%0 Journal Article
%@ 1359-7345
%A García-García, Amalia
%A Rojas, Sara
%A Rivas-García, Lorenzo
%A Navarro-Hortal, María D.
%A Romero-Márquez, Jose M.
%A Fernández-Bolaños, José G.
%A Choquesillo-Lazarte, Duane
%A Salinas-Castillo, Alfonso
%A López, Óscar
%A Quiles, José L.
%A Rodríguez-Diéguez, Antonio
%D 2022
%F uneatlantico:584
%J Chemical Communications
%N 10
%P 1514-1517
%T A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans
%U http://repositorio.uneatlantico.es/id/eprint/584/
%V 58
%X A new palladium coordination compound based on gliclazide with the chemical formula [Pd(glz)2] (where glz = gliclazide) has been synthesized and characterised. The structural characterization reveals that this material consists of mononuclear units formed by a Pd2+ ion coordinated to two molecules of the glz ligand, in which palladium ions exhibit a distorted plane-square coordination sphere. This novel material behaves like a good and selective inhibitor of butyrylcholinesterase, one of the most relevant therapeutic targets against Alzheimer's disease. Analysis of the enzyme kinetics showed a mixed mode of inhibition, the title compound being capable of interacting with both the free enzyme and the enzyme-substrate complex. Finally, the palladium compound shows promising protective activity against Aβ-induced toxicity in the Caenorhabditis elegans model, which has never been reported.