eprintid: 7347 rev_number: 9 eprint_status: archive userid: 2 dir: disk0/00/00/73/47 datestamp: 2023-05-31 23:30:05 lastmod: 2023-05-31 23:30:14 status_changed: 2023-05-31 23:30:05 type: article metadata_visibility: show creators_name: Varela-López, Alfonso creators_name: Romero-Márquez, José M. creators_name: Navarro-Hortal, María D. creators_name: Ramirez-Tortosa, César L. creators_name: Battino, Maurizio creators_name: Forbes-Hernández, Tamara Y. creators_name: Quiles, José L. creators_id: creators_id: creators_id: creators_id: creators_id: maurizio.battino@uneatlantico.es creators_id: creators_id: jose.quiles@uneatlantico.es title: Dietary antioxidants and lifespan: Relevance of environmental conditions, diet, and genotype of experimental models ispublished: pub subjects: uneat_bm subjects: uneat_sn divisions: uneatlantico_produccion_cientifica full_text_status: public keywords: Aging; Ageing; Longevity; Bioactive compounds; Nutrient-sensing pathways; Hormesis abstract: The rise of life expectancy in current societies is not accompanied, to date, by a similar increase in healthspan, which represents a great socio-economic problem. It has been suggested that aging can be manipulated and then, the onset of all age-associated chronic disorders can be delayed because these pathologies share age as primary underlying risk factor. One of the most extended ideas is that aging is consequence of the accumulation of molecular damage. According to the oxidative damage theory, antioxidants should slow down aging, extending lifespan and healthspan. The present review analyzes studies evaluating the effect of dietary antioxidants on lifespan of different aging models and discusses the evidence on favor of their antioxidant activity as anti-aging mechanisms. Moreover, possible causes for differences between the reported results are evaluated. date: 2023 publication: Experimental Gerontology volume: 178 pagerange: 112221 id_number: doi:10.1016/j.exger.2023.112221 refereed: TRUE issn: 05315565 official_url: http://doi.org/10.1016/j.exger.2023.112221 access: open language: en citation: Artículo Materias > Biomedicina Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica Abierto Inglés The rise of life expectancy in current societies is not accompanied, to date, by a similar increase in healthspan, which represents a great socio-economic problem. It has been suggested that aging can be manipulated and then, the onset of all age-associated chronic disorders can be delayed because these pathologies share age as primary underlying risk factor. One of the most extended ideas is that aging is consequence of the accumulation of molecular damage. According to the oxidative damage theory, antioxidants should slow down aging, extending lifespan and healthspan. The present review analyzes studies evaluating the effect of dietary antioxidants on lifespan of different aging models and discusses the evidence on favor of their antioxidant activity as anti-aging mechanisms. Moreover, possible causes for differences between the reported results are evaluated. metadata Varela-López, Alfonso; Romero-Márquez, José M.; Navarro-Hortal, María D.; Ramirez-Tortosa, César L.; Battino, Maurizio; Forbes-Hernández, Tamara Y. y Quiles, José L. mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es, SIN ESPECIFICAR, jose.quiles@uneatlantico.es (2023) Dietary antioxidants and lifespan: Relevance of environmental conditions, diet, and genotype of experimental models. Experimental Gerontology, 178. p. 112221. ISSN 05315565 document_url: http://repositorio.uneatlantico.es/id/eprint/7347/1/1-s2.0-S0531556523001420-main.pdf