eprintid: 597 rev_number: 8 eprint_status: archive userid: 2 dir: disk0/00/00/05/97 datestamp: 2022-03-30 23:55:11 lastmod: 2023-07-11 23:30:21 status_changed: 2022-03-30 23:55:11 type: article metadata_visibility: show creators_name: Romero-Márquez, Jose M. creators_name: Navarro-Hortal, María D. creators_name: Jiménez-Trigo, Victoria creators_name: Vera-Ramírez, Laura creators_name: Forbes-Hernández, Tamara J. creators_name: Esteban-Muñoz, Adelaida creators_name: Giampieri, Francesca creators_name: Bullón, Pedro creators_name: Battino, Maurizio creators_name: Sánchez-González, Cristina creators_name: Quiles, José L. creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: francesca.giampieri@uneatlantico.es creators_id: creators_id: creators_id: creators_id: jose.quiles@uneatlantico.es title: An oleuropein rich-olive (Olea europaea L.) leaf extract reduces β-amyloid and tau proteotoxicity through regulation of oxidative- and heat shock-stress responses in Caenorhabditis elegans ispublished: pub subjects: uneat_sn divisions: uneatlantico_produccion_cientifica full_text_status: public keywords: Alzheimer disease; DAF-16/FOXO; HSP-16.2; IIS pathway; RNAi; SKN-1/NRF2 abstract: Olive tree-derived products have been associated with numerous benefits for health. The aim of the present study was to characterize an olive leaf extract enriched in oleuropein (OLE) concerning phenolic content and profile as well as antioxidant capacity. Short-term and long-term toxicity, including oxidative stress, was in vivo evaluated in the experimental model Caenorhabditis elegans. Moreover, the potential therapeutic effect of the extract against Aβ induced- and tau protein induced-toxicity was also evaluated in C. elegans. OLE treatment did not exert toxicity. On the contrary, the extract was able to ameliorate oxidative stress and proteotoxicity related to Aβ and tau aggregation. The potential molecular mechanisms present behind the observed results explored by RNAi technology revealed that DAF-16/FOXO and SKN-1/NRF2, elements of the insulin insulin-like signalling pathway, as well as HSP-16.2 overexpression were involved. date: 2022-04 publication: Food and Chemical Toxicology volume: 162 pagerange: 112914 id_number: doi:10.1016/j.fct.2022.112914 refereed: TRUE issn: 02786915 official_url: http://doi.org/10.1016/j.fct.2022.112914 access: open language: en citation: Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica Abierto Inglés Olive tree-derived products have been associated with numerous benefits for health. The aim of the present study was to characterize an olive leaf extract enriched in oleuropein (OLE) concerning phenolic content and profile as well as antioxidant capacity. Short-term and long-term toxicity, including oxidative stress, was in vivo evaluated in the experimental model Caenorhabditis elegans. Moreover, the potential therapeutic effect of the extract against Aβ induced- and tau protein induced-toxicity was also evaluated in C. elegans. OLE treatment did not exert toxicity. On the contrary, the extract was able to ameliorate oxidative stress and proteotoxicity related to Aβ and tau aggregation. The potential molecular mechanisms present behind the observed results explored by RNAi technology revealed that DAF-16/FOXO and SKN-1/NRF2, elements of the insulin insulin-like signalling pathway, as well as HSP-16.2 overexpression were involved. metadata Romero-Márquez, Jose M.; Navarro-Hortal, María D.; Jiménez-Trigo, Victoria; Vera-Ramírez, Laura; Forbes-Hernández, Tamara J.; Esteban-Muñoz, Adelaida; Giampieri, Francesca; Bullón, Pedro; Battino, Maurizio; Sánchez-González, Cristina y Quiles, José L. mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, francesca.giampieri@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, jose.quiles@uneatlantico.es (2022) An oleuropein rich-olive (Olea europaea L.) leaf extract reduces β-amyloid and tau proteotoxicity through regulation of oxidative- and heat shock-stress responses in Caenorhabditis elegans. Food and Chemical Toxicology, 162. p. 112914. ISSN 02786915 document_url: http://repositorio.uneatlantico.es/id/eprint/597/1/1-s2.0-S0278691522001120-main.pdf