Li, Ping; Zhang, Jiaojiao; Battino, Maurizio; Yang, Baoru y Gu, Qing mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR (2023) Aroma characteristics of volatile compounds brought by variations in microbes in winemaking. Food Chemistry, 420. p. 136075. ISSN 03088146 ["page:item_not_available" not defined] | |
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Artículo
Materias > Biomedicina Materias > Educación física y el deporte Materias > Alimentación Universidad Europea del Atlántico > Investigación > Artículos y libros Cerrado Inglés Background Structural, metabolic and functional signs of skeletal muscle damage have been identified in subjects affected by type 1 diabetes (T1D), but, to date, no guidelines for the diagnosis and treatment of muscle impairment exist and studies on T1D and muscle health are still limited. The aim of this cross-sectional study was to evaluate the prevalence of sarcopenia in a long-term T1D population and to assess the impact of some clinical parameters on muscle mass and function. Methods 39 patients affected by T1D were enrolled, and Body Mass Index (BMI), body composition (Appendicular Lean Mass Index-ALMI and Fat Mass-FM) and muscle strength were measured. Additionally, the relationship between Mediterranean Diet (MD) adherence and sarcopenia was assessed. Results In our sample (mean age 49.32±13.49 years, 41.1% women, mean duration of diabetes 30.13±12.28 years), the prevalence of sarcopenia was 7.7% (12.5 % in women and 4.35% in men), while the prevalence of low ALMI was 23.1% (25% in women and 21.74% in men). We found significant inverse correlations between ALMI and duration of diabetes and ALMI vs. FM; and significant positive correlations between ALMI and BMI, physical activity level and muscle strength. At the same time, significant inverse correlations were observed between muscle strength and duration of diabetes and muscle strength vs. FM. Conclusions We observed a high prevalence of low muscle mass, similar to those found in the older age groups of the general population (25 years in advance) and our findings suggest a possible pathogenetic role of T1D duration on muscle trophism and function. metadata Pollakova, Daniela; Tubili, Claudio; Folco, Ugo Di; De Giuseppe, Rachele; Battino, Maurizio y Giampieri, Francesca mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es, francesca.giampieri@uneatlantico.es (2023) Muscular involvement in long term type 1 diabetes: does it represent an underestimated complication? Nutrition. p. 112060. ISSN 08999007 ["page:item_not_available" not defined] |
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| 55. | Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Artículos y libros Cerrado Inglés Saponins, consisting of sapogenins as their aglycones and carbohydrate chains, are widely found in plants and some marine organisms. Due to the complexity of the structure of saponins, involving different types of sapogenins and sugar moieties, investigation of their absorption and metabolism is limited, which further hinders the explanation of their bioactivities. Large molecular weight and complex structures limit the direct absorption of saponins rendering their low bioavailability. As such, their major modes of action may be due to interaction with the gastrointestinal environment, such as enzymes and nutrients, and interaction with the gut microbiota. Many studies have reported the interaction between saponins and gut microbiota, that is, the effects of saponins on changing the composition of gut microbiota, and gut microbiota playing an indispensable role in the biotransformation of saponins into sapogenins. However, the metabolic routes of saponins by gut microbiota and their mutual interactions are still sparse. Thus, this review summarizes the chemistry, absorption, and metabolic pathways of saponins, as well as their interactions with gut microbiota and impacts on gut health, to better understand how saponins exert their health-promoting functions. metadata Zhang, Yu; Hao, Ruojie; Chen, Junda; Li, Sen; Huang, Kai; Cao, Hongwei; Farag, Mohamed A.; Battino, Maurizio; Daglia, Maria; Capanoglu, Esra; Zhang, Fan; Sun, Qiqi; Xiao, Jianbo; Sun, Zhenliang y Guan, Xiao mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR (2023) Health benefits of saponins and its mechanisms: perspectives from absorption, metabolism, and interaction with gut. Critical Reviews in Food Science and Nutrition. pp. 1-22. ISSN 1040-8398 ["page:item_not_available" not defined] | |
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Artículo
Materias > Alimentación
