eprintid: 528 rev_number: 13 eprint_status: archive userid: 2 dir: disk0/00/00/05/28 datestamp: 2022-03-23 19:44:11 lastmod: 2023-07-03 23:30:21 status_changed: 2022-03-23 19:44:11 type: article metadata_visibility: show creators_name: Morales-Navas, Miguel creators_name: Castaño-Castaño, Sergio creators_name: Pérez-Fernández, Cristian creators_name: Sánchez-Gil, Ainhoa creators_name: Teresa Colomina, María creators_name: Leinekugel, Xavier creators_name: Sánchez-Santed, Fernando creators_id: creators_id: sergio.castano@uneatlantico.es creators_id: creators_id: creators_id: creators_id: creators_id: title: Similarities between the Effects of Prenatal Chlorpyrifos and Valproic Acid on Ultrasonic Vocalization in Infant Wistar Rats ispublished: pub subjects: uneat_bm subjects: uneat_ps divisions: uneatlantico_produccion_cientifica full_text_status: public keywords: autistic spectrum disorder; ultrasonic vocalizations; chlorpyrifos; valproic acid; prenatal exposure; autism; organophosphates abstract: Background: In recent years, ultrasonic vocalizations (USV) in pups has become established as a good tool for evaluating behaviors related to communication deficits and emotional states observed in autism spectrum disorder (ASD). Prenatal valproic acid (VPA) exposure leads to impairments and social behavior deficits associated with autism, with the effects of VPA being considered as a reliable animal model of ASD. Some studies also suggest that prenatal exposure to chlorpyrifos (CPF) could enhance autistic-like behaviors. Methods: In order to explore these similarities, in the present study we tested whether prenatal exposure to CPF at GD12.5–14.5 produces effects that are comparable to those produced by prenatal VPA exposure at GD12.5 in infant Wistar rats. Using Deep Squeek software, we evaluated total number of USVs, latency to the first call, mean call duration, principal frequency peak, high frequency peak, and type of calls. Results: Consistent with our hypothesis, we found that exposure to both CPF and VPA leads to a significantly smaller number of calls along with a longer latency to produce the first call. No significant effects were found for the remaining dependent variables. Conclusions: These results suggest that prenatal exposure to CPF could produce certain behaviors that are reminiscent of those observed in ASD patients date: 2020-09 date_type: published publication: International Journal of Environmental Research and Public Health volume: 17 number: 17 pagerange: 6376 id_number: doi:10.3390/ijerph17176376 refereed: TRUE issn: 1660-4601 official_url: http://doi.org/10.3390/ijerph17176376 access: open language: en citation: Artículo Materias > Biomedicina Materias > Psicología Universidad Europea del Atlántico > Investigación > Producción Científica Abierto Inglés Background: In recent years, ultrasonic vocalizations (USV) in pups has become established as a good tool for evaluating behaviors related to communication deficits and emotional states observed in autism spectrum disorder (ASD). Prenatal valproic acid (VPA) exposure leads to impairments and social behavior deficits associated with autism, with the effects of VPA being considered as a reliable animal model of ASD. Some studies also suggest that prenatal exposure to chlorpyrifos (CPF) could enhance autistic-like behaviors. Methods: In order to explore these similarities, in the present study we tested whether prenatal exposure to CPF at GD12.5–14.5 produces effects that are comparable to those produced by prenatal VPA exposure at GD12.5 in infant Wistar rats. Using Deep Squeek software, we evaluated total number of USVs, latency to the first call, mean call duration, principal frequency peak, high frequency peak, and type of calls. Results: Consistent with our hypothesis, we found that exposure to both CPF and VPA leads to a significantly smaller number of calls along with a longer latency to produce the first call. No significant effects were found for the remaining dependent variables. Conclusions: These results suggest that prenatal exposure to CPF could produce certain behaviors that are reminiscent of those observed in ASD patients metadata Morales-Navas, Miguel; Castaño-Castaño, Sergio; Pérez-Fernández, Cristian; Sánchez-Gil, Ainhoa; Teresa Colomina, María; Leinekugel, Xavier y Sánchez-Santed, Fernando mail SIN ESPECIFICAR, sergio.castano@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR (2020) Similarities between the Effects of Prenatal Chlorpyrifos and Valproic Acid on Ultrasonic Vocalization in Infant Wistar Rats. International Journal of Environmental Research and Public Health, 17 (17). p. 6376. ISSN 1660-4601 document_url: http://repositorio.uneatlantico.es/id/eprint/528/1/ijerph-17-06376.pdf