<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Manuka honey in combination with 5-Fluorouracil decreases physical parameters of colonspheres enriched with cancer stem-like cells and reduces their resistance to apoptosis"^^ . "The aim of the present work was to evaluate the in vitro effect of Manuka honey and its combination with 5-Fu, the most common drug used in the treatment of colon cancer, on the morphological and physical parameters of colonspheres enriched with cancer stem-like cells deriving from HCT-116 colon adenocarcinoma cell line and on the apoptosis rate. Manuka honey, alone and more in combination with 5-Fu, reduced the weight, the diameter and mass density of the spheroids and induced apoptosis through the downregulation of many apoptosis inhibitors, including IAPs (Livin, Survivin, XIAP), IGFs (IGF-I, IGF-II and IGF-IR) and HSPs (HSP-27, HSP-60 and HSP-70). These results led to a reduction in the survival ability of cancer stem-like cells, as well as to a chemosensitizing effect of honey towards 5-Fu, considering that apoptosis resistance is one of the main causes of cancer stem-like cells chemoresistance."^^ . "2022-04" . . "374" . . "Food Chemistry"^^ . . . "03088146" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "José M."^^ . "Alvarez-Suarez"^^ . "José M. Alvarez-Suarez"^^ . . "Lucia"^^ . "Regolo"^^ . "Lucia Regolo"^^ . . "Azzurra"^^ . "Sargenti"^^ . "Azzurra Sargenti"^^ . . "Danila"^^ . "Cianciosi"^^ . "Danila Cianciosi"^^ . . "Denise"^^ . "Quinzi"^^ . "Denise Quinzi"^^ . . "Francesca"^^ . "Giampieri"^^ . "Francesca Giampieri"^^ . . "Lingmin"^^ . "Tian"^^ . "Lingmin Tian"^^ . . "Weibin"^^ . "Bai"^^ . "Weibin Bai"^^ . . "Maurizio"^^ . "Battino"^^ . "Maurizio Battino"^^ . . "Tamara Y."^^ . "Forbes-Hernández"^^ . "Tamara Y. Forbes-Hernández"^^ . . . . . "HTML Summary of #564 \n\nManuka honey in combination with 5-Fluorouracil decreases physical parameters of colonspheres enriched with cancer stem-like cells and reduces their resistance to apoptosis\n\n" . "text/html" . . . "Nutrition"@en . "Alimentación"@es . .