Influence of the properties of different graphene-based nanomaterials dispersed in polycaprolactone membranes on astrocytic differentiation

Artículo Materias > Biomedicina Universidad Europea del Atlántico > Investigación > Producción Científica Abierto Inglés Composites of polymer and graphene-based nanomaterials (GBNs) combine easy processing onto porous 3D membrane geometries due to the polymer and cellular differentiation stimuli due to GBNs fillers. Aiming to step forward to the clinical application of polymer/GBNs composites, this study performs a systematic and detailed comparative analysis of the influence of the properties of four different GBNs: (i) graphene oxide obtained from graphite chemically processes (GO); (ii) reduced graphene oxide (rGO); (iii) multilayered graphene produced by mechanical exfoliation method (Gmec); and (iv) low-oxidized graphene via anodic exfoliation (Ganodic); dispersed in polycaprolactone (PCL) porous membranes to induce astrocytic differentiation. PCL/GBN flat membranes were fabricated by phase inversion technique and broadly characterized in morphology and topography, chemical structure, hydrophilicity, protein adsorption, and electrical properties. Cellular assays with rat C6 glioma cells, as model for cell-specific astrocytes, were performed. Remarkably, low GBN loading (0.67 wt%) caused an important difference in the response of the C6 differentiation among PCL/GBN membranes. PCL/rGO and PCL/GO membranes presented the highest biomolecule markers for astrocyte differentiation. Our results pointed to the chemical structural defects in rGO and GO nanomaterials and the protein adsorption mechanisms as the most plausible cause conferring distinctive properties to PCL/GBN membranes for the promotion of astrocytic differentiation. Overall, our systematic comparative study provides generalizable conclusions and new evidences to discern the role of GBNs features for future research on 3D PCL/graphene composite hollow fiber membranes for in vitro neural models. metadata Mantecón-Oria, Marián; Tapia Martínez, Olga; Lafarga, Miguel; Berciano, María T.; Munuera, Jose M.; Villar-Rodil, Silvia; Paredes, Juan I.; Rivero, María J.; Diban, Nazely y Urtiaga, Ane mail SIN ESPECIFICAR, olga.tapia@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR (2022) Influence of the properties of different graphene-based nanomaterials dispersed in polycaprolactone membranes on astrocytic differentiation. Scientific Reports, 12 (1). ISSN 2045-2322

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Composites of polymer and graphene-based nanomaterials (GBNs) combine easy processing onto porous 3D membrane geometries due to the polymer and cellular differentiation stimuli due to GBNs fillers. Aiming to step forward to the clinical application of polymer/GBNs composites, this study performs a systematic and detailed comparative analysis of the influence of the properties of four different GBNs: (i) graphene oxide obtained from graphite chemically processes (GO); (ii) reduced graphene oxide (rGO); (iii) multilayered graphene produced by mechanical exfoliation method (Gmec); and (iv) low-oxidized graphene via anodic exfoliation (Ganodic); dispersed in polycaprolactone (PCL) porous membranes to induce astrocytic differentiation. PCL/GBN flat membranes were fabricated by phase inversion technique and broadly characterized in morphology and topography, chemical structure, hydrophilicity, protein adsorption, and electrical properties. Cellular assays with rat C6 glioma cells, as model for cell-specific astrocytes, were performed. Remarkably, low GBN loading (0.67 wt%) caused an important difference in the response of the C6 differentiation among PCL/GBN membranes. PCL/rGO and PCL/GO membranes presented the highest biomolecule markers for astrocyte differentiation. Our results pointed to the chemical structural defects in rGO and GO nanomaterials and the protein adsorption mechanisms as the most plausible cause conferring distinctive properties to PCL/GBN membranes for the promotion of astrocytic differentiation. Overall, our systematic comparative study provides generalizable conclusions and new evidences to discern the role of GBNs features for future research on 3D PCL/graphene composite hollow fiber membranes for in vitro neural models.

Tipo de Documento: Artículo
Palabras Clave: Biomaterials – cells; Biomedical engineering; Graphene
Clasificación temática: Materias > Biomedicina
Divisiones: Universidad Europea del Atlántico > Investigación > Producción Científica
Depositado: 06 Sep 2022 17:24
Ultima Modificación: 12 Jul 2023 23:30
URI: https://repositorio.uneatlantico.es/id/eprint/3486

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Influence of E-learning training on the acquisition of competences in basketball coaches in Cantabria

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Josep Alemany Iturriaga mail josep.alemany@uneatlantico.es, Álvaro Velarde-Sotres mail alvaro.velarde@uneatlantico.es, Javier Jorge mail , Kamil Giglio mail ,

Alemany Iturriaga

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Producción Científica

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Unveiling the truth: A systematic review of fact-checking and fake news research in social sciences

The current media ecosystem, marked by immediacy and social networks dynamics, has created a fertile field for disinformation. Faced with its exponential growth, since 2014, research has focused on combating false content in the media. From a descriptive approach, this study has analyzed 200 documents on fact-checking and fake news published between 2014 and 2022 in scientific journals indexed in Scopus. This study has found that Europe and the United States are leading the way in the number of journals and authors publishing on the subject. The United States universities are the ones that host the most significant number of authors working on fact-checking, while the methodologies used, mostly ad hoc due to the novelty of the topic, allow to reflect on the need to promote work focused on the design, testing, and evaluation of prototypes or real experiences within the field. The most common contributions analyzed include typologies of false content and media manipulation mechanisms, models for evaluating and detecting disinformation, proposals to combat false content and strengthen verification mechanisms, studies on the role of social media in the spread of disinformation, efforts to develop media literacy among the public and journalists, case studies of fact-checkers, identification of factors that influence the belief in fake news, and analysis of the relationship between disinformation, verification, politics, and democracy. It is concluded that it is essential to develop research that connects the academy with the industry to raise awareness of the need to address these issues among the different actors in the media scenario.

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