TY - JOUR SN - 03088146 Y1 - 2025/12// A1 - Luo, Peihuan A1 - Ai, Jian A1 - Wang, Qiongyao A1 - Lou, Yihang A1 - Liao, Zhiwei A1 - Giampieri, Francesca A1 - Battino, Maurizio A1 - Sieniawska, Elwira A1 - Bai, Weibin A1 - Tian, Lingmin VL - 469 AV - none TI - Enzymatic treatment shapes in vitro digestion pattern of phenolic compounds in mulberry juice UR - http://doi.org/10.1016/j.foodchem.2024.142555 N2 - The health benefits of mulberry fruit are closely associated with its phenolic compounds. However, the effects of enzymatic treatments on the digestion patterns of these compounds in mulberry juice remain largely unknown. This study investigated the impact of pectinase (PE), pectin lyase (PL), and cellulase (CE) on the release of phenolic compounds in whole mulberry juice. The digestion patterns were further evaluated using an in vitro simulated digestion model. The results revealed that PE significantly increased chlorogenic acid content by 77.8 %, PL enhanced cyanidin-3-O-glucoside by 20.5 %, and CE boosted quercetin by 44.5 %. Following in vitro digestion, the phenolic compound levels decreased differently depending on the treatment, while cyanidin-3-O-rutinoside content increased across all groups. In conclusion, the selected enzymes effectively promoted the release of phenolic compounds in mulberry juice. However, during gastrointestinal digestion, the degradation of phenolic compounds surpassed their enhanced release, with effects varying based on the compound's structure. ID - uneatlantico15982 JF - Food Chemistry ER - TY - CHAP T2 - Bee Products ? Chemical and Biological Properties TI - Chemical Composition of Beeswax N2 - Beeswax is a complex natural substance consisting of more than 300 components. Currently, beeswax has many applications in cosmetics, medicine, food, and handicrafts because of its natural composition. The main chemical components of beeswax are presented in this chapter, such as esters, hydrocarbons, free acids, and free alcohols. As the largest component in beeswax, the main molecules, monoesters, diesters, and hydroxyesters, and the minor components, triesters and acidic esters, of esters compounds are discussed. In addition, other minor substances in beeswax are also described: aromatic and volatile compounds, a few minerals,v small amounts of phenolic compounds, flavonoids, and trace chemical elements such as Ca, Fe, Mn, Zn, and P. UR - http://doi.org/10.1007/978-3-031-89049-9_15 ID - uneatlantico17810 A1 - Chen, Ge A1 - Qian, Jingjing A1 - Bei, Yang A1 - Qi, Zexiu A1 - Cianciosi, Danila A1 - Armas Diaz, Yasmany A1 - Cassotta, Manuela A1 - Álvarez-Suárez, José M. A1 - Battino, Maurizio A1 - Giampieri, Francesca AV - none Y1 - 2025/05// SN - 978-3-031-89049-9 PB - Springer, Cham SP - 495 EP - 504 ER - TY - JOUR IS - 10 Y1 - 2025/05// SN - 2304-8158 AV - public KW - probiotics; psychiatric symptom; lipid profile; glycemic indices; inflammation; oxidative stress; meta-analysis A1 - Li, Lu A1 - Du, Fengqi A1 - Liu, Xilong A1 - Song, Mengyao A1 - Grosso, Giuseppe A1 - Battino, Maurizio A1 - Boesch, Christine A1 - Li, He A1 - Liu, Xinqi VL - 14 JF - Foods N2 - Supplementation with probiotics seems to confer protective effects in individuals with schizophrenia (SZ), although available results are inconclusive. The aim of this study was to systematically review existing randomized clinical trials (RCTs) to critically assess the effect of probiotics on psychiatric symptoms, anthropometric indicators, lipid profiles, glycemic indices, inflammation, and oxidative stress in adults with SZ. A systematic search was conducted in four databases from inception until January 2025. Six RCTs were included in the quantitative analysis that demonstrated beneficial effects of probiotics on SZ severity determined via the Positive and Negative Syndrome Scale (PANSS), with significant reductions in PANSS (MD = ?0.50, p = 0.001), PANSS Negative (MD = ?0.31, p = 0.050), and PANSS General scores (MD = ?0.33, p = 0.036), alongside reductions in body weight (MD = ?0.92, p = 0.000), body mass index (MD = ?0.53, p = 0.016), and total cholesterol (SMD = ?0.34, p = 0.005). Furthermore, probiotic interventions reduced baseline glucose (SMD = ?0.59, p = 0.000), insulin (MD = ?0.68, p = 0.000), and measures of insulin sensitivity/resistance and significantly improved biomarkers of inflammation and oxidative stress. To summarize, this meta-analysis suggests that probiotics may confer beneficial effects in patients with SZ through improving psychiatric symptoms as well as markers of body weight, lipid and glucose metabolism, inflammation, and oxidative stress. UR - http://doi.org/10.3390/foods14101773 ID - uneatlantico17811 TI - Effect of Supplementation with Probiotics in Patients with Schizophrenia: Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials ER - TY - CHAP EP - 519 SP - 505 PB - Springer, Cham SN - 978-3-031-89049-9 Y1 - 2025/05// AV - none A1 - Qian, Jingjing A1 - Chen, Ge A1 - Bei, Yang A1 - Qi, Zexiu A1 - Cianciosi, Danila A1 - Armas Diaz, Yasmany A1 - Cassotta, Manuela A1 - Álvarez-Suárez, José M. A1 - Battino, Maurizio A1 - Giampieri, Francesca UR - http://doi.org/10.1007/978-3-031-89049-9_16 ID - uneatlantico17803 N2 - Beeswax (BW) is the substance that forms the structure of a honeycomb, made by bees to store honey. Compared with honey and propolis, beeswax as a by-product possesses several favorable therapeutic properties and is of great interest to the scientific community. In this chapter, the various health benefits of beeswax and its applications are systematically introduced, including mainly the protection of skin disease, wound healing, oxidative damage, antimicrobial activities, and other health applications, with the aim to make more common the use of this by-product for human health. Beeswax, due to its beneficial components and special structural properties, could even assist in preventing and treating some types of cancers or some metabolic diseases, such as nonalcoholic fatty liver disease. Therefore, this chapter aims to update the major scientific works that have highlighted the various health benefits exerted by beeswax in different types of pathological conditions. T2 - Bee Products ? Chemical and Biological Properties TI - Health Benefits and Uses of Beeswax in Medicine ER - TY - JOUR SN - 08891575 Y1 - 2025/05// VL - 141 A1 - Shen, Lingqin A1 - Li, Jiashen A1 - Zou, Xiaobo A1 - Giampieri, Francesca A1 - Battino, Maurizio A1 - Zhang, Di AV - none TI - A phenol-interference decoupling method for hydroxyl-sanshools detection based on a modified electrode with magnesium-aluminum layered double hydroxide ID - uneatlantico17815 UR - http://doi.org/10.1016/j.jfca.2025.107365 N2 - In this work, a glassy carbon electrode modified with magnesium-aluminum layered double hydroxide (MgAl-LDH) was proposed to enhance the precision of hydroxy-sanshools quantification by mitigating polyphenol interference commonly found in the Zanthoxylum bungeanum pericarp during voltammetric assays. It was demonstrated that the MgAl-LDH-modified glassy carbon electrode effectively avoided the impact of polyphenols on hydroxy-sanshools by recovering their differential pulse voltammetric responses. Furthermore, the optimized method successfully quantified total hydroxy-sanshools in the linear range of 0.20?100.21?mg/g with good sensitivity (limit of detection and limit of quantification were 0.055 mg/L and 0.18 mg/L, respectively), and with recovery ranged from 95.66?% to 108.20?%. The intra-day and interday relative standard deviations were in the range of 0.43?3.13?% and 1.48?4.56?%, respectively. Additionally, the practicality of the developed approach was validated by quantifying hydroxy-sanshools in commercial Zanthoxylum bungeanum pericarp-related products, with results closely matching those obtained by high-performance liquid chromatography. These data reveals that the developed MgAl-LDH offers a novel strategy for modifying electrodes with high selectivity for the rapid monitoring of pungent substances in Zanthoxylum bungeanum pericarp. JF - Journal of Food Composition and Analysis ER - TY - JOUR SN - 2770-5986 Y1 - 2025/04// AV - public A1 - El Boukhari, Reda A1 - Matin, Maima A1 - Bouissane, Latifa A1 - ?awi?ski, Micha? A1 - Lushchak, Oleh A1 - Singla, Rajeev K. A1 - Mickael, Michel?Edwar A1 - Mayneris?Perxachs, Jordi A1 - Grafakou, Maria Eleni A1 - Xu, Shuhua A1 - Liu, Bowen A1 - Guan, Jiayi A1 - Pó?torak, Andrzej A1 - Szpicer, Arkadiusz A1 - Wierzbicka, Agnieszka A1 - Tzvetkov, Nikolay T. A1 - Banach, Maciej A1 - Horba?czuk, Jaros?aw Olav A1 - Jó?wik, Artur A1 - Cascella, Marco A1 - Shen, Bairong A1 - Pirgozliev, Vasil Radoslavov A1 - Wang, Dongdong A1 - Litvinova, Olena A1 - Adamska, Olga A1 - Kami?ska, Agnieszka A1 - ?api?ski, Marcin A1 - Stolarczyk, Artur A1 - Berindan?Neagoe, Ioana A1 - Milella, Luigi A1 - Yeung, Andy Wai Kan A1 - Suravajhala, Prashanth A1 - Bishayee, Anupam A1 - Lordan, Ronan A1 - Iantovics, Laszlo Barna A1 - Lagoa, Ricardo A1 - Michalczuk, Monika A1 - Stoyanov, Jivko A1 - Kinghorn, A. Douglas A1 - Jalil, Banaz A1 - Weckwerth, Wolfram A1 - Goh, Bey Hing A1 - Li, Meng?Yao A1 - Chaubey, Gyaneshwer A1 - Russo, Gian Luigi A1 - Frazzini, Sara A1 - Rossi, Luciana A1 - Battino, Maurizio A1 - Jia, Wei A1 - Su, Qi A1 - Ma, Xiaoqiang A1 - Rollinger, Judith M. A1 - Rittmann, Simon K.?M. R. A1 - Sheridan, Helen A1 - Walsh, John J. A1 - Lizard, Gérard A1 - Karpi?ski, Tomasz M. A1 - Silva, Ana Sanches A1 - Piwowarski, Jakub A1 - Xie, Liwei A1 - Fan, Tai?Ping A1 - Giampieri, Francesca A1 - El Midaoui, Adil A1 - Wong, Ka?Hing A1 - Gan, Ren?You A1 - Fatimi, Ahmed A1 - Atanasov, Atanas G. UR - http://doi.org/10.1002/imt2.70028 N2 - The microbiota, comprising all the microorganisms within the body, plays a critical role in maintaining good health. Dysbiosis represents a condition resulting from an imbalance or alteration of the microbiota. This study comprehensively investigates the patent literature on dysbiosis over the past 20 years. ID - uneatlantico17789 TI - Enhancing human gut health: Global innovations in dysbiosis management JF - iMeta ER - TY - JOUR Y1 - 2025/04// SN - 2666-3066 IS - 2 JF - eFood TI - Effects of a Garlic Hydrophilic Extract Rich in Sulfur Compounds on Redox Biology and Alzheimer's Disease Markers in Caenorhabditis Elegans N2 - Garlic is a horticultural product highly valued for its culinary and medicinal attributes. The aim of this study was to evaluate the composition of a garlic hydrophilic extract as well as the influence on redox biology, Alzheimer's Disease (AD) markers and aging, using Caenorhabditis elegans as experimental model. The extract was rich in sulfur compounds, highlighting the presence of other compounds like phenolics, and the antioxidant property was corroborated. Regarding AD markers, the acetylcholinesterase inhibitory capacity was demonstrated in vitro. Although the extract did not modify the amyloid ?-induced paralysis degree, it was able to improve, in a dose-dependent manner, some locomotive parameters affected by the hyperphosphorylated tau protein in C. elegans. It could be related to the effect found on GFP-transgenic stains, mainly regarding to the increase in the gene expression of HSP-16.2. Moreover, an initial investigation into the aging process revealed that the extract successfully inhibited the accumulation of intracellular and mitochondrial reactive oxygen species in aged worms. These results provide valuable insights into the multifaceted impact of garlic extract, particularly in the context of aging and neurodegenerative processes. This study lays a foundation for further research avenues exploring the intricate molecular mechanisms underlying garlic effects and its translation into potential therapeutic interventions for age-related neurodegenerative conditions. UR - http://doi.org/10.1002/efd2.70044 ID - uneatlantico17570 A1 - Navarro?Hortal, María D. A1 - Romero?Marquez, Jose M. A1 - Ansary, Johura A1 - Montalbán?Hernández, Cristina A1 - Varela?López, Alfonso A1 - Giampieri, Francesca A1 - Xiao, Jianbo A1 - Calderón Iglesias, Rubén A1 - Battino, Maurizio A1 - Sánchez?González, Cristina A1 - Forbes?Hernández, Tamara Y. A1 - Quiles, José L. VL - 6 KW - acetylcholinesterase | aging | amyloid | heat shock protein | natural product | tau protein AV - public ER - TY - JOUR AV - public KW - acetylcholinesterase (AChE) | by-product | Caenorhabditis elegans | cyclooxygenase-2 (COX-2) | ferric reducing antioxidant power (FRAP) |glutathione (GSH) | phytochemical A1 - Romero?Marquez, Jose M. A1 - Navarro?Hortal, María D. A1 - Varela?López, Alfonso A1 - Calderón Iglesias, Rubén A1 - Puentes, Juan G. A1 - Giampieri, Francesca A1 - Battino, Maurizio A1 - Sánchez?González, Cristina A1 - Xiao, Jianbo A1 - García?Ruiz, Roberto A1 - Sánchez, Sebastián A1 - Forbes?Hernández, Tamara Y. A1 - Quiles, José L. N2 - Alzheimer's disease (AD) involves ?-amyloid plaques and tau hyperphosphorylation, driven by oxidative stress and neuroinflammation. Cyclooxygenase-2 (COX-2) and acetylcholinesterase (AChE) activities exacerbate AD pathology. Olive leaf (OL) extracts, rich in bioactive compounds, offer potential therapeutic benefits. This study aimed to assess the anti-inflammatory, anti-cholinergic, and antioxidant effects of three OL extracts (low, mid, and high bioactive content) in vitro and their protective effects against AD-related proteinopathies in Caenorhabditis elegans models. OL extracts were characterized for phenolic composition, AChE and COX-2 inhibition, as well as antioxidant capacity. Their effects on intracellular and mitochondrial reactive oxygen species (ROS) were tested in C. elegans models expressing human A? and tau proteins. Gene expression analyses examined transcription factors (DAF-16, skinhead [SKN]-1) and their targets (superoxide dismutase [SOD]-2, SOD-3, GST-4, and heat shock protein [HSP]-16.2). High-OL extract demonstrated superior AChE and COX-2 inhibition and antioxidant capacity. Low- and high-OL extracts reduced A? aggregation, ROS levels, and proteotoxicity via SKN-1/NRF-2 and DAF-16/FOXO pathways, whereas mid-OL showed moderate effects through proteostasis modulation. In tau models, low- and high-OL extracts mitigated mitochondrial ROS levels via SOD-2 but had limited effects on intracellular ROS levels. High-OL extract also increased GST-4 levels, whereas low and mid extracts enhanced GST-4 levels. OL extracts protect against AD-related proteinopathies by modulating oxidative stress, inflammation, and proteostasis. High-OL extract showed the most promise for nutraceutical development due to its robust phenolic profile and activation of key antioxidant pathways. Further research is needed to confirm long-term efficacy. UR - http://doi.org/10.1002/fft2.70013 ID - uneatlantico17569 TI - Olive Leaf Extracts With High, Medium, or Low Bioactive Compounds Content Differentially Modulate Alzheimer's Disease via Redox Biology JF - Food Frontiers SN - 2643-8429 Y1 - 2025/04// ER - TY - JOUR UR - http://doi.org/10.1016/j.tifs.2025.104980 ID - uneatlantico17541 N2 - Background The gut-brain axis is a complex communication network that connects the gastrointestinal system with the central nervous system, significantly influencing various health outcomes, such as mental health, cognitive function, metabolic regulation, and immune responses. While traditional research models, particularly animal studies, have provided valuable insights, they often overlook the intricate and human-specific interactions within this axis. Consequently, translating findings from these models into clinical applications has been challenging. However, recent advancements in human-based Novel Approach Methodologies (NAMs), like organoids, organs-on-chip, and omic sciences, present innovative tools for investigating the gut-brain axis with improved accuracy and relevance to human physiology. These methodologies facilitate a deeper understanding of the molecular and cellular mechanisms by which nutritional interventions affect not only mental health but also a wider range of gut-brain-related health outcomes. Scope and approach: Scope and approach: This paper explores how NAMs are revolutionizing gut-brain axis research by providing more accurate models that replicate human physiology, thereby replacing less effective traditional approaches. Key findings and conclusion By using these advanced methods, researchers can produce detailed data that better mirror human responses to dietary components, resulting in more effective and personalized strategies for managing and enhancing gut-brain health. Future research should concentrate on utilizing NAMs to deepen our understanding of the gut-brain axis in nutritional science, which will ultimately lead to more targeted and effective health interventions for various conditions. TI - Modernizing gut-brain axis research in nutritional Science: The role of human-centered New Approach Methodologies JF - Trends in Food Science & Technology AV - public KW - Gut-brain axis; Nutrition; Organoids; Organs-on-chip; Omics A1 - Cassotta, Manuela A1 - Armas Diaz, Yasmany A1 - Qi, Zexiu A1 - Yang, Bei A1 - Grosso, Giuseppe A1 - Quiles, José L. A1 - Battino, Maurizio A1 - Godos, Justyna A1 - Giampieri, Francesca VL - 159 SN - 09242244 Y1 - 2025/03// ER - TY - JOUR A1 - Cassotta, Manuela A1 - Elexpuru Zabaleta, Maria A1 - Sumalla Cano, Sandra A1 - Diaz, Yasmany Armas A1 - Giampieri, Francesca A1 - Xiaobo, Zou A1 - Zhang, Di A1 - Grosso, Giuseppe A1 - Battino, Maurizio AV - public KW - alternatives to animal testing; ecotoxicology; food safety; nutrition research; One Health; organ-on-chip TI - Organ?on?Chip: The Future of Nutrition Research in a One Health World UR - http://doi.org/10.1002/fft2.70000 ID - uneatlantico17451 N2 - The One Health approach emphasizes the interconnectedness of human, animal, and environmental health, recognizing that the health of each is interdependent and influenced by shared ecosystems. Nutrition research plays a critical role in improving health outcomes across these domains, with implications for sustainability and food security. Organ-on-chip (OoC) technologies have emerged as innovative tools replicating key organ functions, supporting disease modeling, drug discovery, and personalized medicine. They also hold promise as alternatives to traditional animal models. This systematic review examines the potential of OoC technologies within the One Health framework and nutrition research, focusing on (1) their ability to replicate human and animal organ functions, (2) applications in food safety and ecotoxicology, and (3) their use in studying food components? health effects. Challenges and future directions for adoption are also discussed. Although fully replicating the complexity of in vivo physiology remains a challenge, OoCs offer a promising platform to simulate organ functions and interactions. These systems hold significant potential for advancing food safety assessments, studying food impacts on health, and addressing sustainability in food systems. Challenges such as standardization, scalability, accessibility, and biases toward traditional models remain. Despite these hurdles, current advancements underscore the versatility and promise of OoCs, positioning them as valuable tools for driving innovation in nutrition research, food and feed safety, and ecotoxicology. With continued progress, OoCs are poised to make significant contributions to the goals of the One Health framework. JF - Food Frontiers SN - 2643-8429 Y1 - 2025/03// ER - TY - JOUR A1 - Qi, Zexiu A1 - Yang, Bei A1 - Armas Diaz, Yasmany A1 - Cassotta, Manuela A1 - Cianciosi, Danila A1 - Mezzetti, Bruno A1 - Quiles, José L. A1 - Bo Xiao, Jian A1 - Zhang, Di A1 - Xiaobo, Zou A1 - Chen, Xiumin A1 - Battino, Maurizio A1 - Giampieri, Francesca VL - 15 AV - none KW - mulberry leaf; mulberry branch; mulberry root; cardiovascular diseases JF - Journal of Berry Research TI - Therapeutic potential of mulberry ( Morus alba L. ) byproducts for cardiovascular diseases N2 - Besides mulberry fruit, mulberry (Morus alba L.) has many byproducts, including leaves, branches, and roots. Although these byproducts have long been used as traditional Chinese medicine, their use is limited mainly to rheumatism, diabetes, arthritis. These natural products have a variety of bioactive ingredients, including flavonoids, alkaloids, polysaccharides, with antioxidant, anti-inflammatory, lipid-lowering and other biological functions. This review introduces the bioactive ingredients of mulberry leaves, branches, and roots and discusses their potential in alleviating cardiovascular diseases from antioxidant, anti-inflammatory, lipid regulation, blood glucose regulation, vascular protection and other aspects. UR - http://doi.org/10.1177/18785093251320209 ID - uneatlantico17816 EP - 11 SP - 3 IS - 1 Y1 - 2025/03// SN - 1878-5093 ER - TY - JOUR IS - 3 SN - 2072-6643 Y1 - 2025/01// VL - 17 A1 - Godos, Justyna A1 - Giampieri, Francesca A1 - Frias-Toral, Evelyn A1 - Zambrano-Villacres, Raynier A1 - Rojas Vistorte, Angel Olider A1 - Yélamos Torres, Vanessa A1 - Battino, Maurizio A1 - Galvano, Fabio A1 - Castellano, Sabrina A1 - Grosso, Giuseppe AV - public KW - nuts; cognitive; Mediterranean diet TI - Nut Consumption Is Associated with Cognitive Status in Southern Italian Adults UR - http://doi.org/10.3390/nu17030521 ID - uneatlantico16577 N2 - Background: Nut consumption has been considered a potential protective factor against cognitive decline. The aim of this study was to test whether higher total and specific nut intake was associated with better cognitive status in a sample of older Italian adults. Methods: A cross-sectional analysis on 883 older adults (>50 y) was conducted. A 110-item food frequency questionnaire was used to collect information on the consumption of various types of nuts. The Short Portable Mental Status Questionnaire was used to assess cognitive status. Multivariate logistic regression analyses were performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between nut intake and cognitive status after adjusting for potential confounding factors. Results: The median intake of total nuts was 11.7 g/day and served as a cut-off to categorize low and high consumers (mean intake 4.3 g/day vs. 39.7 g/day, respectively). Higher total nut intake was significantly associated with a lower prevalence of impaired cognitive status among older individuals (OR = 0.35, CI 95%: 0.15, 0.84) after adjusting for potential confounding factors. Notably, this association remained significant after additional adjustment for adherence to the Mediterranean dietary pattern as an indicator of diet quality, (OR = 0.32, CI 95%: 0.13, 0.77). No significant associations were found between cognitive status and specific types of nuts. Conclusions: Habitual nut intake is associated with better cognitive status in older adults. JF - Nutrients ER - TY - JOUR IS - 3 Y1 - 2025/01// SN - 2072-6643 KW - pyroptosis; dietary bioactive compounds; inflammation; inflammasome; human disease treatment AV - public VL - 17 A1 - Yang, Bei A1 - Qi, Zexiu A1 - Armas Diaz, Yasmany A1 - Cassotta, Manuela A1 - Grosso, Giuseppe A1 - Cianciosi, Danila A1 - Zhang, Di A1 - Zou, Xiaobo A1 - Quiles, José L. A1 - Battino, Maurizio A1 - Giampieri, Francesca JF - Nutrients N2 - Background/Objectives: Bioactive compounds possess the ability to maintain health and improve diseases by regulating inflammation and cell death processes. Pyroptosis is programmed cell death related to inflammation and exerts a critical role in the development and progression of different types of diseases. This narrative review aims to investigate and discuss the effects of dietary bioactive compounds on pyroptosis in different common human pathologies, such as inflammatory disease, bacterial infection, injury disease, cancer, diabetes and heart disease, etc. Method: Studies published in the major databases until December 2024 in English were considered, for a total of 50 papers. Results: The current evidence demonstrated that the bioactive compounds are able to regulate the pyroptosis process by modulating different inflammasome sensors (NLRP1, NLRP3, and AIM2), caspase family proteins (caspase-1, caspase-3, and caspase-11), and gasdermins (GSDMD and GSDME) in many pathological conditions related to inflammation, including cancer and cardiovascular diseases. Conclusions: Bioactive compounds have powerful potential to be the candidate drug for pyroptosis modulation in inflammatory diseases, even if more clinical studies are needed to confirm the effects and establish efficient doses for humans. UR - http://doi.org/10.3390/nu17030461 ID - uneatlantico16579 TI - Pyroptosis: A Novel Therapeutic Target for Bioactive Compounds in Human Disease Treatment? A Narrative Review ER - TY - CHAP SN - 978-1-83916-686-0 Y1 - 2025/// M1 - 45 PB - Royal Society of Chemistry EP - 180 SP - 165 TI - Coffee and Oxidative Stress T2 - Coffee and Human Health UR - http://doi.org/10.1039/9781839166853-00165 ID - uneatlantico17801 N2 - Oxidative stress and inflammation are two of the main risk factors for the onset and progression of many common human pathologies, including metabolic disorders, cardiovascular diseases and some types of cancer. A successful strategy to reduce the chronic state of oxidative stress and inflammation could be the adoption of a healthy diet, enriched with food and beverages with well-known antioxidant and anti-inflammatory compounds. Coffee, one of the most common beverages in the world, is a very complex mixture of more than one thousand bioactive compounds, which play a key role in human health, thanks to their antioxidant and anti-inflammatory activities. In this chapter, the most important results obtained from human studies evaluating the effects of coffee consumption on the main biomarkers of oxidative stress and inflammation will be presented and discussed. A1 - Qi, Zexiu A1 - Yang, Bei A1 - Cianciosi, Danila A1 - Diaz, Yasmany Armas A1 - Salinari, Alessia A1 - Machì, Michele A1 - Alvarez-Suarez, José Miguel A1 - Battino, Maurizio A1 - Giampieri, Francesca AV - none ER - TY - JOUR JF - Foods TI - A Plant-Based Food Guide Adapted for Low-Fat Diets: The VegPlate Low-Fat (VP_LF) ID - uneatlantico16271 UR - http://doi.org/10.3390/foods13244050 N2 - Strong evidence supports the paramount importance of the composition of the diet for health. Not only diet should provide nutritional adequacy, but some foods and dietary components can also support the management of common chronic diseases, with mechanisms independent of nutritional adequacy. Among the various intervention diets, low-fat vegan diets have been shown to be effective for cardiometabolic health, mainly influencing insulin resistance, adiposity, and blood lipids. This type of diet relies on reducing or eliminating all added fats and choosing low-fat foods, mainly unprocessed whole-plant foods. We hereby propose a tool for planning low-fat vegan diets, the VegPlate Low-Fat (VP_LF), which has been obtained from a specific adaptation of the VegPlate method, which was already presented in previous publications for adults and some life stages and situations. The reduction in fats in the diet, which ranges between 10% and 15% of total energy, and the varied inclusion of foods from plant groups make it easier to provide adequate amounts of all nutrients with a normal- or lower-calorie intake, in comparison with diets that do not limit fat intakes. We expect that this new proposal will help nutrition professionals embrace low-fat diets as a first-line intervention for individuals affected by different health conditions who can benefit from these diets. A1 - Baroni, Luciana A1 - Rizzo, Gianluca A1 - Zavoli, Martina A1 - Battino, Maurizio VL - 13 AV - public KW - low-fat diet; vegan diet; food guide; VegPlate Y1 - 2024/12// SN - 2304-8158 IS - 24 ER - TY - JOUR SN - 1933-7191 Y1 - 2024/11// TI - Establishment of 3D Cultures of Myometrium, Leiomyoma, and Leiomyosarcoma Cells: Advantages and Disadvantages of Two Different Models ID - uneatlantico15286 UR - http://doi.org/10.1007/s43032-024-01724-3 N2 - Uterine leiomyomas are the most common benign, monoclonal, gynaecological tumors in a woman?s uterus, while leiomyosarcoma is a rare but aggressive condition caused by the malignant transformation of the myometrium. To overcome the common obstacles related to the methods usually used to study these pathologies, we aimed to devise three-dimensional models of myometrium, uterine leiomyoma and leiomyosarcoma cell lines, using two different types of biocompatible scaffolds. Specifically, we exploited the agarose gel matrix in common 6-well plates and the alginate matrix using Bioprinting INKREDIBLE?+?(CELLINK), a pneumatic extruded base equipped with a system with double printheads, and a UV printer LED curing system. Both methods allowed the development of 3D spheroids of all three cell types, that were also suitable for morphological investigations. We showed that all cell types embedded in both agarose and alginate formed spheroids in their growth medium. The spheroids successfully proliferated and self-organized into complex structures, developing a sustainable system that emulated the condition of the tissues through the accumulation of extracellular matrix. These models could be useful for a better understanding of pathophysiology, etiopathogenesis, and testing new methods or molecules from a preventive and therapeutic point of view. JF - Reproductive Sciences A1 - Pellegrino, Pamela A1 - Greco, Stefania A1 - Duménigo Gonzàlez, Abel A1 - Giampieri, Francesca A1 - Giannubilo, Stefano Raffaele A1 - Delli Carpini, Giovanni A1 - Capocasa, Franco A1 - Mezzetti, Bruno A1 - Battino, Maurizio A1 - Ciavattini, Andrea A1 - Ciarmela, Pasquapina AV - none KW - Agarose; 3D Bioprinter;Spheroid; Myometrium; Leiomyoma; Leiomyosarcoma ER - TY - JOUR A1 - Cassotta, Manuela A1 - Quiles, José L. A1 - Giampieri, Francesca A1 - Battino, Maurizio VL - 17 AV - none TI - Aging, age-related diseases, oxidative stress and plant polyphenols: Is this a true relationship? N2 - Aging is a physiological process characterized by a progressive deterioration of all the biological functions and a marked reduction in stress resistance, thus resulting in an increased susceptibility to several pathologies UR - http://doi.org/10.3233/MNM-240057 ID - uneatlantico14370 JF - Mediterranean Journal of Nutrition and Metabolism IS - 3 SP - 255 EP - 259 SN - 1973798X Y1 - 2024/09// ER - TY - JOUR IS - 1 Y1 - 2024/08// SN - 1720-8319 AV - public KW - Fish; Dementia; Cognitive status; Alzheimer?s disease; Meta-analysis VL - 36 A1 - Godos, Justyna A1 - Micek, Agnieszka A1 - Currenti, Walter A1 - Franchi, Carlotta A1 - Poli, Andrea A1 - Battino, Maurizio A1 - Dolci, Alberto A1 - Ricci, Cristian A1 - Ungvari, Zoltan A1 - Grosso, Giuseppe JF - Aging Clinical and Experimental Research UR - http://doi.org/10.1007/s40520-024-02823-6 N2 - Background Cognitive impairment is projected to affect a preponderant proportion of the aging population. Lifelong dietary habits have been hypothesized to play a role in preventing cognitive decline. Among the most studied dietary components, fish consumptionhas been extensively studied for its potential effects on the human brain. Aims To perform a meta-analysis of observational studies exploring the association between fish intake and cognitive impairment/decline and all types of dementia. Methods A systematic search of electronic databases was performed to identify observational studies providing quantitative data on fish consumption and outcomes of interest. Random effects models for meta-analyses using only extreme exposure categories, subgroup analyses, and dose-response analyses were performed to estimate cumulative risk ratios (RRs) and 95% confidence intervals (CIs). Results The meta-analysis comprised 35 studies. Individuals reporting the highest vs. the lowest fish consumption were associated with a lower likelihood of cognitive impairment/decline (RR?=?0.82, 95% CI: 0.75, 0.90, I2?=?61.1%), dementia (RR?=?0.82, 95% CI: 0.73, 0.93, I2?=?38.7%), and Alzheimer?s disease (RR?=?0.80, 95% CI: 0.67, 0.96, I2?=?20.3%). The dose-response relation revealed a significantly decreased risk of cognitive impairment/decline and all cognitive outcomes across higher levels of fish intake up to 30% for 150 g/d (RR?