TY  - JOUR
ID  - uneatlantico574
TI  - Oral microbiota and Alzheimer?s disease: Do all roads lead to Rome?
AV  - none
A1  - Sureda, Antoni
A1  - Daglia, Maria
A1  - Argüelles Castilla, Sandro
A1  - Sanadgol, Nima
A1  - Fazel Nabavi, Seyed
A1  - Khan, Haroon
A1  - Belwal, Tarun
A1  - Jeandet, Philippe
A1  - Marchese, Anna
A1  - Pistollato, Francesca
A1  - Forbes-Hernandez, Tamara
A1  - Battino, Maurizio
A1  - Berindan-Neagoe, Ioana
A1  - D?Onofrio, Grazia
A1  - Nabavi, Seyed Mohammad
KW  - Alzheimer?s disease; Amyloid-?; Oral microbiome; Periodontal disease
JF  - Pharmacological Research
N2  - Alzheimer?s disease (AD) is a progressive neurodegenerative pathology affecting milions of people worldwide associated with deposition of senile plaques. While the genetic and environmental risk factors associated with the onset and consolidation of late onset AD are heterogeneous and sporadic, growing evidence also suggests a potential link between some infectious diseases caused by oral microbiota and AD. Oral microbiota dysbiosis is purported to contribute either directly to amyloid protein production, or indirectly to neuroinflammation, occurring as a consequence of bacterial invasion. Over the last decade, the development of Human Oral Microbiome database (HOMD) has deepened our understanding of oral microbes and their different roles during the human lifetime. Oral pathogens mostly cause caries, periodontal disease, and edentulism in aged population, and, in particular, alterations of the oral microbiota causing chronic periodontal disease have been associated with the risk of AD. Here we describe how different alterations of the oral microbiota may be linked to AD, highlighting the importance of a good oral hygiene for the prevention of oral microbiota dysbiosis.
Y1  - 2020/01//
VL  - 151
UR  - http://doi.org/10.1016/j.phrs.2019.104582
SN  - 10436618
ER  -