The Effect of Dietary Polyphenols on Vascular Health and Hypertension: Current Evidence and Mechanisms of Action
Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica Abierto Inglés The aim of this review was to explore existing evidence from studies conducted on humans and summarize the mechanisms of action of dietary polyphenols on vascular health, blood pressure and hypertension. There is evidence that some polyphenol-rich foods, including berry fruits rich in anthocyanins, cocoa and green tea rich in flavan-3-ols, almonds and pistachios rich in hydroxycinnamic acids, and soy products rich in isoflavones, are able to improve blood pressure levels. A variety of mechanisms can elucidate the observed effects. Some limitations of the evidence, including variability of polyphenol content in plant-derived foods and human absorption, difficulty disentangling the effects of polyphenols from other dietary compounds, and discrepancy of doses between animal and human studies should be taken into account. While no single food counteracts hypertension, adopting a plant-based dietary pattern including a variety of polyphenol-rich foods is an advisable practice to improve blood pressure metadata Grosso, Giuseppe; Godos, Justyna; Currenti, Walter; Micek, Agnieszka; Falzone, Luca; Libra, Massimo; Giampieri, Francesca; Forbes-Hernández, Tamara Y.; Quiles, José L.; Battino, Maurizio; La Vignera, Sandro y Galvano, Fabio mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, francesca.giampieri@uneatlantico.es, SIN ESPECIFICAR, jose.quiles@uneatlantico.es, maurizio.battino@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR (2022) The Effect of Dietary Polyphenols on Vascular Health and Hypertension: Current Evidence and Mechanisms of Action. Nutrients, 14 (3). p. 545. ISSN 2072-6643
|
Texto
nutrients-14-00545.pdf - Versión Publicada Available under License Creative Commons Attribution. Descargar (1MB) | Vista Previa |
Resumen
The aim of this review was to explore existing evidence from studies conducted on humans and summarize the mechanisms of action of dietary polyphenols on vascular health, blood pressure and hypertension. There is evidence that some polyphenol-rich foods, including berry fruits rich in anthocyanins, cocoa and green tea rich in flavan-3-ols, almonds and pistachios rich in hydroxycinnamic acids, and soy products rich in isoflavones, are able to improve blood pressure levels. A variety of mechanisms can elucidate the observed effects. Some limitations of the evidence, including variability of polyphenol content in plant-derived foods and human absorption, difficulty disentangling the effects of polyphenols from other dietary compounds, and discrepancy of doses between animal and human studies should be taken into account. While no single food counteracts hypertension, adopting a plant-based dietary pattern including a variety of polyphenol-rich foods is an advisable practice to improve blood pressure
| Tipo de Documento: | Artículo |
|---|---|
| Palabras Clave: | polyphenols; flavonoids; phenolic acids; hypertension; blood pressure; endothelial |
| Clasificación temática: | Materias > Alimentación |
| Divisiones: | Universidad Europea del Atlántico > Investigación > Producción Científica |
| Depositado: | 30 Mar 2022 23:55 |
| Ultima Modificación: | 17 Jul 2023 23:30 |
| URI: | https://repositorio.uneatlantico.es/id/eprint/594 |
Acciones (logins necesarios)
 |
Ver Objeto |
<a href="/10290/1/Influence%20of%20E-learning%20training%20on%20the%20acquisition%20of%20competences%20in%20basketball%20coaches%20in%20Cantabria.pdf" class="ep_document_link"><img class="ep_doc_icon" alt="[img]" src="/10290/1.hassmallThumbnailVersion/Influence%20of%20E-learning%20training%20on%20the%20acquisition%20of%20competences%20in%20basketball%20coaches%20in%20Cantabria.pdf" border="0"/></a>
en
open
The main aim of this study was to analyse the influence of e-learning training on the acquisition of competences in basketball coaches in Cantabria. The current landscape of basketball coach training shows an increasing demand for innovative training models and emerging pedagogies, including e-learning-based methodologies. The study sample consisted of fifty students from these courses, all above 16 years of age (36 males, 14 females). Among them, 16% resided outside the autonomous community of Cantabria, 10% resided more than 50 km from the city of Santander, 36% between 10 and 50 km, 14% less than 10 km, and 24% resided within Santander city. Data were collected through a Google Forms survey distributed by the Cantabrian Basketball Federation to training course students. Participation was voluntary and anonymous. The survey, consisting of 56 questions, was validated by two sports and health doctors and two senior basketball coaches. The collected data were processed and analysed using Microsoft® Excel version 16.74, and the results were expressed in percentages. The analysis revealed that 24.60% of the students trained through the e-learning methodology considered themselves fully qualified as basketball coaches, contrasting with 10.98% of those trained via traditional face-to-face methodology. The results of the study provide insights into important characteristics that can be adjusted and improved within the investigated educational process. Moreover, the study concludes that e-learning training effectively qualifies basketball coaches in Cantabria.
