relation: http://repositorio.uneatlantico.es/id/eprint/597/ canonical: http://repositorio.uneatlantico.es/id/eprint/597/ title: An oleuropein rich-olive (Olea europaea L.) leaf extract reduces β-amyloid and tau proteotoxicity through regulation of oxidative- and heat shock-stress responses in Caenorhabditis elegans creator: Romero-Márquez, Jose M. creator: Navarro-Hortal, María D. creator: Jiménez-Trigo, Victoria creator: Vera-Ramírez, Laura creator: Forbes-Hernández, Tamara J. creator: Esteban-Muñoz, Adelaida creator: Giampieri, Francesca creator: Bullón, Pedro creator: Battino, Maurizio creator: Sánchez-González, Cristina creator: Quiles, José L. subject: Alimentación description: Olive tree-derived products have been associated with numerous benefits for health. The aim of the present study was to characterize an olive leaf extract enriched in oleuropein (OLE) concerning phenolic content and profile as well as antioxidant capacity. Short-term and long-term toxicity, including oxidative stress, was in vivo evaluated in the experimental model Caenorhabditis elegans. Moreover, the potential therapeutic effect of the extract against Aβ induced- and tau protein induced-toxicity was also evaluated in C. elegans. OLE treatment did not exert toxicity. On the contrary, the extract was able to ameliorate oxidative stress and proteotoxicity related to Aβ and tau aggregation. The potential molecular mechanisms present behind the observed results explored by RNAi technology revealed that DAF-16/FOXO and SKN-1/NRF2, elements of the insulin insulin-like signalling pathway, as well as HSP-16.2 overexpression were involved. date: 2022-04 type: Artículo type: PeerReviewed format: text language: en rights: cc_by_4 identifier: http://repositorio.uneatlantico.es/id/eprint/597/1/1-s2.0-S0278691522001120-main.pdf identifier: Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica Abierto Inglés Olive tree-derived products have been associated with numerous benefits for health. The aim of the present study was to characterize an olive leaf extract enriched in oleuropein (OLE) concerning phenolic content and profile as well as antioxidant capacity. Short-term and long-term toxicity, including oxidative stress, was in vivo evaluated in the experimental model Caenorhabditis elegans. Moreover, the potential therapeutic effect of the extract against Aβ induced- and tau protein induced-toxicity was also evaluated in C. elegans. OLE treatment did not exert toxicity. On the contrary, the extract was able to ameliorate oxidative stress and proteotoxicity related to Aβ and tau aggregation. The potential molecular mechanisms present behind the observed results explored by RNAi technology revealed that DAF-16/FOXO and SKN-1/NRF2, elements of the insulin insulin-like signalling pathway, as well as HSP-16.2 overexpression were involved. metadata Romero-Márquez, Jose M.; Navarro-Hortal, María D.; Jiménez-Trigo, Victoria; Vera-Ramírez, Laura; Forbes-Hernández, Tamara J.; Esteban-Muñoz, Adelaida; Giampieri, Francesca; Bullón, Pedro; Battino, Maurizio; Sánchez-González, Cristina y Quiles, José L. mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, francesca.giampieri@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, jose.quiles@uneatlantico.es (2022) An oleuropein rich-olive (Olea europaea L.) leaf extract reduces β-amyloid and tau proteotoxicity through regulation of oxidative- and heat shock-stress responses in Caenorhabditis elegans. Food and Chemical Toxicology, 162. p. 112914. ISSN 02786915 relation: http://doi.org/10.1016/j.fct.2022.112914 relation: doi:10.1016/j.fct.2022.112914 language: en