eprintid: 6096 rev_number: 8 eprint_status: archive userid: 2 dir: disk0/00/00/60/96 datestamp: 2023-03-01 23:30:13 lastmod: 2023-03-01 23:30:14 status_changed: 2023-03-01 23:30:13 type: article metadata_visibility: show creators_name: Romero-Márquez, Jose M. creators_name: Forbes-Hernández, Tamara Y. creators_name: Navarro-Hortal, María D. creators_name: Quirantes-Piné, Rosa creators_name: Grosso, Giuseppe creators_name: Giampieri, Francesca creators_name: Lipari, Vivian creators_name: Sánchez-González, Cristina creators_name: Battino, Maurizio creators_name: Quiles, José L. creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: francesca.giampieri@uneatlantico.es creators_id: vivian.lipari@uneatlantico.es creators_id: creators_id: maurizio.battino@uneatlantico.es creators_id: jose.quiles@uneatlantico.es title: Molecular Mechanisms of the Protective Effects of Olive Leaf Polyphenols against Alzheimer’s Disease ispublished: pub subjects: uneat_sn divisions: uneatlantico_produccion_cientifica divisions: uninimx_produccion_cientifica divisions: unic_produccion_cientifica full_text_status: public keywords: olive leaves; bioactive compounds; Alzheimer’s Disease; oleuropein; hydroxytyrosol abstract: Alzheimer’s Disease (AD) is the cause of around 60–70% of global cases of dementia and approximately 50 million people have been reported to suffer this disease worldwide. The leaves of olive trees (Olea europaea) are the most abundant by-products of the olive grove industry. These by-products have been highlighted due to the wide variety of bioactive compounds such as oleuropein (OLE) and hydroxytyrosol (HT) with demonstrated medicinal properties to fight AD. In particular, the olive leaf (OL), OLE, and HT reduced not only amyloid-β formation but also neurofibrillary tangles formation through amyloid protein precursor processing modulation. Although the isolated olive phytochemicals exerted lower cholinesterase inhibitory activity, OL demonstrated high inhibitory activity in the cholinergic tests evaluated. The mechanisms underlying these protective effects may be associated with decreased neuroinflammation and oxidative stress via NF-κB and Nrf2 modulation, respectively. Despite the limited research, evidence indicates that OL consumption promotes autophagy and restores loss of proteostasis, which was reflected in lower toxic protein aggregation in AD models. Therefore, olive phytochemicals may be a promising tool as an adjuvant in the treatment of AD. date: 2023 publication: International Journal of Molecular Sciences volume: 24 number: 5 pagerange: 4353 id_number: doi:10.3390/ijms24054353 refereed: TRUE issn: 1422-0067 official_url: http://doi.org/10.3390/ijms24054353 access: open language: en citation: Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica Universidad Internacional Iberoamericana México > Investigación > Producción Científica Universidad Internacional do Cuanza > Investigación > Producción Científica Abierto Inglés Alzheimer’s Disease (AD) is the cause of around 60–70% of global cases of dementia and approximately 50 million people have been reported to suffer this disease worldwide. The leaves of olive trees (Olea europaea) are the most abundant by-products of the olive grove industry. These by-products have been highlighted due to the wide variety of bioactive compounds such as oleuropein (OLE) and hydroxytyrosol (HT) with demonstrated medicinal properties to fight AD. In particular, the olive leaf (OL), OLE, and HT reduced not only amyloid-β formation but also neurofibrillary tangles formation through amyloid protein precursor processing modulation. Although the isolated olive phytochemicals exerted lower cholinesterase inhibitory activity, OL demonstrated high inhibitory activity in the cholinergic tests evaluated. The mechanisms underlying these protective effects may be associated with decreased neuroinflammation and oxidative stress via NF-κB and Nrf2 modulation, respectively. Despite the limited research, evidence indicates that OL consumption promotes autophagy and restores loss of proteostasis, which was reflected in lower toxic protein aggregation in AD models. Therefore, olive phytochemicals may be a promising tool as an adjuvant in the treatment of AD. metadata Romero-Márquez, Jose M.; Forbes-Hernández, Tamara Y.; Navarro-Hortal, María D.; Quirantes-Piné, Rosa; Grosso, Giuseppe; Giampieri, Francesca; Lipari, Vivian; Sánchez-González, Cristina; Battino, Maurizio y Quiles, José L. mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, francesca.giampieri@uneatlantico.es, vivian.lipari@uneatlantico.es, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es, jose.quiles@uneatlantico.es (2023) Molecular Mechanisms of the Protective Effects of Olive Leaf Polyphenols against Alzheimer’s Disease. International Journal of Molecular Sciences, 24 (5). p. 4353. ISSN 1422-0067 document_url: http://repositorio.uneatlantico.es/id/eprint/6096/1/ijms-24-04353.pdf