@article{uneatlantico88,
          author = {Jos{\'e} M. Alvarez-Suarez and Estefan{\'i}a Carrillo-Perdomo and Angel Aller and Francesca Giampieri and Massimiliano Gasparrini and Lien Gonz{\'a}lez-P{\'e}rez and Pablo Beltr{\'a}n-Ayala and Maurizio Battino},
          volume = {102},
           pages = {46--52},
         journal = {Food and Chemical Toxicology},
           title = {Anti-inflammatory effect of Capuli cherry against LPS-induced cytotoxic damage in RAW 264.7 macrophages},
           month = {Sin especificar},
            year = {2017},
        abstract = {Capuli cherry (Prunus serotina Ehr. subsp. capuli (Cav.) McVaugh) fruits from the inter-Andean region of Ecuador were analysed to determine their bioactive compounds content, total antioxidant capacity, radical scavenging activity and their anti-inflammatory and protective effects against the cytotoxic damage mediated by lipopolysaccharide (LPS) in RAW 264.7 macrophages. Capuli fruits proved to be a natural source of bioactive compounds such as anthocyanins, vitamin C and {\ensuremath{\beta}}-carotene as well as to present an important total antioxidant capacity and radical scavenging activities. RAW 264.7 macrophages were incubated with different concentration of Capuli crude extract and subsequently activated by LPS to determine the markers related to oxidative damage and the proinflammatory cytokine production. The markers of oxidative damage, nitrite levels, the interleukin 1{\ensuremath{\beta}} messenger RNA levels and the tumor necrosis factor {\ensuremath{\alpha}} mRNA levels and secretion were significantly decreased after the pre-incubated with Capuli extract and subsequently stimulated with LPS. In summary, Capuli extract attenuated the LPS-induced damage in RAW 264.7 macrophages due to its antioxidant and anti-inflammatory properties, showing that Capuli fruits may represent a relevant source of bioactive compounds with promising benefits for human health.},
             url = {http://repositorio.uneatlantico.es/id/eprint/88/},
        keywords = {Prunus serotina; Capuli cherry; Antioxidant capacity; Oxidative stress; Inflammation.}
}