=?0.70, 95% CI: 0.52, 0.95). The results of this relation based on APOE ?4 allele status was mixed based on the outcome investigated. Conclusions Current findings suggest fish consumption is associated with a lower risk of cognitive impairment/decline in a dose-response manner, while for dementia and Alzheimer?s disease there is a need for further studies to improve the strength of evidence. ID - uneatlantico14336 TI - Fish consumption, cognitive impairment and dementia: an updated dose-response meta-analysis of observational studies ER - TY - JOUR Y1 - 2024/07// SN - 2304-8158 IS - 15 JF - Foods N2 - Vegetarian diets are plant-based diets including all the edible foods from the Plant Kingdom, such as grains, legumes, vegetables, fruits, nuts, and seeds. Dairy and eggs can be added in small amounts in the lacto-ovo-vegetarian subtype, or not at all in the vegan subtype. The abundance of non-processed plant foods?typical of all well-planned diets, including vegetarian ones?can provide the body with numerous protective factors (fiber, phytocompounds), while limiting the intake of harmful nutrients like saturated fats, heme-iron, and cholesterol. The beneficial effects on health of this balance have been reported for many main chronic diseases, in both observational and intervention studies. The scientific literature indicates that vegetarians have a lower risk of certain types of cancer, overall cancer, overweight-obesity, type 2 diabetes, dyslipidemia, hypertension, and vascular diseases. Since the trend of following a vegetarian diet is increasing among citizens of developed countries, the knowledge in the field will benefit from further studies confirming the consistency of these findings and clarifying the effects of vegetarian diets on other controversial topics. UR - http://doi.org/10.3390/foods13152398 ID - uneatlantico14364 TI - Health Benefits of Vegetarian Diets: An Insight into the Main Topics KW - vegetarian diet; lacto-ovo-vegetarian diet; vegan diet; plant-based diet; health; noncommunicable diseases AV - public VL - 13 A1 - Baroni, Luciana A1 - Rizzo, Gianluca A1 - Galchenko, Alexey Vladimirovich A1 - Zavoli, Martina A1 - Serventi, Luca A1 - Battino, Maurizio ER - TY - JOUR SN - 2072-6643 Y1 - 2024/07// IS - 15 ID - uneatlantico14366 UR - http://doi.org/10.3390/nu16152471 N2 - Cardiovascular diseases (CVDs) are one of the main causes of mortality and morbidity worldwide. A healthy diet rich in plant-derived compounds such as (poly)phenols appears to have a key role in improving cardiovascular health. Flavan-3-ols represent a subclass of (poly)phenols of great interest for their possible health benefits. In this review, we summarized the results of clinical studies on vascular outcomes of flavan-3-ol supplementation and we focused on the role of the microbiota in CVD. Clinical trials included in this review showed that supplementation with flavan-3-ols mostly derived from cocoa products significantly reduces blood pressure and improves endothelial function. Studies on catechins from green tea demonstrated better results when involving healthy individuals. From a mechanistic point of view, emerging evidence suggests that microbial metabolites may play a role in the observed effects. Their function extends beyond the previous belief of ROS scavenging activity and encompasses a direct impact on gene expression and protein function. Although flavan-3-ols appear to have effects on cardiovascular health, further studies are needed to clarify and confirm these potential benefits and the rising evidence of the potential involvement of the microbiota. TI - Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action JF - Nutrients KW - flavan-3-ols; polyphenols; inflammation; vascular; gut microbiota AV - public A1 - Godos, Justyna A1 - Romano, Giovanni Luca A1 - Laudani, Samuele A1 - Gozzo, Lucia A1 - Guerrera, Ida A1 - Dominguez Azpíroz, Irma A1 - Martínez Díaz, Raquel A1 - Quiles, José L. A1 - Battino, Maurizio A1 - Drago, Filippo A1 - Giampieri, Francesca A1 - Galvano, Fabio A1 - Grosso, Giuseppe VL - 16 ER - TY - JOUR SN - 2042-6496 Y1 - 2024/06// UR - http://doi.org/10.1039/D4FO00943F ID - uneatlantico12748 N2 - Colorectal cancer often leads to metastasis, with cancer stem cells (CSCs) playing a pivotal role in this process. Two closely linked mechanisms, epithelial-mesenchymal transition and angiogenesis, contribute to metastasis and recent research has also highlighted the impact of telomere replication on this harmful tumor progression. Standard chemotherapy alone can inadvertently promote drug-resistant CSCs, posing a challenge. Combining chemotherapy with other compounds, including natural ones, shows promise in enhancing effectiveness while minimizing side effects. This study investigated the anti-metastatic potential of Manuka honey, both alone and in combination with 5-Fluorouracil, using a 3D model of colon spheres enriched with CSCs-like cells. In summary, it was observed that the treatment reduced migration ability by increasing the expression of E-cadherin through the downregulation of transcription factors Slug, Snail, and Twist. Additionally, it downregulated pro-angiogenic factors and shortened CSC telomeres by downregulating c-Myc, demonstrating an effective anti-metastatic potential. This study suggests new research opportunities for studying the impact of natural compounds when combined with pharmaceuticals, with the potential to enhance effectiveness and reduce side effects. TI - The anti-metastatic effect of Manuka honey on colonspheres enriched with cancer stem cells: how does it influence the epithelial-mesenchymal transition process, angiogenesis, and telomere length? JF - Food & Function AV - none A1 - Cianciosi, Danila A1 - Forbes-Hernández, Tamara Yuliett A1 - Armas Diaz, Yasmany A1 - Elexpuru Zabaleta, Maria A1 - Quiles, José L. A1 - Battino, Maurizio A1 - Giampieri, Francesca ER - TY - JOUR VL - 11 A1 - Regolo, Lucia A1 - Giampieri, Francesca A1 - Battino, Maurizio A1 - Armas Diaz, Yasmany A1 - Mezzetti, Bruno A1 - Elexpuru Zabaleta, Maria A1 - Mazas Pérez-Oleaga, Cristina A1 - Tutusaus, Kilian A1 - Mazzoni, Luca KW - circular economy KW - leaves KW - bioactive compounds KW - health KW - food industry KW - cosmetics AV - public TI - From by-products to new application opportunities: the enhancement of the leaves deriving from the fruit plants for new potential healthy products UR - http://doi.org/10.3389/fnut.2024.1083759 N2 - In the last decades, the world population and demand for any kind of product have grown exponentially. The rhythm of production to satisfy the request of the population has become unsustainable and the concept of the linear economy, introduced after the Industrial Revolution, has been replaced by a new economic approach, the circular economy. In this new economic model, the concept of ?the end of life? is substituted by the concept of restoration, providing a new life to many industrial wastes. Leaves are a by-product of several agricultural cultivations. In recent years, the scientific interest regarding leaf biochemical composition grew, recording that plant leaves may be considered an alternative source of bioactive substances. Plant leaves? main bioactive compounds are similar to those in fruits, i.e., phenolic acids and esters, flavonols, anthocyanins, and procyanidins. Bioactive compounds can positively influence human health; in fact, it is no coincidence that the leaves were used by our ancestors as a natural remedy for various pathological conditions. Therefore, leaves can be exploited to manufacture many products in food (e.g., being incorporated in food formulations as natural antioxidants, or used to create edible coatings or films for food packaging), cosmetic and pharmaceutical industries (e.g., promising ingredients in anti-aging cosmetics such as oils, serums, dermatological creams, bath gels, and other products). This review focuses on the leaves? main bioactive compounds and their beneficial health effects, indicating their applications until today to enhance them as a harvesting by-product and highlight their possible reuse for new potential healthy products. ID - uneatlantico12749 JF - Frontiers in Nutrition SN - 2296-861X Y1 - 2024/06// ER - TY - JOUR JF - Postharvest Biology and Technology TI - Blue light inhibits gray mold infection by inducing disease resistance in cherry tomato ID - uneatlantico13004 UR - http://doi.org/10.1016/j.postharvbio.2024.113006 N2 - Induced resistance is considered as a sustainable strategy to control postharvest decay of fruits, while light emitting diodes (LEDs) as a green physical technology are of more and more interest in postharvest fruit preservation field. In this study, we evaluated for the first time the resistance inducing ability of LED irradiation with different light wavelengths and photoperiods for cherry tomatoes (Solanum lycopersicum L. ?Qianxi?). Results indicated the exposure to 40?W?m-2 of four light wavelengths for 3 d decreased B. cinerea lesion diameter on harvested cherry tomatoes, notably the best effect in blue light (470?nm). Meanwhile, the mechanism of blue light-induced disease resistance is the enhancement of defense-enzyme activity and the expression of defense-related genes. Moreover, results revealed that blue light enhanced vitamin C content and the firmness of the fruit exocarp, suggesting the potential usage of blue light in the postharvest preservation of cherry tomatoes. VL - 215 A1 - Sun, Jiayi A1 - Tan, Xinhui A1 - Liu, Bingjie A1 - Battino, Maurizio A1 - Meng, Xianghong A1 - Zhang, Fang AV - none Y1 - 2024/06// SN - 09255214 ER - TY - JOUR A1 - Cassotta, Manuela A1 - Cianciosi, Danila A1 - Elexpuru Zabaleta, Maria A1 - Elío Pascual, Iñaki A1 - Sumalla Cano, Sandra A1 - Giampieri, Francesca A1 - Battino, Maurizio KW - alternatives to animal testing KW - food-risk assessment KW - human-based research KW - NAMs KW - newapproachmethodologies KW - novelfoodproducts KW - nutritionresearch AV - public JF - Food Frontiers TI - Human?based new approach methodologies to accelerate advances in nutrition research ID - uneatlantico11265 UR - http://doi.org/10.1002/fft2.369 N2 - Much of nutrition research has been conventionally based on the use of simplistic in vitro systems or animal models, which have been extensively employed in an effort to better understand the relationships between diet and complex diseases as well as to evaluate food safety. Although these models have undeniably contributed to increase our mechanistic understanding of basic biological processes, they do not adequately model complex human physiopathological phenomena, creating concerns about the translatability to humans. During the last decade, extraordinary advancement in stem cell culturing, three-dimensional cell cultures, sequencing technologies, and computer science has occurred, which has originated a wealth of novel human-based and more physiologically relevant tools. These tools, also known as ?new approach methodologies,? which comprise patient-derived organoids, organs-on-chip, multi-omics approach, along with computational models and analysis, represent innovative and exciting tools to forward nutrition research from a human-biology-oriented perspective. After considering some shortcomings of conventional in vitro and vivo approaches, here we describe the main novel available and emerging tools that are appropriate for designing a more human-relevant nutrition research. Our aim is to encourage discussion on the opportunity to explore innovative paths in nutrition research and to promote a paradigm-change toward a more human biology-focused approach to better understand human nutritional pathophysiology, to evaluate novel food products, and to develop more effective targeted preventive or therapeutic strategies while helping in reducing the number and replacing animals employed in nutrition research. SP - 1 EP - 32 Y1 - 2024/03// SN - 2643-8429 ER - TY - JOUR Y1 - 2024/03// SN - 1663-9812 JF - Frontiers in Pharmacology UR - http://doi.org/10.3389/fphar.2024.1368949 ID - uneatlantico12107 N2 - Cardiovascular diseases are among the leading causes of mortality worldwide, with dietary factors being the main risk contributors. Diets rich in bioactive compounds, such as (poly)phenols, have been shown to potentially exert positive effects on vascular health. Among them, resveratrol has gained particular attention due to its potential antioxidant and anti-inflammatory action. Nevertheless, the results in humans are conflicting possibly due to interindividual different responses. The gut microbiota, a complex microbial community that inhabits the gastrointestinal tract, has been called out as potentially responsible for modulating the biological activities of phenolic metabolites in humans. The present review aims to summarize the main findings from clinical trials on the effects of resveratrol interventions on endothelial and vascular outcomes and review potential mechanisms interesting the role of gut microbiota on the metabolism of this molecule and its cardioprotective metabolites. The findings from randomized controlled trials show contrasting results on the effects of resveratrol supplementation and vascular biomarkers without dose-dependent effect. In particular, studies in which resveratrol was integrated using food sources, i.e., red wine, reported significant effects although the resveratrol content was, on average, much lower compared to tablet supplementation, while other studies with often extreme resveratrol supplementation resulted in null findings. The results from experimental studies suggest that resveratrol exerts cardioprotective effects through the modulation of various antioxidant, anti-inflammatory, and anti-hypertensive pathways, and microbiota composition. Recent studies on resveratrol-derived metabolites, such as piceatannol, have demonstrated its effects on biomarkers of vascular health. Moreover, resveratrol itself has been shown to improve the gut microbiota composition toward an anti-inflammatory profile. Considering the contrasting findings from clinical studies, future research exploring the bidirectional link between resveratrol metabolism and gut microbiota as well as the mediating effect of gut microbiota in resveratrol effect on cardiovascular health is warranted. TI - Resveratrol and vascular health: evidence from clinical studies and mechanisms of actions related to its metabolites produced by gut microbiota KW - resveratrol KW - polyphenols KW - metabolites KW - vascular KW - gut microbiota AV - public VL - 15 A1 - Godos, Justyna A1 - Romano, Giovanni Luca A1 - Gozzo, Lucia A1 - Laudani, Samuele A1 - Paladino, Nadia A1 - Dominguez Azpíroz, Irma A1 - Martínez López, Nohora Milena A1 - Giampieri, Francesca A1 - Quiles, José L. A1 - Battino, Maurizio A1 - Galvano, Fabio A1 - Drago, Filippo A1 - Grosso, Giuseppe ER - TY - JOUR IS - 1 Y1 - 2024/03// SN - 1479-5876 KW - Mediterranean diet; Plant-based; Sustainability; Planetary diet; Grains; Spices; Olive oil; Legumes; Fish; Herbs AV - public A1 - Godos, Justyna A1 - Scazzina, Francesca A1 - Paternò Castello, Corrado A1 - Giampieri, Francesca A1 - Quiles, José L. A1 - Briones Urbano, Mercedes A1 - Battino, Maurizio A1 - Galvano, Fabio A1 - Iacoviello, Licia A1 - de Gaetano, Giovanni A1 - Bonaccio, Marialaura A1 - Grosso, Giuseppe VL - 22 JF - Journal of Translational Medicine N2 - Over the last decades, the Mediterranean diet gained enormous scientific, social, and commercial attention due to proven positive effects on health and undeniable taste that facilitated a widespread popularity. Researchers have investigated the role of Mediterranean-type dietary patterns on human health all around the world, reporting consistent findings concerning its benefits. However, what does truly define the Mediterranean diet? The myriad of dietary scores synthesizes the nutritional content of a Mediterranean-type diet, but a variety of aspects are generally unexplored when studying the adherence to this dietary pattern. Among dietary factors, the main characteristics of the Mediterranean diet, such as consumption of fruit and vegetables, olive oil, and cereals should be accompanied by other underrated features, such as the following: (i) specific reference to whole-grain consumption; (ii) considering the consumption of legumes, nuts, seeds, herbs and spices often untested when exploring the adherence to the Mediterranean diet; (iii) consumption of eggs and dairy products as common foods consumed in the Mediterranean region (irrespectively of the modern demonization of dietary fat intake). Another main feature of the Mediterranean diet includes (red) wine consumption, but more general patterns of alcohol intake are generally unmeasured, lacking specificity concerning the drinking occasion and intensity (i.e., alcohol drinking during meals). Among other underrated aspects, cooking methods are rather simple and yet extremely varied. Several underrated aspects are related to the quality of food consumed when the Mediterranean diet was first investigated: foods are locally produced, minimally processed, and preserved with more natural methods (i.e., fermentation), strongly connected with the territory with limited and controlled impact on the environment. Dietary habits are also associated with lifestyle behaviors, such as sleeping patterns, and social and cultural values, favoring commensality and frugality. In conclusion, it is rather reductive to consider the Mediterranean diet as just a pattern of food groups to be consumed decontextualized from the social and geographical background of Mediterranean culture. While the methodologies to study the Mediterranean diet have demonstrated to be useful up to date, a more holistic approach should be considered in future studies by considering the aforementioned underrated features and values to be potentially applied globally through the concept of a ?Planeterranean? diet. UR - http://doi.org/10.1186/s12967-024-05095-w ID - uneatlantico11426 TI - Underrated aspects of a true Mediterranean diet: understanding traditional features for worldwide application of a ?Planeterranean? diet ER - TY - JOUR Y1 - 2024/03// SN - 0021-8561 SP - 5197 EP - 5211 IS - 10 JF - Journal of Agricultural and Food Chemistry UR - http://doi.org/10.1021/acs.jafc.3c05609 ID - uneatlantico11324 N2 - Broccoli has gained popularity as a highly consumed vegetable due to its nutritional and health properties. This study aimed to evaluate the composition profile and the antioxidant capacity of a hydrophilic extract derived from broccoli byproducts, as well as its influence on redox biology, Alzheimer?s disease markers, and aging in the Caenorhabditis elegans model. The presence of glucosinolate was observed and antioxidant capacity was demonstrated both in vitro and in vivo. The in vitro acetylcholinesterase inhibitory capacity was quantified, and the treatment ameliorated the amyloid-?- and tau-induced proteotoxicity in transgenic strains via SOD-3 and SKN-1, respectively, and HSP-16.2 for both parameters. Furthermore, a preliminary study on aging indicated that the extract effectively reduced reactive oxygen species levels in aged worms and extended their lifespan. Utilizing broccoli byproducts for nutraceutical or functional foods could manage vegetable processing waste, enhancing productivity and sustainability while providing significant health benefits. TI - In Vitro and In Vivo Insights into a Broccoli Byproduct as a Healthy Ingredient for the Management of Alzheimer?s Disease and Aging through Redox Biology KW - sulfur compounds amyloid-? hyperphosphorylated tau SKN-1/Nrf2 heat shock protein lipofuscin AV - public VL - 72 A1 - Navarro-Hortal, María D. A1 - Romero-Márquez, Jose M. A1 - López-Bascón, M. Asunción A1 - Sánchez-González, Cristina A1 - Xiao, Jianbo A1 - Sumalla Cano, Sandra A1 - Battino, Maurizio A1 - Forbes-Hernande, Tamara Y. A1 - Quiles, José L. ER - TY - JOUR IS - 1 SP - 61 EP - 71 SN - 18785093 Y1 - 2024/03// AV - public KW - Red raspberry KW - anthocyanins KW - ellagitannins KW - oxidative stress KW - cancer A1 - Qi, Zexiu A1 - Yang, Bei A1 - Giampieri, Francesca A1 - Cianciosi, Danila A1 - Alvarez-Suarez, José Miguel A1 - Elexpuru Zabaleta, Maria A1 - Quiles, José L. A1 - Forbes-Hernandez, Tamara Y. A1 - Zhang, Di A1 - Bai, Weibin A1 - Tian, Lingmin A1 - Mezzetti, Bruno A1 - Battino, Maurizio A1 - Armas Diaz, Yasmany VL - 14 UR - http://doi.org/10.3233/JBR-240004 ID - uneatlantico14385 N2 - Red raspberries are gaining attention more and more for their nutritional and bioactive components, with potential health effects such as antitumor properties. This review aims to describe the antioxidant activities of red raspberries, emphasizing the role of anthocyanins and ellagitannins as primary contributors among red raspberry polyphenols; it also outlined the connection between red raspberries and their role in inhibiting cancer cell growth by regulating oxidative stress. Numerous studies suggest that red raspberries are able to block cancer cell progression by inhibiting proliferation, migration, and autophagy, as well as regulating the cell cycle, angiogenesis, and DNA damage repair. This review sheds light to the growing evidence supporting antioxidants as a crucial link between fruit consumption and cancer prevention. TI - The preventive and inhibitory effects of red raspberries on cancer JF - Journal of Berry Research ER - TY - JOUR VL - 17 A1 - Laudani, Samuele A1 - Godos, Justyna A1 - Romano, Giovanni Luca A1 - Gozzo, Lucia A1 - Di Domenico, Federica Martina A1 - Dominguez Azpíroz, Irma A1 - Martínez Díaz, Raquel A1 - Giampieri, Francesca A1 - Quiles, José L. A1 - Battino, Maurizio A1 - Drago, Filippo A1 - Galvano, Fabio A1 - Grosso, Giuseppe AV - public KW - isoflavones; polyphenols; phytoestrogens; equol; vascular; gut microbiota TI - Isoflavones Effects on Vascular and Endothelial Outcomes: How Is the Gut Microbiota Involved? ID - uneatlantico10845 UR - http://doi.org/10.3390/ph17020236 N2 - Isoflavones are a group of (poly)phenols, also defined as phytoestrogens, with chemical structures comparable with estrogen, that exert weak estrogenic effects. These phytochemical compounds have been targeted for their proven antioxidant and protective effects. Recognizing the increasing prevalence of cardiovascular diseases (CVD), there is a growing interest in understanding the potential cardiovascular benefits associated with these phytochemical compounds. Gut microbiota may play a key role in mediating the effects of isoflavones on vascular and endothelial functions, as it is directly implicated in isoflavones metabolism. The findings from randomized clinical trials indicate that isoflavone supplementation may exert putative effects on vascular biomarkers among healthy individuals, but not among patients affected by cardiometabolic disorders. These results might be explained by the enzymatic transformation to which isoflavones are subjected by the gut microbiota, suggesting that a diverse composition of the microbiota may determine the diverse bioavailability of these compounds. Specifically, the conversion of isoflavones in equol?a microbiota-derived metabolite?seems to differ between individuals. Further studies are needed to clarify the intricate molecular mechanisms behind these contrasting results. JF - Pharmaceuticals IS - 2 SN - 1424-8247 Y1 - 2024/02// ER - TY - JOUR JF - Food Hydrocolloids ID - uneatlantico8685 UR - http://doi.org/10.1016/j.foodhyd.2023.109223 N2 - The aim of this study was to investigate the effects of enzymatic treatments (pectinase, pectin lyase, and cellulase) on the in vitro digestion and fermentation characteristics of whole mulberry fruit juice. The analysis focused on changes in carbohydrate properties within the black mulberry fruit matrix during simulated digestion and fermentation. Human fecal microbiota were collected and introduced to the fruit matrix to monitor the fate of both soluble and insoluble polysaccharides during fermentation. The results revealed that enzymatic treatments enhanced the solubilization of carbohydrates from mulberry fruits, with pectinase showing the most significant effect. Throughout the process of in vitro digestion, there was a gradual increase in the percentage of solubilized carbohydrates from the mulberry juice substrate. The digested suspensions underwent dialysis to remove degradation fragments, and a lower quantity of carbohydrate in the enzyme-treated groups compared to the control. Polysaccharide populations with varying molecular weights (Mw) were obtained from the soluble fractions of mulberry residues for subsequent fermentation. An increase in Mw of soluble polysaccharides was detected by HPSEC during fermentation in certain cases. The gut microbiota demonstrated the ability to convert specific insoluble fractions into soluble components, which were subsequently subjected to microbial utilization. Enzymatic treatments during mulberry juice preparation can potentially positively impact health by influencing gut microbiota and short-chain fatty acid (SCFA) modulations. Enzymes could serve as valuable tools for producing functional fruit and vegetable juices, with the need to specify processing conditions for specific raw materials remaining a subject of further investigation. TI - Effects of enzymatic treatment on the in vitro digestion and fermentation patterns of mulberry fruit juice: A focus on carbohydrates AV - none A1 - Luo, Peihuan A1 - Ai, Jian A1 - Wang, Yuxin A1 - Wang, Songen A1 - Schols, Henk A. A1 - Smidt, Hauke A1 - Battino, Maurizio A1 - Bai, Weibin A1 - Tian, Lingmin VL - 146 Y1 - 2024/01// SN - 0268005X ER - TY - JOUR JF - Food Chemistry TI - Effect of olive leaf phytochemicals on the anti-acetylcholinesterase, anti-cyclooxygenase-2 and ferric reducing antioxidant capacity UR - http://doi.org/10.1016/j.foodchem.2024.138516 N2 - In this study, the phytochemical profile of fifty olive leaves (OL) extracts from Spain, Italy, Greece, Portugal, and Morocco was characterized and their anti-cholinergic, anti-inflammatory, and antioxidant activities were evaluated. Luteolin-7-O-glucoside, isoharmnentin, and apigenin were involved in the acetylcholinesterase (AChE) inhibitory activity, while oleuropein and hydroxytyrosol showed noteworthy potential. Secoiridoids contributed to the cyclooxygenase-2 inhibitory activity and antioxidant capacity. Compounds such as oleuropein, ligstroside and luteolin-7-O-glucoside, may exert an important role in the ferric reducing antioxidant capacity. It should be also highlighted the role of hydroxytyrosol, hydroxycoumarins, and verbascoside concerning the antioxidant activity. This research provides valuable insights and confirms that specific compounds within OL extracts contribute to distinct anti-cholinergic, anti-inflammatory, and anti-oxidative effects. ID - uneatlantico10843 A1 - Romero-Márquez, Jose M. A1 - Navarro-Hortal, María D. A1 - Forbes-Hernández, Tamara Y. A1 - Varela-López, Alfonso A1 - Puentes, Juan G. A1 - Sánchez-González, Cristina A1 - Sumalla Cano, Sandra A1 - Battino, Maurizio A1 - García-Ruiz, Roberto A1 - Sánchez, Sebastián A1 - Quiles, José L. VL - 444 KW - Cholinergic; AChE; COX; Inflammation; Iron; Oxidative stress; Olive; Leaves AV - public Y1 - 2024/01// SN - 03088146 ER - TY - JOUR IS - 3 SP - 1135 EP - 1143 SN - 2042-6496 Y1 - 2024/01// A1 - Saz-Lara, Alicia A1 - Battino, Maurizio A1 - del Saz Lara, Andrea A1 - Cavero-Redondo, Iván A1 - Dávalos, Alberto A1 - López de Las Hazas, María-Carmen A1 - Visioli, Francesco A1 - Lucerón-Lucas-Torres, Maribel A1 - Giampieri, Francesca VL - 15 AV - none TI - Differences in carotid to femoral pulse wave velocity and carotid intima media thickness between vegetarian and omnivorous diets in healthy subjects: a systematic review and meta-analysis UR - http://doi.org/10.1039/D3FO05061K ID - uneatlantico11261 N2 - Background: Arterial stiffness and atherosclerosis are known risk factors for cardiovascular morbidity and mortality. Vegetarian diets have been associated with cardiovascular benefits, including improvements in metabolic parameters. However, the impact of a vegetarian diet on cardiovascular parameters, specifically arterial stiffness and atherosclerosis, in healthy individuals remains unclear. Thus, this study aims to analyze differences in arterial stiffness and atherosclerosis between vegetarian and omnivorous diets in healthy subjects. Methods: A systematic review and meta-analysis were conducted following established guidelines. PubMed, Scopus, Web of Science, and Cochrane Library databases were searched for studies examining the association between vegetarian and omnivorous diets with arterial stiffness and atherosclerosis. Cross-sectional studies reporting carotid to femoral pulse wave velocity (cf-PWv) as a measure of arterial stiffness and carotid intima media thickness (c-IMT) as a measure of atherosclerosis were included. Data were synthesized using random effects models, and sensitivity analyses, meta-regressions, and assessment of publication bias were performed. Results: Ten studies were included in the systematic review, and seven studies were included in the meta-analysis. The pooled analysis demonstrated that individuals following a vegetarian diet had differences in the levels of arterial stiffness (cf-PWv) compared to those following an omnivorous diet (MD: ?0.43 m s?1; 95% CI: ?0.63, ?0.23). Similarly, atherosclerosis (c-IMT) was found to be different in individuals adhering to a vegetarian dietary pattern (MD = ?29.86 mm; 95% CI: ?58.41, ?1.32). Conclusions: Our findings suggest that a vegetarian diet is associated with improved arterial stiffness and reduced atherosclerosis in healthy individuals. These results support the inclusion of a well-balanced vegetarian dietary pattern in the prevention and management of cardiovascular diseases. However, further research is needed to explore the effects of a vegetarian diet on arterial health in diverse populations and to assess long-term cardiovascular outcomes. JF - Food & Function ER - TY - JOUR Y1 - 2023/12// SN - 2072-6643 IS - 24 JF - Nutrients TI - Nutritional Modulation of Hepcidin in the Treatment of Various Anemic States N2 - Twenty years after its discovery, hepcidin is still considered the main regulator of iron homeostasis in humans. The increase in hepcidin expression drastically blocks the flow of iron, which can come from one?s diet, from iron stores, and from erythrophagocytosis. Many anemic conditions are caused by non-physiologic increases in hepcidin. The sequestration of iron in the intestine and in other tissues poses worrying premises in view of discoveries about the mechanisms of ferroptosis. The nutritional treatment of these anemic states cannot ignore the nutritional modulation of hepcidin, in addition to the bioavailability of iron. This work aims to describe and summarize the few findings about the role of hepcidin in anemic diseases and ferroptosis, as well as the modulation of hepcidin levels by diet and nutrients. UR - http://doi.org/10.3390/nu15245081 ID - uneatlantico10095 A1 - D?Andrea, Patrizia A1 - Giampieri, Francesca A1 - Battino, Maurizio VL - 15 KW - hepcidin; iron homeostasis; ferroptosis; anemia AV - public ER - TY - JOUR AV - none A1 - Cianciosi, Danila A1 - Armas Diaz, Yasmany A1 - Alvarez-Suarez, José M. A1 - Chen, Xiumin A1 - Zhang, Di A1 - Martínez López, Nohora Milena A1 - Briones Urbano, Mercedes A1 - Quiles, José L. A1 - Amici, Adolfo A1 - Battino, Maurizio A1 - Giampieri, Francesca VL - 427 JF - Food Chemistry N2 - Manuka honey, which is rich in pinocembrin, quercetin, naringenin, salicylic, p-coumaric, ferulic, syringic and 3,4-dihydroxybenzoic acids, has been shown to have pleiotropic effects against colon cancer cells. In this study, potential chemosensitizing effects of Manuka honey against 5-Fluorouracil were investigated in colonspheres enriched with cancer stem cells (CSCs), which are responsible for chemoresistance. Results showed that 5-Fluorouracil increased when it was combined with Manuka honey by downregulating the gene expression of both ATP-binding cassette sub-family G member 2, an efflux pump and thymidylate synthase, the main target of 5-Fluorouracil which regulates the ex novo DNA synthesis. Manuka honey was associated with decreased self-renewal ability by CSCs, regulating expression of several genes in Wnt/?