The healthy effects of strawberry bioactive compounds on molecular pathways related to chronic diseases

Francesca Giampieri; Tamara Y. Forbes-Hernandez; Massimiliano Gasparrini; Sadia Afrin; Danila Cianciosi; Patricia Reboredo-Rodriguez; Alfonso Varela-Lopez; Jose L. Quiles; Bruno Mezzetti; Maurizio Battino

Resumen:

It is generally accepted that a fruit and vegetable–enriched diet is favorable for human health. The consumption of strawberries, in particular, has been related to the maintenance of well-being and the prevention of several chronic diseases, owing to the high contents of antioxidants and phytochemicals present in the fruit. Several biological effects have been explained through the total antioxidant capacity exerted by these bioactive compounds, but recently more intricate mechanisms have begun to be examined. In this context, it has been reported that strawberry phenolics are able to exert anti-inflammatory, anticarcinogenic, antiproliferative, and antiatherosclerotic activities, acting on specific molecular pathways related to antioxidant defenses, metabolism, survival, and proliferation. The overall aim of this work is to discuss and update the cellular and molecular mechanisms recently proposed to clarify the effects of strawberry phenolics on human health, with particular attention to the most common chronic diseases, such as metabolic syndrome, cardiovascular disease, and cancer.