TY  - JOUR
IS  - 11
SN  - 1422-0067
A1  - Rivas-García, Lorenzo
A1  - López-Varela, Alfonso
A1  - Quiles, José L.
A1  - Montes-Bayón, María
A1  - Aranda, Pilar
A1  - Llopis, Juan
A1  - Sánchez-González, Cristina
JF  - International Journal of Molecular Sciences
KW  - vanadium; copper; mineral; nutrition; mitochondria; DNA
AV  - public
N2  - Vanadium (V) is a trace mineral whose biological activity, role as a micronutrient, and pharmacotherapeutic applications remain unknown. Over the last years, interest in V has increased due to its potential use as an antidiabetic agent mediated by its ability to improve glycemic metabolism. However, some toxicological aspects limit its potential therapeutic application. The present study aims to evaluate the effect of the co-treatment with copper (Cu) and bis(maltolato)oxovanadium(IV) (BMOV) as a possible strategy to reduce the toxicity of BMOV. Treating hepatic cells with BMOV reduced cell viability under the present conditions, but cell viability was corrected when cells were co-incubated with BMOV and Cu. Additionally, the effect of these two minerals on nuclear and mitochondrial DNA was evaluated. Co-treatment with both metals reduced the nuclear damage caused by BMOV. Moreover, treatment with these two metals simultaneously tended to reduce the ND1/ND4 deletion of the mitochondrial DNA produced with the treatment using BMOV alone. In conclusion, these results showed that combining Cu and V could effectively reduce the toxicity associated with V and enhance its potential therapeutic applications.
UR  - http://doi.org/10.3390/ijms24119367
Y1  - 2023///
VL  - 24
TI  - Elucidating the Therapeutic Potential of Bis(Maltolato)OxoVanadium(IV): The Protective Role of Copper in Cellular Metabolism
ID  - uneatlantico7510
ER  -