eprintid: 519 rev_number: 13 eprint_status: archive userid: 2 dir: disk0/00/00/05/19 datestamp: 2022-03-08 23:55:08 lastmod: 2023-07-07 23:30:24 status_changed: 2022-03-08 23:55:08 type: article metadata_visibility: show creators_name: Cassotta, Manuela creators_name: Forbes-Hernandez, Tamara Y. creators_name: Cianciosi, Danila creators_name: Elexpuru Zabaleta, Maria creators_name: Sumalla Cano, Sandra creators_name: Dominguez Azpíroz, Irma creators_name: Bullon, Beatriz creators_name: Regolo, Lucia creators_name: Alvarez-Suarez, Josè Miguel creators_name: Giampieri, Francesca creators_name: Battino, Maurizio creators_id: manucassotta@gmail.com creators_id: creators_id: creators_id: maria.elexpuru@uneatlantico.es creators_id: sandra.sumalla@uneatlantico.es creators_id: irma.dominguez@uneatlantico.es creators_id: creators_id: creators_id: creators_id: francesca.giampieri@uneatlantico.es creators_id: maurizio.battino@uneatlantico.es title: Nutrition and Rheumatoid Arthritis in the ‘Omics’ Era ispublished: pub subjects: uneat_bm subjects: uneat_sn divisions: uneatlantico_produccion_cientifica full_text_status: public keywords: Rheumatoid Arthritis; Diet; Nutrigenomics; Proteomics; Metabolomics; Microbiome; Microbiomics abstract: Modern high-throughput ‘omics’ science tools (including genomics, transcriptomics, proteomics, metabolomics and microbiomics) are currently being applied to nutritional sciences to unravel the fundamental processes of health effects ascribed to particular nutrients in humans and to contribute to more precise nutritional advice. Diet and food components are key environmental factors that interact with the genome, transcriptome, proteome, metabolome and the microbiota, and this life-long interplay defines health and diseases state of the individual. Rheumatoid arthritis (RA) is a chronic autoimmune disease featured by a systemic immune-inflammatory response, in genetically susceptible individuals exposed to environmental triggers, including diet. In recent years increasing evidences suggested that nutritional factors and gut microbiome have a central role in RA risk and progression. The aim of this review is to summarize the main and most recent applications of ‘omics’ technologies in human nutrition and in RA research, examining the possible influences of some nutrients and nutritional patterns on RA pathogenesis, following a nutrigenomics approach. The opportunities and challenges of novel ‘omics technologies’ in the exploration of new avenues in RA and nutritional research to prevent and manage RA will be also discussed. date: 2021-02 date_type: published publication: Nutrients volume: 13 number: 3 pagerange: 763 id_number: doi:10.3390/nu13030763 refereed: TRUE issn: 2072-6643 official_url: http://doi.org/10.3390/nu13030763 access: open language: en citation: Artículo Materias > Biomedicina Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica Abierto Inglés Modern high-throughput ‘omics’ science tools (including genomics, transcriptomics, proteomics, metabolomics and microbiomics) are currently being applied to nutritional sciences to unravel the fundamental processes of health effects ascribed to particular nutrients in humans and to contribute to more precise nutritional advice. Diet and food components are key environmental factors that interact with the genome, transcriptome, proteome, metabolome and the microbiota, and this life-long interplay defines health and diseases state of the individual. Rheumatoid arthritis (RA) is a chronic autoimmune disease featured by a systemic immune-inflammatory response, in genetically susceptible individuals exposed to environmental triggers, including diet. In recent years increasing evidences suggested that nutritional factors and gut microbiome have a central role in RA risk and progression. The aim of this review is to summarize the main and most recent applications of ‘omics’ technologies in human nutrition and in RA research, examining the possible influences of some nutrients and nutritional patterns on RA pathogenesis, following a nutrigenomics approach. The opportunities and challenges of novel ‘omics technologies’ in the exploration of new avenues in RA and nutritional research to prevent and manage RA will be also discussed. metadata Cassotta, Manuela; Forbes-Hernandez, Tamara Y.; Cianciosi, Danila; Elexpuru Zabaleta, Maria; Sumalla Cano, Sandra; Dominguez Azpíroz, Irma; Bullon, Beatriz; Regolo, Lucia; Alvarez-Suarez, Josè Miguel; Giampieri, Francesca y Battino, Maurizio mail manucassotta@gmail.com, SIN ESPECIFICAR, SIN ESPECIFICAR, maria.elexpuru@uneatlantico.es, sandra.sumalla@uneatlantico.es, irma.dominguez@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es (2021) Nutrition and Rheumatoid Arthritis in the ‘Omics’ Era. Nutrients, 13 (3). p. 763. ISSN 2072-6643 document_url: http://repositorio.uneatlantico.es/id/eprint/519/1/nutrients-13-00763-v3.pdf