Universidad Europea del Atlántico > Investigación > Artículos y libros Fundación Universitaria Internacional de Colombia > Investigación > Producción Científica Universidad Internacional Iberoamericana México > Investigación > Producción Científica Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica Cerrado Inglés Manuka honey, which is rich in pinocembrin, quercetin, naringenin, salicylic, p-coumaric, ferulic, syringic and 3,4-dihydroxybenzoic acids, has been shown to have pleiotropic effects against colon cancer cells. In this study, potential chemosensitizing effects of Manuka honey against 5-Fluorouracil were investigated in colonspheres enriched with cancer stem cells (CSCs), which are responsible for chemoresistance. Results showed that 5-Fluorouracil increased when it was combined with Manuka honey by downregulating the gene expression of both ATP-binding cassette sub-family G member 2, an efflux pump and thymidylate synthase, the main target of 5-Fluorouracil which regulates the ex novo DNA synthesis. Manuka honey was associated with decreased self-renewal ability by CSCs, regulating expression of several genes in Wnt/β-catenin, Hedgehog and Notch pathways. This preliminary study opens new areas of research into the effects of natural compounds in combination with pharmaceuticals and, potentially, increase efficacy or reduce adverse effects. metadata Cianciosi, Danila; Armas Diaz, Yasmany; Alvarez-Suarez, José M.; Chen, Xiumin; Zhang, Di; Martínez López, Nohora Milena; Briones Urbano, Mercedes; Quiles, José L.; Amici, Adolfo; Battino, Maurizio y Giampieri, Francesca mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, nohora.martinez@uneatlantico.es, mercedes.briones@uneatlantico.es, jose.quiles@uneatlantico.es, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es, francesca.giampieri@uneatlantico.es (2023) Can the phenolic compounds of Manuka honey chemosensitize colon cancer stem cells? A deep insight into the effect on chemoresistance and self-renewal. Food Chemistry, 427. p. 136684. ISSN 03088146 ["page:item_not_available" not defined] |
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| 57. | Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Artículos y libros Cerrado Inglés Asparagus species is recognized as a perennial herb with several valuable functional ingredients, and has been widely used as medicine and food since ancient times. Among its main chemical constituents, saponins play a vital role in the health benefits and biological activities including anti-cancer, antioxidant, immunomodulatory, anti-microbial, anti-inflammatory, and hypoglycemic. This review summarizes the preparation methods, structure and classification, biological functions, as well as the food and non-food applications of asparagus saponins, with a special emphasis on its anti-cancer effects in vitro and in vivo. Further, the main challenges and limitations of the current research trends in asparagus saponins are highlighted after a detailed analysis of the recent research information. This review bridges the gap between bioactive components and human health and aids current research on functional and health-promoting foods and medicinal application of Asparagus saponins. metadata Zhang, Fan; Chen, Shengxiong; Zhang, Jianguo; Thakur, Kiran; Battino, Maurizio; Cao, Hui; Farag, Mohamed A.; Xiao, Jianbo y Wei, Zhaojun mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR (2023) Asparagus saponins: effective natural beneficial ingredient in functional foods, from preparation to applications. Critical Reviews in Food Science and Nutrition. pp. 1-19. ISSN 1040-8398 ["page:item_not_available" not defined] | |
| 58. | Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Artículos y libros Cerrado Inglés The aim of this study was to investigate the effects of enzymatic treatments (pectinase, pectin lyase, and cellulase) on the in vitro digestion and fermentation characteristics of whole mulberry fruit juice. The analysis focused on changes in carbohydrate properties within the black mulberry fruit matrix during simulated digestion and fermentation. Human fecal microbiota were collected and introduced to the fruit matrix to monitor the fate of both soluble and insoluble polysaccharides during fermentation. The results revealed that enzymatic treatments enhanced the solubilization of carbohydrates from mulberry fruits, with pectinase showing the most significant effect. Throughout the process of in vitro digestion, there was a gradual increase in the percentage of solubilized carbohydrates from the mulberry juice substrate. The digested suspensions underwent dialysis to remove degradation fragments, and a lower quantity of carbohydrate in the enzyme-treated groups compared to the control. Polysaccharide populations with varying molecular weights (Mw) were obtained from the soluble fractions of mulberry residues for