%D 2018
%T Intracellular signaling pathways of inflammation modulated by dietary flavonoids: The most recent evidence
%V 58
%J Critical Reviews in Food Science and Nutrition
%K Flavonoids; Inflammation; Intracellular signaling pathways; Strectyre-activity relationship.
%A Lei Chen
%A Hui Teng
%A Zhen Jia
%A Maurizio Battino
%A Anca Miron
%A Zhiling Yu
%A Hui Cao
%A Jianbo Xiao
%N 17
%R doi:10.1080/10408398.2017.1345853
%X Dietary flavonoids, which occur in many plant foods, are considered as the most active constituents among the plant-derived ones in vitro and in vivo. To date, many studies have addressed the anti-inflammatory activity of flavonoids. However, their considerable structural diversity and in vivo bioavailability make them able to modulate different signaling pathways. The present review attempted to summarize and highlight a broad range of inflammation-associated signaling pathways modulated by flavonoids. Finally, based on the current scientist's literature, structure-activity relationships were concluded. Dietary flavonoids have the ability to attenuate inflammation by targeting different intracellular signaling pathways triggered by NF-κB, AP-1, PPAR, Nrf2, and MAPKs. Identification of the main structural features required for the modulation of these inflammation-related pathways (hydroxylation pattern, C2=C3 double bond) have an important role to play in the development of new anti-inflammatory drugs.
%P 2908-2924
%L uneatlantico85