@article{uneatlantico564,
         journal = {Food Chemistry},
          volume = {374},
          author = {Danila Cianciosi and Tamara Y. Forbes-Hern{\'a}ndez and Lucia Regolo and Jos{\'e} M. Alvarez-Suarez and Denise Quinzi and Azzurra Sargenti and Weibin Bai and Lingmin Tian and Francesca Giampieri and Maurizio Battino},
           title = {Manuka honey in combination with 5-Fluorouracil decreases physical parameters of colonspheres enriched with cancer stem-like cells and reduces their resistance to apoptosis},
           pages = {131753},
           month = {Abril},
            year = {2022},
        keywords = {Apoptosis; Cancer; Chemosensibility; Honey; Spheroids; Stemness.},
             url = {http://repositorio.uneatlantico.es/id/eprint/564/},
        abstract = {The aim of the present work was to evaluate the in vitro effect of Manuka honey and its combination with 5-Fu, the most common drug used in the treatment of colon cancer, on the morphological and physical parameters of colonspheres enriched with cancer stem-like cells deriving from HCT-116 colon adenocarcinoma cell line and on the apoptosis rate. Manuka honey, alone and more in combination with 5-Fu, reduced the weight, the diameter and mass density of the spheroids and induced apoptosis through the downregulation of many apoptosis inhibitors, including IAPs (Livin, Survivin, XIAP), IGFs (IGF-I, IGF-II and IGF-IR) and HSPs (HSP-27, HSP-60 and HSP-70). These results led to a reduction in the survival ability of cancer stem-like cells, as well as to a chemosensitizing effect of honey towards 5-Fu, considering that apoptosis resistance is one of the main causes of cancer stem-like cells chemoresistance.}
}