@article{uneatlantico584,
           pages = {1514--1517},
          volume = {58},
          author = {Amalia Garc{\'i}a-Garc{\'i}a and Sara Rojas and Lorenzo Rivas-Garc{\'i}a and Mar{\'i}a D. Navarro-Hortal and Jose M. Romero-M{\'a}rquez and Jos{\'e} G. Fern{\'a}ndez-Bola{\~n}os and Duane Choquesillo-Lazarte and Alfonso Salinas-Castillo and {\'O}scar L{\'o}pez and Jos{\'e} L. Quiles and Antonio Rodr{\'i}guez-Di{\'e}guez},
           month = {Febrero},
           title = {A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against A{\ensuremath{\beta}}-induced toxicity in C. elegans},
         journal = {Chemical Communications},
            year = {2022},
          number = {10},
        abstract = {A new palladium coordination compound based on gliclazide with the chemical formula [Pd(glz)2] (where glz = gliclazide) has been synthesized and characterised. The structural characterization reveals that this material consists of mononuclear units formed by a Pd2+ ion coordinated to two molecules of the glz ligand, in which palladium ions exhibit a distorted plane-square coordination sphere. This novel material behaves like a good and selective inhibitor of butyrylcholinesterase, one of the most relevant therapeutic targets against Alzheimer's disease. Analysis of the enzyme kinetics showed a mixed mode of inhibition, the title compound being capable of interacting with both the free enzyme and the enzyme-substrate complex. Finally, the palladium compound shows promising protective activity against A{\ensuremath{\beta}}-induced toxicity in the Caenorhabditis elegans model, which has never been reported.},
             url = {http://repositorio.uneatlantico.es/id/eprint/584/}
}