@article{uneatlantico8802,
           title = {Insights into the cellular, molecular, and epigenetic targets of gamma-aminobutyric acid against diabetes: a comprehensive review on its mechanisms},
            year = {2023},
          author = {Yu Sun and Arshad Mehmood and Francesca Giampieri and Maurizio Battino and Xiumin Chen},
           pages = {1--18},
           month = {Septiembre},
         journal = {Critical Reviews in Food Science and Nutrition},
             url = {http://repositorio.uneatlantico.es/id/eprint/8802/},
        keywords = {Gamma-aminobutyric aciddiabetes{\ensuremath{\beta}}-cellsinsulinanti-inflammatory activity},
        abstract = {Diabetes is a metabolic disease due to impaired or defective insulin secretion and is considered one of the most serious chronic diseases worldwide. Gamma-aminobutyric acid (GABA) is a naturally occurring non-protein amino acid commonly present in a wide range of foods. A number of studies documented that GABA has good anti-diabetic potential. This review summarized the available dietary sources of GABA as well as animal and human studies on the anti-diabetic properties of GABA, while also discussing the underlying mechanisms. GABA may modulate diabetes through various pathways such as inhibiting the activities of {\ensuremath{\alpha}}-amylase and {\ensuremath{\alpha}}-glucosidase, promoting {\ensuremath{\beta}}-cell proliferation, stimulating insulin secretion from {\ensuremath{\beta}}-cells, inhibiting glucagon secretion from {\ensuremath{\alpha}}-cells, improving insulin resistance and glucose tolerance, and increasing antioxidant and anti-inflammatory activities. However, further mechanistic studies on animals and human are needed to confirm the therapeutic effects of GABA against diabetes.}
}