TY  - JOUR
Y1  - 2023///
JF  - Nutrition
N2  - Inflammatory bowel disease (IBD) patients are at substantially higher risk of colorectal cancer (CRC) and IBD-associated CRC accounts for roughly 10-15% of the annual mortality in IBD patients. IBD-related CRC also affects younger patients if compared with sporadic CRC, with a 5-year survival rate of 50%. Regardless of medical therapies, the persistent inflammation state characterizing IBD raises the risk for precancerous changes and CRC, with additional input from several elements including genetic and environmental risk factors, IBD-associated comorbidities, intestinal barrier disfunction, and gut microbiota modifications. It is well known that nutritional habits and dietary bioactive compounds can influence IBD-associated inflammation, microbiome abundance and composition, oxidative stress balance, and gut permeability. In addition, in the last years, results from broad epidemiological and experimental studies have associated certain foods or nutritional patterns with the risk of colorectal neoplasia. Here we review the possible role of nutrition in the prevention of IBD-related CRC, focusing specifically on human studies. In conclusion it emerges that nutritional interventions based on healthy, nutrient-dense dietary patterns characterized by a high intake of fiber, vegetables, fruit, Omega-3 PUFAs, and low amount of animal proteins, processed foods and alcohol, combined with probiotic supplementation have the potential of reducing IBD-activity and preventing the risk of IBD-related CRC through different mechanisms, suggesting that targeted nutritional interventions may represent a novel promising approach for the prevention and management of IBD-associated CRC.
SN  - 08999007
UR  - http://doi.org/10.1016/j.nut.2023.111980
TI  - Possible role of nutrition in the prevention of Inflammatory Bowel Disease-related colorectal cancer: a focus on human studies
ID  - uneatlantico5793
AV  - none
A1  - Cassotta, Manuela
A1  - Cianciosi, Danila
A1  - De Giuseppe, Rachele
A1  - Navarro-Hortal, Maria Dolores
A1  - Diaz, Yasmany Armas
A1  - Forbes-Hernández, Tamara Yuliett
A1  - Tutusaus, Kilian
A1  - Pascual Barrera, Alina Eugenia
A1  - Grosso, Giuseppe
A1  - Xiao, Jianbo
A1  - Battino, Maurizio
A1  - Giampieri, Francesca
KW  - diet; colitis-associated cancer; CAC; CRC; IBD-colorectal cancer
ER  -