eprintid: 574 rev_number: 7 eprint_status: archive userid: 2 dir: disk0/00/00/05/74 datestamp: 2022-03-17 23:55:06 lastmod: 2023-07-03 23:30:21 status_changed: 2022-03-17 23:55:06 type: article metadata_visibility: show creators_name: Sureda, Antoni creators_name: Daglia, Maria creators_name: Argüelles Castilla, Sandro creators_name: Sanadgol, Nima creators_name: Fazel Nabavi, Seyed creators_name: Khan, Haroon creators_name: Belwal, Tarun creators_name: Jeandet, Philippe creators_name: Marchese, Anna creators_name: Pistollato, Francesca creators_name: Forbes-Hernandez, Tamara creators_name: Battino, Maurizio creators_name: Berindan-Neagoe, Ioana creators_name: D’Onofrio, Grazia creators_name: Nabavi, Seyed Mohammad creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: francesca.pistollato@uneatlantico.es creators_id: creators_id: maurizio.battino@uneatlantico.es creators_id: creators_id: creators_id: title: Oral microbiota and Alzheimer’s disease: Do all roads lead to Rome? ispublished: pub subjects: uneat_bm divisions: uneatlantico_produccion_cientifica full_text_status: none keywords: Alzheimer’s disease; Amyloid-β; Oral microbiome; Periodontal disease abstract: Alzheimer’s disease (AD) is a progressive neurodegenerative pathology affecting milions of people worldwide associated with deposition of senile plaques. While the genetic and environmental risk factors associated with the onset and consolidation of late onset AD are heterogeneous and sporadic, growing evidence also suggests a potential link between some infectious diseases caused by oral microbiota and AD. Oral microbiota dysbiosis is purported to contribute either directly to amyloid protein production, or indirectly to neuroinflammation, occurring as a consequence of bacterial invasion. Over the last decade, the development of Human Oral Microbiome database (HOMD) has deepened our understanding of oral microbes and their different roles during the human lifetime. Oral pathogens mostly cause caries, periodontal disease, and edentulism in aged population, and, in particular, alterations of the oral microbiota causing chronic periodontal disease have been associated with the risk of AD. Here we describe how different alterations of the oral microbiota may be linked to AD, highlighting the importance of a good oral hygiene for the prevention of oral microbiota dysbiosis. date: 2020-01 date_type: published publication: Pharmacological Research volume: 151 pagerange: 104582 id_number: doi:10.1016/j.phrs.2019.104582 refereed: TRUE issn: 10436618 official_url: http://doi.org/10.1016/j.phrs.2019.104582 access: close language: en citation: Artículo Materias > Biomedicina Universidad Europea del Atlántico > Investigación > Producción Científica Cerrado Inglés Alzheimer’s disease (AD) is a progressive neurodegenerative pathology affecting milions of people worldwide associated with deposition of senile plaques. While the genetic and environmental risk factors associated with the onset and consolidation of late onset AD are heterogeneous and sporadic, growing evidence also suggests a potential link between some infectious diseases caused by oral microbiota and AD. Oral microbiota dysbiosis is purported to contribute either directly to amyloid protein production, or indirectly to neuroinflammation, occurring as a consequence of bacterial invasion. Over the last decade, the development of Human Oral Microbiome database (HOMD) has deepened our understanding of oral microbes and their different roles during the human lifetime. Oral pathogens mostly cause caries, periodontal disease, and edentulism in aged population, and, in particular, alterations of the oral microbiota causing chronic periodontal disease have been associated with the risk of AD. Here we describe how different alterations of the oral microbiota may be linked to AD, highlighting the importance of a good oral hygiene for the prevention of oral microbiota dysbiosis. metadata Sureda, Antoni; Daglia, Maria; Argüelles Castilla, Sandro; Sanadgol, Nima; Fazel Nabavi, Seyed; Khan, Haroon; Belwal, Tarun; Jeandet, Philippe; Marchese, Anna; Pistollato, Francesca; Forbes-Hernandez, Tamara; Battino, Maurizio; Berindan-Neagoe, Ioana; D’Onofrio, Grazia y Nabavi, Seyed Mohammad mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, francesca.pistollato@uneatlantico.es, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR (2020) Oral microbiota and Alzheimer’s disease: Do all roads lead to Rome? Pharmacological Research, 151. p. 104582. ISSN 10436618