TY  - JOUR
AV  - none
SP  - 1
KW  - Gamma-aminobutyric aciddiabetes?-cellsinsulinanti-inflammatory activity
TI  - Insights into the cellular, molecular, and epigenetic targets of gamma-aminobutyric acid against diabetes: a comprehensive review on its mechanisms
JF  - Critical Reviews in Food Science and Nutrition
A1  - Sun, Yu
A1  - Mehmood, Arshad
A1  - Giampieri, Francesca
A1  - Battino, Maurizio
A1  - Chen, Xiumin
SN  - 1040-8398
EP  - 18
Y1  - 2023/09//
UR  - http://doi.org/10.1080/10408398.2023.2255666
N2  - Diabetes is a metabolic disease due to impaired or defective insulin secretion and is considered one of the most serious chronic diseases worldwide. Gamma-aminobutyric acid (GABA) is a naturally occurring non-protein amino acid commonly present in a wide range of foods. A number of studies documented that GABA has good anti-diabetic potential. This review summarized the available dietary sources of GABA as well as animal and human studies on the anti-diabetic properties of GABA, while also discussing the underlying mechanisms. GABA may modulate diabetes through various pathways such as inhibiting the activities of ?-amylase and ?-glucosidase, promoting ?-cell proliferation, stimulating insulin secretion from ?-cells, inhibiting glucagon secretion from ?-cells, improving insulin resistance and glucose tolerance, and increasing antioxidant and anti-inflammatory activities. However, further mechanistic studies on animals and human are needed to confirm the therapeutic effects of GABA against diabetes.
ID  - uneatlantico8802
ER  -