-catenin, Hedgehog and Notch pathways. This preliminary study opens new areas of research into the effects of natural compounds in combination with pharmaceuticals and, potentially, increase efficacy or reduce adverse effects. UR - http://doi.org/10.1016/j.foodchem.2023.136684 ID - uneatlantico7844 TI - Can the phenolic compounds of Manuka honey chemosensitize colon cancer stem cells? A deep insight into the effect on chemoresistance and self-renewal Y1 - 2023/11// SN - 03088146 ER - TY - JOUR Y1 - 2023/11// SN - 22147993 JF - Current Opinion in Food Science N2 - Metabolic syndrome, obesity and diabetes mellitus are the most common metabolic disorders (MDs) in the world, characterized by abnormalities in body's metabolic processes. The typical diagnosis of MDs is usually executed by monitoring the levels of specific biochemical markers, but diagnostic imaging may provide valuable complementary information in MDs, offering advantages in diagnosis, target organ monitoring, follow-up, and development of new therapeutic approaches. The aim of this review is to summarize and discuss the studies published in the literature about the connection between images deriving from the diagnostic techniques and the key biochemical markers in the main MDs, in order to gain a comprehensive view of the different disorders. UR - http://doi.org/10.1016/j.cofs.2023.101109 ID - uneatlantico9884 TI - Association between diagnostic imaging and biochemical markers: a possible tool for monitoring metabolic disorders AV - none A1 - Cianciosi, Danila A1 - Diaz, Yasmany Armas A1 - Grosso, Giuseppe A1 - Quiles, José L. A1 - Giampieri, Francesca A1 - Battino, Maurizio ER - TY - JOUR A1 - Pilco-Romero, Gabriela A1 - Chisaguano-Tonato, Aida M. A1 - Herrera-Fontana, María E. A1 - Chimbo-Gándara, Luis F. A1 - Sharifi-Rad, Majid A1 - Giampieri, Francesca A1 - Battino, Maurizio A1 - Vernaza, María Gabriela A1 - Álvarez-Suárez, José M. VL - 142 AV - none TI - House cricket (Acheta domesticus): A review based on its nutritional composition, quality, and potential uses in the food industry UR - http://doi.org/10.1016/j.tifs.2023.104226 ID - uneatlantico9665 N2 - Background The house cricket (A. domesticus) is one of the edible insects that are gaining attention as a new source of protein and nutrients with potential use in the food industry as a safe and environmentally sustainable option with high biological value. Scope and approach Here, we review the published literature on studies of chemical composition, nutritional value, and potential risks that the consumption of house crickets entails. We discuss the benefits of consuming A. domesticus from a nutritional point of view, as well as information concerning the properties of its components for use in the food industry. JF - Trends in Food Science & Technology SN - 09242244 Y1 - 2023/11// ER - TY - JOUR SN - 2643-8429 Y1 - 2023/10// AV - none KW - lpha-linolenic acid; COVID-19; cytokine storm; inflammation; oxidative stress; SARS-CoV-2 A1 - Cianciosi, Danila A1 - Diaz, Yasmany Armas A1 - Gaddi, Antonio Vittorino A1 - Capello, Fabio A1 - Savo, Maria Teresa A1 - Pali-Casanova, Ramón A1 - Martínez Espinosa, Julio César A1 - Pascual Barrera, Alina Eugenia A1 - Navarro?Hortal, Maria?Dolores A1 - Tian, Lingmin A1 - Bai, Weibin A1 - Giampieri, Francesca A1 - Battino, Maurizio ID - uneatlantico9375 UR - http://doi.org/10.1002/fft2.319 N2 - Alpha-linolenic acid (ALA) is a long-chain polyunsaturated essential fatty acid of the ?3 series found mainly in vegetables, especially in the fatty part of oilseeds, dried fruit, berries, and legumes. It is very popular for its preventive use in several diseases: It seems to reduce the risk of the onset or decrease some phenomena related to inflammation, oxidative stress, and conditions of dysregulation of the immune response. Recent studies have confirmed these unhealthy situations also in patients with severe coronavirus disease 2019 (COVID-19). Different findings (in vitro, in vivo, and clinical ones), summarized and analyzed in this review, have showed an important role of ALA in other various non-COVID physiological and pathological situations against ?cytokines storm,? chemokines secretion, oxidative stress, and dysregulation of immune cells that are also involved in the infection of the 2019 novel coronavirus. According to the effects of ALA against all the aforementioned situations (also present in patients with a severe clinical picture of severe acute respiratory syndrome-(CoV-2) infection), there may be the biologic plausibility of a prophylactic effect of this compound against COVID-19 symptoms and fatality. TI - Can alpha?linolenic acid be a modulator of ?cytokine storm,? oxidative stress and immune response in SARS?CoV?2 infection? JF - Food Frontiers ER - TY - JOUR A1 - Ricci, Hannah A1 - Gaeta, Maddalena A1 - Franchi, Carlotta A1 - Poli, Andrea A1 - Battino, Maurizio A1 - Dolci, Alberto A1 - Schmid, Daniela A1 - Ricci, Cristian VL - 15 AV - public KW - fish; fatty fish; nutrition; cardiovascular risk; cardiovascular mortality; systematic review; meta-analysis; meta-regression; cohort study JF - Nutrients TI - Fish Intake in Relation to Fatal and Non-Fatal Cardiovascular Risk: A Systematic Review and Meta-Analysis of Cohort Studies UR - http://doi.org/10.3390/nu15214539 N2 - Epidemiological studies have shown that eating fish significantly reduces cardiovascular disease (CVD) incidence and mortality. However, more focused meta-analyses based on the most recent results from prospective cohort studies are needed. This systematic review and meta-analysis aims to update the association between fish intake and cardiovascular disease (CVD) risk using recent prospective studies. A systematic review and meta-analysis following the PRISMA guideline was conducted based on a random effects synthesis of multivariable-adjusted relative risks (RRs) of high vs. low categories of fish intake in relation to CVD incidence and mortality. Non-linear meta-regression was applied to investigate the shape of the association between fish intake and CVD risk. Sensitivity analysis and stratifications by type of CVD outcome, type of fish intake and type of cooking were performed. Based on 18 papers reporting 17 independent estimates of CVD risk (1,442,407 participants and 78,805 fatal and non-fatal CVD events), high vs. low intake of fish corresponded to about 8% reduced CVD risk (RR = 0.93 [0.88?0.98]). According to a non-linear dose?response meta-regression, 50 g of fish intake per day corresponded to a statistically significant 9% reduced fatal and non-fatal CVD risk (RR = 0.92 [0.90?0.95]). Similarly, fish intake in the range of a weekly intake of two to three portions of fish with a size of 150 g resulted in 8% fatal and non-fatal CVD risk reduction (RR = 0.93 [0.91?0.96]). The recommended two portions of fish a week reduces the risk of CVD outcomes by approximately 10%. A full portion of fish a day reduces CVD risk by up to 30%. ID - uneatlantico9562 IS - 21 Y1 - 2023/10// SN - 2072-6643 ER - TY - JOUR SN - 03088146 Y1 - 2023/09// VL - 420 A1 - Liu, Shuxun A1 - Lou, Ying A1 - Li, Yixian A1 - Zhao, Yan A1 - Laaksonen, Oskar A1 - Li, Ping A1 - Zhang, Jiaojiao A1 - Battino, Maurizio A1 - Yang, Baoru A1 - Gu, Qing AV - none TI - Aroma characteristics of volatile compounds brought by variations in microbes in winemaking N2 - Wine is a highly complex mixture of components with different chemical natures. These components largely define wine?s appearance, aroma, taste, and mouthfeel properties. Among them, aroma is among the most important indicators of wine?s sensory characteristics. The essence of winemaking ecosystem is the process of metabolic activities of diverse microbes including yeasts, lactic acid bacteria, and molds, which result in wines with complicated and diversified aromas. A better understanding of how these microbes affect wine?s aroma is a crucial step to producing premium quality wine. This study illustrates existing knowledge on the diversity and classification of wine aroma compounds and their microbial origin. Their contributions to wine characteristics are discussed, as well. Furthermore, we review the relationship between these microbes and wine aroma characteristics. This review broadens the discussion of wine aroma compounds to include more modern microbiological concepts, and it provides relevant background and suggests new directions for future research. UR - http://doi.org/10.1016/j.foodchem.2023.136075 ID - uneatlantico6772 JF - Food Chemistry ER - TY - JOUR SP - 1 EP - 18 SN - 1040-8398 Y1 - 2023/09// A1 - Sun, Yu A1 - Mehmood, Arshad A1 - Giampieri, Francesca A1 - Battino, Maurizio A1 - Chen, Xiumin KW - Gamma-aminobutyric aciddiabetes?-cellsinsulinanti-inflammatory activity AV - none TI - Insights into the cellular, molecular, and epigenetic targets of gamma-aminobutyric acid against diabetes: a comprehensive review on its mechanisms N2 - Diabetes is a metabolic disease due to impaired or defective insulin secretion and is considered one of the most serious chronic diseases worldwide. Gamma-aminobutyric acid (GABA) is a naturally occurring non-protein amino acid commonly present in a wide range of foods. A number of studies documented that GABA has good anti-diabetic potential. This review summarized the available dietary sources of GABA as well as animal and human studies on the anti-diabetic properties of GABA, while also discussing the underlying mechanisms. GABA may modulate diabetes through various pathways such as inhibiting the activities of ?-amylase and ?-glucosidase, promoting ?-cell proliferation, stimulating insulin secretion from ?-cells, inhibiting glucagon secretion from ?-cells, improving insulin resistance and glucose tolerance, and increasing antioxidant and anti-inflammatory activities. However, further mechanistic studies on animals and human are needed to confirm the therapeutic effects of GABA against diabetes. UR - http://doi.org/10.1080/10408398.2023.2255666 ID - uneatlantico8802 JF - Critical Reviews in Food Science and Nutrition ER - TY - JOUR A1 - Pollakova, Daniela A1 - Tubili, Claudio A1 - Folco, Ugo Di A1 - De Giuseppe, Rachele A1 - Battino, Maurizio A1 - Giampieri, Francesca KW - muscle mass; muscle function; type 1 diabetes; accelerated muscle aging; sarcopenia AV - none TI - Muscular involvement in long term type 1 diabetes: does it represent an underestimated complication? ID - uneatlantico6978 UR - http://doi.org/10.1016/j.nut.2023.112060 N2 - Background Structural, metabolic and functional signs of skeletal muscle damage have been identified in subjects affected by type 1 diabetes (T1D), but, to date, no guidelines for the diagnosis and treatment of muscle impairment exist and studies on T1D and muscle health are still limited. The aim of this cross-sectional study was to evaluate the prevalence of sarcopenia in a long-term T1D population and to assess the impact of some clinical parameters on muscle mass and function. Methods 39 patients affected by T1D were enrolled, and Body Mass Index (BMI), body composition (Appendicular Lean Mass Index-ALMI and Fat Mass-FM) and muscle strength were measured. Additionally, the relationship between Mediterranean Diet (MD) adherence and sarcopenia was assessed. Results In our sample (mean age 49.32±13.49 years, 41.1% women, mean duration of diabetes 30.13±12.28 years), the prevalence of sarcopenia was 7.7% (12.5 % in women and 4.35% in men), while the prevalence of low ALMI was 23.1% (25% in women and 21.74% in men). We found significant inverse correlations between ALMI and duration of diabetes and ALMI vs. FM; and significant positive correlations between ALMI and BMI, physical activity level and muscle strength. At the same time, significant inverse correlations were observed between muscle strength and duration of diabetes and muscle strength vs. FM. Conclusions We observed a high prevalence of low muscle mass, similar to those found in the older age groups of the general population (25 years in advance) and our findings suggest a possible pathogenetic role of T1D duration on muscle trophism and function. JF - Nutrition SN - 08999007 Y1 - 2023/08// ER - TY - JOUR SP - 1 EP - 19 SN - 1040-8398 Y1 - 2023/08// KW - Saponin; asparagus; extraction;health benefits; anticancer; applications AV - none A1 - Zhang, Fan A1 - Chen, Shengxiong A1 - Zhang, Jianguo A1 - Thakur, Kiran A1 - Battino, Maurizio A1 - Cao, Hui A1 - Farag, Mohamed A. A1 - Xiao, Jianbo A1 - Wei, Zhaojun N2 - Asparagus species is recognized as a perennial herb with several valuable functional ingredients, and has been widely used as medicine and food since ancient times. Among its main chemical constituents, saponins play a vital role in the health benefits and biological activities including anti-cancer, antioxidant, immunomodulatory, anti-microbial, anti-inflammatory, and hypoglycemic. This review summarizes the preparation methods, structure and classification, biological functions, as well as the food and non-food applications of asparagus saponins, with a special emphasis on its anti-cancer effects in vitro and in vivo. Further, the main challenges and limitations of the current research trends in asparagus saponins are highlighted after a detailed analysis of the recent research information. This review bridges the gap between bioactive components and human health and aids current research on functional and health-promoting foods and medicinal application of Asparagus saponins. UR - http://doi.org/10.1080/10408398.2023.2249097 ID - uneatlantico8682 TI - Asparagus saponins: effective natural beneficial ingredient in functional foods, from preparation to applications JF - Critical Reviews in Food Science and Nutrition ER - TY - JOUR KW - Malvidin; Bioactivity; Antioxidant; Antidiabetic; Anti-inflammatory; Anticancer activity AV - none A1 - Alvarez-Suarez, José M. A1 - Giampieri, Francesca A1 - Tejera, Eduardo A1 - Battino, Maurizio JF - Handbook of Dietary Flavonoids UR - http://doi.org/10.1007/978-3-030-94753-8_57-1 ID - uneatlantico8686 N2 - Malvidin is an O-methylated anthocyanidin, the 3?,5?-methoxy derivative of delphinidin responsible for the blue-red color found in flowers and fruits. Its distribution covers a wide group of sources, such as flowers (edible and nonedible), medicinal plants, and fruits. It is the main substance responsible for the color of red grapes and red wine, being Vitis vinifera one of its main sources. Its consumption is important as it has been associated with important biological effects, such as anti-inflammatory activity, powerful antioxidant activity, and anticancer activity. Against this background, this chapter presents a general overview of malvidin?s main sources, biosynthesis pathway and biotransformation properties, physicochemical properties and stability, and aspects of its absorption, metabolism, and excretion. Additionally, we summarize recent studies using in vitro and in vivo models related to its various biological properties. In conclusion, this chapter aims to provide as detailed a picture as possible of the potential of malvidin in human health, as well as its main sources, chemical characteristics, and biotransformation. TI - Malvidin: Advances in the Resources, Biosynthesis Pathway, Bioavailability, Bioactivity, and Pharmacology SP - 1 EP - 35 Y1 - 2023/07// ER - TY - JOUR TI - The role of dietary polyphenols in the control of chronic noncommunicable diseases UR - http://doi.org/10.1002/fsh3.12013 N2 - Noncommunicable chronic diseases (NCDs) are among the leading causes of death and disability worldwide. The most common NCDs are cancer, obesity, cardiovascular diseases, and diabetes. Nowadays, they represent one of the greatest challenges health systems face worldwide. The increase in the consumption of polyphenol-rich foods could contribute to the reduction of these pathologies, due to their antioxidant, anti-inflammatory, anticancer, immunomodulatory, and cardiovascular protective properties, among others. This review aims to highlight some studies carried out in recent years to enhance the possible benefits of a diet rich in polyphenols in the prevention or treatment of NCDs. ID - uneatlantico8687 JF - Food Safety and Health VL - 1 A1 - Armas Díaz, Yasmany A1 - Ferreiro Cotorruelo, Maria Soledad A1 - Battino, Maurizio AV - public SN - 2835-1096 Y1 - 2023/07// IS - 1 EP - 21 SP - 13 ER - TY - JOUR IS - 8 SN - 2076-3921 Y1 - 2023/07// KW - acetylcholinesterase; cyclooxygenase-2; flavonoids; hydroxyoleuropein; hydroxytyrosol; luteolin; oleuropein; p-hydroxybenzoic acid; phenolics; verbascoside AV - public VL - 12 A1 - Romero-Márquez, Jose M. A1 - Navarro-Hortal, María D. A1 - Forbes-Hernández, Tamara Y. A1 - Varela-López, Alfonso A1 - Puentes, Juan G. A1 - Pino-García, Raquel Del A1 - Sánchez-González, Cristina A1 - Elío Pascual, Iñaki A1 - Battino, Maurizio A1 - García, Roberto A1 - Sánchez, Sebastián A1 - Quiles, José L. UR - http://doi.org/10.3390/antiox12081538 ID - uneatlantico8656 N2 - The leaves of the olive tree (Olea europaea L.) are one of the major solid wastes from the olive industry. Globally, the European Union is the largest producer of olive by-products, with Spain, Italy, Greece, and Portugal accounting for almost the entire production. Many questions remain to be solved concerning olive leaves (OL), including those related to possible differences in composition and/or biological activities depending on their geographical origin. In the present work, OL from Spain, Italy, Greece, and Portugal have been characterized according to their phytochemical profile, antioxidant capacity, neuroprotective activity, and anti-inflammatory effects. The Spanish and Italian OL samples presented the highest antioxidant and neuroprotective activities, while the Greek OL showed the lowest. These results were strongly associated with the content of oleoside methyl ester and p-hydroxybenzoic acid for the Spanish and Italian samples, respectively, whereas the content of decarboxymethyl elenolic acid dialdehyde form (hydrated) was negatively associated with the mentioned biological activities of the Greek samples. No country-related effect was observed in the anti-inflammatory activity of OL. Comprehensively, this work could provide a useful tool for manufacturers and R&D departments in making environmentally friendly decisions on how OL can be used to generate nutraceutical products based on the composition and origin of this by-product. TI - Exploring the Antioxidant, Neuroprotective, and Anti-Inflammatory Potential of Olive Leaf Extracts from Spain, Portugal, Greece, and Italy JF - Antioxidants ER - TY - JOUR N1 - COMENTARIO, no artículo de investigación IS - 3 SN - 2079-9721 Y1 - 2023/07// KW - deep learning; machine learning; mobile health applications; natural language processing; wearable trackers devices AV - public A1 - Salinari, Alessia A1 - Machì, Michele A1 - Armas Diaz, Yasmany A1 - Cianciosi, Danila A1 - Qi, Zexiu A1 - Yang, Bei A1 - Ferreiro Cotorruelo, Maria Soledad A1 - Gracia Villar, Santos A1 - Dzul López, Luis Alonso A1 - Battino, Maurizio A1 - Giampieri, Francesca VL - 11 UR - http://doi.org/10.3390/diseases11030097 N2 - In the last decade, artificial intelligence (AI) and AI-mediated technologies have undergone rapid evolution in healthcare and medicine, from apps to computer software able to analyze medical images, robotic surgery and advanced data storage system. The main aim of the present commentary is to briefly describe the evolution of AI and its applications in healthcare, particularly in nutrition and clinical biochemistry. Indeed, AI is revealing itself to be an important tool in clinical nutrition by using telematic means to self-monitor various health metrics, including blood glucose levels, body weight, heart rate, fat percentage, blood pressure, activity tracking and calorie intake trackers. In particular, the application of the most common digital technologies used in the field of nutrition as well as the employment of AI in the management of diabetes and obesity, two of the most common nutrition-related pathologies worldwide, will be presented. ID - uneatlantico8036 TI - The Application of Digital Technologies and Artificial Intelligence in Healthcare: An Overview on Nutrition Assessment JF - Diseases ER - TY - JOUR Y1 - 2023/07// SN - 05315565 A1 - Varela-López, Alfonso A1 - Romero-Márquez, José M. A1 - Navarro-Hortal, María D. A1 - Ramirez-Tortosa, César L. A1 - Battino, Maurizio A1 - Forbes-Hernández, Tamara Y. A1 - Quiles, José L. VL - 178 KW - Aging; Ageing; Longevity; Bioactive compounds; Nutrient-sensing pathways; Hormesis AV - public JF - Experimental Gerontology TI - Dietary antioxidants and lifespan: Relevance of environmental conditions, diet, and genotype of experimental models UR - http://doi.org/10.1016/j.exger.2023.112221 ID - uneatlantico7347 N2 - The rise of life expectancy in current societies is not accompanied, to date, by a similar increase in healthspan, which represents a great socio-economic problem. It has been suggested that aging can be manipulated and then, the onset of all age-associated chronic disorders can be delayed because these pathologies share age as primary underlying risk factor. One of the most extended ideas is that aging is consequence of the accumulation of molecular damage. According to the oxidative damage theory, antioxidants should slow down aging, extending lifespan and healthspan. The present review analyzes studies evaluating the effect of dietary antioxidants on lifespan of different aging models and discusses the evidence on favor of their antioxidant activity as anti-aging mechanisms. Moreover, possible causes for differences between the reported results are evaluated. ER - TY - JOUR Y1 - 2023/06// SN - 08999007 AV - none KW - diet; colitis-associated cancer; CAC; CRC; IBD-colorectal cancer A1 - Cassotta, Manuela A1 - Cianciosi, Danila A1 - De Giuseppe, Rachele A1 - Navarro-Hortal, Maria Dolores A1 - Diaz, Yasmany Armas A1 - Forbes-Hernández, Tamara Yuliett A1 - Tutusaus, Kilian A1 - Pascual Barrera, Alina Eugenia A1 - Grosso, Giuseppe A1 - Xiao, Jianbo A1 - Battino, Maurizio A1 - Giampieri, Francesca JF - Nutrition UR - http://doi.org/10.1016/j.nut.2023.111980 N2 - Inflammatory bowel disease (IBD) patients are at substantially higher risk of colorectal cancer (CRC) and IBD-associated CRC accounts for roughly 10-15% of the annual mortality in IBD patients. IBD-related CRC also affects younger patients if compared with sporadic CRC, with a 5-year survival rate of 50%. Regardless of medical therapies, the persistent inflammation state characterizing IBD raises the risk for precancerous changes and CRC, with additional input from several elements including genetic and environmental risk factors, IBD-associated comorbidities, intestinal barrier disfunction, and gut microbiota modifications. It is well known that nutritional habits and dietary bioactive compounds can influence IBD-associated inflammation, microbiome abundance and composition, oxidative stress balance, and gut permeability. In addition, in the last years, results from broad epidemiological and experimental studies have associated certain foods or nutritional patterns with the risk of colorectal neoplasia. Here we review the possible role of nutrition in the prevention of IBD-related CRC, focusing specifically on human studies. In conclusion it emerges that nutritional interventions based on healthy, nutrient-dense dietary patterns characterized by a high intake of fiber, vegetables, fruit, Omega-3 PUFAs, and low amount of animal proteins, processed foods and alcohol, combined with probiotic supplementation have the potential of reducing IBD-activity and preventing the risk of IBD-related CRC through different mechanisms, suggesting that targeted nutritional interventions may represent a novel promising approach for the prevention and management of IBD-associated CRC. ID - uneatlantico5793 TI - Possible role of nutrition in the prevention of Inflammatory Bowel Disease-related colorectal cancer: a focus on human studies ER - TY - JOUR N2 - Leiomyosarcoma is an aggressive soft tissue sarcoma derived from the smooth muscle cells of the uterus. We tested the effect of Romina strawberry extract treatment on three-dimensional cultured uterine leiomyosarcoma cells. We established 3D cultures in agarose gel, where the cells seeded were able to form spheroids. We performed the observation and counting of the spheroids with a phase-contrast optical microscope, finding a decrease in the number of spheroids formed in the plates after 24 and 48 h treatment with 250 µg/mL of cultivar Romina strawberry extract. We also characterized the spheroids morphology by DNA binding fluorescent-stain observation, hematoxylin and eosin stain, and Masson?s trichrome stain. Finally, the real-time PCR showed a reduced expression of extracellular matrix genes after strawberry treatment. Overall, our data suggest that the fruit extract of this strawberry cultivar may be a useful therapeutic adjuvant for the management of uterine leiomyosarcoma. UR - http://doi.org/10.3390/nu15112557 ID - uneatlantico7353 TI - The In Vitro Effects of Romina Strawberry Extract on 3D Uterine Leiomyosarcoma Cells JF - Nutrients KW - leiomyosarcoma; phytochemicals; strawberry; 3D culture AV - public A1 - Greco, Stefania A1 - Pellegrino, Pamela A1 - Giampieri, Francesca A1 - Capocasa, Franco A1 - Delli Carpini, Giovanni A1 - Battino, Maurizio A1 - Mezzetti, Bruno A1 - Giannubilo, Stefano Raffaele A1 - Ciavattini, Andrea A1 - Ciarmela, Pasquapina VL - 15 SN - 2072-6643 Y1 - 2023/05// IS - 11 ER - TY - JOUR EP - 22 SP - 1 SN - 1040-8398 Y1 - 2023/05// A1 - Zhang, Yu A1 - Hao, Ruojie A1 - Chen, Junda A1 - Li, Sen A1 - Huang, Kai A1 - Cao, Hongwei A1 - Farag, Mohamed A. A1 - Battino, Maurizio A1 - Daglia, Maria A1 - Capanoglu, Esra A1 - Zhang, Fan A1 - Sun, Qiqi A1 - Xiao, Jianbo A1 - Sun, Zhenliang A1 - Guan, Xiao AV - none KW - Absorption; gut microbiota; metabolism; sapogenins; saponins TI - Health benefits of saponins and its mechanisms: perspectives from absorption, metabolism, and interaction with gut N2 - Saponins, consisting of sapogenins as their aglycones and carbohydrate chains, are widely found in plants and some marine organisms. Due to the complexity of the structure of saponins, involving different types of sapogenins and sugar moieties, investigation of their absorption and metabolism is limited, which further hinders the explanation of their bioactivities. Large molecular weight and complex structures limit the direct absorption of saponins rendering their low bioavailability. As such, their major modes of action may be due to interaction with the gastrointestinal environment, such as enzymes and nutrients, and interaction with the gut microbiota. Many studies have reported the interaction between saponins and gut microbiota, that is, the effects of saponins on changing the composition of gut microbiota, and gut microbiota playing an indispensable role in the biotransformation of saponins into sapogenins. However, the metabolic routes of saponins by gut microbiota and their mutual interactions are still sparse. Thus, this review summarizes the chemistry, absorption, and metabolic pathways of saponins, as well as their interactions with gut microbiota and impacts on gut health, to better understand how saponins exert their health-promoting functions. UR - http://doi.org/10.1080/10408398.2023.2212063 ID - uneatlantico7314 JF - Critical Reviews in Food Science and Nutrition ER - TY - JOUR IS - 7 SN - 2072-6643 Y1 - 2023/04// VL - 15 A1 - Baroni, Luciana A1 - Pelosi, Ettore A1 - Giampieri, Francesca A1 - Battino, Maurizio AV - public KW - VegPlate; sport; athlete; plant-based; vegetarian; vegan; lacto-ovo-vegetarian TI - The VegPlate for Sports: A Plant-Based Food Guide for Athletes N2 - Background: Nutrition strategies improve physiological and biochemical adaptation to training, facilitate more intense workouts, promote faster recoveries after a workout in anticipation of the next, and help to prepare for a race and maintain the body?s hydration status. Although vegetarianism (i.e., lacto-ovo and veganism) has become increasingly popular in recent years, the number of vegetarian athletes is not known, and no specific recommendations have been made for vegetarian dietary planning in sports. Well-planned diets are mandatory to obtain the best performance, and the available literature reports that those excluding all types of flesh foods (meat, poultry, game, and seafood) neither find advantages nor suffer from disadvantages, compared to omnivorous diets, for strength, anaerobic, or aerobic exercise performance; additionally, some benefits can be derived for general health. Methods: We conceived the VegPlate for Sports, a vegetarian food guide (VFG) based on the already-validated VegPlate facilitating method, designed according to the Italian dietary reference intakes (DRIs). Results: The VegPlate for Sports is suitable for men and women who are active in sports and adhere to a vegetarian (i.e., lacto-ovo and vegan) diet, and provides weight-based, adequate dietary planning. Conclusions: The VegPlate for Sports represents a practical tool for nutrition professionals and gives the possibility to plan diets based on energy, carbohydrate (CHO), and protein (PRO) necessities, from 50 to 90 Kg body weight (BW). UR - http://doi.org/10.3390/nu15071746 ID - uneatlantico6648 JF - Nutrients ER - TY - JOUR Y1 - 2023/04// SN - 2304-8158 IS - 7 JF - Foods TI - Plant-Based Milk Alternatives in Child Nutrition UR - http://doi.org/10.3390/foods12071544 N2 - Plant-based milk alternatives can be distinguished in two main categories, differing in production processes and regulation: plant-based formulas and plant-based drinks. They are now a widely accepted class of products on the international market. The various plant-based milk alternatives differ in nutritional characteristics due to their origin and manufacturing; more importantly, whereas formulas from plant and cow origin can be used interchangeably, plant-based drinks are nutritionally different from cow?s milk and can be consumed by children subsequently to the use of formula. Several scientific organizations have expressed differing opinions on the use of these products in the diets of children. In the face of unanimous conclusions regarding the use of these products during the first year of life, in subsequent ages there were conflicting opinions regarding the timing, quantities, and type of product to be used. From the viewpoint of the child?s overall diet and health, it could be suggested that these foods be considered not as simple substitutes for cow?s milk, but as part of a varied diet, within individual advice of use. We suggest accepting the presence of these products in a baby?s diet (omnivores included), planning their use correctly in the context of a balanced diet, according to the specific product and the needs of the individual. ID - uneatlantico6770 VL - 12 A1 - Brusati, Marco A1 - Baroni, Luciana A1 - Rizzo, Gianluca A1 - Giampieri, Francesca A1 - Battino, Maurizio AV - public KW - functional foods; plant-based formula; plant-based drinks; plant-based milk alternatives; child; infant; pediatric guidelines ER - TY - JOUR KW - enzyme activity KW - mechanism KW - microwave irradiation KW - reaction kinetics KW - structure AV - public A1 - Cao, Hongwei A1 - Wang, Xiaoxue A1 - Liu, Jing A1 - Sun, Zhu A1 - Yu, Zhiquan A1 - Battino, Maurizio A1 - El?Seedi, Hesham A1 - Guan, Xiao UR - http://doi.org/10.1111/1541-4337.13154 ID - uneatlantico6771 N2 - Microwave (MW) and enzyme catalysis are two emerging processing tools in the field of food industry. Recently, MW has been widely utilized as a novel type of green and safe heating energy. However, the effect of MW irradiation on enzyme activity is not described clearly. The intrinsic mechanisms behind enzyme activation and inactivation remain obscure. To apply better MW to the field of enzyme catalysis, it is essential to gain insights into the mechanism of MW action on enzyme activity. This review summarizes the changes in various enzyme activity during food processing, especially under MW irradiation. The intrinsic mechanism of thermal and nonthermal effects of MW irradiation was analyzed from the perspective of enzyme reaction kinetics and spatial structure. MW irradiation temperature is a vital parameter affecting the catalytic activity of enzymes. Activation of the enzyme activity is achieved even at high MW power when the enzyme is operating at its optimum temperature. However, when the temperature exceeds the optimum temperature, the enzyme activity is inhibited. In addition to MW dielectric heating effect, nonthermal MW effects also alter the microenvironment of reactive system. Taken together, enzyme activity is influenced by both thermal and nonthermal MW effects TI - Mechanistic insights into the changes of enzyme activity in food processing under microwave irradiation JF - Comprehensive Reviews in Food Science and Food Safety SN - 1541-4337 Y1 - 2023/04// ER - TY - JOUR UR - http://doi.org/10.1016/j.foodchem.2022.134181 N2 - Functional foods have emerged as an attractive option for many consumers, given their wide-ranging and long-term benefits. The functional food market size was valued at USD 177,770 Million in 2019 and is estimated to reach USD 267,924.4 Million by 2027, registering a CAGR of 6.7% from 2021 to 2027. Various natural products/compounds exert significant functional activity, and could also added value to food products alone or in combination, provided functional activity. The use of natural compounds in preparation of functional foods is important due to its higher safety, superior organoleptic properties, and functional attributes, resulted in wider consumer acceptance. Also, the use of advanced technologies in formulation of functional foods provides a better means of utilizing natural compounds for organoleptic and functional attributes. ID - uneatlantico3866 TI - Valorization of food products using natural functional compounds for improving organoleptic and functional chemistry JF - Food Chemistry AV - none VL - 403 A1 - Battino, Maurizio A1 - Belwal, Tarun A1 - Prieto, Miguel A. SN - 03088146 Y1 - 2023/03// N1 - Editorial ER - TY - JOUR Y1 - 2023/03// SN - 2470-1343 JF - ACS Omega TI - Exploring the Chemistry of Ocimum Species under Specific Extractions and Chromatographic Methods: A Systematic Review ID - uneatlantico6448 UR - http://doi.org/10.1021/acsomega.3c00043 N2 - Ocimum is considered the largest genus in the Lamiacea family. The genus includes basil, a group of aromatic plants with a wide range of culinary uses that nowadays draws attention for its medicinal and pharmaceutical potential. This systematic review intends to explore the chemical composition of nonessential oils and their variation across different Ocimum species. Moreover, we aimed to identify the state of knowledge regarding the molecular space in this genus as well as the different methods of extraction/identification and geographical location. Seventy-nine eligible articles were selected for the final analysis, from which we extracted more than 300 molecules. We found that the countries with the highest number of studies into Ocimum species are India, Nigeria, Brazil, and Egypt. However, from all known species of Ocimum, only 12 were found to have an extensive chemical characterization, particularly Ocimum basilicum and Ocimum tenuiflorum. Our study focused especially on alcoholic, hydroalcoholic, and water extracts, in which the main techniques for compound identifications are GC-MS, LC-MS, and LC-UV. Across the compiled molecules, we found a wide variety of compounds, especially flavonoids, phenolic acids, and terpenoids, suggesting that this genus could be a very useful source of possible bioactive compounds. The information collected in this review also emphasizes the huge gap between the vast number of Ocimum species discovered and the number of studies in each of them that determined the chemical characterization. A1 - Beltrán-Noboa, Andrea A1 - Jordan-Álvarez, Alejandro A1 - Guevara-Terán, Mabel A1 - Gallo, Blanca A1 - Berrueta, Luis A. A1 - Giampieri, Francesca A1 - Battino, Maurizio A1 - Álvarez-Suarez, José M. A1 - Tejera, Eduardo KW - Chemical composition KW - Extraction KW - Mathematical methods KW - Molecules KW - Organic acids AV - public ER - TY - JOUR SP - 1 EP - 6 Y1 - 2023/03// SN - 18785093 A1 - Giampieri, Francesca A1 - Cianciosi, Danila A1 - Alvarez-Suarez, José M. A1 - Quiles, José L. A1 - Forbes-Hernández, Tamara Y. A1 - Navarro-Hortal, María D. A1 - Machì, Michele A1 - Pali-Casanova, Ramón A1 - Martínez Espinosa, Julio César A1 - Chen, Xiumin A1 - Zhang, Di A1 - Bai, Weibin A1 - Lingmin, Tian A1 - Mezzetti, Bruno A1 - Battino, Maurizio A1 - Diaz, Yasmany Armas AV - none KW - Anthocyanins KW - bioavailability KW - disease prevention KW - gut microbiota JF - Journal of Berry Research TI - Anthocyanins: what do we know until now? UR - http://doi.org/10.3233/JBR-220087 ID - uneatlantico5529 N2 - Diets enriched in plant-based foods are associated with the maintenance of a good well-being and with the prevention of many non-communicable diseases. The health effects of fruits and vegetables consumption are mainly due to the presence of micronutrients, including vitamins and minerals, and polyphenols, plant secondary metabolites. One of the most important classes of phenolic compounds are anthocyanins, that confer the typical purple-red color to many foods, such as berries, peaches, plums, red onions, purple corn, eggplants, as well as purple carrots, sweet potatoes and red cabbages, among others. This commentary aims to briefly highlight the progress made by science in the last years, focusing on some unexpected aspects related with anthocyanins, such as their bioavailability, their health effects and their relationship with gut microbiota ER - TY - JOUR IS - 5 SN - 1422-0067 Y1 - 2023/02// AV - public KW - olive leaves; bioactive compounds; Alzheimer?s