<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans"^^ . "A new palladium coordination compound based on gliclazide with the chemical formula [Pd(glz)2] (where glz = gliclazide) has been synthesized and characterised. The structural characterization reveals that this material consists of mononuclear units formed by a Pd2+ ion coordinated to two molecules of the glz ligand, in which palladium ions exhibit a distorted plane-square coordination sphere. This novel material behaves like a good and selective inhibitor of butyrylcholinesterase, one of the most relevant therapeutic targets against Alzheimer's disease. Analysis of the enzyme kinetics showed a mixed mode of inhibition, the title compound being capable of interacting with both the free enzyme and the enzyme-substrate complex. Finally, the palladium compound shows promising protective activity against Aβ-induced toxicity in the Caenorhabditis elegans model, which has never been reported."^^ . "2022-02" . . . "58" . "10" . . "Chemical Communications"^^ . . . "13597345" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "José G."^^ . "Fernández-Bolaños"^^ . "José G. Fernández-Bolaños"^^ . . "Amalia"^^ . "García-García"^^ . "Amalia García-García"^^ . . "Jose M."^^ . "Romero-Márquez"^^ . "Jose M. Romero-Márquez"^^ . . "José L."^^ . "Quiles"^^ . "José L. Quiles"^^ . . "Sara"^^ . "Rojas"^^ . "Sara Rojas"^^ . . "Lorenzo"^^ . "Rivas-García"^^ . "Lorenzo Rivas-García"^^ . . "María D."^^ . "Navarro-Hortal"^^ . "María D. Navarro-Hortal"^^ . . "Duane"^^ . "Choquesillo-Lazarte"^^ . "Duane Choquesillo-Lazarte"^^ . . "Óscar"^^ . "López"^^ . "Óscar López"^^ . . "Antonio"^^ . "Rodríguez-Diéguez"^^ . "Antonio Rodríguez-Diéguez"^^ . . "Alfonso"^^ . "Salinas-Castillo"^^ . "Alfonso Salinas-Castillo"^^ . . . . . . "A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans (Texto)"^^ . . . . . "d1cc04404d.pdf"^^ . . . "A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans (Otro)"^^ . . . . . . "indexcodes.txt"^^ . . . "A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans (Otro)"^^ . . . . . . "lightbox.jpg"^^ . . . "A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans (Otro)"^^ . . . . . . "preview.jpg"^^ . . . "A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans (Otro)"^^ . . . . . . "medium.jpg"^^ . . . "A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans (Otro)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #584 \n\nA gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans\n\n" . "text/html" . . . "Biomedicine"@en . "Biomedicina"@es . .