eprintid: 517 rev_number: 13 eprint_status: archive userid: 2 dir: disk0/00/00/05/17 datestamp: 2022-03-07 23:55:07 lastmod: 2023-07-17 23:30:18 status_changed: 2022-03-07 23:55:07 type: article metadata_visibility: show creators_name: Navarro-Hortal, María D. creators_name: Romero-Márquez, Jose M. creators_name: Esteban-Muñoz, Adelaida creators_name: Sánchez-González, Cristina creators_name: Rivas-García, Lorenzo creators_name: Llopis, Juan creators_name: Cianciosi, Danila creators_name: Giampieri, Francesca creators_name: Sumalla Cano, Sandra creators_name: Battino, Maurizio creators_name: Quiles, José L. creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: creators_id: sandra.sumalla@uneatlantico.es creators_id: maurizio.battino@uneatlantico.es creators_id: jose.quiles@uneatlantico.es title: Strawberry (Fragaria × ananassa cv. Romina) methanolic extract attenuates Alzheimer’s beta amyloid production and oxidative stress by SKN-1/NRF and DAF-16/FOXO mediated mechanisms in C. elegans ispublished: pub subjects: uneat_bm subjects: uneat_sn divisions: uneatlantico_produccion_cientifica full_text_status: public keywords: Berries; Antioxidant; Anthocyanins; Minerals; RNAi; ROS abstract: Bioactive compounds from strawberries have been associated with multiple healthy benefits. The present study aimed to assess chemical characterization of a methanolic extract of the Romina strawberry variety in terms of antioxidant capacity, polyphenols profile and chemical elements content. Additionally, potential toxicity, the effect on amyloid-β production and oxidative stress of the extract was in vivo evaluated in the experimental model Caenorhabditis elegans. Results revealed an important content in phenolic compounds (mainly ellagic acid and pelargonidin-3-glucoside) and minerals (K, Mg, P and Ca). The treatment with 100, 500 or 1000 μg/mL of strawberry extract did not show toxicity. On the contrary, the extract was able to delay amyloid β-protein induced paralysis, reduced amyloid-β aggregation and prevented oxidative stress. The potential molecular mechanisms present behind the observed results explored by RNAi technology revealed that DAF-16/FOXO and SKN-1/NRF2 signaling pathways were, at least partially, involved. date: 2022-03 publication: Food Chemistry volume: 372 pagerange: 131272 id_number: doi:10.1016/j.foodchem.2021.131272 refereed: TRUE issn: 03088146 official_url: http://doi.org/10.1016/j.foodchem.2021.131272 access: open language: en citation: Artículo Materias > Biomedicina Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica Abierto Inglés Bioactive compounds from strawberries have been associated with multiple healthy benefits. The present study aimed to assess chemical characterization of a methanolic extract of the Romina strawberry variety in terms of antioxidant capacity, polyphenols profile and chemical elements content. Additionally, potential toxicity, the effect on amyloid-β production and oxidative stress of the extract was in vivo evaluated in the experimental model Caenorhabditis elegans. Results revealed an important content in phenolic compounds (mainly ellagic acid and pelargonidin-3-glucoside) and minerals (K, Mg, P and Ca). The treatment with 100, 500 or 1000 μg/mL of strawberry extract did not show toxicity. On the contrary, the extract was able to delay amyloid β-protein induced paralysis, reduced amyloid-β aggregation and prevented oxidative stress. The potential molecular mechanisms present behind the observed results explored by RNAi technology revealed that DAF-16/FOXO and SKN-1/NRF2 signaling pathways were, at least partially, involved. metadata Navarro-Hortal, María D.; Romero-Márquez, Jose M.; Esteban-Muñoz, Adelaida; Sánchez-González, Cristina; Rivas-García, Lorenzo; Llopis, Juan; Cianciosi, Danila; Giampieri, Francesca; Sumalla Cano, Sandra; Battino, Maurizio y Quiles, José L. mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, sandra.sumalla@uneatlantico.es, maurizio.battino@uneatlantico.es, jose.quiles@uneatlantico.es (2022) Strawberry (Fragaria × ananassa cv. Romina) methanolic extract attenuates Alzheimer’s beta amyloid production and oxidative stress by SKN-1/NRF and DAF-16/FOXO mediated mechanisms in C. elegans. Food Chemistry, 372. p. 131272. ISSN 03088146 document_url: http://repositorio.uneatlantico.es/id/eprint/517/1/1-s2.0-S0308814621022780-main.pdf