Disease; oleuropein; hydroxytyrosol A1 - Romero-Márquez, Jose M. A1 - Forbes-Hernández, Tamara Y. A1 - Navarro-Hortal, María D. A1 - Quirantes-Piné, Rosa A1 - Grosso, Giuseppe A1 - Giampieri, Francesca A1 - Lipari, Vivian A1 - Sánchez-González, Cristina A1 - Battino, Maurizio A1 - Quiles, José L. VL - 24 N2 - Alzheimer?s Disease (AD) is the cause of around 60?70% of global cases of dementia and approximately 50 million people have been reported to suffer this disease worldwide. The leaves of olive trees (Olea europaea) are the most abundant by-products of the olive grove industry. These by-products have been highlighted due to the wide variety of bioactive compounds such as oleuropein (OLE) and hydroxytyrosol (HT) with demonstrated medicinal properties to fight AD. In particular, the olive leaf (OL), OLE, and HT reduced not only amyloid-? formation but also neurofibrillary tangles formation through amyloid protein precursor processing modulation. Although the isolated olive phytochemicals exerted lower cholinesterase inhibitory activity, OL demonstrated high inhibitory activity in the cholinergic tests evaluated. The mechanisms underlying these protective effects may be associated with decreased neuroinflammation and oxidative stress via NF-?B and Nrf2 modulation, respectively. Despite the limited research, evidence indicates that OL consumption promotes autophagy and restores loss of proteostasis, which was reflected in lower toxic protein aggregation in AD models. Therefore, olive phytochemicals may be a promising tool as an adjuvant in the treatment of AD. UR - http://doi.org/10.3390/ijms24054353 ID - uneatlantico6096 TI - Molecular Mechanisms of the Protective Effects of Olive Leaf Polyphenols against Alzheimer?s Disease JF - International Journal of Molecular Sciences ER - TY - JOUR Y1 - 2023/02// SN - 2076-3921 IS - 2 JF - Antioxidants UR - http://doi.org/10.3390/antiox12020404 ID - uneatlantico5929 N2 - There is growing evidence that Alzheimer?s disease (AD) can be prevented by reducing risk factors involved in its pathophysiology. Food-derived bioactive molecules can help in the prevention and reduction of the progression of AD. Honey, a good source of antioxidants and bioactive molecules, has been tied to many health benefits, including those from neurological origin. Monofloral avocado honey (AH) has recently been characterized but its biomedical properties are still unknown. The aim of this study is to further its characterization, focusing on the phenolic profile. Moreover, its antioxidant capacity was assayed both in vitro and in vivo. Finally, a deep analysis on the pathophysiological features of AD such as oxidative stress, amyloid-? aggregation, and protein-tau-induced neurotoxicity were evaluated by using the experimental model C. elegans. AH exerted a high antioxidant capacity in vitro and in vivo. No toxicity was found in C. elegans at the dosages used. AH prevented ROS accumulation under AAPH-induced oxidative stress. Additionally, AH exerted a great anti-amyloidogenic capacity, which is relevant from the point of view of AD prevention. AH exacerbated the locomotive impairment in a C. elegans model of tauopathy, although the real contribution of AH remains unclear. The mechanisms under the observed effects might be attributed to an upregulation of daf-16 as well as to a strong ROS scavenging activity. These results increase the interest to study the biomedical applications of AH; however, more research is needed to deepen the mechanisms under the observed effects TI - In Vivo Anti-Alzheimer and Antioxidant Properties of Avocado (Persea americana Mill.) Honey from Southern Spain KW - A?; tau; AAPH; oxidative stress; ROS; phytochemical; Alzheimer; tauopathies AV - public A1 - Romero-Márquez, Jose M. A1 - Navarro-Hortal, María D. A1 - Orantes, Francisco J. A1 - Esteban-Muñoz, Adelaida A1 - Mazas Pérez-Oleaga, Cristina A1 - Battino, Maurizio A1 - Sánchez-González, Cristina A1 - Rivas-García, Lorenzo A1 - Giampieri, Francesca A1 - Quiles, José L. A1 - Forbes-Hernandez, Tamara Y. VL - 12 ER - TY - JOUR JF - Antioxidants TI - Oleuropein Attenuates Oxidative Stress in Human Trophoblast Cells UR - http://doi.org/10.3390/antiox12010197 N2 - Olive-derived bioactive compound oleuropein was evaluated against damage induced by hydrogen peroxide in human trophoblast cells in vitro, by examining the changes in several markers implicated in oxidative stress interactions in the placenta. Trophoblast HTR-8/SVneo cells were preincubated with OLE at 10 and 100 µM and exposed to H2O2, as a model of oxidative stress. Protein and lipid peroxidation, as well as antioxidant enzymes? activity, were determined spectrophotometrically, and DNA damage was evaluated by comet assay. iNOS protein expression was assessed by Western blot, while the mRNA expression of pro- and anti-apoptotic genes BAX and BCL2 and transcription factor NFE2L2, as well as cytokines IL-6 and TNF ? were determined by qPCR. Oleuropein demonstrated cytoprotective effects against H2O2 in trophoblast cells by significantly improving the antioxidant status and preventing protein and lipid damage, as well as reducing the iNOS levels. OLE reduced the mRNA expression of IL-6 and TNF ?, however, it did not influence the expression of NFE2L2 or the BAX/BCL2 ratio after H2O2 exposure. Oleuropein per se did not lead to any adverse effects in HTR-8/SVneo cells under the described conditions, confirming its safety in vitro. In conclusion, it significantly attenuated oxidative damage and restored antioxidant functioning, confirming its protective role in trophoblast ID - uneatlantico5528 VL - 12 A1 - Pirkovi?, Andrea A1 - Viloti?, Aleksandra A1 - Borozan, Sun?ica A1 - Nacka-Aleksi?, Mirjana A1 - Boji?-Trbojevi?, ?anka A1 - Krivoku?a, Milica Jovanovi? A1 - Battino, Maurizio A1 - Giampieri, Francesca A1 - Dekanski, Dragana AV - public KW - oleuropein; trophoblast; oxidative stress; pregnancy Y1 - 2023/01// SN - 2076-3921 IS - 1 ER - TY - JOUR TI - The International Natural Product Sciences Taskforce (INPST) and the power of Twitter networking exemplified through #INPST hashtag analysis UR - http://doi.org/10.1016/j.phymed.2022.154520 N2 - The development of digital technologies and the evolution of open innovation approaches have enabled the creation of diverse virtual organizations and enterprises coordinating their activities primarily online. The open innovation platform titled ?International Natural Product Sciences Taskforce? (INPST) was established in 2018, to bring together in collaborative environment individuals and organizations interested in natural product scientific research, and to empower their interactions by using digital communication tools. Methods In this work, we present a general overview of INPST activities and showcase the specific use of Twitter as a powerful networking tool that was used to host a one-week ?2021 INPST Twitter Networking Event? (spanning from 31st May 2021 to 6th June 2021) based on the application of the Twitter hashtag #INPST. Results and Conclusion The use of this hashtag during the networking event period was analyzed with Symplur Signals (https://www.symplur.com/), revealing a total of 6,036 tweets, shared by 686 users, which generated a total of 65,004,773 impressions (views of the respective tweets). This networking event's achieved high visibility and participation rate showcases a convincing example of how this social media platform can be used as a highly effective tool to host virtual Twitter-based international biomedical research events. ID - uneatlantico5021 JF - Phytomedicine VL - 108 A1 - Singla, Rajeev K. A1 - De, Ronita A1 - Efferth, Thomas A1 - Mezzetti, Bruno A1 - Sahab Uddin, Md. A1 - Sanusi, X. A1 - Ntie-Kang, Fidele A1 - Wang, Dongdong A1 - Schultz, Fabien A1 - Kharat, Kiran R. A1 - Devkota, Hari Prasad A1 - Battino, Maurizio A1 - Sur, Daniel A1 - Lordan, Ronan A1 - Patnaik, Sourav S A1 - Tsagkaris, Christos A1 - Sai, Chandragiri Siva A1 - Tripathi, Surya Kant A1 - G?man, Mihnea-Alexandru A1 - Ahmed, Mosa E.O. A1 - González-Burgos, Elena A1 - Babiaka, Smith B. A1 - Paswan, Shravan Kumar A1 - Odimegwu, Joy Ifunanya A1 - Akram, Faizan A1 - Simal-Gandara, Jesus A1 - Urquiza, Mágali S. A1 - Tikhonov, Aleksei A1 - Mondal, Himel A1 - Singla, Shailja A1 - Lonardo, Sara Di A1 - Mulholland, Eoghan J A1 - Cenanovic, Merisa A1 - Maigoro, Abdulkadir Yusif A1 - Giampieri, Francesca A1 - Lee, Soojin A1 - Tzvetkov, Nikolay T. A1 - Louka, Anna Maria A1 - Verma, Pritt A1 - Chopra, Hitesh A1 - Olea, Scarlett Perez A1 - Khan, Johra A1 - Alvarez Suarez, José M. A1 - Zheng, Xiaonan A1 - Tomczyk, Micha? A1 - Sabnani, Manoj Kumar A1 - Medina, Christhian Delfino Villanueva A1 - Khalid, Garba M. A1 - Boyina, Hemanth Kumar A1 - Georgiev, Milen I. A1 - Supuran, Claudiu T. A1 - Sobarzo-Sánchez, Eduardo A1 - Fan, Tai-Ping A1 - Pittala, Valeria A1 - Sureda, Antoni A1 - Braidy, Nady A1 - Russo, Gian Luigi A1 - Vacca, Rosa Anna A1 - Banach, Maciej A1 - Lizard, Gérard A1 - Zarrouk, Amira A1 - Hammami, Sonia A1 - Orhan, Ilkay Erdogan A1 - Aggarwal, Bharat B. A1 - Perry, George A1 - Miller, Mark JS A1 - Heinrich, Michael A1 - Bishayee, Anupam A1 - Kijjoa, Anake A1 - Arkells, Nicolas A1 - Bredt, David A1 - Wink, Michael A1 - Fiebich, Bernd l. A1 - Kiran, Gangarapu A1 - Yeung, Andy Wai Kan A1 - Gupta, Girish Kumar A1 - Santini, Antonello A1 - Lucarini, Massimo A1 - Durazzo, Alessandra A1 - El-Demerdash, Amr A1 - Dinkova-Kostova, Albena T. A1 - Cifuentes, Alejandro A1 - Souto, Eliana B. A1 - Zubair, Muhammad Asim Masoom A1 - Badhe, Pravin A1 - Echeverría, Javier A1 - Horba?czuk, Jaros?aw Olav A1 - Horbanczuk, Olaf K. A1 - Sheridan, Helen A1 - Sheshe, Sadeeq Muhammad A1 - Witkowska, Anna Maria A1 - Abu-Reidah, Ibrahim M. A1 - Riaz, Muhammad A1 - Ullah, Hammad A1 - Oladipupo, Akolade R. A1 - Lopez, Víctor A1 - Sethiya, Neeraj Kumar A1 - Shrestha, Bhupal Govinda A1 - Ravanan, Palaniyandi A1 - Gupta, Subash Chandra A1 - Alzahrani, Qushmua E. A1 - Dama Sreedhar, Preethidan A1 - Xiao, Jianbo A1 - Moosavi, Mohammad Amin A1 - Subramani, Parasuraman Aiya A1 - Singh, Amit Kumar A1 - Chettupalli, Ananda Kumar A1 - Patra, Jayanta Kumar A1 - Singh, Gopal A1 - Karpi?ski, Tomasz M. A1 - Al-Rimawi, Fuad A1 - Abiri, Rambod A1 - Ahmed, Atallah F. A1 - Barreca, Davide A1 - Vats, Sharad A1 - Amrani, Said A1 - Fimognari, Carmela A1 - Mocan, Andrei A1 - Hritcu, Lucian A1 - Semwal, Prabhakar A1 - Shiblur Rahaman, Md. A1 - Emerald, Mila A1 - Akinrinde, Akinleye Stephen A1 - Singh, Abhilasha A1 - Joshi, Ashima A1 - Joshi, Tanuj A1 - Khan, Shafaat Yar A1 - Balla, Gareeballah Osman Adam A1 - Lu, Aiping A1 - Pai, Sandeep Ramchandra A1 - Ghzaiel, Imen A1 - Acar, Niyazi A1 - Es-Safi, Nour Eddine A1 - Zengin, Gokhan A1 - Kureshi, Azazahemad A. A1 - Sharma, Arvind Kumar A1 - Baral, Bikash A1 - Rani, Neeraj A1 - Jeandet, Philippe A1 - Gulati, Monica A1 - Kapoor, Bhupinder A1 - Mohanta, Yugal Kishore A1 - Emam-Djomeh, Zahra A1 - Onuku, Raphael A1 - Depew, Jennifer R. A1 - Atrooz, Omar M. A1 - Goh, Bey Hing A1 - Andrade, Jose Carlos A1 - Konwar, Bikramjit A1 - Shine, VJ A1 - Ferreira, João Miguel Lousa Dias A1 - Ahmad, Jamil A1 - Chaturvedi, Vivek K. A1 - Skalicka-Wo?niak, Krystyna A1 - Sharma, Rohit A1 - Gautam, Rupesh K. A1 - Granica, Sebastian A1 - Parisi, Salvatore A1 - Kumar, Rishabh A1 - Atanasov, Atanas G. A1 - Shen, Bairong KW - Natural productsOpen innovationSocial mediaHashtag analysisTwitter researchDigital tools AV - public SN - 09447113 Y1 - 2023/01// ER - TY - JOUR VL - 14 A1 - Nacka-Aleksi?, Mirjana A1 - Pirkovi?, Andrea A1 - Viloti?, Aleksandra A1 - Boji?-Trbojevi?, ?anka A1 - Jovanovi? Krivoku?a, Milica A1 - Giampieri, Francesca A1 - Battino, Maurizio A1 - Dekanski, Dragana AV - public KW - polyphenols; early pregnancy; trophoblast; gestational diabetes mellitus; preeclampsia TI - The Role of Dietary Polyphenols in Pregnancy and Pregnancy-Related Disorders N2 - Polyphenols are a group of phytochemicals with extensive biological functions and health-promoting potential. These compounds are present in most foods of plant origin and their increased widespread availability through the intake of nutritional supplements, fortified foods, and beverages, has also led to increased exposure throughout gestation. In this narrative review, we focus on the role of polyphenols in both healthy and pathological pregnancy. General information related to their classification and function is followed by an overview of their known effects in early-pregnancy events, including the current insights into molecular mechanisms involved. Further, we provide an overview of their involvement in some of the most common pregnancy-associated pathological conditions, such as preeclampsia and gestational diabetes mellitus. Additionally, we also discuss the estimated possible risk of polyphenol consumption on pregnancy outcomes. The consumption of dietary polyphenols during pregnancy needs particular attention considering the possible effects of polyphenols on the mechanisms involved in maternal adaptation and fetal development. Further studies are strongly needed to unravel the in vivo effects of polyphenol metabolites during pregnancy, as well as their role on advanced maternal age, prenatal nutrition, and metabolic risk of the offspring. UR - http://doi.org/10.3390/nu14245246 ID - uneatlantico5020 JF - Nutrients IS - 24 SN - 2072-6643 Y1 - 2022/12// ER - TY - JOUR AV - public KW - Blueberry pomace; Anthocyanins; HPLCUl; trasound-assisted extraction; Box-Behnken Design VL - 16 A1 - Zhang, Xuan A1 - Wang, Songen A1 - Wu, Qixia A1 - Battino, Maurizio A1 - Giampieri, Francesca A1 - Bai, Weibin A1 - Tian, Lingmin JF - Food Chemistry: X UR - http://doi.org/10.1016/j.fochx.2022.100476 ID - uneatlantico4196 N2 - Food waste is a potential source to replace fresh materials for obtaining functional ingredients. Blueberry pomace contains considerable amounts of anthocyanins. In this study, we investigated ultrasonic-assisted extraction (UAE) of anthocyanins from blueberry pomace. We used a Box-Behnken design (BBD) to screen and optimize the important factors influencing yield. The optimum extraction conditions were a temperature of 40 °C, an ultrasonic power of 400 W and an extraction time of 40 min. The optimum yield was 108.23 mg/100 g DW. In addition, we used a cation column to separate anthocyanins, and optimized the chromatographic conditions of HPLC to analyze and identify the main anthocyanins. Thirteen anthocyanins were found in blueberry pomace, of which Malvidin-3-Galactoside (22.65 %) was the highest. These findings provide a theoretical basis and optimized process parameters for the recovery of high value-added anthocyanins from blueberry pomace with ultrasound-assisted extraction, thus facilitating the comprehensive utilization of blueberry pomace. TI - Recovering high value-added anthocyanins from blueberry pomace with ultrasound-assisted extraction Y1 - 2022/12// SN - 25901575 ER - TY - JOUR IS - 21 Y1 - 2022/11// SN - 1420-3049 A1 - Guevara-Terán, Mabel A1 - Padilla-Arias, Katherine A1 - Beltrán-Novoa, Andrea A1 - González-Paramás, Ana M. A1 - Giampieri, Francesca A1 - Battino, Maurizio A1 - Vásquez-Castillo, Wilson A1 - Fernandez-Soto, Paulina A1 - Tejera, Eduardo A1 - Alvarez-Suarez, José M. VL - 27 KW - Andean blueberry; altitude; ripeness; chemical composition; antioxidant capacity; antimicrobial activity AV - public JF - Molecules TI - Influence of Altitudes and Development Stages on the Chemical Composition, Antioxidant, and Antimicrobial Capacity of the Wild Andean Blueberry (Vaccinium floribundum Kunth) UR - http://doi.org/10.3390/molecules27217525 ID - uneatlantico4406 N2 - The chemical composition and biological capacities of berries depend on environmental parameters, maturity, and location. The Andean blueberry (Vaccinium floribundum Kunth), also known as mortiño, presents a unique combination of several phytochemicals, which play a synergistic role in its characterization as a functional food. We aimed to expose the possible variations that exist in the profile of the phenolic compounds as well as the antioxidant and antimicrobial capacity of the wild Andean blueberry with respect to three ripeness stages and two different altitudes. We found that polyphenols are the predominant compounds in the berry during the early ripeness stage and are the main bioactive compounds that give rise to the antioxidant capacity and inhibition effect on the growth of gram-positive and gram-negative bacteria. Moreover, the accumulation of ascorbic acid, free amino acids, and anthocyanins increases as the ripening process progresses, and they were the main bioactive compounds in the ripe berry. The latter compounds influence the production of the typical bluish or reddish coloration of ripe blueberries. In addition, it was determined that environmental conditions at high altitudes could have a positive influence in all cases. Overall, our data provide evidence regarding the high functional value of the wild Andean blueberry. ER - TY - JOUR UR - http://doi.org/10.1039/D2FO01739C ID - uneatlantico4009 N2 - Alzheimer's is a chronic degenerative disease of the central nervous system considered the leading cause of dementia in the world. It is characterized by two etiopathological events related to oxidative stress: the aggregation of ?-amyloid peptide and the formation of neurofibrillary tangles of hyperphosphorylated Tau protein in the brain. The incidence of this disease increases with age and has been associated with inadequate lifestyles. Some natural compounds have been shown to improve the hallmarks of the disease. However, despite its potential, there is no scientific evidence about Manuka honey (MH) in this regard. In the present work we evaluated the effect of MH on the toxicity induced by A? aggregation and Tau in a Caenorhabditis elegans model. Our results demonstrated that MH was able to improve indicators of oxidative stress and delayed A?-induced paralysis in the AD model CL4176 through HSP-16.2 and SKN-1/NRF2 pathways. Nevertheless, its sugar content impaired the indicators of locomotion (an indicator of tau neurotoxicity) in both the transgenic strain BR5706 and in the wild-type N2 worms. TI - Amyloid ?-but not Tau-induced neurotoxicity is suppressed by Manuka honey via HSP-16.2 and SKN-1/Nrf2 pathways in an in vivo model of Alzheimer's disease JF - Food & Function AV - public A1 - Navarro-Hortal, María D. A1 - Romero-Márquez, Jose M. A1 - Muñoz-Ollero, Pedro A1 - Jiménez-Trigo, Victoria A1 - Esteban-Muñoz, Adelaida A1 - Tutusaus, Kilian A1 - Giampieri, Francesca A1 - Battino, Maurizio A1 - Sánchez-González, Cristina A1 - Rivas-García, Lorenzo A1 - Llopis, Juan A1 - Forbes-Hernández, Tamara Y. A1 - Quiles, José L. SN - 2042-6496 Y1 - 2022/10// ER - TY - JOUR VL - 168 A1 - Varela-López, Alfonso A1 - Ramírez-Tortosa, César L. A1 - Ramos-Pleguezuelos, Francisco M. A1 - Márquez-Lobo, Bélgica A1 - Battino, Maurizio A1 - Quiles, José L. KW - Aging; Geropathology; Histopathology; Lipotoxicity; Nutrition AV - public JF - Food and Chemical Toxicology TI - Differences reported in the lifespan and aging of male Wistar rats maintained on diets containing fat with different fatty acid profiles (virgin olive, sunflower or fish oils) are not reflected by histopathological lesions found at death in central nervous and endocrine systems N2 - The present study was designed to examine if dietary fat sources that have shown differences in lifespan and if some aging-related aspects can modulate the range of histopathologic changes in central nervous and endocrine systems that occur during the lifespan of Wistar rats. Moreover, it was attempted to gain insight into the relationship between longevity and the development of the different pathological changes, as well as possible interaction with diet. In order to achieve this, male Wistar rats were randomly assigned to three experimental groups fed semisynthetic and isoenergetic diets from weaning until death with different dietary fat sources, namely virgin olive, sunflower, or fish oil. An individual follow-up until death of each animal was performed. Incidence, severity, and burden of specific or group (i.e., neoplastic or non-neoplastic proliferative and non-proliferative) of lesions was calculated along with individual's disease and individual organ lesion burden. Most of the histopathological lesions found have been described in previous studies. Neoplasms, and in particular pituitary adenomas followed by brain tumors, were the most prevalent lesions found in the rats and the main cause of death involving both systems. Incidence of brain lesions was associated with age-at-death. Assayed dietary fats did not present differential effects on pathological changes occurring in endocrine and central nervous systems throughout rat lifespan. UR - http://doi.org/10.1016/j.fct.2022.113357 ID - uneatlantico3488 Y1 - 2022/10// SN - 02786915 ER - TY - JOUR JF - Trends in Food Science & Technology TI - The rise of processed meat alternatives: A narrative review of the manufacturing, composition, nutritional profile and health effects of newer sources of protein, and their place in healthier diets ID - uneatlantico3006 UR - http://doi.org/10.1016/j.tifs.2022.07.005 N2 - Background The drive to reduce the negative impact of the global food system on the environment and human health, and to feed a growing global population, has led to the rapid development of meat alternatives, including plant-based and mycoprotein-based products such as burgers, cured meat and nuggets. These are generally food items manufactured with highly refined ingredients, so health professionals interested in promoting plant-based diets, or a reduction in meat consumption, need a deeper understanding about the potential health effects of these products in order to present them to the public in an objective and helpful manner. Scope and approaches In this narrative review, a search of the current available scientific literature was performed with the aim of exploring all these foods by delving into the way they are manufactured, their nutritional characteristics, their impact on health, as well as trying to understand their place in modern, diets. Key findings and conclusion Processed meat alternatives, despite being highly refined products, can be a good source of healthy food groups and nutrients often underrepresented in omnivores diets such as grains, legumes, plant protein and fibre, although attention must be paid to their salt and saturated fat content. For people wanting to move away from a meat-heavy diet, the consumption of these items can represent a stepping stone towards the adoption of more healthful dietary patterns centred on whole plant-foods. In addition, they might help to increase compliance with the new lifestyle as they tend to replicate some of the organoleptic properties of meat. A1 - Gastaldello, Annalisa A1 - Giampieri, Francesca A1 - de Giuseppe, Rachele A1 - Grosso, Giuseppe A1 - Baroni, Luciana A1 - Battino, Maurizio KW - Meat substitutes; Plant-based diets; Mycoprotein; Whole-plant foods; Alternative proteins AV - none Y1 - 2022/09// SN - 09242244 ER - TY - JOUR JF - Food Frontiers TI - Edible insects: A novel nutritious, functional, and safe food alternative UR - http://doi.org/10.1002/fft2.167 ID - uneatlantico2788 N2 - In a world where 1 billion people suffer from hunger, lands and seas are overexploited and production systems are unsustainable, and there is an urgent need to find alternative foods. In this context, insects represent a good source of macro- and micronutrients and even bioactive compounds that could contribute to reducing nutritional deficiency and preventing some human diseases. However, some aspects related to their consumption, including health risks, need to be clarified. This communication aims to summarize the nutritional/phytochemical profile of common edible insects and the main safety concerns, highlighting the possible strategies to promote entomophagy in a more conscious way. A1 - Giampieri, Francesca A1 - Alvarez?Suarez, José M. A1 - Machì, Michele A1 - Cianciosi, Danila A1 - Navarro?Hortal, Maria D. A1 - Battino, Maurizio AV - public KW - allergens KW - biological and toxicological risks KW - entomophagy KW - fats KW - flavonoids KW - proteins Y1 - 2022/09// SN - 2643-8429 ER - TY - JOUR SN - 1568-7767 Y1 - 2022/09// A1 - Guevara-Terán, Mabel A1 - Gonzalez-Paramás, Ana M. A1 - Beltrán-Noboa, Andrea A1 - Giampieri, Francesca A1 - Battino, Maurizio A1 - Tejera, Eduardo A1 - Alvarez-Suarez, José M. KW - Strawberry; Altitude; Physicochemical composition; Antioxidant capacity; Random model; Meta-analysis AV - public TI - Influence of altitude on the physicochemical composition and antioxidant capacity of strawberry: a preliminary systematic review and meta-analysis UR - http://doi.org/10.1007/s11101-022-09834-z ID - uneatlantico3544 N2 - Several climatic trends are generally associated with altitude, that may influence the nutritional and phytochemical composition of plants. Strawberry is considered a functional food due to biological activities and health benefits. This systematic review and meta-analysis intend to expose possible variations on physicochemical composition and antioxidant capacity of strawberries in regard to altitude. Thirty eligible studies were included for the final meta-analysis. Two altitude ranges were established: 0 ? 1000 and 1000?2000 m above sea level. A random-effects model was used to obtain the results. It was discovered that total soluble solids significantly decreased with altitude. Total titratable acidity increased with altitude. Vitamin C and total anthocyanins showed a significant difference between the groups before we discarded some studies. The analysis of altitude for phenolics and antioxidant capacity evaluated for the DPPH radical scavenging method did not identify any significant differences between the studies. The findings suggest that altitude does not affect the physicochemical composition and antioxidant capacity of strawberries; nonetheless, a more exhaustive study is recommended. JF - Phytochemistry Reviews ER - TY - JOUR TI - The Molecular Weaponry Produced by the Bacterium Hafnia alvei in Foods UR - http://doi.org/10.3390/molecules27175585 ID - uneatlantico3545 N2 - Hafnia alvei is receiving increasing attention from both a medical and veterinary point of view, but the diversity of molecules it produces has made the interest in this bacterium extend to the field of probiotics, the microbiota, and above all, to its presence and action on consumer foods. The production of Acyl Homoserine Lactones (AHLs), a type of quorum-sensing (QS) signaling molecule, is the most often-studied chemical signaling molecule in Gram-negative bacteria. H. alvei can use this communication mechanism to promote the expression of certain enzymatic activities in fermented foods, where this bacterium is frequently present. H. alvei also produces a series of molecules involved in the modification of the organoleptic properties of different products, especially cheeses, where it shares space with other microorganisms. Although some strains of this species are implicated in infections in humans, many produce antibacterial compounds, such as bacteriocins, that inhibit the growth of true pathogens, so the characterization of these molecules could be very interesting from the point of view of clinical medicine and the food industry. Lastly, in some cases, H. alvei is responsible for the production of biogenic amines or other compounds of special interest in food health. In this article, we will review the most interesting molecules that produce the H. alvei strains and will discuss some of their properties, both from the point of view of their biological activity on other microorganisms and the properties of different food matrices in which this bacterium usually thrives. JF - Molecules VL - 27 A1 - Ramos Vivas, Jose A1 - Tapia Martínez, Olga A1 - Elexpuru Zabaleta, Maria A1 - Tutusaus, Kilian A1 - Armas Diaz, Yasmany A1 - Battino, Maurizio A1 - Giampieri, Francesca KW - Hafnia alvei; quorum-sensing; probiotics; biopreservation; foodborne pathogens AV - public SN - 1420-3049 Y1 - 2022/08// IS - 17 ER - TY - JOUR A1 - Giampieri, Francesca A1 - Mazzoni, Luca A1 - Cianciosi, Danila A1 - Alvarez-Suarez, José M. A1 - Regolo, Lucia A1 - Sánchez-González, Cristina A1 - Capocasa, Franco A1 - Xiao, Jianbo A1 - Mezzetti, Bruno A1 - Battino, Maurizio VL - 383 AV - none KW - Environmental impact; Nutritional quality; Residues; Safety; Sustainability JF - Food Chemistry TI - Organic vs conventional plant-based foods: A review UR - http://doi.org/10.1016/j.foodchem.2022.132352 N2 - Organic farming is characterized by the prohibition of the use of chemical synthetic fertilizers, pesticides, feed additives and genetically modified organisms and by the application of sustainable agricultural technologies based on ecological principles and natural rules. Organic products are believed to be more nutritious and safer foods compared to the conventional alternatives by consumers, with the consequent increase of demand and price of these foodstuffs. However, in academic circles there is much debate on these issues, since there is not a clear scientific evidence of the difference on the environmental impact and on the nutritional quality, safety and health effects between conventional and organic foods. Therefore, this work aims to describe and update the most relevant data on organic foods, by describing the impact of this practice on environment, producers, consumers and society, as well as by comparing the physicochemical, nutritional and phytochemical quality of conventional and organic plant foods. ID - uneatlantico568 Y1 - 2022/07// SN - 03088146 ER - TY - JOUR TI - Molecular bases for the use of functional foods in the management of healthy aging: Berries, curcumin, virgin olive oil and honey; three realities and a promise ID - uneatlantico2804 UR - http://doi.org/10.1080/10408398.2022.2098244 N2 - As the number of older people has grown in recent decades, the search for new approaches to manage or delay aging is also growing. Among the modifiable factors, diet plays a crucial role in healthy aging and in the prevention of age-related diseases. Thus, the interest in the use of foods, which are rich in bioactive compounds such as functional foods with anti-aging effects is a growing market. This review summarizes the current knowledge about the molecular mechanisms of action of foods considered as functional foods in aging, namely berries, curcumin, and virgin olive oil. Moreover, honey is also analyzed as a food with well-known healthy benefits, but which has not been deeply evaluated from the point of view of aging. The effects of these foods on aging are analyzed from the point of view of molecular mechanisms including oxidative stress, mitochondrial dysfunction, inflammation, genomic stability, telomere attrition, cellular senescence, and deregulated nutrient-sensing. A comprehensive study of the scientific literature shows that the aforementioned foods have demonstrated positive effects on certain aspects of aging, which might justify their use as functional foods in elderly. However, more research is needed, especially in humans, designed to understand in depth the mechanisms of action through which they act. JF - Critical Reviews in Food Science and Nutrition A1 - Navarro-Hortal, María D. A1 - Romero-Márquez, Jose M. A1 - Jiménez-Trigo, Victoria A1 - Xiao, Jianbo A1 - Giampieri, Francesca A1 - Forbes-Hernández, Tamara Y. A1 - Grosso, Giuseppe A1 - Battino, Maurizio A1 - Sánchez-González, Cristina A1 - Quiles, José L. KW - Dietary fat; hydroxytyrosol; monounsaturated fatty acids; nutraceutics; strawberry; turmeric AV - none SN - 1040-8398 Y1 - 2022/07// EP - 20 SP - 1 ER - TY - JOUR VL - 381 A1 - Rivas-García, Lorenzo A1 - Romero-Márquez, Jose M. A1 - Navarro-Hortal, M.D. A1 - Esteban-Muñoz, Adelaida A1 - Giampieri, Francesca A1 - Sumalla Cano, Sandra A1 - Battino, Maurizio A1 - Quiles, José L. A1 - Llopis, Juan A1 - Sánchez-González, Cristina AV - none KW - Flower; Quercetin; Autophagy; ROS; Antioxidants; Alzheimer disease TI - Unravelling potential biomedical applications of the edible flower Tulbaghia violacea N2 - Traditionally, edible flowers have been used as foods and for therapeutic purposes, today they have gained importance due to their bioactive compounds such as flavonols, anthocyanins or other phenolic compounds, which give them potential for biomedical applications. This work evaluated a methanolic extract of Tulbaghia violacea. Eleven individual phenolic compounds were found and quantified by mass spectrometry in the extract. Antioxidant activity tests (TEAC, FRAP and DPPH) and other characterization parameters were assayed (total phenolic content and total flavonoid content). In vitro studies showed antitumoral activity against ovarian tumoral cells mediated by the induction of non-dependent caspase cell death and by the activation of reactive oxygen species. The effect of the extract against features of Alzheimer disease was in vivo assayed in Caenorhabditis elegans. Tulbaghia extract led to a reduction in the 1?42 beta amyloid peptide formation and prevented oxidative stress. These results suggested that Tulbaghia violacea could be a new source of phenolic compounds for nutraceuticals and functional food development. UR - http://doi.org/10.1016/j.foodchem.2022.132096 ID - uneatlantico567 JF - Food Chemistry SN - 03088146 Y1 - 2022/07// ER - TY - JOUR TI - Metabolomic profile and computational analysis for the identification of the potential anti-inflammatory mechanisms of action of the traditional medicinal plants Ocimum basilicum and Ocimum tenuiflorum ID - uneatlantico664 UR - http://doi.org/10.1016/j.fct.2022.113039 N2 - Ocimum basilicum and Ocimum tenuiflorum are two basil species widely used medicinally as an anti-inflammatory, antimicrobial and cardioprotective agent. This study focuses on the chemical characterization of the majoritarian compounds of both species and their anti-inflammatory potential. Up to 22 compounds such as various types of salvianolic acids, derivatives of rosmaniric acid and flavones were identified in both plants. The identified compounds were very similar