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primary topic: Insights into the cellular, molecular, and epigenetic targets of gamma-aminobutyric acid against diabetes: a comprehensive review on its mechanisms

Insights into the cellular, molecular, and epigenetic targets of gamma-aminobutyric acid against diabetes: a comprehensive review on its mechanisms
type: AcademicArticle
type: Article
abstract: Diabetes is a metabolic disease due to impaired or defective insulin secretion and is considered one of the most serious chronic diseases worldwide. Gamma-aminobutyric acid (GABA) is a naturally occurring non-protein amino acid commonly present in a wide range of foods. A number of studies documented that GABA has good anti-diabetic potential. This review summarized the available dietary sources of GABA as well as animal and human studies on the anti-diabetic properties of GABA, while also discussing the underlying mechanisms. GABA may modulate diabetes through various pathways such as inhibiting the activities of α-amylase and α-glucosidase, promoting β-cell proliferation, stimulating insulin secretion from β-cells, inhibiting glucagon secretion from α-cells, improving insulin resistance and glucose tolerance, and increasing antioxidant and anti-inflammatory activities. However, further mechanistic studies on animals and human are needed to confirm the therapeutic effects of GABA against diabetes.
date: 2023-09
is part of: Critical Reviews in Food Science and Nutrition
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
subject: Nutrition

Critical Reviews in Food Science and Nutrition
type: Collection
issn: 10408398

Arshad Mehmood
type: Person
given name: Arshad
family name: Mehmood

Maurizio Battino
type: Person
given name: Maurizio
family name: Battino

Francesca Giampieri
type: Person
given name: Francesca
family name: Giampieri

Yu Sun
type: Person
given name: Yu
family name: Sun

Xiumin Chen
type: Person
given name: Xiumin
family name: Chen

HTML Summary of #8802 Insights into the cellular, molecular, and epigenetic targets of gamma-aminobutyric acid against diabetes: a comprehensive review on its mechanisms
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primary topic: Insights into the cellular, molecular, and epigenetic targets of gamma-aminobutyric acid against diabetes: a comprehensive review on its mechanisms

Nutrition
type: Concept
preferred label: Alimentación @es