subsequent fermentation. An increase in Mw of soluble polysaccharides was detected by HPSEC during fermentation in certain cases. The gut microbiota demonstrated the ability to convert specific insoluble fractions into soluble components, which were subsequently subjected to microbial utilization. Enzymatic treatments during mulberry juice preparation can potentially positively impact health by influencing gut microbiota and short-chain fatty acid (SCFA) modulations. Enzymes could serve as valuable tools for producing functional fruit and vegetable juices, with the need to specify processing conditions for specific raw materials remaining a subject of further investigation. metadata Luo, Peihuan; Ai, Jian; Wang, Yuxin; Wang, Songen; Schols, Henk A.; Smidt, Hauke; Battino, Maurizio; Bai, Weibin y Tian, Lingmin mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR (2024) Effects of enzymatic treatment on the in vitro digestion and fermentation patterns of mulberry fruit juice: A focus on carbohydrates. Food Hydrocolloids, 146. p. 109223. ISSN 0268005X ["page:item_not_available" not defined] | |
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Artículo
Materias > Biomedicina Materias > Alimentación Universidad Europea del Atlántico > Investigación > Artículos y libros Cerrado Inglés Malvidin is an O-methylated anthocyanidin, the 3′,5′-methoxy derivative of delphinidin responsible for the blue-red color found in flowers and fruits. Its distribution covers a wide group of sources, such as flowers (edible and nonedible), medicinal plants, and fruits. It is the main substance responsible for the color of red grapes and red wine, being Vitis vinifera one of its main sources. Its consumption is important as it has been associated with important biological effects, such as anti-inflammatory activity, powerful antioxidant activity, and anticancer activity. Against this background, this chapter presents a general overview of malvidin’s main sources, biosynthesis pathway and biotransformation properties, physicochemical properties and stability, and aspects of its absorption, metabolism, and excretion. Additionally, we summarize recent studies using in vitro and in vivo models related to its various biological properties. In conclusion, this chapter aims to provide as detailed a picture as possible of the potential of malvidin in human health, as well as its main sources, chemical characteristics, and biotransformation. metadata Alvarez-Suarez, José M.; Giampieri, Francesca; Tejera, Eduardo y Battino, Maurizio mail SIN ESPECIFICAR, francesca.giampieri@uneatlantico.es, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es (2023) Malvidin: Advances in the Resources, Biosynthesis Pathway, Bioavailability, Bioactivity, and Pharmacology. Handbook of Dietary Flavonoids. pp. 1-35. ["page:item_not_available" not defined] |
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| 60. | Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Artículos y libros Cerrado Inglés Diabetes is a metabolic disease due to impaired or defective insulin secretion and is considered one of the most serious chronic diseases worldwide. Gamma-aminobutyric acid (GABA) is a naturally occurring non-protein amino acid commonly present in a wide range of foods. A number of studies documented that GABA has good anti-diabetic potential. This review summarized the available dietary sources of GABA as well as animal and human studies on the anti-diabetic properties of GABA, while also discussing the underlying mechanisms. GABA may modulate diabetes through various pathways such as inhibiting the activities of α-amylase and α-glucosidase, promoting β-cell proliferation, stimulating insulin secretion from β-cells, inhibiting glucagon secretion from α-cells, improving insulin resistance and glucose tolerance, and increasing antioxidant and anti-inflammatory activities. However, further mechanistic studies on animals and human are needed to confirm the therapeutic effects of GABA against diabetes. metadata Sun, Yu; Mehmood, Arshad; Giampieri, Francesca; Battino, Maurizio y Chen, Xiumin mail SIN ESPECIFICAR, SIN ESPECIFICAR, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es, SIN ESPECIFICAR (2023) Insights into the cellular, molecular, and epigenetic targets of gamma-aminobutyric acid against diabetes: a comprehensive review on its mechanisms. Critical Reviews in Food Science and Nutrition. pp. 1-18. ISSN 1040-8398 ["page:item_not_available" not defined] |
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Enzymatic treatment shapes in vitro digestion pattern of phenolic compounds in mulberry juice