between both plants and are consistent with previous finding in other studies in Portugal and Italy. Based on the identified molecules a consensus target prediction was carried out. Among the main predicted target proteins, we found a high representation of the carbonic anhydrase family (CA2, CA7 and CA12) and several key proteins from the arachidonic pathway (LOX5, PLA2, COX1 and COX2). Both pathways are well related to inflammation. The interaction between the compounds and these targets were explored through molecular docking and molecular dynamics simulation. Our results suggest that some molecules present in both plants can induce an anti-inflammatory response through a non-steroidal mechanism of action connected to the carbon dioxide metabolism. JF - Food and Chemical Toxicology VL - 164 A1 - Beltrán-Noboa, Andrea A1 - Proaño-Ojeda, John A1 - Guevara, Mabel A1 - Gallo, Blanca A1 - Berrueta, Luis A. A1 - Giampieri, Francesca A1 - Perez-Castillo, Yunierkis A1 - Battino, Maurizio A1 - Álvarez-Suarez, José M. A1 - Tejera, Eduardo KW - Ocimum basilicum; Ocimum tenuiflorum; Phenolic composition; Anti-inflammatory response; Non-steroidal mechanism AV - none SN - 02786915 Y1 - 2022/06// ER - TY - JOUR AV - public KW - Plant by-products; Phenolic compounds; Polyphenols; Extraction; Up-cycling; Technical-assisted methods A1 - Gil-Martín, Emilio A1 - Forbes-Hernández, Tamara A1 - Romero, Alejandro A1 - Cianciosi, Danila A1 - Giampieri, Francesca A1 - Battino, Maurizio VL - 378 JF - Food Chemistry UR - http://doi.org/10.1016/j.foodchem.2021.131918 N2 - Agro-foodindustries generate colossal amounts of non-edible waste and by-products, easily accessible as raw materials for up-cycling active phytochemicals. Phenolic compounds are particularly relevant in this field given their abundance in plant residues and the market interest of their functionalities (e.g. natural antioxidant activity) as part of nutraceutical, cosmetological and biomedical formulations. In ?bench-to-bedside? achievements, sample extraction is essential because valorization benefits from matrix desorption and solubilization of targeted phytocompounds. Specifically, the composition and polarity of the extractant, the optimal sample particle size and sample:solvent ratio, as well as pH, pressure and temperature are strategic for the release and stability of mobilized species. On the other hand, current green chemistry environmental rules require extraction approaches that eliminate polluting consumables and reduce energy needs. Thus, the following pages provide an update on advanced technologies for the sustainable and efficient recovery of phenolics from plant matrices. ID - uneatlantico566 TI - Influence of the extraction method on the recovery of bioactive phenolic compounds from food industry by-products Y1 - 2022/06// SN - 03088146 ER - TY - JOUR AV - public KW - Column chromatography; 001X7; Anthocyanins; Copigments; Isolation; Scale-up A1 - Liao, Zhiwei A1 - Zhang, Xuan A1 - Chen, Xi A1 - Battino, Maurizio A1 - Giampieri, Francesca A1 - Bai, Weibin A1 - Tian, Lingmin VL - 5 JF - Current Research in Food Science UR - http://doi.org/10.1016/j.crfs.2022.08.022 N2 - Anthocyanins are often targets in polyphenol analysis. However, it's hard to effectively separate anthocyanin from copigments such as phenolic acid and flavanols due to their similar structure. Thus, a cation exchange chromatography with 001 × 7 has been developed, which is available for anthocyanins isolation both on a small and large scale. The optimal process condition of anthocyanins isolation was determined. Compared to the macroporous adsorbent resins and Strong Cation Exchange resin (SCX), 001X7 shows greater economic advantages in large-scale purification of anthocyanins. More than 95% purity of the anthocyanin fraction can be achieved through this approach. This method shows a path to provide large quantities of copigments-free anthocyanins from mulberry polyphenols for the further study of its biological effects and may be extended to other analytical methods of polyphenol isolation from other plant materials. ID - uneatlantico3588 TI - Recovery of value-added anthocyanins from mulberry by a cation exchange chromatography SP - 1445 EP - 1451 Y1 - 2022/06// SN - 26659271 ER - TY - JOUR SN - 03088146 Y1 - 2022/05// N2 - Polyphenols are plant secondary metabolites, whose biological activity has been widely demonstrated. However, the research in this field is a bit reductive, as very frequently the effect of individual compound is investigated in different experimental models, neglecting more complex, but common, relationships that are established in the diet. This review summarizes the data that highlighted the interaction between polyphenols and other food components, especially macro- (lipids, proteins, carbohydrates and fibers) and micronutrients (minerals, vitamins and organic pigments), paying particular attention on their bioavailability, antioxidant capacity and chemical, physical, organoleptic and nutritional characteristics. The topic of food interaction has yet to be extensively studied because a greater knowledge of the food chemistry behind these interactions and the variables that modify their effects, could offer innovations and improvements in various fields ranging from organoleptic, nutritional to health and economic field. UR - http://doi.org/10.1016/j.foodchem.2021.131904 ID - uneatlantico565 TI - The reciprocal interaction between polyphenols and other dietary compounds: Impact on bioavailability, antioxidant capacity and other physico-chemical and nutritional parameters JF - Food Chemistry KW - Antioxidant capacity; Bioavailability; Dietary compounds; Food industry; Food interaction; Polyphenols AV - none VL - 375 A1 - Cianciosi, Danila A1 - Forbes-Hernández, Tamara Y. A1 - Regolo, Lucia A1 - Alvarez-Suarez, José M. A1 - Navarro-Hortal, Maria Dolores A1 - Xiao, Jianbo A1 - Quiles, José L. A1 - Battino, Maurizio A1 - Giampieri, Francesca ER - TY - JOUR IS - 10 SN - 2072-6643 Y1 - 2022/05// A1 - Gastaldello, Annalisa A1 - Giampieri, Francesca A1 - Quiles, José L. A1 - Navarro-Hortal, María D. A1 - Aparicio Obregón, Silvia A1 - García Villena, Eduardo A1 - Tutusaus, Kilian A1 - De Giuseppe, Rachele A1 - Grosso, Giuseppe A1 - Cianciosi, Danila A1 - Forbes-Hernández, Tamara Y. A1 - Nabavi, Seyed M. A1 - Battino, Maurizio VL - 14 AV - public KW - macular degeneration; retinal disease; eye disease; maculopathy; drusen; Mediterranean diet; plant-based diets; dietary pattern; eating pattern TI - Adherence to the Mediterranean-Style Eating Pattern and Macular Degeneration: A Systematic Review of Observational Studies ID - uneatlantico2117 UR - http://doi.org/10.3390/nu14102028 N2 - Age-related macular degeneration (AMD) is a serious degenerative disease affecting the eyes, and is the main cause of severe vision loss among people >55 years of age in developed countries. Its onset and progression have been associated with several genetic and lifestyle factors, with diet appearing to play a pivotal role in the latter. In particular, dietary eating patterns rich in plant foods have been shown to lower the risk of developing the disease, and to decrease the odds of progressing to more advanced stages in individuals already burdened with early AMD. We systematically reviewed the literature to analyse the relationship between the adherence to a Mediterranean diet, a mainly plant-based dietary pattern, and the onset/progression of AMD. Eight human observational studies were analysed. Despite some differences, they consistently indicate that higher adherence to a Mediterranean eating pattern lowers the odds of developing AMD and decreases the risk of progression to more advanced stages of the disease, establishing the way for preventative measures emphasizing dietary patterns rich in plant-foods JF - Nutrients ER - TY - JOUR TI - Manuka honey in combination with 5-Fluorouracil decreases physical parameters of colonspheres enriched with cancer stem-like cells and reduces their resistance to apoptosis UR - http://doi.org/10.1016/j.foodchem.2021.131753 N2 - The aim of the present work was to evaluate the in vitro effect of Manuka honey and its combination with 5-Fu, the most common drug used in the treatment of colon cancer, on the morphological and physical parameters of colonspheres enriched with cancer stem-like cells deriving from HCT-116 colon adenocarcinoma cell line and on the apoptosis rate. Manuka honey, alone and more in combination with 5-Fu, reduced the weight, the diameter and mass density of the spheroids and induced apoptosis through the downregulation of many apoptosis inhibitors, including IAPs (Livin, Survivin, XIAP), IGFs (IGF-I, IGF-II and IGF-IR) and HSPs (HSP-27, HSP-60 and HSP-70). These results led to a reduction in the survival ability of cancer stem-like cells, as well as to a chemosensitizing effect of honey towards 5-Fu, considering that apoptosis resistance is one of the main causes of cancer stem-like cells chemoresistance. ID - uneatlantico564 JF - Food Chemistry VL - 374 A1 - Cianciosi, Danila A1 - Forbes-Hernández, Tamara Y. A1 - Regolo, Lucia A1 - Alvarez-Suarez, José M. A1 - Quinzi, Denise A1 - Sargenti, Azzurra A1 - Bai, Weibin A1 - Tian, Lingmin A1 - Giampieri, Francesca A1 - Battino, Maurizio AV - none KW - Apoptosis; Cancer; Chemosensibility; Honey; Spheroids; Stemness. SN - 03088146 Y1 - 2022/04// ER - TY - JOUR A1 - Romero-Márquez, Jose M. A1 - Navarro-Hortal, María D. A1 - Jiménez-Trigo, Victoria A1 - Vera-Ramírez, Laura A1 - Forbes-Hernández, Tamara J. A1 - Esteban-Muñoz, Adelaida A1 - Giampieri, Francesca A1 - Bullón, Pedro A1 - Battino, Maurizio A1 - Sánchez-González, Cristina A1 - Quiles, José L. VL - 162 AV - public KW - Alzheimer disease; DAF-16/FOXO; HSP-16.2; IIS pathway; RNAi; SKN-1/NRF2 JF - Food and Chemical Toxicology TI - An oleuropein rich-olive (Olea europaea L.) leaf extract reduces ?-amyloid and tau proteotoxicity through regulation of oxidative- and heat shock-stress responses in Caenorhabditis elegans N2 - Olive tree-derived products have been associated with numerous benefits for health. The aim of the present study was to characterize an olive leaf extract enriched in oleuropein (OLE) concerning phenolic content and profile as well as antioxidant capacity. Short-term and long-term toxicity, including oxidative stress, was in vivo evaluated in the experimental model Caenorhabditis elegans. Moreover, the potential therapeutic effect of the extract against A? induced- and tau protein induced-toxicity was also evaluated in C. elegans. OLE treatment did not exert toxicity. On the contrary, the extract was able to ameliorate oxidative stress and proteotoxicity related to A? and tau aggregation. The potential molecular mechanisms present behind the observed results explored by RNAi technology revealed that DAF-16/FOXO and SKN-1/NRF2, elements of the insulin insulin-like signalling pathway, as well as HSP-16.2 overexpression were involved. UR - http://doi.org/10.1016/j.fct.2022.112914 ID - uneatlantico597 Y1 - 2022/04// SN - 02786915 ER - TY - JOUR VL - 10 A1 - Battino, Maurizio AV - public TI - Feature Paper Special Issue for Editorial Board Members (EBMs) of Diseases UR - http://doi.org/10.3390/diseases10020018 ID - uneatlantico655 N2 - When you are part of a community, especially a scientific one, you are required to contribute significantly to its welfare, because the community as a whole represents each individual within it and, in turn, determines the wellbeing of the participants themselves. JF - Diseases IS - 2 N1 - EDITORIAL SN - 2079-9721 Y1 - 2022/03// ER - TY - JOUR SN - 03088146 Y1 - 2022/03// N2 - Bioactive compounds from strawberries have been associated with multiple healthy benefits. The present study aimed to assess chemical characterization of a methanolic extract of the Romina strawberry variety in terms of antioxidant capacity, polyphenols profile and chemical elements content. Additionally, potential toxicity, the effect on amyloid-? production and oxidative stress of the extract was in vivo evaluated in the experimental model Caenorhabditis elegans. Results revealed an important content in phenolic compounds (mainly ellagic acid and pelargonidin-3-glucoside) and minerals (K, Mg, P and Ca). The treatment with 100, 500 or 1000 ?g/mL of strawberry extract did not show toxicity. On the contrary, the extract was able to delay amyloid ?-protein induced paralysis, reduced amyloid-? aggregation and prevented oxidative stress. The potential molecular mechanisms present behind the observed results explored by RNAi technology revealed that DAF-16/FOXO and SKN-1/NRF2 signaling pathways were, at least partially, involved. UR - http://doi.org/10.1016/j.foodchem.2021.131272 ID - uneatlantico517 TI - Strawberry (Fragaria × ananassa cv. Romina) methanolic extract attenuates Alzheimer?s beta amyloid production and oxidative stress by SKN-1/NRF and DAF-16/FOXO mediated mechanisms in C. elegans JF - Food Chemistry AV - public KW - Berries; Antioxidant; Anthocyanins; Minerals; RNAi; ROS VL - 372 A1 - Navarro-Hortal, María D. A1 - Romero-Márquez, Jose M. A1 - Esteban-Muñoz, Adelaida A1 - Sánchez-González, Cristina A1 - Rivas-García, Lorenzo A1 - Llopis, Juan A1 - Cianciosi, Danila A1 - Giampieri, Francesca A1 - Sumalla Cano, Sandra A1 - Battino, Maurizio A1 - Quiles, José L. ER - TY - JOUR A1 - Romero-Márquez, Jose M. A1 - Navarro-Hortal, María D. A1 - Jiménez-Trigo, Victoria A1 - Muñoz-Ollero, Pedro A1 - Forbes-Hernández, Tamara Y. A1 - Esteban-Muñoz, Adelaida A1 - Giampieri, Francesca A1 - Delgado Noya, Irene A1 - Bullón, Pedro A1 - Vera-Ramírez, Laura A1 - Battino, Maurizio A1 - Sánchez-González, Cristina A1 - Quiles, José L. VL - 11 KW - age-related diseases; antioxidants; HSP-16.2; neuroprotection; Olea europaea; olive by-products; polyphenols; RNAi; tau protein AV - public JF - Antioxidants TI - An Olive-Derived Extract 20% Rich in Hydroxytyrosol Prevents ?-Amyloid Aggregation and Oxidative Stress, Two Features of Alzheimer Disease, via SKN-1/NRF2 and HSP-16.2 in Caenorhabditis elegans ID - uneatlantico656 UR - http://doi.org/10.3390/antiox11040629 N2 - Olive milling produces olive oil and different by-products, all of them very rich in different bioactive compounds like the phenolic alcohol hydroxytyrosol. The aim of the present study was to investigate the effects of an olive fruit extract 20% rich in hydroxytyrosol on the molecular mechanisms associated with Alzheimer disease features like A?- and tau- induced toxicity, as well as on oxidative stress in Caenorhabditis elegans. Moreover, characterization of the extracts, regarding the profile and content of phenolics, as well as total antioxidant ability, was investigated. The study of lethality, growth, pharyngeal pumping, and longevity in vivo demonstrated the lack of toxicity of the extract. One hundred ?g/mL of extract treatment revealed prevention of oxidative stress and a delay in A?-induced paralysis related with a lower presence of A? aggregates. Indeed, the extract showed the ability to avoid a certain degree of proteotoxicity associated with aggregation of the tau protein. According to RNAi tests, SKN-1/NRF2 transcription factor and the overexpression of HSP-16.2 were mechanistically associated in the observed effects IS - 4 Y1 - 2022/03// SN - 2076-3921 ER - TY - JOUR VL - 11 A1 - Godos, Justyna A1 - Giampieri, Francesca A1 - Micek, Agnieszka A1 - Battino, Maurizio A1 - Forbes-Hernández, Tamara Y. A1 - Quiles, José L. A1 - Paladino, Nadia A1 - Falzone, Luca A1 - Grosso, Giuseppe AV - public KW - Brazil nuts; selenium; glutathione peroxidase; antioxidant; oxidative stress; cholesterol; blood lipids; meta-analysis; clinical trial TI - Effect of Brazil Nuts on Selenium Status, Blood Lipids, and Biomarkers of Oxidative Stress and Inflammation: A Systematic Review and Meta-Analysis of Randomized Clinical Trials UR - http://doi.org/10.3390/antiox11020403 N2 - Tree nuts, including Brazil nuts, have been hypothesized to impact cardiovascular health through the modulation of oxidative stress and inflammation. Nonetheless, a quantitative analysis of these effects has not been performed. Therefore, the aim of this study was to systematically revise and quantify the effect of Brazil nut intervention on selenium status, blood lipids, and biomarkers of oxidative stress and inflammation using a meta-analytical approach. To meet the goals of this study, a systematic search of PubMed, EMBASE, and Web of Science databases of published randomised clinical trials reporting on dietary interventions with Brazil nuts and their effects on selenium status, blood lipids, and markers of oxidative stress and inflammation was performed. Eight articles were included for systematic review and meta-analysis. Based on the conducted analysis, a significant positive effect of Brazil nuts on selenium blood concentration (SMD = 6.93, 95% CI: 3.99; 9.87) was found. Additionally, a positive effect of Brazil nut intervention on glutathione peroxidase activity (SMD = 0.53, 95% CI: 0.07; 0.99) was observed. However, no significant results were found when considering blood lipid levels, including results for total cholesterol (SMD = ?0.22, 95% CI: ?0.57; 0.14), HDL cholesterol (SMD = ?0.04, 95% CI: ?0.28; 0.19) and LDL cholesterol (SMD = ?0.15; 95% CI: ?0.43; 0.13). In conclusion, the findings from this study suggest that Brazil nut consumption improves selenium status and exerts antioxidant effects, which could be considered a potential pathway for the prevention of metabolic disorders related to altered blood lipid profiles. However, further studies are needed to elucidate the effect of Brazil nuts toward blood lipid profile, also preferably controlling for other biomarkers. ID - uneatlantico533 JF - Antioxidants IS - 2 SN - 2076-3921 Y1 - 2022/02// ER - TY - JOUR IS - 3 Y1 - 2022/01// SN - 1660-4601 VL - 19 A1 - Cubas-Basterrechea, Gloria A1 - Elío Pascual, Iñaki A1 - Sumalla Cano, Sandra A1 - Aparicio Obregón, Silvia A1 - González-Antón, Carolina Teresa A1 - Muñoz-Cacho, Pedro AV - public KW - Elderly KW - Nuts KW - metabolic syndrome X KW - Aging KW - Spain JF - International Journal of Environmental Research and Public Health TI - The Regular Consumption of Nuts Is Associated with a Lower Prevalence of Abdominal Obesity and Metabolic Syndrome in Older People from the North of Spain UR - http://doi.org/10.3390/ijerph19031256 ID - uneatlantico495 N2 - Background: The aim of this study was to relate the adherence to nut consumption (30 g) three or more days per week to the prevalence of abdominal obesity and metabolic syndrome (MetS) in an elderly population from the north of Spain. Methods: The study consists of an observational, descriptive, cross-sectional, and correlational study conducted in 556 non-institutionalised individuals between 65 and 79 years of age. To define the consumption recommendation of nuts the indication of the questionnaire MEDAS-14 was followed. The diagnosis of MetS was conducted using the International Diabetes Federation (IDF) criteria. Results: In 264 subjects aged 71.9 (SD: ±4.2) years old, 39% of whom were men, the adherence to nut consumption recommendations was 40.2%. Of these individuals, 79.5% had abdominal obesity. The prevalence of MetS was 40.2%, being 47.6% in men and 35.4% in women (p < 0.05). A nut consumption lower than recommended was associated with a 19% higher prevalence of abdominal obesity (Prevalence Ratio: 1.19; 95% CI: 1.03?1.37; p < 0.05) and a 61% higher prevalence of MetS (Prevalence Ratio: 1.61; 95% CI: 1.16?2.25; p = 0.005) compared to a consumption of ?3 servings per week. Conclusion: An inverse relationship was established between nut consumption and the prevalence of abdominal obesity and metabolic syndrome. ER - TY - JOUR AV - public KW - honeybee byproducts; bee pollen; propolis; bee bread; royal jelly; beeswax A1 - Giampieri, Francesca A1 - Quiles, José L. A1 - Cianciosi, Danila A1 - Forbes-Hernández, Tamara Yuliett A1 - Orantes-Bermejo, Francisco Josè A1 - Alvarez-Suarez, José Miguel A1 - Battino, Maurizio JF - Journal of Agricultural and Food Chemistry N2 - Beside honey, honeybees (Apis mellifera L.) are able to produce many byproducts, including bee pollen, propolis, bee bread, royal jelly, and beeswax. Even if the medicinal properties of these byproducts have been recognized for thousands of years by the ancient civilizations, in the modern era, they have a limited use, essentially as nutritional supplements or health products. However, these natural products are excellent sources of bioactive compounds, macro- and micronutrients, that, in a synergistic way, confer multiple biological activities to these byproducts, such as, for example, antimicrobial, antioxidant, and anti-inflammatory properties. This work aims to update the chemical and phytochemical composition of bee pollen, propolis, bee bread, royal jelly, and beeswax and to summarize the main effects exerted by these byproducts on human health, from the anticancer and immune-modulatory activities to the antidiabetic, hypolipidemic, hypotensive, and anti-allergic properties. UR - http://doi.org/10.1021/acs.jafc.1c05822 ID - uneatlantico578 TI - Bee Products: An Emblematic Example of Underutilized Sources of Bioactive Compounds Y1 - 2022/01// SN - 0021-8561 ER - TY - JOUR VL - 19 A1 - Godos, Justyna A1 - Giampieri, Francesca A1 - Chisari, Emanuele A1 - Micek, Agnieszka A1 - Paladino, Nadia A1 - Forbes-Hernández, Tamara Y. A1 - Quiles, José L. A1 - Battino, Maurizio A1 - La Vignera, Sandro A1 - Musumeci, Giuseppe A1 - Grosso, Giuseppe KW - Alcohol; Osteoporosis; Bone mineral density; Meta-analysis; Bone health; Fractures AV - public TI - Alcohol Consumption, Bone Mineral Density, and Risk of Osteoporotic Fractures: A Dose?Response Meta-Analysis UR - http://doi.org/10.3390/ijerph19031515 ID - uneatlantico525 N2 - Excess alcohol consumption is known to be detrimental to human health. However, the role of light-to-moderate alcohol intake is under investigation for potential certain health benefits?mostly related to the cardiovascular system. Nevertheless, there is no univocal agreement on this matter, and research is still ongoing to clarify whether there might be other potential outcomes affected by alcohol intake. In this regard, there is evidence that excess alcohol intake may negatively influence the risk of osteoporotic fractures. However, there is no comprehensive evidence of literature assessing the role of alcohol consumption in bone mineral density (BMD) and the risk of osteoporotic fractures. Thus, the aim of this study was to quantitatively assess the dose?response relationship between alcohol intake and BMD and risk of osteoporotic fractures. The Embase and MEDLINE electronic databases were searched from their inception to December 2021 for articles providing a quantifiable measurement of alcohol consumption for at least three categories and (1) a measurement of BMD (and dispersion as continuous variables) in some area of the body or (2) risk of osteoporotic fracture provided as relative risk (RR) or hazard ratio (HR), with a 95% confidence interval (CI) as the measure of the association of each category with alcohol intake. A total of 11 studies including 46,916 individuals with BMD assessment and 8 studies including 240,871 individuals with risk of fracture analysis were included. Compared to non-drinkers, consumption of up to two standard drinks of alcohol per day was correlated with higher lumbar and femur neck BMD values, while up to one standard drink of alcohol was correlated with higher hip BMD compared to no alcohol consumption. Higher risk of hip fractures was found starting from three standard drinks of alcohol per day (RR = 1.33, 95% CI: 1.04; 1.69 for three alcoholic drinks/d, and RR = 1.59, 95% CI: 1.23; 2.05 for four alcoholic drinks/d) compared to no alcohol consumption, with no evidence of heterogeneity. Concerning the risk of any osteoporotic fractures, the risk steadily increased with higher intake of alcohol, although never reaching statistical significance. In conclusion, there is consistent evidence that increased alcohol consumption is associated with higher risk of osteoporotic hip fracture; however, the role of alcohol at lower doses is uncertain, as BMD was even higher in light drinkers compared to abstainers. JF - International Journal of Environmental Research and Public Health IS - 3 SN - 1660-4601 Y1 - 2022/01// ER - TY - JOUR TI - The Effect of Dietary Polyphenols on Vascular Health and Hypertension: Current Evidence and Mechanisms of Action UR - http://doi.org/10.3390/nu14030545 N2 - The aim of this review was to explore existing evidence from studies conducted on humans and summarize the mechanisms of action of dietary polyphenols on vascular health, blood pressure and hypertension. There is evidence that some polyphenol-rich foods, including berry fruits rich in anthocyanins, cocoa and green tea rich in flavan-3-ols, almonds and pistachios rich in hydroxycinnamic acids, and soy products rich in isoflavones, are able to improve blood pressure levels. A variety of mechanisms can elucidate the observed effects. Some limitations of the evidence, including variability of polyphenol content in plant-derived foods and human absorption, difficulty disentangling the effects of polyphenols from other dietary compounds, and discrepancy of doses between animal and human studies should be taken into account. While no single food counteracts hypertension, adopting a plant-based dietary pattern including a variety of polyphenol-rich foods is an advisable practice to improve blood pressure ID - uneatlantico594 JF - Nutrients VL - 14 A1 - Grosso, Giuseppe A1 - Godos, Justyna A1 - Currenti, Walter A1 - Micek, Agnieszka A1 - Falzone, Luca A1 - Libra, Massimo A1 - Giampieri, Francesca A1 - Forbes-Hernández, Tamara Y. A1 - Quiles, José L. A1 - Battino, Maurizio A1 - La Vignera, Sandro A1 - Galvano, Fabio AV - public KW - polyphenols; flavonoids; phenolic acids; hypertension; blood pressure; endothelial SN - 2072-6643 Y1 - 2022/01// IS - 3 ER - TY - JOUR Y1 - 2021/12// SN - 17564646 A1 - Cianciosi, Danila A1 - Forbes-Hernandez, Tamara Y. A1 - Alvarez-Suarez, José M. A1 - Ansary, Johura A1 - Quinzi, Denise A1 - Amici, Adolfo A1 - Navarro-Hortal, María D. A1 - Esteban-Muñoz, Adelaida A1 - Quiles, José Luis A1 - Battino, Maurizio A1 - Giampieri, Francesca VL - 87 KW - Honey; Inflammation; Mitochondrial respiration; Apoptosis; Wound healing; Antioxidant enzymes AV - public JF - Journal of Functional Foods TI - Anti-inflammatory activities of Italian Chestnut and Eucalyptus honeys on murine RAW 264.7 macrophages UR - http://doi.org/10.1016/j.jff.2021.104752 ID - uneatlantico627 N2 - The aim of this study was to evaluate for the first time the anti-inflammatory effects of chestnut (Castanea sativa) and Eucalyptus (Eucalyptus occidentalis) honeys collected in Italy on murine RAW 264.7 macrophages stressed with the bacterial endotoxin lipopolysaccharide (LPS). Pre-treatment with the two honeys markedly decreased apoptosis and stimulated wound healing in macrophages stressed with LPS, where they also reduced the intracellular levels of ROS and nitrite. Additionally, treatment with LPS decreased the levels of glutathione and suppressed the antioxidant enzyme activities, which were significantly (p < 0.05) increased in the presence of the two honeys, through the modulation of Nrf2 expression; in LPS-stressed macrophages, Chestnut or Eucalyptus honeys protected against inflammation by regulating the main inflammatory biomarkers, including TNF-?, IL-10 and iNOS, through the decrease of NF-?B expression. Finally, they improved mitochondrial respiration and the main related parameters. ER - TY - JOUR TI - Diabetes Mellitus and Periodontitis Share Intracellular Disorders as the Main Meeting Point ID - uneatlantico532 UR - http://doi.org/10.3390/cells10092411 N2 - Diabetes and periodontitis are two of the most prevalent diseases worldwide that negatively impact the quality of life of the individual suffering from them. They are part of the chronic inflammatory disease group or, as recently mentioned, non-communicable diseases, with inflammation being the meeting point among them. Inflammation hitherto includes vascular and tissue changes, but new technologies provide data at the intracellular level that could explain how the cells respond to the aggression more clearly. This review aims to emphasize the molecular pathophysiological mechanisms in patients with type 2 diabetes mellitus and periodontitis, which are marked by different impaired central regulators including mitochondrial dysfunction, impaired immune system and autophagy pathways, oxidative stress, and the crosstalk between adenosine monophosphate-activated protein kinase (AMPK) and the renin-angiotensin system (RAS). All of them are the shared background behind both diseases that could explain its relationship. These should be taken in consideration if we would like to improve the treatment outcomes. Currently, the main treatment strategies in diabetes try to reduce glycemia index as the most important aspect, and in periodontitis try to reduce the presence of oral bacteria. We propose to add to the therapeutic guidelines the handling of all the intracellular disorders to try to obtain better treatment success. JF - Cells VL - 10 A1 - Portes, Juliana A1 - Bullón, Beatriz A1 - Quiles, José L. A1 - Battino, Maurizio A1 - Bullón, Pedro KW - periodontal disease; diabetes; mitochondrial dysfunction; oxidative stress; AMPK; autophagy AV - public SN - 2073-4409 Y1 - 2021/09// IS - 9 ER - TY - JOUR A1 - Pistollato, Francesca A1 - Forbes-Hernández, Tamara Y. A1 - Calderón Iglesias, Rubén A1 - Ruiz Salces, Roberto A1 - Elexpuru Zabaleta, Maria A1 - Dominguez Azpíroz, Irma A1 - Cianciosi, Danila A1 - Quiles, José L. A1 - Giampieri, Francesca A1 - Battino, Maurizio AV - none KW - Caloric restriction; Fasting; Autophagy; Immune system; Gut microbiota; Cancer stem cells. JF - Seminars in Cancer Biology TI - Effects of caloric restriction on immunosurveillance, microbiota and cancer cell phenotype: Possible implications for cancer treatment UR - http://doi.org/10.1016/j.semcancer.2020.11.017 ID - uneatlantico126 N2 - Fasting, caloric restriction and foods or compounds mimicking the biological effects of caloric restriction, known as caloric restriction mimetics, have been associated with a lower risk of age-related diseases, including cardiovascular diseases, cancer and cognitive decline, and a longer lifespan. Reduced calorie intake has been shown to stimulate cancer immunosurveillance, reducing the migration of immunosuppressive regulatory T cells towards the tumor bulk. Autophagy stimulation via reduction of lysine acetylation, increased sensitivity to chemo- and immunotherapy, along with a reduction of insulin-like growth factor 1 and reactive oxygen species have been described as some of the major effects triggered by caloric restriction. Fasting and caloric restriction have also been shown to beneficially influence gut microbiota composition, modify host metabolism, reduce total cholesterol and triglyceride levels, lower diastolic blood pressure and elevate morning cortisol level, with beneficial modulatory effects on cardiopulmonary fitness, body fat and weight, fatigue and weakness, and general quality of life. Moreover, caloric restriction may reduce the carcinogenic and metastatic potential of cancer stem cells, which are generally considered responsible of tumor formation and relapse. Here, we reviewed in vitro and in vivo studies describing the effects of fasting, caloric restriction and some caloric restriction mimetics on immunosurveillance, gut microbiota, metabolism, and cancer stem cell growth, highlighting the molecular and cellular mechanisms underlying these effects. Additionally, studies on caloric restriction interventions in cancer patients or cancer risk subjects are discussed. Considering the promising effects associated with caloric restriction and caloric restriction mimetics, we think that controlled-randomized large clinical trials are warranted to evaluate the inclusion of these non-pharmacological approaches in clinical practice. EP - 57 SP - 45 Y1 - 2021/08// SN - 1044-579X ER - TY - JOUR IS - 17 SN - 1420-3049 Y1 - 2021/08// AV - none KW - Bacteriophage KW - Endolysin KW - Enzybiotics KW - Biopreservation A1 - Ramos Vivas, Jose A1 - Elexpuru Zabaleta, Maria A1 - Sámano Celorio, María Luisa A1 - Pascual Barrera, Alina Eugenia A1 - Forbes-Hernandez, Tamara Y. A1 - Giampieri, Francesca A1 - Battino, Maurizio VL - 26 ID - uneatlantico287 UR - http://doi.org/10.3390/molecules26175138 N2 - Presently, biopreservation through protective bacterial cultures and their antimicrobial products or using antibacterial compounds derived from plants are proposed as feasible strategies to maintain the long shelf-life of products. Another emerging category of food biopreservatives are bacteriophages or their antibacterial enzymes called ?phage lysins? or ?enzybiotics?, which can be used directly as antibacterial agents due to their ability to act on the membranes of bacteria and destroy them. Bacteriophages are an alternative to antimicrobials in the fight against bacteria, mainly because they have a practically unique host range that gives them great specificity. In addition to their potential ability to specifically control strains of pathogenic bacteria, their use does not generate a negative environmental impact as in the case of antibiotics. Both phages and their enzymes can favor a reduction in antibiotic use, which is desirable given the alarming increase in resistance to antibiotics used not only in human medicine but also in veterinary medicine, agriculture, and in general all processes of manufacturing, preservation, and distribution of food. We present here an overview of the scientific background of phages and enzybiotics in the food industry, as well as food applications of these biopreservatives. TI - Phages and Enzybiotics in Food Biopreservation JF - Molecules ER - TY - JOUR A1 - Varela-López, Alfonso A1 - Vera-Ramírez, Laura A1 - Giampieri, Francesca A1 - Navarro-Hortal, María D. A1 - Forbes-Hernandez, Tamara Y. A1 - Battino, Maurizio A1 - Quiles, José L. AV - none KW - Apoptosis; Autophagy; Bioenergetics; Lipogenesis; Redox biology. TI - The central role of mitochondria in the relationship between dietary lipids and cancer progression N2 - Evidence demonstrates the importance of lipid metabolism and signaling in cancer cell biology. De novo lipogenesis is an important source of lipids for cancer cells, but exogenous lipid uptake remains essential for many cancer cells. Dietary lipids can modify lipids present in tumor microenvironment affecting cancer cell metabolism. Clinical trials have shown that diets rich in polyunsaturated fatty acids (PUFA) can negatively affect tumor growth. However, certain n-6 PUFAs can also contribute to cancer progression. Identifying the molecular mechanisms through which lipids affect cancer progression will provide an opportunity for focused dietary interventions that could translate into the development of personalized diets for cancer control. However, the effective mechanisms of action of PUFAs have not been fully clarified yet. Mitochondria controls ATP generation, redox homeostasis, metabolic signaling, apoptotic pathways and many aspects of autophagy, and it has been recognized to play a key role in cancer. The purpose of this review is to summarize the current evidence linking dietary lipids effects on mitochondrial aspects with consequences for cancer progression and the molecular mechanisms that underlie this association. UR - http://doi.org/10.1016/j.semcancer.2021.01.001 ID - uneatlantico110 JF - Seminars in Cancer Biology EP - 0 SN - 1044579X Y1 - 2021/08// ER - TY - JOUR KW - Dietary lipids; Hallmarks of aging; Oxidative stress; Saturated fat diet AV - public A1 - Romero-Márquez, Jose M. A1 - Varela-López, Alfonso A1 - Navarro-Hortal, María D. A1 - Badillo-Carrasco, Alberto A1 - Forbes-Hernández, Tamara Y. A1 - Giampieri, Francesca A1 - Dominguez Azpíroz, Irma A1 - Madrigal-Hoyos, Lorena A1 - Battino, Maurizio A1 - Quiles, José L. VL - 22 JF - International Journal of Molecular Sciences ID - uneatlantico522 UR - http://doi.org/10.3390/ijms22126473 N2 - Age-related bone disorders such as osteoporosis or osteoarthritis are a major public health problem due to the functional disability for millions of people worldwide. Furthermore, fractures are associated with a higher degree of morbidity and mortality in the long term, which generates greater financial and health costs. As the world population becomes older, the incidence of this type of disease increases and this effect seems notably greater in those countries that present a more westernized lifestyle. Thus, increased efforts are directed toward reducing risks that need to focus not only on the prevention of bone diseases, but also on the treatment of persons already afflicted. Evidence is accumulating that dietary lipids play an important role in bone health which results relevant to develop effective interventions for prevent bone diseases or alterations, especially in the elderly segment of the population. This review focuses on evidence about the effects of dietary lipids on bone health and describes possible mechanisms to explain how lipids act on bone metabolism during aging. Little work, however, has been accomplished in humans, so this is a challenge for future research. TI - Molecular Interactions between Dietary Lipids and Bone Tissue during Aging IS - 12 Y1 - 2021/06// SN - 1422-0067 ER - TY - JOUR ID - uneatlantico77 UR - http://doi.org/10.3390/molecules26082108 N2 - In recent times, scientific attention has been paid to different foods and their bioactive components for the ability to inhibit the onset and progress of different types of cancer. Nigella sativa extract, powder and seed oil and its main components, thymoquinone and ?