eprintid: 567 rev_number: 7 eprint_status: archive userid: 2 dir: disk0/00/00/05/67 datestamp: 2022-03-15 23:55:11 lastmod: 2023-07-18 23:30:06 status_changed: 2022-03-15 23:55:11 type: article metadata_visibility: show creators_name: Rivas-García, Lorenzo creators_name: Romero-Márquez, Jose M. creators_name: Navarro-Hortal, M.D. creators_name: Esteban-Muñoz, Adelaida creators_name: Giampieri, Francesca creators_name: Sumalla Cano, Sandra creators_name: Battino, Maurizio creators_name: Quiles, José L. creators_name: Llopis, Juan creators_name: Sánchez-González, Cristina creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: sandra.sumalla@uneatlantico.es creators_id: creators_id: jose.quiles@uneatlantico.es creators_id: creators_id: title: Unravelling potential biomedical applications of the edible flower Tulbaghia violacea ispublished: pub subjects: uneat_sn divisions: uneatlantico_produccion_cientifica full_text_status: none keywords: Flower; Quercetin; Autophagy; ROS; Antioxidants; Alzheimer disease abstract: Traditionally, edible flowers have been used as foods and for therapeutic purposes, today they have gained importance due to their bioactive compounds such as flavonols, anthocyanins or other phenolic compounds, which give them potential for biomedical applications. This work evaluated a methanolic extract of Tulbaghia violacea. Eleven individual phenolic compounds were found and quantified by mass spectrometry in the extract. Antioxidant activity tests (TEAC, FRAP and DPPH) and other characterization parameters were assayed (total phenolic content and total flavonoid content). In vitro studies showed antitumoral activity against ovarian tumoral cells mediated by the induction of non-dependent caspase cell death and by the activation of reactive oxygen species. The effect of the extract against features of Alzheimer disease was in vivo assayed in Caenorhabditis elegans. Tulbaghia extract led to a reduction in the 1–42 beta amyloid peptide formation and prevented oxidative stress. These results suggested that Tulbaghia violacea could be a new source of phenolic compounds for nutraceuticals and functional food development. date: 2022-07 publication: Food Chemistry volume: 381 pagerange: 132096 id_number: doi:10.1016/j.foodchem.2022.132096 refereed: TRUE issn: 03088146 official_url: http://doi.org/10.1016/j.foodchem.2022.132096 access: close language: en citation: Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica Cerrado Inglés Traditionally, edible flowers have been used as foods and for therapeutic purposes, today they have gained importance due to their bioactive compounds such as flavonols, anthocyanins or other phenolic compounds, which give them potential for biomedical applications. This work evaluated a methanolic extract of Tulbaghia violacea. Eleven individual phenolic compounds were found and quantified by mass spectrometry in the extract. Antioxidant activity tests (TEAC, FRAP and DPPH) and other characterization parameters were assayed (total phenolic content and total flavonoid content). In vitro studies showed antitumoral activity against ovarian tumoral cells mediated by the induction of non-dependent caspase cell death and by the activation of reactive oxygen species. The effect of the extract against features of Alzheimer disease was in vivo assayed in Caenorhabditis elegans. Tulbaghia extract led to a reduction in the 1–42 beta amyloid peptide formation and prevented oxidative stress. These results suggested that Tulbaghia violacea could be a new source of phenolic compounds for nutraceuticals and functional food development. metadata Rivas-García, Lorenzo; Romero-Márquez, Jose M.; Navarro-Hortal, M.D.; Esteban-Muñoz, Adelaida; Giampieri, Francesca; Sumalla Cano, Sandra; Battino, Maurizio; Quiles, José L.; Llopis, Juan y Sánchez-González, Cristina mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, sandra.sumalla@uneatlantico.es, SIN ESPECIFICAR, jose.quiles@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR (2022) Unravelling potential biomedical applications of the edible flower Tulbaghia violacea. Food Chemistry, 381. p. 132096. ISSN 03088146