Josep Alemany Iturriaga mail josep.alemany@uneatlantico.es, Álvaro Velarde-Sotres mail alvaro.velarde@uneatlantico.es, Javier Jorge mail , Kamil Giglio mail ,
Alemany Iturriaga
en
close
Technological firms invest in R&D looking for innovative solutions but assuming high costs and great (technological) uncertainty regarding final results and returns. Additionally, they face other problems related to R&D management. This empirical study tries to determine which of the factors favour or constrain the decision of these firms to engage in R&D. The analysis uses financial data of 14,619 ICT listed companies of 22 countries from 2003 to 2018. Additionally, macroeconomic data specific for the countries and the sector were used. For the analysis of dynamic panel data, a System-GMM method is used. Among the findings, we highlight that cash flow, contrary to the known theoretical models and empirical evidences, negatively impacts on R&D investment. Debt is neither the right source for R&D funding, as the effect is also negative. This suggests that ICT companies are forced to manage their R&D activities differently, relying more on other funding sources, taking advantage of growth opportunities and benefiting from a favourable macroeconomic environment in terms of growth and increased business sector spending on R&D. These results are similar in both sub-sectors and in all countries, both bank- and market based. The exception is firms with few growth opportunities and little debt.
Inna Alexeeva-Alexeev mail inna.alexeeva@uneatlantico.es, Cristina Mazas Pérez-Oleag mail cristina.mazas@uneatlantico.es,
Alexeeva-Alexeev
<a href="/11592/1/fchem-12-1361980.pdf" class="ep_document_link"><img class="ep_doc_icon" alt="[img]" src="/11592/1.hassmallThumbnailVersion/fchem-12-1361980.pdf" border="0"/></a>
en
open
Background and objectives: As microbes are developing resistance to antibiotics, natural, botanical drugs or traditional herbal medicine are presently being studied with an eye of great curiosity and hope. Hence, complementary and alternative treatments for uncomplicated pelvic inflammatory disease (uPID) are explored for their efficacy. Therefore, this study determined the therapeutic efficacy and safety of Sesamum indicum Linn seeds with Rosa damascena Mill Oil in uPID with standard control. Additionally, we analyzed the data with machine learning. Materials and methods: We included 60 participants in a double-blind, double-dummy, randomized standard-controlled study. Participants in the Sesame and Rose oil group (SR group) (n = 30) received 14 days course of black sesame powder (5 gm) mixed with rose oil (10 mL) per vaginum at bedtime once daily plus placebo capsules orally. The standard group (SC), received doxycycline 100 mg twice and metronidazole 400 mg thrice orally plus placebo per vaginum for the same duration. The primary outcome was a clinical cure at post-intervention for visual analogue scale (VAS) for lower abdominal pain (LAP), and McCormack pain scale (McPS) for abdominal-pelvic tenderness. The secondary outcome included white blood cells (WBC) cells in the vaginal wet mount test, safety profile, and health-related quality of life assessed by SF-12. In addition, we used AdaBoost (AB), Naïve Bayes (NB), and Decision Tree (DT) classifiers in this study to analyze the experimental data. Results: The clinical cure for LAP and McPS in the SR vs SC group was 82.85% vs 81.48% and 83.85% vs 81.60% on Day 15 respectively. On Day 15, pus cells less than 10 in the SR vs SC group were 86.6% vs 76.6% respectively. No adverse effects were reported in both groups. The improvement in total SF-12 score on Day 30 for the SR vs SC group was 82.79% vs 80.04% respectively. In addition, our Naive Bayes classifier based on the leave-one-out model achieved the maximum accuracy (68.30%) for the classification of both groups of uPID. Conclusion: We concluded that the SR group is cost-effective, safer, and efficacious for curing uPID. Proposed alternative treatment (test drug) could be a substitute of standard drug used for Female genital tract infections.