-hederin, have showed potent anticancer and chemosensitizing effects against various types of cancer, such as liver, colon, breast, renal, cervical, lung, ovarian, pancreatic, prostate and skin tumors, through the modulation of various molecular signaling pathways. Herein, the purpose of this review was to highlight the anticancer activity of Nigella sativa and it constitutes, focusing on different in vitro, in vivo and clinical studies and projects, in order to underline their antiproliferative, proapoptotic, cytotoxic and antimetastatic effects. Particular attention has been also given to the synergistic effect of Nigella sativa and it constitutes with chemotherapeutic drugs, and to the synthesized analogs of thymoquinone that seem to enhance the chemo-sensitizing potential. This review could be a useful step towards new research on N. sativa and cancer, to include this plant in the dietary treatments in support to conventional therapies, for the best achievement of therapeutic goals. TI - Nutritional Value and Preventive Role of Nigella sativa L. and Its Main Component Thymoquinone in Cancer: An Evidenced-Based Review of Preclinical and Clinical Studies JF - Molecules KW - Nigella sativa KW - Nutritional composition KW - Anticancer properties KW - Molecular pathways KW - Combined therapy. AV - public VL - 26 A1 - Ansary, Johura A1 - Giampieri, Francesca A1 - Forbes-Hernandez, Tamara Y. A1 - Regolo, Lucia A1 - Quinzi, Denise A1 - Gracia Villar, Santos A1 - Garcia Villena, Eduardo A1 - Tutusaus, Kilian A1 - Alvarez-Suarez, José M. A1 - Battino, Maurizio A1 - Cianciosi, Danila SN - 1420-3049 Y1 - 2021/04// IS - 8 ER - TY - JOUR JF - Molecules ID - uneatlantico105 UR - http://doi.org/10.3390/molecules26092615 N2 - Cancer stem cells (CSCs) are a rare tumor subpopulation with high differentiation, proliferative and tumorigenic potential compared to the remaining tumor population. CSCs were first discovered by Bonnet and Dick in 1997 in acute myeloid leukemia. The identification and isolation of these cells in this pioneering study were carried out through the flow cytometry, exploiting the presence of specific cell surface molecular markers (CD34+/CD38?). In the following years, different strategies and projects have been developed for the study of CSCs, which are basically divided into surface markers assays and functional assays; some of these techniques also allow working with a cellular model that better mimics the tumor architecture. The purpose of this mini review is to summarize and briefly describe all the current methods used for the identification, isolation and enrichment of CSCs, describing, where possible, the molecular basis, the advantages and disadvantages of each technique with a particular focus on those that offer a three-dimensional culture. TI - The Molecular Basis of Different Approaches for the Study of Cancer Stem Cells and the Advantages and Disadvantages of a Three-Dimensional Culture AV - public KW - Cancer stem cells KW - Identification KW - Isolation KW - Enrichment KW - Methodology KW - Three-dimensional culture KW - Surface molecular markers KW - Functional assays. VL - 26 A1 - Cianciosi, Danila A1 - Ansary, Johura A1 - Forbes-Hernandez, Tamara Y. A1 - Regolo, Lucia A1 - Quinzi, Denise A1 - Gracia Villar, Santos A1 - Garcia Villena, Eduardo A1 - Tutusaus Pifarre, Kilian A1 - Alvarez-Suarez, José M. A1 - Battino, Maurizio A1 - Giampieri, Francesca Y1 - 2021/04// SN - 1420-3049 IS - 9 ER - TY - JOUR A1 - Cassotta, Manuela A1 - Forbes-Hernandez, Tamara Y. A1 - Cianciosi, Danila A1 - Elexpuru Zabaleta, Maria A1 - Sumalla Cano, Sandra A1 - Dominguez Azpíroz, Irma A1 - Bullon, Beatriz A1 - Regolo, Lucia A1 - Alvarez-Suarez, Josè Miguel A1 - Giampieri, Francesca A1 - Battino, Maurizio VL - 13 AV - public KW - Rheumatoid Arthritis; Diet; Nutrigenomics; Proteomics; Metabolomics; Microbiome; Microbiomics TI - Nutrition and Rheumatoid Arthritis in the ?Omics? Era UR - http://doi.org/10.3390/nu13030763 N2 - Modern high-throughput ?omics? science tools (including genomics, transcriptomics, proteomics, metabolomics and microbiomics) are currently being applied to nutritional sciences to unravel the fundamental processes of health effects ascribed to particular nutrients in humans and to contribute to more precise nutritional advice. Diet and food components are key environmental factors that interact with the genome, transcriptome, proteome, metabolome and the microbiota, and this life-long interplay defines health and diseases state of the individual. Rheumatoid arthritis (RA) is a chronic autoimmune disease featured by a systemic immune-inflammatory response, in genetically susceptible individuals exposed to environmental triggers, including diet. In recent years increasing evidences suggested that nutritional factors and gut microbiome have a central role in RA risk and progression. The aim of this review is to summarize the main and most recent applications of ?omics? technologies in human nutrition and in RA research, examining the possible influences of some nutrients and nutritional patterns on RA pathogenesis, following a nutrigenomics approach. The opportunities and challenges of novel ?omics technologies? in the exploration of new avenues in RA and nutritional research to prevent and manage RA will be also discussed. ID - uneatlantico519 JF - Nutrients IS - 3 SN - 2072-6643 Y1 - 2021/02// ER - TY - JOUR ID - uneatlantico558 UR - http://doi.org/10.1016/bs.afnr.2020.12.001 N2 - Inflammation is a key mechanism of the immune system that can be elicited by several factors, among them several chemical, physical and biological agents. Once stimulated, the inflammatory response activates a series of signaling pathways and a number of immune cells which promote, in a very coordinated manner, the neutralization of the infectious agent. However, if uncontrolled, the inflammatory status may become chronic leading, potentially, to tissue damage and disease onset. Several risk factors are associated with the development of chronic inflammation and, among these factors, diet plays an essential role. In this chapter the effects of some dietary bioactive compounds, including micronutrients, omega-3 fatty acids, nucleotides and polyphenols, on the immunoinflammatory responses in different cellular, animal and human studies have been summarized. TI - Immunoinflammatory effects of dietary bioactive compounds JF - Advances in Food and Nutrition Research KW - Inflammation; Inflammatory cells; Inflammatory markers; Inflammatory signal pathways; Minerals; Nucleotides; Omega-3 fatty acids; Polyphenols; Surface pattern receptors; Vitamins. AV - none VL - 95 A1 - Giampieri, Francesca A1 - Cianciosi, Danila A1 - Ansary, Johura A1 - Elexpuru Zabaleta, Maria A1 - Forbes-Hernandez, Tamara Y. A1 - Battino, Maurizio SN - 10434526 Y1 - 2021/02// EP - 336 SP - 295 PB - ELSEVIER ER - TY - JOUR VL - 10 A1 - Castejón-Vega, Beatriz A1 - Battino, Maurizio A1 - Quiles, José L. A1 - Bullon, Beatriz A1 - Cordero, Mario D. A1 - Bullón, Pedro KW - Papillon?Lefèvre syndrome KW - Mitochondria KW - Coenzyme Q10. AV - public TI - Potential Role of the Mitochondria for the Dermatological Treatment of Papillon-Lefèvre N2 - The Papillon?Lefèvre syndrome (PLS) is a rare autosomal recessive disorder caused by mutations in the Cathepsin C (CTSC) gene, characterized by periodontitis and palmoplantar hyperkeratosis. The main inflammatory deficiencies include oxidative stress and autophagic dysfunction. Mitochondria are the main source of reactive oxygen species; their impaired function is related to skin diseases and periodontitis. The mitochondrial function has been evaluated in PLS and mitochondria have been targeted as a possible treatment for PLS. We show for the first time an important mitochondrial dysfunction associated with increased oxidative damage of mtDNA, reduced CoQ10 and mitochondrial mass and aberrant morphologies of the mitochondria in PLS patients. Mitochondrial dysfunction, determined by oxygen consumption rate (OCR) in PLS fibroblasts, was treated with CoQ10 supplementation, which determined an improvement in OCR and a remission of skin damage in a patient receiving a topical administration of a cream enriched with CoQ10 0.1%. We provide the first evidence of the role of mitochondrial dysfunction and CoQ10 deficiency in the pathophysiology of PLS and a future therapeutic option for PLS. UR - http://doi.org/10.3390/antiox10010095 ID - uneatlantico104 JF - Antioxidants IS - 1 SN - 2076-3921 Y1 - 2021/01// ER - TY - JOUR IS - 1 SN - 1999-4923 Y1 - 2021/01// A1 - Rivas-García, Lorenzo A1 - Quiles, José L. A1 - Varela-López, Alfonso A1 - Giampieri, Francesca A1 - Battino, Maurizio A1 - Bettmer, Jörg A1 - Montes-Bayón, María A1 - Llopis, Juan A1 - Sánchez-González, Cristina VL - 13 AV - public KW - Copy number KW - Metals KW - Mitochondria KW - MtDNA deletions KW - Nanotechnology KW - Respiration. TI - Ultra-Small Iron Nanoparticles Target Mitochondria Inducing Autophagy, Acting on Mitochondrial DNA and Reducing Respiration ID - uneatlantico109 UR - http://doi.org/10.3390/pharmaceutics13010090 N2 - The application of metallic nanoparticles (materials with size at least in one dimension ranging from 1 to 100 nm) as a new therapeutic tool will improve the diagnosis and treatment of diseases. The mitochondria could be a therapeutic target to treat pathologies whose origin lies in mitochondrial dysfunctions or whose progression is dependent on mitochondrial function. We aimed to study the subcellular distribution of 2-4 nm iron nanoparticles and its effect on mitochondrial DNA (mtDNA), mitochondrial function, and autophagy in colorectal cell lines (HT-29). Results showed that when cells were exposed to ultra-small iron nanoparticles, their subcellular fate was mainly mitochondria, affecting its respiratory and glycolytic parameters, inducing the migration of the cellular state towards quiescence, and promoting and triggering the autophagic process. These effects support the potential use of nanoparticles as therapeutic agents using mitochondria as a target for cancer and other treatments for mitochondria-dependent pathologies. JF - Pharmaceutics ER - TY - JOUR Y1 - 2021/// SN - 0278-6915 VL - 149 A1 - Rivas-García, Lorenzo A1 - Quiles, José L. A1 - Roma-Rodrigues, Catarina A1 - Raposo, Luis R. A1 - Navarro-Hortal, María D. A1 - Romero-Márquez, Jose M. A1 - Esteban-Muñoz, Adelaida A1 - Varela-López, Alfonso A1 - García, Laura Carrera A1 - Cianciosi, Danila A1 - Forbes Hernandez, Tamara Y. A1 - Battino, Maurizio A1 - Llopis, Juan A1 - Fernandes, Alexandra R. A1 - Baptista, Pedro V. A1 - Sánchez-González, Cristina KW - Antioxidants; Autophagy; Edible flowers; Flavonoids; Polyphenols; ROS. AV - none JF - Food and Chemical Toxicology TI - Rosa x hybrida extracts with dual actions: Antiproliferative effects against tumour cells and inhibitor of Alzheimer disease N2 - Edible flowers are being used as a new ingredient in modern gastronomy. Recently, these products have also gained interest as an important source of phenolic compounds with potential for biomedical applications. The present work studied a methanolic extract of Rosa x hybrida in which 35 individual phenolic compounds were identified. The extract has been evaluated for its antiproliferative properties in ovarian carcinoma cells. Results showed that the antiproliferative effect was associated with the induction of autophagy and apoptosis with the concomitant ROS increase probably related to mitochondria dysfunction. These antiproliferative effects might be associated with some components of the extract such as quercetin. The extract did not induce damage in healthy cells and that it was able to improve the wound healing activity. The present study also evaluated the properties of the mentioned extract in vivo in C. elegans. Tests demonstrated a lack of toxicity in the worm model. Promising results have been obtained in transgenic strains of C. elegans that produce human beta amyloid peptide, suggesting the possible utility of the extract from the point of view of Alzheimer disease. Altogether, results suggest that Rosa x hybrida extracts could be a new tool for the development of functional foods. UR - http://doi.org/10.1016/j.fct.2021.112018 ID - uneatlantico108 ER - TY - JOUR IS - 6 Y1 - 2020/06// SN - 2072-6643 KW - Macrobiotica KW - Infectious diseases KW - Nutrition KW - Human-bases methods KW - Gut-on-a-chip KW - gut-organoids KW - Third generation sequencing. AV - public A1 - Cassotta, Manuela A1 - Forbes-Hernández, Tamara Y. A1 - Calderón Iglesias, Ruben A1 - Ruiz, Roberto A1 - Elexpuru Zabaleta, Maria A1 - Giampieri, Francesca A1 - Battino, Maurizio VL - 12 JF - Nutrients UR - http://doi.org/10.3390/nu12061827 N2 - The interaction between nutrition and human infectious diseases has always been recognized. With the emergence of molecular tools and post-genomics, high-resolution sequencing technologies, the gut microbiota has been emerging as a key moderator in the complex interplay between nutrients, human body, and infections. Much of the host?microbial and nutrition research is currently based on animals or simplistic in vitro models. Although traditional in vivo and in vitro models have helped to develop mechanistic hypotheses and assess the causality of the host?microbiota interactions, they often fail to faithfully recapitulate the complexity of the human nutrient?microbiome axis in gastrointestinal homeostasis and infections. Over the last decade, remarkable progress in tissue engineering, stem cell biology, microfluidics, sequencing technologies, and computing power has taken place, which has produced a new generation of human-focused, relevant, and predictive tools. These tools, which include patient-derived organoids, organs-on-a-chip, computational analyses, and models, together with multi-omics readouts, represent novel and exciting equipment to advance the research into microbiota, infectious diseases, and nutrition from a human-biology-based perspective. After considering some limitations of the conventional in vivo and in vitro approaches, in this review, we present the main novel available and emerging tools that are suitable for designing human-oriented research. ID - uneatlantico78 TI - Links between Nutrition, Infectious Diseases, and Microbiota: Emerging Technologies and Opportunities for Human-Focused Research ER - TY - JOUR Y1 - 2020/02// SN - 1043-6618 JF - Pharmacological Research N2 - In the last decade, the prevalence of autism spectrum disorders (ASD) has dramatically escalated worldwide. Currently available drugs mainly target some co-occurring symptoms of ASD, but are not effective on the core symptoms, namely impairments in communication and social interaction, and the presence of restricted and repetitive behaviors. On the other hand, transplantation of hematopoietic and mesenchymal stem cells in ASD children has been shown promising to stimulate the recruitment, proliferation, and differentiation of tissue-residing native stem cells, reducing inflammation, and improving some ASD symptoms. Moreover, several comorbidities have also been associated with ASD, such as immune dysregulation, gastrointestinal issues and gut microbiota dysbiosis. Non-pharmacological approaches, such as dietary supplementations with certain vitamins, omega-3 polyunsaturated fatty acids, probiotics, some phytochemicals (e.g., luteolin and sulforaphane), or overall diet interventions (e.g., gluten free and casein free diets) have been considered for the reduction of such comorbidities and the management of ASD. Here, interventional studies describing pharmacological and non-pharmacological treatments in ASD children and adolescents, along with stem cell-based therapies, are reviewed. UR - http://doi.org/10.1016/j.phrs.2019.104579 ID - uneatlantico125 TI - Pharmacological, non-pharmacological and stem cell therapies for the management of autism spectrum disorders: A focus on human studies AV - none KW - Autism spectrum disorder; Pharmacological interventions; Non-Pharmacological strategies; Stem cell therapies; Dietary supplementations; Exclusion diets. A1 - Pistollato, Francesca A1 - Forbes-Hernandez, Tamara Y. A1 - Calderón Iglesias, Rubén A1 - Ruiz Salces, Roberto A1 - Elexpuru Zabaleta, Maria A1 - Cianciosi, Danila A1 - Giampieri, Francesca A1 - Battino, Maurizio VL - 152 ER - TY - JOUR SN - 10436618 Y1 - 2020/01// UR - http://doi.org/10.1016/j.phrs.2019.104582 N2 - Alzheimer?s disease (AD) is a progressive neurodegenerative pathology affecting milions of people worldwide associated with deposition of senile plaques. While the genetic and environmental risk factors associated with the onset and consolidation of late onset AD are heterogeneous and sporadic, growing evidence also suggests a potential link between some infectious diseases caused by oral microbiota and AD. Oral microbiota dysbiosis is purported to contribute either directly to amyloid protein production, or indirectly to neuroinflammation, occurring as a consequence of bacterial invasion. Over the last decade, the development of Human Oral Microbiome database (HOMD) has deepened our understanding of oral microbes and their different roles during the human lifetime. Oral pathogens mostly cause caries, periodontal disease, and edentulism in aged population, and, in particular, alterations of the oral microbiota causing chronic periodontal disease have been associated with the risk of AD. Here we describe how different alterations of the oral microbiota may be linked to AD, highlighting the importance of a good oral hygiene for the prevention of oral microbiota dysbiosis. ID - uneatlantico574 TI - Oral microbiota and Alzheimer?s disease: Do all roads lead to Rome? JF - Pharmacological Research KW - Alzheimer?s disease; Amyloid-?; Oral microbiome; Periodontal disease AV - none A1 - Sureda, Antoni A1 - Daglia, Maria A1 - Argüelles Castilla, Sandro A1 - Sanadgol, Nima A1 - Fazel Nabavi, Seyed A1 - Khan, Haroon A1 - Belwal, Tarun A1 - Jeandet, Philippe A1 - Marchese, Anna A1 - Pistollato, Francesca A1 - Forbes-Hernandez, Tamara A1 - Battino, Maurizio A1 - Berindan-Neagoe, Ioana A1 - D?Onofrio, Grazia A1 - Nabavi, Seyed Mohammad VL - 151 ER - TY - JOUR A1 - Varela-López, Alfonso A1 - Bullón, Pedro A1 - Ramírez-Tortosa, César L. A1 - Navarro-Hortal, María D. A1 - Robles-Almazán, María A1 - Bullón, Beatriz A1 - Cordero, Mario D. A1 - Battino, Maurizio A1 - Quiles, José L. VL - 12 AV - public KW - Atherogenic KW - Atherosclerosis KW - NASH KW - Non-alcoholic fatty liver disease KW - Periodontal diseases KW - Periodontitis KW - Rabbits. TI - A Diet Rich in Saturated Fat and Cholesterol Aggravates the Effect of Bacterial Lipopolysaccharide on Alveolar Bone Loss in a Rabbit Model of Periodontal Disease UR - http://doi.org/10.3390/nu12051405 N2 - Increasing evidence connects periodontitis with a variety of systemic diseases, including metabolic syndrome, atherosclerosis, and non-alcoholic fatty liver disease (NAFLD). The proposal of this study was to evaluate the role of diets rich in saturated fat and cholesterol in some aspects of periodontal diseases in a lipopolysaccharide (LPS)-induced model of periodontal disease in rabbits and to assess the influence of a periodontal intervention on hyperlipidemia, atherosclerosis, and NAFLD progression to non-alcoholic steatohepatitis. Male rabbits were maintained on a commercial standard diet or a diet rich in saturated fat (3% lard w/w) and cholesterol (1.3% w/w) (HFD) for 40 days. Half of the rabbits on each diet were treated 2 days per week with intragingival injections of LPS from Porphyromonas gingivalis. Morphometric analyses revealed that LPS induced higher alveolar bone loss (ABL) around the first premolar in animals receiving standard diets, which was exacerbated by the HFD diet. A higher score of acinar inflammation in the liver and higher blood levels of triglycerides and phospholipids were found in HFD-fed rabbits receiving LPS. These results suggest that certain dietary habits can exacerbate some aspects of periodontitis and that bad periodontal health can contribute to dyslipidemia and promote NAFLD progression, but only under certain conditions. ID - uneatlantico117 JF - Nutrients IS - 5 SN - 2072-6643 Y1 - 2020/// ER - TY - JOUR A1 - Giampieri, Francesca A1 - Afrin, Sadia A1 - Forbes-Hernandez, Tamara Y. A1 - Gasparrini, Massimiliano A1 - Cianciosi, Danila A1 - Reboredo-Rodriguez, Patricia A1 - Varela-Lopez, Alfonso A1 - Quiles, Jose L. A1 - Battino, Maurizio VL - 30 AV - none KW - Autophagy; Natural bioactive compounds; Disease prevention; Molecular target; Epignetic modifcation. TI - Autophagy in Human Health and Disease: Novel Therapeutic Opportunities UR - http://doi.org/10.1089/ars.2017.7234 N2 - Significance: In eukaryotes, autophagy represents a highly evolutionary conserved process, through which macromolecules and cytoplasmic material are degraded into lysosomes and recycled for biosynthetic or energetic purposes. Dysfunction of the autophagic process has been associated with the onset and development of many human chronic pathologies, such as cardiovascular, metabolic, and neurodegenerative diseases as well as cancer. Recent Advances: Currently, comprehensive research is being carried out to discover new therapeutic agents that are able to modulate the autophagic process in vivo. Recent evidence has shown that a large number of natural bioactive compounds are involved in the regulation of autophagy by modulating several transcriptional factors and signaling pathways. Critical Issues: Critical issues that deserve particular attention are the inadequate understanding of the complex role of autophagy in disease pathogenesis, the limited availability of therapeutic drugs, and the lack of clinical trials. In this context, the effects that natural bioactive compounds exert on autophagic modulation should be clearly highlighted, since they depend on the type and stage of the pathological conditions of diseases. Future Directions: Research efforts should now focus on understanding the survival-supporting and death-promoting roles of autophagy, how natural compounds interact exactly with the autophagic targets so as to induce or inhibit autophagy and on the evaluation of their pharmacological effects in a more in-depth and mechanistic way. In addition, clinical studies on autophagy-inducing natural products are strongly encouraged, also to highlight some fundamental aspects, such as the dose, the duration, and the possible synergistic action of these compounds with conventional therapy. ID - uneatlantico81 JF - Antioxidants & Redox Signaling IS - 4 SP - 577 EP - 634 SN - 1523-0864 Y1 - 2019/00/00/ ER - TY - JOUR SN - 0077-8923 Y1 - 2019/// IS - 1 EP - 19 SP - 3 TI - Effects of phytochemicals on thyroid function and their possible role in thyroid disease UR - http://doi.org/10.1111/nyas.13980 N2 - About 1 of 10 women, particularly those older than 60 years of age, shows some degree of thyroid hormone deficiency. Thyroid diseases are generally characterized by perturbations of thyroid signaling homeostasis. The most common examples of thyroid diseases include hypothyroidism, hyperthyroidism, and several types of thyroid cancers. Phytochemicals have been shown to have either beneficial or detrimental effects on thyroid function. Some flavonoids have been reported to affect the expression and the activity of several thyroid-related enzymes and proteins, and for this reason some concerns have been raised about the possible thyroid-disruptive properties of foods enriched in these substances. On the other hand, the beneficial effects of some plant-derived compounds, such as myricetin, quercetin, apigenin, rutin, genistein, and curcumin, and their possible role as adjuvants for the treatment of thyroid cancers have been described. Here, the role of phytochemicals in thyroid signaling modulation and their possible beneficial or detrimental effects on thyroid disease risk are discussed. ID - uneatlantico555 JF - Annals of the New York Academy of Sciences VL - 1443 A1 - Pistollato, Francesca A1 - Masías Vergara, Manuel A1 - Agudo-Toyos, Pablo A1 - Giampieri, Francesca A1 - Battino, Maurizio KW - flavonoids; hyperthyroidism; hypothyroidism; isoflavones; phytochemicals; thyroid cancer AV - none ER - TY - JOUR AV - none KW - Honey; Polyphenols; Mollipona beecherii; Total antioxidant capacity; Antimicrobial activity. VL - 87 A1 - Alvarez-Suarez, José M. A1 - Giampieri, Francesca A1 - Brenciani, Andrea A1 - Mazzoni, Luca A1 - Gasparrini, Massimiliano A1 - González-Paramás, Ana M. A1 - Santos-Buelga, Celestino A1 - Morroni, Gianluca A1 - Simoni, Serena A1 - Forbes-Hernández, Tamara Y. A1 - Afrin, Sadia A1 - Giovanetti, Eleonora A1 - Battino, Maurizio UR - http://doi.org/10.1016/j.lwt.2017.08.079 N2 - Several polifloral honeys from the Apis mellifera and Melipona beecheii bee were analyzed to evaluate their pollen profile, physicochemical parameters, chemical composition and their antioxidant and antimicrobial activity. Flavonoids and other phenolic derivatives, 16 compounds in Apis mellifera honeys and 19 compounds in Melipona beecheii honeys, were identified using the HPLC-DAD-ESI-MS/MS analysis. The physicochemical parameters were within the ranges reported for these honeys, showing some of the distinctive characteristics of M. beecheii honeys compared to A. mellifera honeys, such as their high moisture and acidity. M. beecheii honey showed the highest values of total antioxidant capacity and total phenolic, flavonoid, carotenoids, ascorbic acid, free amino acid and protein contents compared to A. mellifera honey. M. beecheii honey also exhibited a higher antimicrobial activity. Our result shows that M. beecheii honeys is an important source of bioactive compounds with relevant biological properties compared to A. mellifera honey. ID - uneatlantico82 TI - Apis mellifera vs Melipona beecheii Cuban polifloral honeys: A comparison based on their physicochemical parameters, chemical composition and biological properties JF - LWT EP - 279 SP - 272 SN - 0023-6438 Y1 - 2018/00/00/ ER - TY - JOUR UR - http://doi.org/10.1007/s11130-018-0657-2 ID - uneatlantico83 N2 - We analyzed guava fruits (Psidium guajava L. cv. Red Suprema) from Cuba to determine their chemical composition, total antioxidant capacity, as well as their protective effect against oxidative damage using an in vitro model of human dermal fibroblasts. The guava fruit is a natural source of bioactive compounds, such as polyphenols, vitamin C, folates and beta carotenes with proven health benefits. Human dermal fibroblasts were pre-incubated with different concentrations of guava crude extract and then subjected to oxidative stress using the AAPH stressor. The number of apoptotic and dead cells, as well as the markers of oxidative damage such as lipid and protein oxidation significantly decreased when cells were pre-incubated with guava crude extract and then exposed to the stressor. The activity of antioxidant enzymes also improved when cells were pre-incubated with guava crude extract in comparison to cells subjected to stress without prior pre-incubation with the guava extract. The results obtained in this study highlight the health benefits of guava regarding oxidative stress, proving it to be an important source of bioactive compounds associated with important biological properties. TI - Guava (Psidium guajava L. cv. Red Suprema) Crude Extract Protect Human Dermal Fibroblasts against Cytotoxic Damage Mediated by Oxidative Stress JF - Plant Foods for Human Nutrition KW - Guava fruit; Antioxidant capacity; Human dermal fibroblast; Oxidative stress. AV - none A1 - Alvarez-Suarez, José M. A1 - Giampieri, Francesca A1 - Gasparrini, Massimiliano A1 - Mazzoni, Luca A1 - Forbes-Hernández, Tamara Y. A1 - Afrin, Sadia A1 - Battino, Maurizio VL - 73 SN - 0921-9668 Y1 - 2018/00/00/ IS - 1 SP - 18 EP - 24 ER - TY - JOUR SN - 0734-9750 Y1 - 2018/00/00/ IS - 2 EP - 370 SP - 358 TI - Nrf2 as regulator of innate immunity: A molecular Swiss army knife! UR - http://doi.org/10.1016/j.biotechadv.2017.12.012 N2 - Organisms are constantly exposed to a broad range of pathological and stress-inducing agents, allergens and environmental chemicals that can induce infections, toxicity or other undesirable reactions. Our immune system has evolved over time in order to efficiently respond to these exogenous insults and maintain homeostasis. In particular, the innate immune system acts as primary barrier to prevent the entrance of invasive agents or allergens. This system is comprised of a diversity of cell types that are rapidly activated by recognition of common structures present in many potential pathogens known as pathogen-associated molecular patterns (PAMPs). The nuclear factor erythroid 2 related factor 2 (Nrf2) is a relevant basic leucine zipper (bZIP) transcription factor that is essential in the regulation of cell cycle homeostasis, cytoprotection, and innate immunity when cells are under stressful conditions. Although the role of Nrf2 in activating the expression of protective genes ? such as antioxidant or anti-inflammatory ? is known, its role in innate immunity and immune-related gene expression remains not yet clear. The present review summarizes current knowledge on Nrf2 signaling pathway structure and activity under both physiological state and upon oxidative stress. In addition, the relation between Nrf2 signaling pathway and the innate immune system is discussed, highlighting the potential therapeutic effects of diverse natural and synthetic compounds as Nrf2 regulators. ID - uneatlantico84 JF - Biotechnology Advances VL - 36 A1 - Battino, Maurizio A1 - Giampieri, Francesca A1 - Pistollato, Francesca A1 - Sureda, Antoni A1 - de Oliveira, Marcos Roberto A1 - Pittalà, Valeria A1 - Fallarino, Francesca A1 - Nabavi, Seyed Fazel A1 - Atanasov, Atanas Georgiev A1 - Nabavi, Seyed Mohammad KW - Immune system; Inflammation; Natural compounds; Nuclear factor; Oxidative stress. AV - none ER - TY - JOUR KW - Flavonoids; Inflammation; Intracellular signaling pathways; Strectyre-activity relationship. AV - none VL - 58 A1 - Chen, Lei A1 - Teng, Hui A1 - Jia, Zhen A1 - Battino, Maurizio A1 - Miron, Anca A1 - Yu, Zhiling A1 - Cao, Hui A1 - Xiao, Jianbo JF - Critical Reviews in Food Science and Nutrition ID - uneatlantico85 UR - http://doi.org/10.1080/10408398.2017.1345853 N2 - Dietary flavonoids, which occur in many plant foods, are considered as the most active constituents among the plant-derived ones in vitro and in vivo. To date, many studies have addressed