TY  - JOUR
ID  - uneatlantico564
TI  - Manuka honey in combination with 5-Fluorouracil decreases physical parameters of colonspheres enriched with cancer stem-like cells and reduces their resistance to apoptosis
A1  - Cianciosi, Danila
A1  - Forbes-Hernández, Tamara Y.
A1  - Regolo, Lucia
A1  - Alvarez-Suarez, José M.
A1  - Quinzi, Denise
A1  - Sargenti, Azzurra
A1  - Bai, Weibin
A1  - Tian, Lingmin
A1  - Giampieri, Francesca
A1  - Battino, Maurizio
AV  - none
KW  - Apoptosis; Cancer; Chemosensibility; Honey; Spheroids; Stemness.
N2  - The aim of the present work was to evaluate the in vitro effect of Manuka honey and its combination with 5-Fu, the most common drug used in the treatment of colon cancer, on the morphological and physical parameters of colonspheres enriched with cancer stem-like cells deriving from HCT-116 colon adenocarcinoma cell line and on the apoptosis rate. Manuka honey, alone and more in combination with 5-Fu, reduced the weight, the diameter and mass density of the spheroids and induced apoptosis through the downregulation of many apoptosis inhibitors, including IAPs (Livin, Survivin, XIAP), IGFs (IGF-I, IGF-II and IGF-IR) and HSPs (HSP-27, HSP-60 and HSP-70). These results led to a reduction in the survival ability of cancer stem-like cells, as well as to a chemosensitizing effect of honey towards 5-Fu, considering that apoptosis resistance is one of the main causes of cancer stem-like cells chemoresistance.
JF  - Food Chemistry
Y1  - 2022/04//
VL  - 374
UR  - http://doi.org/10.1016/j.foodchem.2021.131753
SN  - 03088146
ER  -