Nutritional Modulation of Hepcidin in the Treatment of Various Anemic States

Article Subjects > Nutrition Europe University of Atlantic > Research > Articles and books Abierto Inglés Twenty years after its discovery, hepcidin is still considered the main regulator of iron homeostasis in humans. The increase in hepcidin expression drastically blocks the flow of iron, which can come from one’s diet, from iron stores, and from erythrophagocytosis. Many anemic conditions are caused by non-physiologic increases in hepcidin. The sequestration of iron in the intestine and in other tissues poses worrying premises in view of discoveries about the mechanisms of ferroptosis. The nutritional treatment of these anemic states cannot ignore the nutritional modulation of hepcidin, in addition to the bioavailability of iron. This work aims to describe and summarize the few findings about the role of hepcidin in anemic diseases and ferroptosis, as well as the modulation of hepcidin levels by diet and nutrients. metadata D’Andrea, Patrizia and Giampieri, Francesca and Battino, Maurizio mail UNSPECIFIED, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es (2023) Nutritional Modulation of Hepcidin in the Treatment of Various Anemic States. Nutrients, 15 (24). p. 5081. ISSN 2072-6643

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Abstract

Twenty years after its discovery, hepcidin is still considered the main regulator of iron homeostasis in humans. The increase in hepcidin expression drastically blocks the flow of iron, which can come from one’s diet, from iron stores, and from erythrophagocytosis. Many anemic conditions are caused by non-physiologic increases in hepcidin. The sequestration of iron in the intestine and in other tissues poses worrying premises in view of discoveries about the mechanisms of ferroptosis. The nutritional treatment of these anemic states cannot ignore the nutritional modulation of hepcidin, in addition to the bioavailability of iron. This work aims to describe and summarize the few findings about the role of hepcidin in anemic diseases and ferroptosis, as well as the modulation of hepcidin levels by diet and nutrients.

Item Type: Article
Uncontrolled Keywords: hepcidin; iron homeostasis; ferroptosis; anemia
Subjects: Subjects > Nutrition
Divisions: Europe University of Atlantic > Research > Articles and books
Date Deposited: 14 Dec 2023 23:30
Last Modified: 14 Dec 2023 23:30
URI: https://repositorio.uneatlantico.es/id/eprint/10095

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