the anti-inflammatory activity of flavonoids. However, their considerable structural diversity and in vivo bioavailability make them able to modulate different signaling pathways. The present review attempted to summarize and highlight a broad range of inflammation-associated signaling pathways modulated by flavonoids. Finally, based on the current scientist's literature, structure-activity relationships were concluded. Dietary flavonoids have the ability to attenuate inflammation by targeting different intracellular signaling pathways triggered by NF-?B, AP-1, PPAR, Nrf2, and MAPKs. Identification of the main structural features required for the modulation of these inflammation-related pathways (hydroxylation pattern, C2=C3 double bond) have an important role to play in the development of new anti-inflammatory drugs. TI - Intracellular signaling pathways of inflammation modulated by dietary flavonoids: The most recent evidence EP - 2924 SP - 2908 IS - 17 Y1 - 2018/00/00/ SN - 1040-8398 ER - TY - JOUR Y1 - 2018/00/00/ SN - 1420-3049 IS - 9 JF - Molecules N2 - Honey is a natural substance appreciated for its therapeutic abilities since ancient times. Its content in flavonoids and phenolic acids plays a key role on human health, thanks to the high antioxidant and anti-inflammatory properties that they exert. Honey possesses antimicrobial capacity and anticancer activity against different types of tumors, acting on different molecular pathways that are involved on cellular proliferation. In addition, an antidiabetic activity has also been highlighted, with the reduction of glucose, fructosamine, and glycosylated hemoglobin serum concentration. Honey exerts also a protective effect in the cardiovascular system, where it mainly prevents the oxidation of low-density lipoproteins, in the nervous system, in the respiratory system against asthma and bacterial infections, and in the gastrointestinal system. A beneficial effect of honey can also be demonstrated in athletes. The purpose of this review is to summarize and update the current information regarding the role of honey in health and diseases. UR - http://doi.org/10.3390/molecules23092322 ID - uneatlantico86 TI - Phenolic Compounds in Honey and Their Associated Health Benefits: A Review AV - public KW - Honey; Antioxidants; Polyphenols; Antimicrobial activities; Cancer; Diabetes; Disease prevention. A1 - Cianciosi, Danila A1 - Forbes-Hernández, Tamara Y. A1 - Afrin, Sadia A1 - Gasparrini, Massimiliano A1 - Reboredo-Rodriguez, Patricia A1 - Manna, Piera A1 - Zhang, Jiaojiao A1 - Bravo Lamas, Leire A1 - Martínez Flórez, Susana A1 - Agudo Toyos, Pablo A1 - Quiles, José A1 - Giampieri, Francesca A1 - Battino, Maurizio VL - 23 ER - TY - JOUR SP - 128 EP - 140 SN - 0278-6915 Y1 - 2018/// A1 - Gasparrini, Massimiliano A1 - Giampieri, Francesca A1 - Forbes-Hernandez, Tamara Y. A1 - Afrin, Sadia A1 - Cianciosi, Danila A1 - Reboredo-Rodriguez, Patricia A1 - Varela-Lopez, Alfonso A1 - Zhang, JiaoJiao A1 - Quiles, Josè L. A1 - Mezzetti, Bruno A1 - Bompadre, Stefano A1 - Battino, Maurizio VL - 114 AV - none KW - Strawberry; LPS; Human Dermal Fibroblast; Inflammation; Oxidative stress; Antioxidant response; Prevention. TI - Strawberry extracts efficiently counteract inflammatory stress induced by the endotoxin lipopolysaccharide in Human Dermal Fibroblast UR - http://doi.org/10.1016/j.fct.2018.02.038 ID - uneatlantico129 N2 - A protracted pro-inflammatory state is the common denominator in the development, progression and complication of the common chronic diseases. Dietary antioxidants represent an efficient tool to counteract this inflammatory state. The aim of the present work was to evaluate the effects of strawberry extracts on inflammation evoked by E. Coli lipopolysaccharide in Human Dermal Fibroblast, by measuring reactive oxygen species production, apoptosis rate, antioxidant enzymes activity, mitochondria functionality and also investigating the molecular pathway involved in inflammatory and antioxidant response. The results demonstrated that strawberry pre-treatment reduced intracellular reactive oxygen species levels, apoptotic rate, improved antioxidant defences and mitochondria functionality in lipopolysaccharide -treated cells. Strawberry exerted these protective activities through the inhibition of the NF-kB signalling pathway and the stimulation of the Nrf2 pathway, with a mechanism AMPK-dependent. These results confirm the health benefits of strawberry in the prevention of inflammation and oxidative stress condition in lipopolysaccharide-treated cells. JF - Food and Chemical Toxicology ER - TY - JOUR TI - Phytochemical Composition and Cytotoxic Effects on Liver Hepatocellular Carcinoma Cells of Different Berries Following a Simulated In Vitro Gastrointestinal Digestion UR - http://doi.org/10.3390/molecules23081918 ID - uneatlantico130 N2 - Berry fruits are rich in nutrients and polyphenols, providing potential health benefits. Understanding the factors that affect their bioavailability is becoming of utmost importance for evaluating their biological significance and efficacy as functional food. In this study, the phytochemical composition and the total antioxidant capacity of different varieties of five berries (blackberry, blackcurrant, blueberry, raspberry, and strawberry) were evaluated after an in vitro gastrointestinal digestion process. The cultivar of each berry that showed the higher content of total phenols and flavonoids was selected to study its cytotoxic effect on human hepatoma cells. Digestion resulted in a high reduction (p ? 0.05) of total phenolic, flavonoid and anthocyanin contents and total antioxidant capacity, in the ?IN? samples compared to the ?OUT? extracts, which represent the ?serum-available? and the ?colon-available? fractions, respectively. Incubation of the digested fraction for 24 h didn?t exert any effect on cellular viability, while a dose- and time-dependent cytotoxicity was observed after 48 h and 72 h of incubation for all the berries analyzed. Our results suggest that the approach proposed in this work may represent a rapid tool for evaluating and identifying new berries with increased phytochemical bioavailability, highlighting their antiproliferative agents after an in vitro digestion. JF - Molecules VL - 23 A1 - Giampieri, Francesca A1 - Afrin, Sadia A1 - Stewart, Derek A1 - McDougall, Gordon A1 - Brennan, Rex A1 - Blyth, Lesley A1 - Gasparrini, Massimiliano A1 - Mazzoni, Luca A1 - Capocasa, Franco A1 - Alvarez-Suarez, José M. A1 - Bompadre, Stefano A1 - Nogueira Brás de Oliveira, Pedro A1 - N. Santos, Claudia A1 - Masias Vergara, Manuel A1 - Agudo Toyos, Pablo A1 - Crespo-Álvarez, Jorge A1 - Mezzetti, Bruno A1 - Forbes-Hernandez, Tamara Y. A1 - Battino, Maurizio KW - Berry; Polyphenols; In vitro gastrointestinal digestion; Bioavailability; Cytotoxicity. AV - public SN - 1420-3049 Y1 - 2018/// IS - 8 ER - TY - JOUR UR - http://doi.org/10.1021/acs.jafc.7b04177 ID - uneatlantico87 N2 - Food fortification through the increase and/or modulation of bioactive compounds has become a major goal for preventing several diseases, including cancer. Here, strawberry lines of cv. Calypso transformed with a construct containing an anthocyanidin synthase (ANS) gene were produced to study the effects on anthocyanin biosynthesis, metabolism, and transcriptome. Three strawberry ANS transgenic lines (ANS L5, ANS L15, and ANS L18) were analyzed for phytochemical composition and total antioxidant capacity (TAC), and their fruit extracts were assessed for cytotoxic effects on hepatocellular carcinoma. ANS L18 fruits had the highest levels of total phenolics and flavonoids, while those of ANS L15 had the highest anthocyanin concentration; TAC positively correlated with total polyphenol content. Fruit transcriptome was also specifically affected in the polyphenol biosynthesis and in other related metabolic pathways. Fruit extracts of all lines exerted cytotoxic effects in a dose/time-dependent manner, increasing cellular apoptosis and free radical levels and impairing mitochondrial functionality. TI - Overexpression of the Anthocyanidin Synthase Gene in Strawberry Enhances Antioxidant Capacity and Cytotoxic Effects on Human Hepatic Cancer Cells JF - Journal of Agricultural and Food Chemistry KW - Anthocyanidin synthase; Anticancer effects; Apoptosis; Flavonoids; RNA-seq. AV - none A1 - Giampieri, Francesca A1 - Gasparrini, Massimiliano A1 - Forbes-Hernandez, Tamara Y. A1 - Mazzoni, Luca A1 - Capocasa, Franco A1 - Sabbadini, Silvia A1 - Alvarez-Suarez, José M. A1 - Afrin, Sadia A1 - Rosati, Carlo A1 - Pandolfini, Tiziana A1 - Molesini, Barbara A1 - Sánchez-Sevilla, José Federico A1 - Amaya, Iraida A1 - Mezzetti, Bruno A1 - Battino, Maurizio VL - 66 SN - 0021-8561 Y1 - 2018/// IS - 3 SP - 581 EP - 592 ER - TY - JOUR SP - 126 EP - 133 Y1 - 2018/// SN - 0278-6915 KW - Honey; Beeswax; Food waste; Recycling process; Chemical and phytochemical composition; Biological properties. AV - none VL - 112 A1 - Giampieri, Francesca A1 - Quiles, José L. A1 - Orantes-Bermejo, Francisco J. A1 - Gasparrini, Massimiliano A1 - Forbes-Hernandez, Tamara Y. A1 - Sánchez-González, Cristina A1 - Llopis, Juan A1 - Rivas-García, Lorenzo A1 - Afrin, Sadia A1 - Varela-López, Alfonso A1 - Cianciosi, Danila A1 - Reboredo-Rodriguez, Patricia A1 - Fernández-Piñar, Cristina Torres A1 - Caderón Iglesia, Rubén A1 - Ruiz Salces, Roberto A1 - Aparicio Obregón, Silvia A1 - Crespo-Álvarez, Jorge A1 - Dzul Lopez, Luis A1 - Xiao, Jianbo A1 - Battino, Maurizio JF - Food and Chemical Toxicology N2 - During the process of beeswax recycling, many industrial derivatives are obtained. These matrices may have an interesting healthy and commercial potential but to date they have not been properly studied. The aim of the present work was to evaluate the proximal and phytochemical composition, the antioxidant capacity and cytotoxic effects of two by-products from beeswax recycling process named MUD 1 and MUD 2 on liver hepatocellular carcinoma. Our results showed that MUD 1 presented the highest (P?95 cm. The controls also had higher systolic blood pressure (p > 0.001), total and low-density lipoprotein cholesterol, dietary nutrient, and calorific intake. Fuster BEWAT score (FBS) correlated more closely than Framingham risk score (FRS) with most CVRF, groups. However, only the FBS showed a correlation with inflammasome cytokine interleukin 1? (IL-1?). Several CVRFs were significantly better in AMI patients; however, this group also had higher mRNA expression of the inflammasome gene NLRP3 and lower expression of the autophagy gene MAP-LC3. The controls had high levels of CVRF, probably reflecting unhealthy lifestyle. FBS reflects the efficiency of strategies to induce lifestyle changes such as cardiac rehabilitation programs, and could provide a sensitive evaluation CVR. These results lead to the hypothesis that NLRP3-inflammasome and associated IL-1? release have potential as CVR biomarkers, particularly in post-AMI patients with otherwise low risk scores. Antioxid. Redox Signal. 27, 269-275. JF - Antioxidants & Redox Signaling IS - 5 EP - 275 SP - 269 SN - 1523-0864 Y1 - 2017/// ER - TY - JOUR JF - International Journal of Molecular Sciences TI - Strawberry (cv. Romina) Methanolic Extract and Anthocyanin-Enriched Fraction Improve Lipid Profile and Antioxidant Status in HepG2 Cells N2 - Dyslipidemia and oxidation of low density lipoproteins (LDL) are recognized as critical factors in the development of atherosclerosis. Healthy dietary patterns, with abundant fruit and vegetable consumption, may prevent the onset of these risk factors due to the presence of phytochemical compounds. Strawberries are known for their high content of polyphenols; among them, flavonoids are the major constituents, and it is presumed that they are responsible for the biological activity of the fruit. Nevertheless, there are only a few studies that actually evaluate the effects of different fractions isolated from strawberries. In order to assess the effects of two different strawberry extracts (whole methanolic extract/anthocyanin-enriched fraction) on the lipid profile and antioxidant status in human hepatocellular carcinoma (HepG2) cells, the triglycerides and LDL-cholesterol content, lipid peroxidation, intracellular reactive oxygen species (ROS) content and antioxidant enzymes? activity on cell lysates were determined. Results demonstrated that both strawberry extracts not only improved the lipid metabolism by decreasing triglycerides and LDL-cholesterol contents, but also improved the redox state of HepG2 cells by modulating thiobarbituric acid-reactive substances production, antioxidant enzyme activity and ROS generation. The observed effects were more pronounced for the anthocyanin-enriched fraction. UR - http://doi.org/10.3390/ijms18061149 ID - uneatlantico134 A1 - Forbes-Hernandez, Tamara Y. A1 - Gasparrini, Massimiliano A1 - Afrin, Sadia A1 - Cianciosi, Danila A1 - González-Paramás, Ana A1 - Santos-Buelga, Celestino A1 - Mezzetti, Bruno A1 - Quiles, José L. A1 - Battino, Maurizio A1 - Giampieri, Francesca A1 - Bompadre, Stefano VL - 18 KW - Strawberry; Anthocyanins; Hypocholesterolemic; Intracellular reactive oxygen species diminution; Antioxidant. AV - public Y1 - 2017/// SN - 1422-0067 IS - 6 ER - TY - JOUR Y1 - 2017/// SN - 2072-6643 IS - 6 JF - Nutrients TI - Lipid Accumulation in HepG2 Cells Is Attenuated by Strawberry Extract through AMPK Activation UR - http://doi.org/10.3390/nu9060621 N2 - Regulation of lipid metabolism is essential for treatment and prevention of several chronic diseases such as obesity, diabetes, and cardiovascular diseases, which are responsible for most deaths worldwide. It has been demonstrated that the AMP-activated protein kinase (AMPK) has a direct impact on lipid metabolism by modulating several downstream-signaling components. The main objective of the present work was to evaluate the in vitro effect of a methanolic strawberry extract on AMPK and its possible repercussion on lipid metabolism in human hepatocellular carcinoma cells (HepG2). For such purpose, the lipid profile and the expression of proteins metabolically related to AMPK were determined on cells lysates. The results demonstrated that strawberry methanolic extract decreased total cholesterol, low-density lipoprotein (LDL)-cholesterol, and triglycerides levels (up to 0.50-, 0.30-, and 0.40-fold, respectively) while it stimulated the p-AMPK/AMPK expression (up to 3.06-fold), compared to the control. AMPK stimulation led to the phosphorylation and consequent inactivation of acetyl coenzyme A carboxylase (ACC) and inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the major regulators of fatty acids and cholesterol synthesis, respectively. Strawberry treatment also entailed a 4.34-, 2.37-, and 2.47-fold overexpression of LDL receptor, sirtuin 1 (Sirt1), and the peroxisome proliferator activated receptor gamma coactivator 1-alpha (PGC-1?), respectively, compared to control. The observed results were counteracted by treatment with compound C, an AMPK pharmacological inhibitor, confirming that multiple effects of strawberries on lipid metabolism are mediated by the activation of this protein. ID - uneatlantico135 VL - 9 A1 - Forbes-Hernandez, Tamara Y. A1 - Giampieri, Francesca A1 - Gasparrini, Massimiliano A1 - Afrin, Sadia A1 - Mazzoni, Luca A1 - Cordero, Mario A1 - Mezzetti, Bruno A1 - Quiles, José L. A1 - Battino, Maurizio AV - public KW - Strawberry; Cholesterol synthesis; Fatty acids synthesis; Hypolipidemic agent. ER - TY - JOUR ID - uneatlantico279 UR - http://doi.org/10.17660/ActaHortic.2017.1156.61 N2 - Strawberry represents the most important berry in the Mediterranean diet. It is the most consumed berry as both fresh and processed products, the most studied berry from the agronomic, genomic and nutritional point of view, and it is also a remarkable source of micronutrients and phytochemicals with a relevant biologically activity on human health. Although individual bioactive compounds present in strawberries have been studied for their biological activities, the mechanisms by which they are metabolized and exert their beneficial effects on human health are still unknown. For this reason, the first objective of this research is the development of an enzymatic in vitro system which simulates the gastrointestinal conditions that occur in vivo during the digestive process. Briefly, the method consists on an initial pepsin-HCl digestion for simulating gastric conditions (pH~1.7) followed by an intestinal digestion with pancreatin and bile salts through a dialysis membrane. The dialysates were concentrated under vacuum, resuspended in H2O2/glacial acetic acid and purified with a C-18 SepPaks Vac 6 cc cartridge. The strawberry cultivar chosen for the study is 'Romina', one of the most promising cultivars developed in the context of the European Euberry project. The total antioxidant capacity of both the fresh fruit and the digested fraction was tested through the DPPH, FRAP and TEAC assays. The results obtained have shown a significant variation in the antioxidant capacity of 'omina', before and after the enzymatic digestion process. Significant decreases were found in all the performed assay, highlighting how the antioxidant capacity present in fresh fruit is drastically reduced following digestion. Further studies are required to elucidate the mechanisms of transport and metabolism of these compounds, with the aim of providing predictive results on their bioavailability and thus their effect on human health. TI - The effect of an enzymatic digestion process on strawberry antioxidant capacity JF - Acta Horticulturae AV - none KW - strawberry KW - bioactive compounds KW - antioxidant capacity KW - in vitro digestion A1 - Forbes-Hernández, Tamara Y. A1 - Gasparrini, Massimiliano A1 - Afrin, Sadia A1 - Battino, Maurizio A1 - Giampieri, Francesca SN - 2406-6168 Y1 - 2017/// IS - 1156 SP - 413 EP - 418 ER - TY - JOUR Y1 - 2017/// SN - 2072-6643 IS - 6 JF - Nutrients ID - uneatlantico141 UR - http://doi.org/10.3390/nu9060605 N2 - Extreme exposure of skin to Ultraviolet A (UVA)-radiation may induce a dysregulated production of reactive oxygen species (ROS) which can interact with cellular biomolecules leading to oxidative stress, inflammation, DNA damage, and alteration of cellular molecular pathways, responsible for skin photoaging, hyperplasia, erythema, and cancer. For these reasons, the use of dietary natural bioactive compounds with remarkable antioxidant activity could be a strategic tool to counteract these UVA-radiation-caused deleterious effects. Thus, the purpose of the present work was to test the efficacy of strawberry (50 ?g/mL)-based formulations supplemented with Coenzyme Q10 (100 ?g/mL) and sun protection factor 10 in human dermal fibroblasts irradiated with UVA-radiation. The apoptosis rate, the amount of intracellular reactive oxygen species (ROS) production, the expression of proteins involved in antioxidant and inflammatory response, and mitochondrial functionality were evaluated. The results showed that the synergic topical use of strawberry and Coenzyme Q10 provided a significant (p < 0.05) photoprotective effect, reducing cell death and ROS, increasing antioxidant defense, lowering inflammatory markers, and improving mitochondrial functionality. The obtained results suggest the use of strawberry-based formulations as an innovative, natural, and useful tool for the prevention of UVA exposure-induced skin diseases in order to decrease or substitute the amount of synthetic sunscreen agents. TI - Strawberry-Based Cosmetic Formulations Protect Human Dermal Fibroblasts against UVA-Induced Damage KW - Skin damage; UVA-radiation; ROS; Apoptosis; Mitochondria functionality; Antioxidant defense; Inflammatory status; Strawberry polyphenols; Cosmetic formulation. AV - public VL - 9 A1 - Gasparrini, Massimiliano A1 - Forbes-Hernandez, Tamara Y. A1 - Afrin, Sadia A1 - Reboredo-Rodriguez, Patricia A1 - Cianciosi, Danila A1 - Mezzetti, Bruno A1 - Quiles, José L. A1 - Bompadre, Stefano A1 - Battino, Maurizio A1 - Giampieri, Francesca ER - TY - JOUR SN - 0278-6915 Y1 - 2017/// SP - 1 EP - 10 UR - http://doi.org/10.1016/j.fct.2017.01.018 N2 - A common denominator in the pathogenesis of most chronic inflammatory diseases is the involvement of oxidative stress, related to ROS production by all aerobic organisms. Dietary antioxidants from plant foods represent an efficient strategy to counteract this condition. The aim of the present study was to evaluate the protective effects of strawberry extracts on inflammatory status induced by E. Coli LPS on RAW 264.7 macrophages by measuring the main oxidative and inflammatory biomarkers and investigating the molecular pathways involved. Strawberry pre-treatment efficiently counteracted LPS-induced oxidative stress reducing the amount of ROS and nitrite production, stimulating endogenous antioxidant enzyme activities and enhancing protection against lipid, protein and DNA damage (P < 0.05). Strawberry pre-treatment exerted these protective effects primarily through the activation of the Nrf2 pathway, which is markedly AMPK-dependent and also by the modulation of the NF-kB signalling pathway. Finally, an improvement in mitochondria functionality was also detected. The results obtained in this work highlight the health benefit of strawberries against inflammatory and oxidative stress in LPS-stimulated RAW 264.7 macrophages, investigating for the first time the possible involved molecular mechanisms. ID - uneatlantico142 TI - Anti-inflammatory effect of strawberry extract against LPS-induced stress in RAW 264.7 macrophages JF - Food and Chemical Toxicology AV - none KW - Strawberry; Phenolic compounds; LPS; Inflammation; ROS; Prevention. VL - 102 A1 - Gasparrini, Massimiliano A1 - Forbes-Hernandez, Tamara Y. A1 - Giampieri, Francesca A1 - Afrin, Sadia A1 - Alvarez-Suarez, Josè M. A1 - Mazzoni, Luca A1 - Mezzetti, Bruno A1 - Quiles, Josè L. A1 - Battino, Maurizio ER - TY - JOUR VL - 22 A1 - Gasparrini, Massimiliano A1 - Forbes-Hernandez, Tamara Y. A1 - Giampieri, Francesca A1 - Afrin, Sadia A1 - Mezzetti, Bruno A1 - Quiles, José L. A1 - Bompadre, Stefano A1 - Battino, Maurizio KW - Strawberry; LPS; Oxidative stress; Inflammation; Prevention. AV - public TI - Protective Effect of Strawberry Extract against Inflammatory Stress Induced in Human Dermal Fibroblasts UR - http://doi.org/10.3390/molecules22010164 ID - uneatlantico143 N2 - A protracted pro-inflammatory state is a major contributing factor in the development, progression and complication of the most common chronic pathologies. Fruit and vegetables represent the main sources of dietary antioxidants and their consumption can be considered an efficient tool to counteract inflammatory states. In this context an evaluation of the protective effects of strawberry extracts on inflammatory stress induced by E. coli LPS on human dermal fibroblast cells was performed in terms of viability assays, ROS and nitrite production and biomarkers of oxidative damage of the main biological macromolecules. The results demonstrated that strawberry extracts exerted an anti-inflammatory effect on LPS-treated cells, through an increase in cell viability, and the reduction of ROS and nitrite levels, and lipid, protein and DNA damage. This work showed for the first time the potential health benefits of strawberry extract against inflammatory and oxidative stress in LPS-treated human dermal fibroblast cells. JF - Molecules IS - 1 SN - 1420-3049 Y1 - 2017/// ER - TY - JOUR N2 - Dietary polyphenols have been recently proposed as activators of the AMP-activated protein kinase (AMPK) signaling pathway and this fact might explain the relationship between the consumption of polyphenol-rich foods and the slowdown of the progression of aging. In the present work, the effects of strawberry consumption were evaluated on biomarkers of oxidative damage and on aging-associated reductions in mitochondrial function and biogenesis for 8weeks in old rats. Strawberry supplementation increased antioxidant enzyme activities, mitochondrial biomass and functionality, and decreased intracellular ROS levels and biomarkers of protein, lipid and DNA damage (P<0.05). Furthermore, a significant (P<0.05) increase in the expression of the AMPK cascade genes, involved in mitochondrial biogenesis and antioxidant defences, was also detected after strawberry intake. These in vivo results were then verified in vitro on HepG2 cells, confirming the involvement of AMPK in the beneficial effects exerted by strawberry against aging progression. UR - http://doi.org/10.1016/j.foodchem.2017.05.017 ID - uneatlantico563 TI - Strawberry consumption improves aging-associated impairments, mitochondrial biogenesis and functionality through the AMP-activated protein kinase signaling cascade JF - Food Chemistry AV - none KW - AMPK activation; Aging; Mitochondrial functionality; Oxidative stress; Strawberry polyphenols. VL - 234 A1 - Giampieri, Francesca A1 - Alvarez-Suarez, Josè M. A1 - Cordero, Mario D. A1 - Gasparrini, Massimiliano A1 - Forbes-Hernandez, Tamara Y. A1 - Afrin, Sadia A1 - Santos-Buelga, Celestino A1 - González-Paramás, Ana M. A1 - Astolfi, Paola A1 - Rubini, Corrado A1 - Zizzi, Antonio A1 - Tulipani, Sara A1 - Quiles, Josè L. A1 - Mezzetti, Bruno A1 - Battino, Maurizio SN - 03088146 Y1 - 2017/// EP - 471 SP - 464 ER - TY - JOUR VL - 1398 A1 - Giampieri, Francesca A1 - Forbes-Hernandez, Tamara Y. A1 - Gasparrini, Massimiliano A1 - Afrin, Sadia A1 - Cianciosi, Danila A1 - Reboredo-Rodriguez, Patricia A1 - Varela-Lopez, Alfonso A1 - Quiles, Jose L. A1 - Mezzetti, Bruno A1 - Battino, Maurizio AV - none JF - Annals of the New York Academy of Sciences TI - The healthy effects of strawberry bioactive compounds on molecular pathways related to chronic diseases UR - http://doi.org/10.1111/nyas.13373 ID - uneatlantico144 N2 - It is generally accepted that a fruit and vegetable?enriched diet is favorable for human health. The consumption of strawberries, in particular, has been related to the maintenance of well-being and the prevention of several chronic diseases, owing to the high contents of antioxidants and phytochemicals present in the fruit. Several biological effects have been explained through the total antioxidant capacity exerted by these bioactive compounds, but recently more intricate mechanisms have begun to be examined. In this context, it has been reported that strawberry phenolics are able to exert anti-inflammatory, anticarcinogenic, antiproliferative, and antiatherosclerotic activities, acting on specific molecular pathways related to antioxidant defenses, metabolism, survival, and proliferation. The overall aim of this work is to discuss and update the cellular and molecular mechanisms recently proposed to clarify the effects of strawberry phenolics on human health, with particular attention to the most common chronic diseases, such as metabolic syndrome, cardiovascular disease, and cancer. SP - 62 EP - 71 IS - 1 Y1 - 2017/// SN - 0077-8923 ER - TY - JOUR JF - Cancer Letters TI - The use of natural compounds for the targeting and chemoprevention of ovarian cancer UR - http://doi.org/10.1016/j.canlet.2017.09.050 N2 - Among gynaecological cancers, ovarian cancer represents the leading cause of death in women. Current treatment for ovarian cancer entails surgery followed by combined chemotherapy with platinum and taxane, which are associated, particularly cisplatin, with severe side effects. While this treatment approach appears to be initially effective in a high number of patients, nearly 70% of them suffer a relapse within a few months after initial treatment. Therefore, more effective and better-tolerated treatment options are clearly needed. In recent years, several natural compounds (such as curcumin, epigallocatechin 3-gallate (EGCG), resveratrol, sulforaphane and Withaferin-A), characterized by long-term safety and negligible and/or inexistent side effects, have been proposed as possible adjuvants of traditional chemotherapy. Indeed, several in vitro and in vivo studies have shown that phytocompounds can effectively inhibit tumor cell proliferation, stimulate autophagy, induce apoptosis, and specifically target ovarian cancer stem cells (CSCs), which are generally considered to be responsible for tumor recurrence in several types of cancer. Here we review current literature on the role of natural products in ovarian cancer chemoprevention, highlighting their effects particularly on the regulation of inflammation, autophagy, proliferation and apoptosis, chemotherapy resistance, and ovarian CSC growth. ID - uneatlantico145 A1 - Pistollato, Francesca A1 - Calderón Iglesias, Rubén A1 - Ruiz Salces, Roberto A1 - Aparicio Obregón, Silvia A1 - Crespo Alvare, Jorge A1 - Dzul Lopez, Luis A1 - Giampieri, Francesca A1 - Battino, Maurizio VL - 411 AV - none KW - Ovarian cancer; Chemotherapy resistance; Natural compounds; Autophagy; Apoptosis; Ovarian cancer stem-like cells. Y1 - 2017/// SN - 0304-3835 SP - 191 EP - 200 ER - TY - JOUR AV - none KW - Strawberry; Polyphenols; Inflammation; Metabolism; Cardiovascular diseases; Cancer. VL - 56 A1 - Forbes-Hernandez, Tamara Y. A1 - Gasparrini, Massimiliano A1 - Afrin, Sadia A1 - Bompadre, Stefano A1 - Mezzetti, Bruno A1 - Quiles, Josè L. A1 - Giampieri, Francesca A1 - Battino, Maurizio UR - http://doi.org/10.1080/10408398.2015.1051919 ID - uneatlantico93 N2 - Current evidence indicates that the consumption of strawberries, a natural source of a wide range of nutritive and bioactive compounds, is associated with the prevention and improvement of chronic-degenerative diseases.. Studies involving cells and animals provide evidence on the anti-inflammatory, anticarcinogenic and antiproliferative activity of the strawberry. Epidemiological and clinical studies demonstrate that its acute consumption increases plasma antioxidant capacity, improves circulating inflammatory markers and ameliorates postprandial glycemic response. At the same time, a protracted intake reduces chronic inflammation and improves plasma lipid profile, supporting cardiovascular health, especially in individuals with increased risk for metabolic syndrome. To explain these beneficial effects, much attention has been paid in the past to the antioxidant properties of strawberry polyphenols. However, recent research has shown that their biological and functional activities are related not only to the antioxidant capacity but also to the modulation of many cellular pathways involved in metabolism, survival, proliferation, and antioxidant defenses. The aim of this review is to update and discuss the molecular and cellular mechanisms proposed in recent studies to elucidate the healthy effects of strawberry polyphenols against the most common chronic diseases, such as cancer, cardiovascular diseases, metabolic syndrome, and inflammation. TI - The Healthy Effects of Strawberry Polyphenols: Which Strategy behind Antioxidant Capacity? JF - Critical Reviews in Food Science and Nutrition IS - sup1 SP - S46 EP - S59 SN - 1040-8398 Y1 - 2016/07/08/ ER - TY - JOUR SN - 0021-8561 Y1 - 2016/00/00/ IS - 22 EP - 4449 SP - 4435 UR - http://doi.org/10.1021/acs.jafc.6b00857 ID - uneatlantico91 N2 - The potential health benefits associated with dietary intake of fruits have attracted increasing interest. Among berries, the strawberry is a rich source of several nutritive and non-nutritive bioactive compounds, which are implicated in various health-promoting and disease preventive effects. A plethora of studies have examined the benefits of strawberry consumption, such as prevention of inflammation disorders and oxidative stress, reduction of obesity related disorders and heart disease risk, and protection against various types of cancer. This review provides an overview of their nutritional and non-nutritional bioactive compounds and which factors affect their content in strawberries. In addition, the bioavailability and metabolism of major strawberry phytochemicals as well as their actions in combating many pathologies, including cancer, metabolic syndrome, cardiovascular disease, obesity, diabetes, neurodegeneration, along with microbial pathogenesis have been reviewed, with a particular attention to human studies. TI - Promising Health Benefits of the Strawberry: A Focus on Clinical Studies JF - Journal of Agricultural and Food Chemistry KW - Strawberry; Phenolic compounds; Anti-inflammation; Cardioprotection; Antimetabolic syndrome; Antidiabetes; Anticancer; Neuroprotection. AV - none VL - 64 A1 - Afrin, Sadia A1 - Gasparrini, Massimiliano A1 - Forbes-Hernandez, Tamara Y. A1 - Reboredo-Rodriguez, Patricia A1 - Mezzetti, Bruno A1 - Varela-López, Alfonso A1 - Giampieri, Francesca A1 - Battino, Maurizio ER - TY - JOUR IS - 4 EP - 689 SP - 679 SN - 2156-5376 Y1 - 2016/00/00/ AV - none KW - Alzheimer disease; Glymphatic system; Sleep; Cortisol; Hippocampus; Western diet; Acidosis; Nutritional interventions; Supplements. VL - 7 A1 - Pistollato, Francesca A1 - Sumalla Cano, Sandra A1 - Elío Pascual, Iñaki A1 - Masias Vergara, Manuel A1 - Giampieri, Francesca A1 - Battino, Maurizio N2 - Accumulation of proteinaceous amyloid ? plaques and tau oligomers may occur several years before the onset of Alzheimer disease (AD). Under normal circumstances, misfolded proteins get cleared by proteasome degradation, autophagy, and the recently discovered brain glymphatic system, an astroglial-mediated interstitial fluid bulk flow. It has been shown that the activity of the glymphatic system is higher during sleep and disengaged or low during wakefulness. As a consequence, poor sleep quality, which is associated with dementia, might negatively affect glymphatic system activity, thus contributing to amyloid accumulation. The diet is another important factor to consider in the regulation of this complex network. Diets characterized by high intakes of refined sugars, salt, animal-derived proteins and fats and by low intakes of fruit and vegetables are associated with a higher risk of AD and can perturb the circadian modulation of cortisol secretion, which is associated with poor sleep quality. For this reason, diets and nutritional interventions aimed at restoring cortisol concentrations may ease sleep disorders and may facilitate brain clearance, consequentially reducing the risk of cognitive impairment and dementia. Here, we describe the associations that exist between sleep, cortisol regulation, and diet and their possible implications for the risk of cognitive impairment and AD. UR - http://doi.org/10.3945/an.115.011775 ID - uneatlantico95 TI - Associations between Sleep, Cortisol Regulation, and Diet: Possible Implications for the Risk of Alzheimer Disease JF - Advances in Nutrition: An International Review Journal ER - TY - JOUR IS - 2 Y1 - 2016/// SN - 1420-3049 A1 - Afrin, Sadia A1 - Giampieri, Francesca A1 - Gasparrini, Massimiliano A1 - Forbes-Hernandez, Tamara A1 - Varela-López, Alfonso A1 - Quiles, José A1 - Mezzetti, Bruno A1 - Battino, Maurizio VL - 21 AV - public KW - Berry; Chemoprevention; Colon cancer; Polyphenol; Bioactive compound. JF - Molecules TI - Chemopreventive and Therapeutic Effects of Edible Berries: A Focus on Colon Cancer Prevention and Treatment UR - http://doi.org/10.3390/molecules21020169 N2 - Colon cancer is one of the most prevalent diseases across the world. Numerous epidemiological studies indicate that diets rich in fruit, such as berries, provide significant health benefits against several types of cancer, including colon cancer. The anticancer activities of berries are attributed to their high content of phytochemicals and to their relevant antioxidant properties. In vitro and in vivo studies have demonstrated that berries and their bioactive components exert therapeutic and preventive effects against colon cancer by the suppression of inflammation, oxidative stress, proliferation and angiogenesis, through the modulation of multiple signaling pathways such as NF-?B, Wnt/?