The health benefits of mulberry fruit are closely associated with its phenolic compounds. However, the effects of enzymatic treatments on the digestion patterns of these compounds in mulberry juice remain largely unknown. This study investigated the impact of pectinase (PE), pectin lyase (PL), and cellulase (CE) on the release of phenolic compounds in whole mulberry juice. The digestion patterns were further evaluated using an in vitro simulated digestion model. The results revealed that PE significantly increased chlorogenic acid content by 77.8 %, PL enhanced cyanidin-3-O-glucoside by 20.5 %, and CE boosted quercetin by 44.5 %. Following in vitro digestion, the phenolic compound levels decreased differently depending on the treatment, while cyanidin-3-O-rutinoside content increased across all groups. In conclusion, the selected enzymes effectively promoted the release of phenolic compounds in mulberry juice. However, during gastrointestinal digestion, the degradation of phenolic compounds surpassed their enhanced release, with effects varying based on the compound's structure.
Peihuan Luo mail , Jian Ai mail , Qiongyao Wang mail , Yihang Lou mail , Zhiwei Liao mail , Francesca Giampieri mail francesca.giampieri@uneatlantico.es, Maurizio Battino mail maurizio.battino@uneatlantico.es, Elwira Sieniawska mail , Weibin Bai mail , Lingmin Tian mail ,
Luo
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Background Before the incorporation of enfortumab vedotin with pembrolizumab, the standard of care for patients with locally advanced or metastatic urothelial carcinoma who do not progress after platinum-based chemotherapy was avelumab maintenance therapy, as demonstrated by the JAVELIN 100 trial. However, real-world European data remain scarce. Patients and Methods AVEBLADDER is a retrospective study conducted at 14 hospitals in Northern Spain, including patients with locally advanced or metastatic urothelial carcinoma diagnosed between January 2021 and June 2023. Outcomes of overall survival (OS) and progression-free survival (PFS) were analyzed for patients treated with platinum-based chemotherapy, with and without subsequent avelumab maintenance therapy. non-avelumab patients. Median PFS was 11.33 months (95% CI: 10–13.6) with avelumab and 6.43 months (95% CI: 6–7.6) without. One-year OS probabilities were 81.6% vs. 45.6% (p < 0.001) in the avelumab and non-avelumab groups, respectively. No unexpected toxicities were reported. Conclusions Despite proven survival benefits, avelumab uptake in real-world practice is limited by barriers like access, reimbursement, and awareness. These findings align with JAVELIN 100 and underscore the need for further real-world studies to address treatment disparities.
Marta Sotelo mail , Mireia Peláez mail mireia.pelaez@uneatlantico.es, Laura Basterretxea mail , Estrella Varga mail , Ricardo Sánchez-Escribano mail , Eduardo Pujol Obis mail , Carmen Santander mail , Mireia Martínez Kareaga mail , Mikel Arruti Ibarbia mail , Inmaculada Rodríguez Ledesma mail , Carlos Álvarez Fernández mail , Pablo Piedra mail , Verónica Calderero Aragón mail , Nuria Lainez mail , Juan Antonio Verdún Aguilar mail , Irene Gil Arnáiz mail , Ricardo Fernández mail , Cristina Mazas Pérez-Oleaga mail cristina.mazas@uneatlantico.es, Ignacio Duran mail ,
Sotelo
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Although financial literacy would seem relevant to university students’ education, it is not currently offered as a transversal subject within European academic curricula. It should therefore come as no surprise that a common solution are ad-hoc specific courses, with students often additionally acquiring valuable learning through their own experiences in business environments. With this and the recent literature on the drivers of financial literacy in mind, the authors decided to explore the context shaped by socio-demographic, academic and work-related factors that either promote or prevent European university students from developing appropriate financial skills, such as managing personal finances, planning for short- and long-term needs, and distinguishing among different sources of non-traditional funding. The study used a sample of 881 undergraduate and postgraduate university students from Romania, Poland and Spain from different studies, with information obtained through an anonymous online survey. The applied econometric model was cumulative regression with location-scale estimation using the R software, version 4.3.2, with variables associated directly with the development of basic financial skills being age, gender, country, but also specific training as well as work and entrepreneurial experience. The authors stress the importance of providing financial management education connected to the reality, especially the business and entrepreneurial environment.
