relation: http://repositorio.uneatlantico.es/id/eprint/584/
canonical: http://repositorio.uneatlantico.es/id/eprint/584/
title: A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans
creator: García-García, Amalia
creator: Rojas, Sara
creator: Rivas-García, Lorenzo
creator: Navarro-Hortal, María D.
creator: Romero-Márquez, Jose M.
creator: Fernández-Bolaños, José G.
creator: Choquesillo-Lazarte, Duane
creator: Salinas-Castillo, Alfonso
creator: López, Óscar
creator: Quiles, José L.
creator: Rodríguez-Diéguez, Antonio
subject: Biomedicina
description: A new palladium coordination compound based on gliclazide with the chemical formula [Pd(glz)2] (where glz = gliclazide) has been synthesized and characterised. The structural characterization reveals that this material consists of mononuclear units formed by a Pd2+ ion coordinated to two molecules of the glz ligand, in which palladium ions exhibit a distorted plane-square coordination sphere. This novel material behaves like a good and selective inhibitor of butyrylcholinesterase, one of the most relevant therapeutic targets against Alzheimer's disease. Analysis of the enzyme kinetics showed a mixed mode of inhibition, the title compound being capable of interacting with both the free enzyme and the enzyme-substrate complex. Finally, the palladium compound shows promising protective activity against Aβ-induced toxicity in the Caenorhabditis elegans model, which has never been reported.
date: 2022-02
type: Artículo
type: PeerReviewed
format: text
language: en
rights: cc_by_nc_4
identifier: http://repositorio.uneatlantico.es/id/eprint/584/1/d1cc04404d.pdf
identifier:   Artículo Materias > Biomedicina <http://repositorio.uneatlantico.es/view/subjects/uneat=5Fbm.html> Universidad Europea del Atlántico > Investigación > Producción Científica <http://repositorio.uneatlantico.es/view/divisions/uneatlantico=5Fproduccion=5Fcientifica.html> Abierto Inglés A new palladium coordination compound based on gliclazide with the chemical formula [Pd(glz)2] (where glz = gliclazide) has been synthesized and characterised. The structural characterization reveals that this material consists of mononuclear units formed by a Pd2+ ion coordinated to two molecules of the glz ligand, in which palladium ions exhibit a distorted plane-square coordination sphere. This novel material behaves like a good and selective inhibitor of butyrylcholinesterase, one of the most relevant therapeutic targets against Alzheimer's disease. Analysis of the enzyme kinetics showed a mixed mode of inhibition, the title compound being capable of interacting with both the free enzyme and the enzyme-substrate complex. Finally, the palladium compound shows promising protective activity against Aβ-induced toxicity in the Caenorhabditis elegans model, which has never been reported. metadata García-García, Amalia; Rojas, Sara; Rivas-García, Lorenzo; Navarro-Hortal, María D.; Romero-Márquez, Jose M.; Fernández-Bolaños, José G.; Choquesillo-Lazarte, Duane; Salinas-Castillo, Alfonso; López, Óscar; Quiles, José L. y Rodríguez-Diéguez, Antonio mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, jose.quiles@uneatlantico.es, SIN ESPECIFICAR     <http://repositorio.uneatlantico.es/id/eprint/584/1/d1cc04404d.pdf>     (2022) A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans.  Chemical Communications, 58 (10).  pp. 1514-1517.  ISSN 1359-7345     
relation: http://doi.org/10.1039/d1cc04404d
relation: doi:10.1039/d1cc04404d
language: en