-catenin, PI3K/AKT/PKB/mTOR, and ERK/MAPK. Based on the exciting outcomes of preclinical studies, a few berries have advanced to the clinical phase. A limited number of human studies have shown that consumption of berries can prevent colorectal cancer, especially in patients at high risk (familial adenopolyposis or aberrant crypt foci, and inflammatory bowel diseases). In this review, we aim to highlight the findings of berries and their bioactive compounds in colon cancer from in vitro and in vivo studies, both on animals and humans. Thus, this review could be a useful step towards the next phase of berry research in colon cancer. ID - uneatlantico146 ER - TY - JOUR N2 - Excessive amounts of free radicals are deleterious for cells, resulting in cell damage, affecting the wound healing process and causing premature ageing or even neoplastic transformation. Here the capacity of Manuka honey (MH) to protect against oxidative damage and improve the process of skin wound healing was investigated. Up to 16 compounds were identified in MH, with leptosin derivatives and methyl syringate as the major ones. MH protected against apoptosis, intracellular ROS production, and lipid and protein oxidative damage. MH also protected mitochondrial functionality, promoted cell proliferation and activated the AMPK/Nrf2/ARE signalling pathway, as well as the expression of the antioxidant enzymes such as SOD and CAT. Here we describe for the first time that one of the possible mechanisms by which MH exhibits its ability to promote wound healing could be due to its capacity to improve the antioxidant response by activating AMPK phosphorylation and the ARE response. UR - http://doi.org/10.1016/j.jff.2016.05.008 ID - uneatlantico176 TI - Activation of AMPK/Nrf2 signalling by Manuka honey protects human dermal fibroblasts against oxidative damage by improving antioxidant response and mitochondrial function promoting wound healing JF - Journal of Functional Foods AV - none KW - Manuka honey KW - ROSAMPK KW - Nrf2Wound healing VL - 25 A1 - Alvarez-Suarez, José Miguel A1 - Giampieri, Francesca A1 - Cordero, Mario A1 - Gasparrini, Massimiliano A1 - Forbes-Hernandez, Tamara Yuliet A1 - Mazzoni, Luca A1 - Afrin, Sadia A1 - Beltrán-Ayala, Pablo A1 - González-Paramás, Ana María A1 - Santos-Buelga, Celestino A1 - Varela-Lopez, Alfonso A1 - Quiles, José Luis A1 - Battino, Maurizio SN - 1756-4646 Y1 - 2016/// EP - 49 SP - 38 PB - ELSEVIER ER - TY - JOUR UR - http://doi.org/10.1038/srep30917 ID - uneatlantico92 N2 - We describe the biological effects of a polyphenol-rich strawberry extract (PRSE), obtained from the ?Alba? variety, on the highly aggressive and invasive basal-like breast cancer cell line A17. Dose-response and time-course experiments showed that PRSE is able to decrease the cellular viability of A17 cells in a time- and dose-dependent manner. PRSE effect on cell survival was investigated in other tumor and normal cell lines of both mouse and human origin, demonstrating that PRSE is more active against breast cancer cells. Cytofluorimetric analysis of A17 cells demonstrated that sub-lethal doses of PRSE reduce the number of cells in S phase, inducing the accumulation of cells in G1 phase of cell cycle. In addition, the migration of A17 cells was studied monitoring the ability of PRSE to inhibit cellular mobility. Gene expression analysis revealed the modulation of 12 genes playing different roles in the cellular migration, adhesion and invasion processes. Finally, in vivo experiments showed the growth inhibition of A17 cells orthotopically transplanted into FVB syngeneic mice fed with PRSE. Overall, we demonstrated that PRSE exerts important biological activities against a highly invasive breast cancer cell line both in vitro and in vivo suggesting the strawberry extracts as preventive/curative food strategy. TI - Polyphenol-rich strawberry extract (PRSE) shows in vitro and in vivo biological activity against invasive breast cancer cells JF - Scientific Reports AV - public VL - 6 A1 - Amatori, Stefano A1 - Mazzoni, Luca A1 - Alvarez-Suarez, José M. A1 - Giampieri, Francesca A1 - Gasparrini, Massimiliano A1 - Forbes-Hernandez, Tamara Y. A1 - Afrin, Sadia A1 - Errico Provenzano, Alfredo A1 - Persico, Giuseppe A1 - Mezzetti, Bruno A1 - Amici, Augusto A1 - Fanelli, Mirco A1 - Battino, Maurizio SN - 2045-2322 Y1 - 2016/// N1 - Breast cancer; Metastasis. IS - 1 EP - 0 ER - TY - JOUR JF - Wiley Online Library TI - Oxidative stress in oral cavity: interplay between reactive oxygen species and antioxidants in health, inflammation, and cancer N2 - This chapter describes the significance of oxidative stress and its involvement in major oral and general diseases, and discusses damage inflicted by oxidative stress to cellular structures. Atmospheric oxygen presents two unpaired electrons in the outer electron shell. Oxygen reduction takes place in a sequential addition of electrons that leads to reactive oxygen species (ROS) formation among which are superoxide, hydrogen peroxide, and hydroxyl radical. There is solid evidence that many oral diseases such as periodontitis or oral cancer are directly linked to loss of balance between antioxidant systems and endogenous or exogenous prooxidants. Moreover, oxidative stress is directly associated with several general pathological conditions, and in many cases, it represents the systemic link between the initiation of general diseases and the development of various oral conditions. These observations thoroughly justify the continuous search for new antioxidants as well as antioxidant usage in the prophylaxis and treatment of oral diseases. UR - http://doi.org/10.1002/9781118832431.ch10 ID - uneatlantico631 A1 - Battino, Maurizio A1 - Greabu, Maria A1 - Calenic, Bogdan AV - none Y1 - 2016/// EP - 166 SP - 155 ER - TY - JOUR JF - Food and Chemical Toxicology TI - Strawberry consumption alleviates doxorubicin-induced toxicity by suppressing oxidative stress ID - uneatlantico147 UR - http://doi.org/10.1016/j.fct.2016.06.003 N2 - Doxorubicin (Dox), one of the most used chemotherapeutic agents, is known to generate oxidative stress and block DNA synthesis, which result in severe dose-limiting toxicity. A strategy to protect against Dox toxic effects could be to use dietary antioxidants of which fruits and vegetable are a rich source. In this context, strawberry consumption is associated with the maintenance of good health and the prevention of several diseases, thanks to the antioxidant capacities of its bioactive compounds. The aim of the present study was to evaluate the protective effects of strawberry consumption against oxidative stress induced by Dox in rats. Animals were fed with strawberry enriched diet (15% of the total calories) for two months and Dox (10 mg/kg; i.p.) was injected at the end of the experimental period. Strawberry consumption significantly inhibited ROS production and oxidative damage biomarkers accumulation in plasma and liver tissue and alleviated histopathological changes in rat livers treated with Dox. The reduction of antioxidant enzyme activities was significantly mitigated after strawberry consumption. In addition, strawberry enriched diet ameliorated liver mitochondrial antioxidant levels and functionality. In conclusion, strawberry intake protects against Dox-induced toxicity, at plasma, liver and mitochondrial levels thanks to its high contents of bioactive compounds. VL - 94 A1 - Giampieri, Francesca A1 - Alvarez-Suarez, Jose M. A1 - Gasparrini, Massimiliano A1 - Forbes- Hernandez, Tamara Y. A1 - Afrin, Sadia A1 - Bompadre, Stefano A1 - Rubini, Corrado A1 - Zizzi, Antonio A1 - Astolfi, Paola A1 - Santos-Buelga, Celestino A1 - González-Paramás, Ana M. A1 - Quiles, Josè L. A1 - Mezzetti, Bruno A1 - Battino, Maurizio AV - none KW - Strawberry KW - Bioactive compounds KW - Oxidative stress KW - Doxorubicin KW - Mitochondrial functionality. Y1 - 2016/// SN - 0278-6915 SP - 128 EP - 137 ER - TY - JOUR IS - 3 SP - 498 EP - 509 SN - 1742464X Y1 - 2016/// A1 - Hamon, Yveline A1 - Legowska, Monika A1 - Fergelot, Patricia A1 - Dallet-Choisy, Sandrine A1 - Newell, Louise A1 - Vanderlynden, Lise A1 - Kord Valeshabad, Ali A1 - Acrich, Karina A1 - Kord, Hadi A1 - Tsamakis, Charalampos A1 - Morice-Picard, Fanny A1 - Surplice, Ian A1 - Zoidakis, Jerome A1 - David, Karen A1 - Vlahou, Antonia A1 - Ragunatha, Shivanna A1 - Nagy, Nikoletta A1 - Farkas, Katalin A1 - Széll, Márta A1 - Goizet, Cyril A1 - Schacher, Beate A1 - Battino, Maurizio A1 - Al Farraj Aldosari, Abdullah A1 - Wang, Xinwen A1 - Liu, Yang A1 - Marchand-Adam, Sylvain A1 - Lesner, Adam A1 - Kara, Elodie A1 - Korkmaz-Icöz, Sevil A1 - Moss, Celia A1 - Eickholz, Peter A1 - Taieb, Alain A1 - Kavukcu, Salih A1 - Jenne, Dieter E. A1 - Gauthier, Francis A1 - Korkmaz, Brice VL - 283 KW - Papillon-Lefèvre syndrome; cathepsin C; diagnostic method; protease; urine analysis. AV - public TI - Analysis of urinary cathepsin C for diagnosing Papillon-Lefèvre syndrome ID - uneatlantico579 UR - http://doi.org/10.1111/febs.13605 N2 - Papillon?Lefèvre syndrome (PLS) (OMIM: 245000) is a rare disease characterized by severe periodontitis and palmoplantar keratoderma. It is caused by mutations in both alleles of the cathepsin C (CatC) gene CTSC that completely abrogate the proteolytic activity of this cysteine proteinase. Most often, a genetic analysis to enable early and rapid diagnosis of PLS is unaffordable or unavailable. In this study, we tested the hypothesis that active CatC is constitutively excreted and can be easily traced in the urine of normal subjects. If this is true, determining its absence in the urine of patients would be an early, simple, reliable, low-cost and easy diagnostic technique. All 75 urine samples from healthy control subjects (aged 3 months to 80 years) contained proteolytically active CatC and its proform, as revealed by kinetic analysis and immunochemical detection. Of the urine samples of 31 patients with a PLS phenotype, 29 contained neither proteolytically active CatC nor the CatC antigen, so that the PLS diagnosis was confirmed. CatC was detected in the urine of the other two patients, and genetic analysis revealed no loss-of-function mutation in CTSC, indicating that they suffer from a PLS-like condition but not from PLS. Screening for the absence of urinary CatC activity soon after birth and early treatment before the onset of PLS manifestations will help to prevent aggressive periodontitis and loss of many teeth, and should considerably improve the quality of life of PLS patients. JF - FEBS Journal ER - TY - JOUR KW - Epidermal growth factor receptor KW - Glioma cell KW - Resveratrol; Cancer stem cell KW - EGCG. AV - none A1 - Pistollato, Francesca A1 - Bremer-Hoffmann, Susanne A1 - Basso, Giuseppe A1 - Sumalla Cano, Sandra A1 - Elío Pascual, Iñaki A1 - Masías Vergara, Manuel A1 - Giampieri, Francesca A1 - Battino, Maurizio VL - 11 UR - http://doi.org/10.1007/s11523-015-0378-5 N2 - Glioblastoma multiforme (GBM) are extremely lethal and still poorly treated primary brain tumors, characterized by the presence of highly tumorigenic cancer stem cell (CSC) subpopulations, considered responsible for tumor relapse. In order to successfully eradicate GBM growth and recurrence, new anti-cancer strategies selectively targeting CSCs should be designed. CSCs might be eradicated by targeting some of their cell surface markers and transporters, inducing their differentiation, impacting their hyper-glycolytic metabolism, inhibiting CSC-related signaling pathways and/or by targeting their microenvironmental niche. In this regard, phytocompounds such as curcumin, isothiocyanates, resveratrol and epigallocatechin-3-gallate have been shown to prevent or reverse cancer-related epigenetic dysfunctions, reducing tumorigenesis, preventing metastasis and/or increasing chemotherapy and radiotherapy efficacy. However, the actual bioavailability and metabolic processing of phytocompounds is generally unknown, and the presence of the blood brain barrier often represents a limitation to glioma treatments. Nowadays, nanoparticles (NPs) can be loaded with therapeutic compounds such as phytochemicals, improving their bioavailability and their targeted delivery within the GBM tumor bulk. Moreover, NPs can be designed to increase their tropism and specificity toward CSCs by conjugating their surface with antibodies specific for CSC antigens, with ligands or with glucose analogues. Here we discuss the use of phytochemicals as anti-glioma agents and the applicability of phytochemical-loaded NPs as drug delivery systems to target GBM. Additionally, we provide some examples on how NPs can be specifically formulated to improve CSC targeting. ID - uneatlantico150 TI - Targeting Glioblastoma with the Use of Phytocompounds and Nanoparticles JF - Targeted Oncology IS - 1 EP - 16 SP - 1 SN - 1776-2596 Y1 - 2016/// ER - TY - JOUR IS - 10 EP - 634 SP - 624 SN - 0029-6643 Y1 - 2016/// AV - none KW - Amyloids; Alzheimer disease; Bacteria; Diet KW - Gut-brain axis; Gut microbiome; Symptom onset. VL - 74 A1 - Pistollato, Francesca A1 - Sumalla Cano, Sandra A1 - Elío Pascual, Iñaki A1 - Masias Vergara, Manuel A1 - Giampieri, Francesca A1 - Battino, Maurizio N2 - It has been hypothesized that alterations in the composition of the gut microbiota might be associated with the onset of certain human pathologies, such as Alzheimer disease, a neurodegenerative syndrome associated with cerebral accumulation of amyloid-? fibrils. It has been shown that bacteria populating the gut microbiota can release significant amounts of amyloids and lipopolysaccharides, which might play a role in the modulation of signaling pathways and the production of proinflammatory cytokines related to the pathogenesis of Alzheimer disease. Additionally, nutrients have been shown to affect the composition of the gut microbiota as well as the formation and aggregation of cerebral amyloid-?. This suggests that modulating the gut microbiome and amyloidogenesis through specific nutritional interventions might prove to be an effective strategy to prevent or reduce the risk of Alzheimer disease. This review examines the possible role of the gut in the dissemination of amyloids, the role of the gut microbiota in the regulation of the gut?brain axis, the potential amyloidogenic properties of gut bacteria, and the possible impact of nutrients on modulation of microbiota composition and amyloid formation in relation to the pathogenesis of Alzheimer disease. UR - http://doi.org/10.1093/nutrit/nuw023 ID - uneatlantico96 TI - Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease JF - Nutrition Reviews ER - TY - JOUR AV - public KW - Aging; Antioxidants; Diet; Mitochondria; Nutrition; Oxidative stress; Ubiquinone VL - 21 A1 - Varela-López, Alfonso A1 - Giampieri, Francesca A1 - Battino, Maurizio A1 - Quiles, Jose L. ID - uneatlantico148 UR - http://doi.org/10.3390/molecules21030373 N2 - Coenzyme Q (CoQ) is a naturally occurring molecule located in the hydrophobic domain of the phospholipid bilayer of all biological membranes. Shortly after being discovered, it was recognized as an essential electron transport chain component in mitochondria where it is particularly abundant. Since then, more additional roles in cell physiology have been reported, including antioxidant, signaling, death prevention, and others. It is known that all cells are able to synthesize functionally sufficient amounts of CoQ under normal physiological conditions. However, CoQ is a molecule found in different dietary sources, which can be taken up and incorporated into biological membranes. It is known that mitochondria have a close relationship with the aging process. Additionally, delaying the aging process through diet has aroused the interest of scientists for many years. These observations have stimulated investigation of the anti-aging potential of CoQ and its possible use in dietary therapies to alleviate the effects of aging. In this context, the present review focus on the current knowledge and evidence the roles of CoQ cells, its relationship with aging, and possible implications of dietary CoQ in relation to aging, lifespan or age-related diseases. TI - Coenzyme Q and Its Role in the Dietary Therapy against Aging JF - Molecules IS - 3 SN - 1420-3049 Y1 - 2016/// ER - TY - JOUR SP - 1 EP - 8 Y1 - 2015/00/00/ SN - 10436618 VL - 91 A1 - Bullón, Pedro A1 - Román-Malo, Lourdes A1 - Marín-Aguilar, Fabiola A1 - Alvarez-Suarez, José Miguel A1 - Giampieri, Francesca A1 - Battino, Maurizio A1 - Cordero, Mario D. AV - none KW - Porphyromonas gingivalis; Lipopolysaccharide; Coenzyme Q10; N-acetylcysteine; Mitochondria JF - Pharmacological Research TI - Lipophilic antioxidants prevent lipopolysaccharide-induced mitochondrial dysfunction through mitochondrial biogenesis improvement N2 - Oxidative stress is implicated in several infectious diseases. In this regard, lipopolysaccharide (LPS), an endotoxic component, induces mitochondrial dysfunction and oxidative stress in several pathological events such as periodontal disease or sepsis. In our experiments, LPS-treated fibroblasts provoked increased oxidative stress, mitochondrial dysfunction, reduced oxygen consumption and mitochondrial biogenesis. After comparing coenzyme Q10 (CoQ10) and N-acetylcysteine (NAC), we observed a more significant protection of CoQ10 than of NAC, which was comparable with other lipophilic and hydrophilic antioxidants such as vitamin E or BHA respectively. CoQ10 improved mitochondrial biogenesis by activating PGC-1? and TFAM. This lipophilic antioxidant protection was observed in mice after LPS injection. These results show that mitochondria-targeted lipophilic antioxidants could be a possible specific therapeutic strategy in pharmacology in the treatment of infectious diseases and their complications. UR - http://doi.org/10.1016/j.phrs.2014.10.007 ID - uneatlantico98 ER - TY - JOUR IS - 5 SP - 581 EP - 591 SN - 2161-8313 Y1 - 2015/00/00/ AV - none KW - Plant-based diets; Human KW - gestation; Preeclampsia; Diabetes; Pediatric tumors; Pediatric diseases. VL - 6 A1 - Pistollato, Francesca A1 - Sumalla Cano, Sandra A1 - Elio Pascual, Iñaki A1 - Masias Vergara, Manuel A1 - Giampieri, Francesca A1 - Battino, Maurizio N2 - Environmental and lifestyle factors are known to play an important role during gestation, determining newborns' health status and influencing their risk of being subject to certain noncommunicable diseases later in life. In particular, maternal nutritional patterns characterized by a low intake of plant-derived foods could increase the risk of gestation-related issues, such as preeclampsia and pregravid obesity, increase genotoxicant susceptibility, and contribute to the onset of pediatric diseases. In particular, the risk of pediatric wheeze, diabetes, neural tube defects, orofacial clefts, and some pediatric tumors seems to be reduced by maternal intake of adequate amounts of vegetables, fruits, and selected antioxidants. Nevertheless, plant-based diets, like any other diet, if improperly balanced, could be deficient in some specific nutrients that are particularly relevant during gestation, such as n?3 (?-3) fatty acids, vitamin B-12, iron, zinc, and iodine, possibly affecting the offspring's health state. Here we review the scientific literature in this field, focusing specifically on observational studies in humans, and highlight protective effects elicited by maternal diets enriched in plant-derived foods and possible issues related to maternal plant-based diets. UR - http://doi.org/10.3945/an.115.009126 ID - uneatlantico101 TI - Plant-Based and Plant-Rich Diet Patterns during Gestation: Beneficial Effects and Possible Shortcomings JF - Advances in Nutrition ER - TY - JOUR KW - Fibromyalgia; AMPK; Mitochondria; Oxidative stress; Metformin; Caloric restriction. AV - none A1 - Alcocer-Gómez, Elísabet A1 - Garrido-Maraver, Juan A1 - Bullón, Pedro A1 - Marín-Aguilar, Fabiola A1 - Cotán, David A1 - Carrión, Angel M. A1 - Alvarez-Suarez, José M. A1 - Giampieri, Francesca A1 - Sánchez-Alcazar, José Antonio A1 - Battino, Maurizio A1 - Cordero, Mario D. VL - 1852 JF - Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease UR - http://doi.org/10.1016/j.bbadis.2015.03.005 N2 - Impaired AMPK is associated with a wide spectrum of clinical and pathological conditions, ranging from obesity, altered responses to exercise or metabolic syndrome, to inflammation, disturbed mitochondrial biogenesis and defective response to energy stress. Fibromyalgia (FM) is a world-wide diffused musculoskeletal chronic pain condition that affects up to 5% of the general population and comprises all the above mentioned pathophysiological states. Here, we tested the involvement of AMPK activation in fibroblasts derived from FM patients. AMPK was not phosphorylated in fibroblasts from FM patients and was associated with decreased mitochondrial biogenesis, reduced oxygen consumption, decreased antioxidant enzymes expression levels and mitochondrial dysfunction. However, mtDNA sequencing analysis did not show any important alterations which could justify the mitochondrial defects. AMPK activation in FM fibroblast was impaired in response to moderate oxidative stress. In contrast, AMPK activation by metformin or incubation with serum from caloric restricted mice improved the response to moderate oxidative stress and mitochondrial metabolism in FM fibroblasts. These results suggest that AMPK plays an essential role in FM pathophysiology and could represent the basis for a valuable new therapeutic target/strategy. Furthermore, both metformin and caloric restriction could be an interesting therapeutic approach in FM. ID - uneatlantico97 TI - Metformin and caloric restriction induce an AMPK-dependent restoration of mitochondrial dysfunction in fibroblasts from Fibromyalgia patients EP - 1267 SP - 1257 IS - 7 Y1 - 2015/// SN - 0925-4439 ER - TY - JOUR AV - none KW - Strawberry KW - Polyphenols KW - Inflammation KW - Cardiovascular diseases KW - Cancer KW - Neurodegenerative diseases. A1 - Giampieri, Francesca A1 - Forbes-Hernandez, Tamara Y. A1 - Gasparrini, Massimiliano A1 - Alvarez-Suarez, José M. A1 - Afrin, Sadia A1 - Bompadre, Stefano A1 - Quiles, José L. A1 - Mezzetti, Bruno A1 - Battino, Maurizio VL - 6 N2 - Since a high intake of fruits and vegetables is inversely related to the incidence of several degenerative diseases, the importance of a balanced diet in relation to human health has received increased consumer attention worldwide. Strawberries (Fragaria X ananassa, Duch.) are a rich source of a wide variety of nutritive compounds such as sugars, vitamins, and minerals, as well as non-nutritive, bioactive compounds such as flavonoids, anthocyanins and phenolic acids. All of these compounds exert a synergistic and cumulative effect on human health promotion and in disease prevention. Strawberry phenolics are indeed able (i) to detoxify free radicals blocking their production, (ii) to modulate the expression of genes involved in metabolism, cell survival and proliferation and antioxidant defense, and (iii) to protect and repair DNA damage. The overall objective of the present review is to update and discuss the key findings, from recent in vivo studies, on the effects of strawberries on human health. Particular attention will be paid to the molecular mechanisms proposed to explain the health effects of polyphenols against the most common diseases related to oxidative stress driven pathologies, such as cancer, cardiovascular diseases, type II diabetes, obesity and neurodegenerative diseases, and inflammation. UR - http://doi.org/10.1039/c5fo00147a ID - uneatlantico149 TI - Strawberry as a health promoter: an evidence based review JF - Food & Function IS - 5 SP - 1386 EP - 1398 SN - 2042-6496 Y1 - 2015/// ER - TY - JOUR KW - Berries; Bioactive compounds; Genetic improvement; Cancer; Inflammation; Neurological diseases. AV - none A1 - Mazzoni, Luca A1 - Perez-Lopez, Patricia A1 - Giampieri, Francesca A1 - Alvarez-Suarez, José M. A1 - Gasparrini, Massimiliano A1 - Forbes-Hernandez, Tamara Y. A1 - Quiles, José L. A1 - Mezzetti, Bruno A1 - Battino, Maurizio VL - 96 JF - Journal of the Science of Food and Agriculture UR - http://doi.org/10.1002/jsfa.7216 N2 - Berries are a relevant source of micronutrients and nonessential phytochemicals, such as polyphenol compounds, that play a synergistic and cumulative role in human health promotion. Several systematic analyses showed that berry phenolics are able to detoxify reactive oxygen and nitrogen species, blocking their production, to intervene in the cell cycle, participating in the transduction and expression of genes involved in apoptosis, and to repair oxidative DNA damage. As a consequence, the improvement of the nutritional quality of berries has become a new quality target of breeding and biotechnological strategies, to control or to increase the content of specific health-related compounds in fruits. This work reviews, on the basis of the in vitro and in vivo evidence, the main berries' phytochemical compounds and their possible mechanisms of action on pathways involved in several type of diseases, with particular attention to cancer, inflammation, neurodegeneration, diabetes and cardiovascular diseases. © 2015 Society of Chemical Industry ID - uneatlantico94 TI - The genetic aspects of berries: from field to health SP - 365 EP - 371 IS - 2 Y1 - 2015/// SN - 00225142 ER - TY - JOUR AV - none KW - Plant compounds; Cancer stem cells; Tumor microenvironment; Hypoxia; Inflammation; Acidic pH. VL - 75 A1 - Pistollato, Francesca A1 - Giampieri, Francesca A1 - Battino, Maurizio JF - Food and Chemical Toxicology UR - http://doi.org/10.1016/j.fct.2014.11.004 ID - uneatlantico100 N2 - In the last decades cancer has been considered as an epigenetic dysfunction, given the profound role of diet and lifestyle in cancer prevention and the determination of cancer risk. A plethora of recent publications have addressed the specific role of several environmental factors, such as nutritional habits, behavior, stress and toxins in the regulation of the physiological and cancer epigenome. In particular, plant-derived bioactive nutrients have been seen to positively affect normal cell growth, proliferation and differentiation and also to revert cancer related epigenetic dysfunctions, reducing tumorigenesis, preventing metastasis and/or increasing chemo and radiotherapy efficacy. Moreover, virtually all cancer types are characterized by the presence of cancer stem cell (CSC) subpopulations, residing in specific hypoxic and acidic microenvironments, or niches, and these cells are currently considered responsible for tumor resistance to therapy and tumor relapse. Modern anti-cancer strategies should be designed to selectively target CSCs and modulate the hypoxic and acidic tumor microenvironment, and, to this end, natural bioactive components seem to play a role. This review aims to discuss the effects elicited by plant-derived bioactive nutrients in the regulation of CSC self-renewal, cancer metabolism and tumor microenvironment. TI - The use of plant-derived bioactive compounds to target cancer stem cells and modulate tumor microenvironment SP - 58 EP - 70 Y1 - 2015/// SN - 02786915 ER - TY - JOUR A1 - Pistollato, Francesca A1 - Sumalla Cano, Sandra A1 - Elío Pascual, Iñaki A1 - Masías Vergara, Manuel A1 - Giampieri, Francesca A1 - Battino, Maurizio VL - 48 KW - Alzheimer?s disease; brain anatomy; imaging; magnetic resonance imaging; metabolic syndrome; mild cognitive impairment; nutrient supplementations; nutritional patterns; positron emission tomography; type 2 diabetes AV - none JF - Journal of Alzheimer's Disease TI - The Use of Neuroimaging to Assess Associations Among Diet, Nutrients, Metabolic Syndrome, and Alzheimer?s Disease N2 - In the last decade, specific dietary patterns, mainly characterized by high consumption of vegetables and fruits, have been proven beneficial for the prevention of both metabolic syndrome (MetS)-related dysfunctions and neurodegenerative disorders, such as Alzheimer?s disease (AD). Nowadays, neuroimaging readouts can be used to diagnose AD, investigate MetS effects on brain functionality and anatomy, and assess the effects of dietary supplementations and nutritional patterns in relation to neurodegeneration and AD-related features. Here we review scientific literature describing the use of the most recent neuroimaging techniques to detect AD- and MetS-related brain features, and also to investigate associations between consolidated dietary patterns or nutritional interventions and AD, specifically focusing on observational and intervention studies in humans. UR - http://doi.org/10.3233/JAD-150301 ID - uneatlantico536 EP - 318 SP - 303 IS - 2 Y1 - 2015/// SN - 13872877 ER - TY - JOUR SN - 1420-3049 Y1 - 2014/// IS - 6 SP - 7798 EP - 7816 N2 - Strawberry bioactive compounds are widely known to be powerful antioxidants. In this study, the antioxidant and anti-aging activities of a polyphenol-rich strawberry extract were evaluated using human dermal fibroblasts exposed to H2O2. Firstly, the phenol and flavonoid contents of strawberry extract were studied, as well as the antioxidant capacity. HPLC-DAD analysis was performed to determine the vitamin C and ?-carotene concentration, while HPLC-DAD/ESI-MS analysis was used for anthocyanin identification. Strawberry extract presented a high antioxidant capacity, and a relevant concentration of vitamins and phenolics. Pelargonidin- and cyanidin-glycosides were the most representative anthocyanin components of the fruits. Fibroblasts incubated with strawberry extract and stressed with H2O2 showed an increase in cell viability, a smaller intracellular amount of ROS, and a reduction of membrane lipid peroxidation and DNA damage. Strawberry extract was also able to improve mitochondrial functionality, increasing the basal respiration of mitochondria and to promote a regenerative capacity of cells after exposure to pro-oxidant stimuli. These findings confirm that strawberries possess antioxidant properties and provide new insights into the beneficial role of strawberry bioactive compounds on protecting skin from oxidative stress and aging. UR - http://doi.org/10.3390/molecules19067798 ID - uneatlantico612 TI - Polyphenol-Rich Strawberry Extract Protects Human Dermal Fibroblasts against Hydrogen Peroxide Oxidative Damage and Improves Mitochondrial Functionality JF - Molecules AV - public KW - strawberry; anthocyanin; ROS; lipid peroxidation; DNA damage; fibroblasts A1 - Giampieri, Francesca A1 - Alvarez-Suarez, José A1 - Mazzoni, Luca A1 - Forbes-Hernandez, Tamara Y. A1 - Gasparrini, Massimiliano A1 - Gonzàlez-Paramàs, Ana A1 - Santos-Buelga, Celestino A1 - Quiles, José A1 - Bompadre, Stefano A1 - Mezzetti, Bruno A1 - Battino, Maurizio VL - 19 ER - TY - JOUR Y1 - 2014/// SN - 09242244 EP - 81 SP - 62 IS - 1 JF - Trends in Food Science & Technology TI - Role of plant-based diets in the prevention and regression of metabolic syndrome and neurodegenerative diseases UR - http://doi.org/10.1016/j.tifs.2014.07.012 N2 - Plant-based diets are known to preserve body tissues from oxidative stress and inflammation, both hallmarks of chronic-degenerative diseases. In particular, plant-derived foods, such as legumes, represent a natural source of bioactive nutrients known to contribute to the prevention and amelioration of insulin resistance, dyslipidemia, hypertension and impaired glucose metabolism, all factors implicated in metabolic syndrome (MetS), but also osteoporosis, neurodegeneration and some types of cancers. Here we revise recent literature on the role of plant-based diets, plant-foods and specific plant-nutrients in the prevention and regression of MetS and neurodegenerative diseases. We describe some of the molecular mechanisms underlying these protective effects, highlighting the role of diet in the control of hyper-homocysteinemia and insulin resistance, often implicated in the etiology of both metabolic and neurodegenerative syndromes. ID - uneatlantico624 VL - 40 A1 - Pistollato, Francesca A1 - Battino, Maurizio AV - none ER - TY - JOUR AV - none VL - 32 A1 - Elío Pascual, Iñaki A1 - Sumalla Cano, Sandra A1 - Dominguez Azpíroz, Irma A1 - Jarrin, Sandra A1 - Montejo, Marylin A1 - Battino, Maurizio JF - Clinical Nutrition ID - uneatlantico103 UR - http://doi.org/10.1016/S0261-5614(13)60504-X TI - PP194-MON assessing the nutritional intake and the profile of a latin american group of nutrition postgraduate students Y1 - 2013/// SN - 0261-5614 ER -