TY  - JOUR
TI  - Intracellular signaling pathways of inflammation modulated by dietary flavonoids: The most recent evidence
EP  - 2924
ID  - uneatlantico85
KW  - Flavonoids; Inflammation; Intracellular signaling pathways; Strectyre-activity relationship.
AV  - none
A1  - Chen, Lei
A1  - Teng, Hui
A1  - Jia, Zhen
A1  - Battino, Maurizio
A1  - Miron, Anca
A1  - Yu, Zhiling
A1  - Cao, Hui
A1  - Xiao, Jianbo
SP  - 2908
IS  - 17
Y1  - 2018/00/00/
JF  - Critical Reviews in Food Science and Nutrition
N2  - Dietary flavonoids, which occur in many plant foods, are considered as the most active constituents among the plant-derived ones in vitro and in vivo. To date, many studies have addressed the anti-inflammatory activity of flavonoids. However, their considerable structural diversity and in vivo bioavailability make them able to modulate different signaling pathways. The present review attempted to summarize and highlight a broad range of inflammation-associated signaling pathways modulated by flavonoids. Finally, based on the current scientist's literature, structure-activity relationships were concluded. Dietary flavonoids have the ability to attenuate inflammation by targeting different intracellular signaling pathways triggered by NF-?B, AP-1, PPAR, Nrf2, and MAPKs. Identification of the main structural features required for the modulation of these inflammation-related pathways (hydroxylation pattern, C2=C3 double bond) have an important role to play in the development of new anti-inflammatory drugs.
SN  - 1040-8398
UR  - http://doi.org/10.1080/10408398.2017.1345853
VL  - 58
ER  -