X. Sumbul mail , Arshiya Sultana mail , Md Belal Bin Heyat mail , Khaleequr Rahman mail , Faijan Akhtar mail , Saba Parveen mail , Mercedes Briones Urbano mail mercedes.briones@uneatlantico.es, Vivian Lipari mail vivian.lipari@uneatlantico.es, Isabel De la Torre Díez mail , Azmat Ali Khan mail , Abdul Malik mail ,
Sumbul
<a class="ep_document_link" href="/11642/1/s41598-024-57547-4.pdf"><img class="ep_doc_icon" alt="[img]" src="/11642/1.hassmallThumbnailVersion/s41598-024-57547-4.pdf" border="0"/></a>
en
open
Extracting knowledge from hybrid data, comprising both categorical and numerical data, poses significant challenges due to the inherent difficulty in preserving information and practical meanings during the conversion process. To address this challenge, hybrid data processing methods, combining complementary rough sets, have emerged as a promising approach for handling uncertainty. However, selecting an appropriate model and effectively utilizing it in data mining requires a thorough qualitative and quantitative comparison of existing hybrid data processing models. This research aims to contribute to the analysis of hybrid data processing models based on neighborhood rough sets by investigating the inherent relationships among these models. We propose a generic neighborhood rough set-based hybrid model specifically designed for processing hybrid data, thereby enhancing the efficacy of the data mining process without resorting to discretization and avoiding information loss or practical meaning degradation in datasets. The proposed scheme dynamically adapts the threshold value for the neighborhood approximation space according to the characteristics of the given datasets, ensuring optimal performance without sacrificing accuracy. To evaluate the effectiveness of the proposed scheme, we develop a testbed tailored for Parkinson’s patients, a domain where hybrid data processing is particularly relevant. The experimental results demonstrate that the proposed scheme consistently outperforms existing schemes in adaptively handling both numerical and categorical data, achieving an impressive accuracy of 95% on the Parkinson’s dataset. Overall, this research contributes to advancing hybrid data processing techniques by providing a robust and adaptive solution that addresses the challenges associated with handling hybrid data, particularly in the context of Parkinson’s disease analysis.
Imran Raza mail , Muhammad Hasan Jamal mail , Rizwan Qureshi mail , Abdul Karim Shahid mail , Angel Olider Rojas Vistorte mail angel.rojas@uneatlantico.es, Md Abdus Samad mail , Imran Ashraf mail ,
Raza
<a href="/11644/1/unveiling-the-truth-a-systematic-review-of-fact-checking-and-fake-news-research-in-social-sciences-14455.pdf" class="ep_document_link"><img class="ep_doc_icon" alt="[img]" src="/11644/1.hassmallThumbnailVersion/unveiling-the-truth-a-systematic-review-of-fact-checking-and-fake-news-research-in-social-sciences-14455.pdf" border="0"/></a>
en
open
Unveiling the truth: A systematic review of fact-checking and fake news research in social sciences
The current media ecosystem, marked by immediacy and social networks dynamics, has created a fertile field for disinformation. Faced with its exponential growth, since 2014, research has focused on combating false content in the media. From a descriptive approach, this study has analyzed 200 documents on fact-checking and fake news published between 2014 and 2022 in scientific journals indexed in Scopus. This study has found that Europe and the United States are leading the way in the number of journals and authors publishing on the subject. The United States universities are the ones that host the most significant number of authors working on fact-checking, while the methodologies used, mostly ad hoc due to the novelty of the topic, allow to reflect on the need to promote work focused on the design, testing, and evaluation of prototypes or real experiences within the field. The most common contributions analyzed include typologies of false content and media manipulation mechanisms, models for evaluating and detecting disinformation, proposals to combat false content and strengthen verification mechanisms, studies on the role of social media in the spread of disinformation, efforts to develop media literacy among the public and journalists, case studies of fact-checkers, identification of factors that influence the belief in fake news, and analysis of the relationship between disinformation, verification, politics, and democracy. It is concluded that it is essential to develop research that connects the academy with the industry to raise awareness of the need to address these issues among the different actors in the media scenario.
Santiago Tejedor mail , Luis M. Romero-Rodríguez mail , Mónica Gracia Villar mail monica.gracia@uneatlantico.es,
Tejedor