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primary topic: A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans

A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans
type: AcademicArticle
type: Article
abstract: A new palladium coordination compound based on gliclazide with the chemical formula [Pd(glz)2] (where glz = gliclazide) has been synthesized and characterised. The structural characterization reveals that this material consists of mononuclear units formed by a Pd2+ ion coordinated to two molecules of the glz ligand, in which palladium ions exhibit a distorted plane-square coordination sphere. This novel material behaves like a good and selective inhibitor of butyrylcholinesterase, one of the most relevant therapeutic targets against Alzheimer's disease. Analysis of the enzyme kinetics showed a mixed mode of inhibition, the title compound being capable of interacting with both the free enzyme and the enzyme-substrate complex. Finally, the palladium compound shows promising protective activity against Aβ-induced toxicity in the Caenorhabditis elegans model, which has never been reported.
date: 2022-02
volume: 58
issue: 10
is part of: Chemical Communications
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans (Texto)
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has document: A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans (Otro)
subject: Biomedicine

A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans (Texto)
type: Document
has file: d1cc04404d.pdf
has part: d1cc04404d.pdf

Chemical Communications
type: Collection
issn: 13597345

Antonio Rodríguez-Diéguez
type: Person
given name: Antonio
family name: Rodríguez-Diéguez

Alfonso Salinas-Castillo
type: Person
given name: Alfonso
family name: Salinas-Castillo

Jose M. Romero-Márquez
type: Person
given name: Jose M.
family name: Romero-Márquez

María D. Navarro-Hortal
type: Person
given name: María D.
family name: Navarro-Hortal

Lorenzo Rivas-García
type: Person
given name: Lorenzo
family name: Rivas-García

Duane Choquesillo-Lazarte
type: Person
given name: Duane
family name: Choquesillo-Lazarte

Amalia García-García
type: Person
given name: Amalia
family name: García-García

Sara Rojas
type: Person
given name: Sara
family name: Rojas

Óscar López
type: Person
given name: Óscar
family name: López

José G. Fernández-Bolaños
type: Person
given name: José G.
family name: Fernández-Bolaños

José L. Quiles
type: Person
given name: José L.
family name: Quiles

A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans (Otro)
type: Document
is version of: A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans (Texto)
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A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans (Otro)
type: Document
is version of: A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans (Texto)
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A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans (Otro)
type: Document
is version of: A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans (Texto)
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A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans (Otro)
type: Document
is version of: A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans (Texto)
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A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans (Otro)
type: Document
is version of: A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans (Texto)
is volatile version of: A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans (Texto)
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primary topic: A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans

Biomedicine
type: Concept
preferred label: Biomedicina @es