Inna Alexeeva-Alexeev mail inna.alexeeva@uneatlantico.es, Ana Kaminska mail , Cristina Mazas Pérez-Oleaga mail cristina.mazas@uneatlantico.es, Sorin Gabriel Anton mail ,
Alexeeva-Alexeev
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A novel machine learning-based proposal for early prediction of endometriosis disease
Background Endometriosis is one of the causes of female infertility, with some studies estimating its prevalence at around 10 % of reproductive-age women worldwide and between 30 and 50 % in symptomatic women. However, its diagnosis is complex and often delayed, highlighting the need for more accessible and accurate diagnostic methods. The difficulty lies in its diverse etiology and the variability of symptoms among those affected. Methods This study proposes a predictive model based on supervised machine learning for the early identification of endometriosis, providing support for decision-making by healthcare professionals. For this purpose, an anonymised dataset of 5,143 female patients diagnosed with endometriosis at the private fertility clinic Inebir was used. The model integrates clinical records and genetic analysis through supervised machine learning algorithms, focusing on clinical variables and pathogenic and potentially pathogenic genetic variants. Results The developed predictive model achieves high accuracy in identifying the presence of endometriosis, highlighting the importance of combining clinical and genetic data in diagnosis. The integration of this data into the DELFOS platform, a clinical decision support system, demonstrates the utility of machine learning in improving the diagnosis of endometriosis. Conclusions The findings underscore the potential of clinical and genetic factors in the early diagnosis of endometriosis using supervised machine learning algorithms. This study contributes to the classification of clinical variables that influence endometriosis, offering a valuable tool for clinicians in making therapeutic and management decisions for their female patients.
Elena Enamorado-Díaz mail , Leticia Morales-Trujillo mail , Julián-Alberto García-García mail , Ana Teresa Marcos Rodríguez mail anateresa.marcos@uneatlantico.es, José Manuel Navarro-Pando mail jose.navarro@uneatlantico.es, María-José Escalona-Cuaresma mail ,
Enamorado-Díaz
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Detecting hate in diversity: a survey of multilingual code-mixed image and video analysis
The proliferation of damaging content on social media in today’s digital environment has increased the need for efficient hate speech identification systems. A thorough examination of hate speech detection methods in a variety of settings, such as code-mixed, multilingual, visual, audio, and textual scenarios, is presented in this paper. Unlike previous research focusing on single modalities, our study thoroughly examines hate speech identification across multiple forms. We classify the numerous types of hate speech, showing how it appears on different platforms and emphasizing the unique difficulties in multi-modal and multilingual settings. We fill research gaps by assessing a variety of methods, including deep learning, machine learning, and natural language processing, especially for complicated data like code-mixed and cross-lingual text. Additionally, we offer key technique comparisons, suggesting future research avenues that prioritize multi-modal analysis and ethical data handling, while acknowledging its benefits and drawbacks. This study attempts to promote scholarly research and real-world applications on social media platforms by acting as an essential resource for improving hate speech identification across various data sources.
Hafiz Muhammad Raza Ur Rehman mail , Mahpara Saleem mail , Muhammad Zeeshan Jhandir mail , Eduardo René Silva Alvarado mail eduardo.silva@funiber.org, Helena Garay mail helena.garay@uneatlantico.es, Imran Ashraf mail ,
Raza Ur Rehman