eprintid: 7314 rev_number: 6 eprint_status: archive userid: 2 dir: disk0/00/00/73/14 datestamp: 2023-05-29 23:30:08 lastmod: 2023-05-29 23:30:08 status_changed: 2023-05-29 23:30:08 type: article metadata_visibility: show creators_name: Zhang, Yu creators_name: Hao, Ruojie creators_name: Chen, Junda creators_name: Li, Sen creators_name: Huang, Kai creators_name: Cao, Hongwei creators_name: Farag, Mohamed A. creators_name: Battino, Maurizio creators_name: Daglia, Maria creators_name: Capanoglu, Esra creators_name: Zhang, Fan creators_name: Sun, Qiqi creators_name: Xiao, Jianbo creators_name: Sun, Zhenliang creators_name: Guan, Xiao creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: maurizio.battino@uneatlantico.es creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: title: Health benefits of saponins and its mechanisms: perspectives from absorption, metabolism, and interaction with gut ispublished: pub subjects: uneat_sn divisions: uneatlantico_produccion_cientifica full_text_status: none keywords: Absorption; gut microbiota; metabolism; sapogenins; saponins abstract: Saponins, consisting of sapogenins as their aglycones and carbohydrate chains, are widely found in plants and some marine organisms. Due to the complexity of the structure of saponins, involving different types of sapogenins and sugar moieties, investigation of their absorption and metabolism is limited, which further hinders the explanation of their bioactivities. Large molecular weight and complex structures limit the direct absorption of saponins rendering their low bioavailability. As such, their major modes of action may be due to interaction with the gastrointestinal environment, such as enzymes and nutrients, and interaction with the gut microbiota. Many studies have reported the interaction between saponins and gut microbiota, that is, the effects of saponins on changing the composition of gut microbiota, and gut microbiota playing an indispensable role in the biotransformation of saponins into sapogenins. However, the metabolic routes of saponins by gut microbiota and their mutual interactions are still sparse. Thus, this review summarizes the chemistry, absorption, and metabolic pathways of saponins, as well as their interactions with gut microbiota and impacts on gut health, to better understand how saponins exert their health-promoting functions. date: 2023 publication: Critical Reviews in Food Science and Nutrition pagerange: 1-22 id_number: doi:10.1080/10408398.2023.2212063 refereed: TRUE issn: 1040-8398 official_url: http://doi.org/10.1080/10408398.2023.2212063 access: close language: en citation: Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica Cerrado Inglés Saponins, consisting of sapogenins as their aglycones and carbohydrate chains, are widely found in plants and some marine organisms. Due to the complexity of the structure of saponins, involving different types of sapogenins and sugar moieties, investigation of their absorption and metabolism is limited, which further hinders the explanation of their bioactivities. Large molecular weight and complex structures limit the direct absorption of saponins rendering their low bioavailability. As such, their major modes of action may be due to interaction with the gastrointestinal environment, such as enzymes and nutrients, and interaction with the gut microbiota. Many studies have reported the interaction between saponins and gut microbiota, that is, the effects of saponins on changing the composition of gut microbiota, and gut microbiota playing an indispensable role in the biotransformation of saponins into sapogenins. However, the metabolic routes of saponins by gut microbiota and their mutual interactions are still sparse. Thus, this review summarizes the chemistry, absorption, and metabolic pathways of saponins, as well as their interactions with gut microbiota and impacts on gut health, to better understand how saponins exert their health-promoting functions. metadata Zhang, Yu; Hao, Ruojie; Chen, Junda; Li, Sen; Huang, Kai; Cao, Hongwei; Farag, Mohamed A.; Battino, Maurizio; Daglia, Maria; Capanoglu, Esra; Zhang, Fan; Sun, Qiqi; Xiao, Jianbo; Sun, Zhenliang y Guan, Xiao mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR (2023) Health benefits of saponins and its mechanisms: perspectives from absorption, metabolism, and interaction with gut. Critical Reviews in Food Science and Nutrition. pp. 1-22. ISSN 1040-8398