eprintid: 584 rev_number: 8 eprint_status: archive userid: 2 dir: disk0/00/00/05/84 datestamp: 2022-03-17 23:55:12 lastmod: 2023-07-11 23:30:18 status_changed: 2022-03-17 23:55:12 type: article metadata_visibility: show creators_name: García-García, Amalia creators_name: Rojas, Sara creators_name: Rivas-García, Lorenzo creators_name: Navarro-Hortal, María D. creators_name: Romero-Márquez, Jose M. creators_name: Fernández-Bolaños, José G. creators_name: Choquesillo-Lazarte, Duane creators_name: Salinas-Castillo, Alfonso creators_name: López, Óscar creators_name: Quiles, José L. creators_name: Rodríguez-Diéguez, Antonio creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: jose.quiles@uneatlantico.es creators_id: title: A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans ispublished: pub subjects: uneat_bm divisions: uneatlantico_produccion_cientifica full_text_status: public abstract: A new palladium coordination compound based on gliclazide with the chemical formula [Pd(glz)2] (where glz = gliclazide) has been synthesized and characterised. The structural characterization reveals that this material consists of mononuclear units formed by a Pd2+ ion coordinated to two molecules of the glz ligand, in which palladium ions exhibit a distorted plane-square coordination sphere. This novel material behaves like a good and selective inhibitor of butyrylcholinesterase, one of the most relevant therapeutic targets against Alzheimer's disease. Analysis of the enzyme kinetics showed a mixed mode of inhibition, the title compound being capable of interacting with both the free enzyme and the enzyme-substrate complex. Finally, the palladium compound shows promising protective activity against Aβ-induced toxicity in the Caenorhabditis elegans model, which has never been reported. date: 2022-02 publication: Chemical Communications volume: 58 number: 10 pagerange: 1514-1517 id_number: doi:10.1039/d1cc04404d refereed: TRUE issn: 1359-7345 official_url: http://doi.org/10.1039/d1cc04404d access: open language: en citation: Artículo Materias > Biomedicina Universidad Europea del Atlántico > Investigación > Producción Científica Abierto Inglés A new palladium coordination compound based on gliclazide with the chemical formula [Pd(glz)2] (where glz = gliclazide) has been synthesized and characterised. The structural characterization reveals that this material consists of mononuclear units formed by a Pd2+ ion coordinated to two molecules of the glz ligand, in which palladium ions exhibit a distorted plane-square coordination sphere. This novel material behaves like a good and selective inhibitor of butyrylcholinesterase, one of the most relevant therapeutic targets against Alzheimer's disease. Analysis of the enzyme kinetics showed a mixed mode of inhibition, the title compound being capable of interacting with both the free enzyme and the enzyme-substrate complex. Finally, the palladium compound shows promising protective activity against Aβ-induced toxicity in the Caenorhabditis elegans model, which has never been reported. metadata García-García, Amalia; Rojas, Sara; Rivas-García, Lorenzo; Navarro-Hortal, María D.; Romero-Márquez, Jose M.; Fernández-Bolaños, José G.; Choquesillo-Lazarte, Duane; Salinas-Castillo, Alfonso; López, Óscar; Quiles, José L. y Rodríguez-Diéguez, Antonio mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, jose.quiles@uneatlantico.es, SIN ESPECIFICAR (2022) A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans. Chemical Communications, 58 (10). pp. 1514-1517. ISSN 1359-7345 document_url: http://repositorio.uneatlantico.es/id/eprint/584/1/d1cc04404d.pdf