eprintid: 85 rev_number: 7 eprint_status: archive userid: 2 importid: 0 dir: disk0/00/00/00/85 datestamp: 2021-05-31 14:17:21 lastmod: 2021-06-30 15:38:28 status_changed: 2021-05-31 14:17:21 type: article succeeds: 0 commentary: 0 metadata_visibility: show item_issues_count: 0 sword_depositor: 0 creators_name: Chen, Lei creators_name: Teng, Hui creators_name: Jia, Zhen creators_name: Battino, Maurizio creators_name: Miron, Anca creators_name: Yu, Zhiling creators_name: Cao, Hui creators_name: Xiao, Jianbo creators_id: creators_id: creators_id: creators_id: maurizio.battino@uneatlantico.es creators_id: creators_id: creators_id: creators_id: title: Intracellular signaling pathways of inflammation modulated by dietary flavonoids: The most recent evidence ispublished: pub subjects: uneat_sn divisions: uneatlantico_produccion_cientifica full_text_status: none keywords: Flavonoids; Inflammation; Intracellular signaling pathways; Strectyre-activity relationship. abstract: Dietary flavonoids, which occur in many plant foods, are considered as the most active constituents among the plant-derived ones in vitro and in vivo. To date, many studies have addressed the anti-inflammatory activity of flavonoids. However, their considerable structural diversity and in vivo bioavailability make them able to modulate different signaling pathways. The present review attempted to summarize and highlight a broad range of inflammation-associated signaling pathways modulated by flavonoids. Finally, based on the current scientist's literature, structure-activity relationships were concluded. Dietary flavonoids have the ability to attenuate inflammation by targeting different intracellular signaling pathways triggered by NF-κB, AP-1, PPAR, Nrf2, and MAPKs. Identification of the main structural features required for the modulation of these inflammation-related pathways (hydroxylation pattern, C2=C3 double bond) have an important role to play in the development of new anti-inflammatory drugs. date: 2018-00-00 date_type: published publication: Critical Reviews in Food Science and Nutrition volume: 58 number: 17 pagerange: 2908-2924 pages: 0 id_number: doi:10.1080/10408398.2017.1345853 refereed: TRUE issn: 1040-8398 official_url: http://doi.org/10.1080/10408398.2017.1345853 num_pieces: 0 gscholar_impact: 0 gscholar_datestamp: 0000-00-00 00:00:00 citation: Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica SIN ESPECIFICAR SIN ESPECIFICAR Dietary flavonoids, which occur in many plant foods, are considered as the most active constituents among the plant-derived ones in vitro and in vivo. To date, many studies have addressed the anti-inflammatory activity of flavonoids. However, their considerable structural diversity and in vivo bioavailability make them able to modulate different signaling pathways. The present review attempted to summarize and highlight a broad range of inflammation-associated signaling pathways modulated by flavonoids. Finally, based on the current scientist's literature, structure-activity relationships were concluded. Dietary flavonoids have the ability to attenuate inflammation by targeting different intracellular signaling pathways triggered by NF-κB, AP-1, PPAR, Nrf2, and MAPKs. Identification of the main structural features required for the modulation of these inflammation-related pathways (hydroxylation pattern, C2=C3 double bond) have an important role to play in the development of new anti-inflammatory drugs. metadata Chen, Lei; Teng, Hui; Jia, Zhen; Battino, Maurizio; Miron, Anca; Yu, Zhiling; Cao, Hui y Xiao, Jianbo mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR (2018) Intracellular signaling pathways of inflammation modulated by dietary flavonoids: The most recent evidence. Critical Reviews in Food Science and Nutrition, 58 (17). pp. 2908-2924. ISSN 1040-8398