%R doi:10.1039/d1cc04404d
%X A new palladium coordination compound based on gliclazide with the chemical formula [Pd(glz)2] (where glz = gliclazide) has been synthesized and characterised. The structural characterization reveals that this material consists of mononuclear units formed by a Pd2+ ion coordinated to two molecules of the glz ligand, in which palladium ions exhibit a distorted plane-square coordination sphere. This novel material behaves like a good and selective inhibitor of butyrylcholinesterase, one of the most relevant therapeutic targets against Alzheimer's disease. Analysis of the enzyme kinetics showed a mixed mode of inhibition, the title compound being capable of interacting with both the free enzyme and the enzyme-substrate complex. Finally, the palladium compound shows promising protective activity against Aβ-induced toxicity in the Caenorhabditis elegans model, which has never been reported.
%P 1514-1517
%L uneatlantico584
%D 2022
%T A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans
%V 58
%J Chemical Communications
%A Amalia García-García
%A Sara Rojas
%A Lorenzo Rivas-García
%A María D. Navarro-Hortal
%A Jose M. Romero-Márquez
%A José G. Fernández-Bolaños
%A Duane Choquesillo-Lazarte
%A Alfonso Salinas-Castillo
%A Óscar López
%A José L. Quiles
%A Antonio Rodríguez-Diéguez
%N 10