%K Berries; Antioxidant; Anthocyanins; Minerals; RNAi; ROS
%J Food Chemistry
%A María D. Navarro-Hortal
%A Jose M. Romero-Márquez
%A Adelaida Esteban-Muñoz
%A Cristina Sánchez-González
%A Lorenzo Rivas-García
%A Juan Llopis
%A Danila Cianciosi
%A Francesca Giampieri
%A Sandra Sumalla Cano
%A Maurizio Battino
%A José L. Quiles
%V 372
%T Strawberry (Fragaria × ananassa cv. Romina) methanolic extract attenuates Alzheimer’s beta amyloid production and oxidative stress by SKN-1/NRF and DAF-16/FOXO mediated mechanisms in C. elegans
%D 2022
%L uneatlantico517
%P 131272
%X Bioactive compounds from strawberries have been associated with multiple healthy benefits. The present study
aimed to assess chemical characterization of a methanolic extract of the Romina strawberry variety in terms of
antioxidant capacity, polyphenols profile and chemical elements content. Additionally, potential toxicity, the
effect on amyloid-β production and oxidative stress of the extract was in vivo evaluated in the experimental model
Caenorhabditis elegans. Results revealed an important content in phenolic compounds (mainly ellagic acid and
pelargonidin-3-glucoside) and minerals (K, Mg, P and Ca). The treatment with 100, 500 or 1000 μg/mL of
strawberry extract did not show toxicity. On the contrary, the extract was able to delay amyloid β-protein
induced paralysis, reduced amyloid-β aggregation and prevented oxidative stress. The potential molecular
mechanisms present behind the observed results explored by RNAi technology revealed that DAF-16/FOXO and
SKN-1/NRF2 signaling pathways were, at least partially, involved.
%R doi:10.1016/j.foodchem.2021.131272