TY  - JOUR
VL  - 58
SN  - 1359-7345
UR  - http://doi.org/10.1039/d1cc04404d
N2  - A new palladium coordination compound based on gliclazide with the chemical formula [Pd(glz)2] (where glz = gliclazide) has been synthesized and characterised. The structural characterization reveals that this material consists of mononuclear units formed by a Pd2+ ion coordinated to two molecules of the glz ligand, in which palladium ions exhibit a distorted plane-square coordination sphere. This novel material behaves like a good and selective inhibitor of butyrylcholinesterase, one of the most relevant therapeutic targets against Alzheimer's disease. Analysis of the enzyme kinetics showed a mixed mode of inhibition, the title compound being capable of interacting with both the free enzyme and the enzyme-substrate complex. Finally, the palladium compound shows promising protective activity against A?-induced toxicity in the Caenorhabditis elegans model, which has never been reported.
JF  - Chemical Communications
Y1  - 2022/02//
IS  - 10
SP  - 1514
A1  - García-García, Amalia
A1  - Rojas, Sara
A1  - Rivas-García, Lorenzo
A1  - Navarro-Hortal, María D.
A1  - Romero-Márquez, Jose M.
A1  - Fernández-Bolaños, José G.
A1  - Choquesillo-Lazarte, Duane
A1  - Salinas-Castillo, Alfonso
A1  - López, Óscar
A1  - Quiles, José L.
A1  - Rodríguez-Diéguez, Antonio
AV  - public
ID  - uneatlantico584
EP  - 1517
TI  - A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against A?-induced toxicity in C. elegans
ER  -