TY  - JOUR
KW  - Berries; Antioxidant; Anthocyanins; Minerals; RNAi; ROS
A1  - Navarro-Hortal, María D.
A1  - Romero-Márquez, Jose M.
A1  - Esteban-Muñoz, Adelaida
A1  - Sánchez-González, Cristina
A1  - Rivas-García, Lorenzo
A1  - Llopis, Juan
A1  - Cianciosi, Danila
A1  - Giampieri, Francesca
A1  - Sumalla Cano, Sandra
A1  - Battino, Maurizio
A1  - Quiles, José L.
AV  - public
ID  - uneatlantico517
TI  - Strawberry (Fragaria × ananassa cv. Romina) methanolic extract attenuates Alzheimer?s beta amyloid production and oxidative stress by SKN-1/NRF and DAF-16/FOXO mediated mechanisms in C. elegans
UR  - http://doi.org/10.1016/j.foodchem.2021.131272
SN  - 03088146
VL  - 372
JF  - Food Chemistry
N2  - Bioactive compounds from strawberries have been associated with multiple healthy benefits. The present study
aimed to assess chemical characterization of a methanolic extract of the Romina strawberry variety in terms of
antioxidant capacity, polyphenols profile and chemical elements content. Additionally, potential toxicity, the
effect on amyloid-? production and oxidative stress of the extract was in vivo evaluated in the experimental model
Caenorhabditis elegans. Results revealed an important content in phenolic compounds (mainly ellagic acid and
pelargonidin-3-glucoside) and minerals (K, Mg, P and Ca). The treatment with 100, 500 or 1000 ?g/mL of
strawberry extract did not show toxicity. On the contrary, the extract was able to delay amyloid ?-protein
induced paralysis, reduced amyloid-? aggregation and prevented oxidative stress. The potential molecular
mechanisms present behind the observed results explored by RNAi technology revealed that DAF-16/FOXO and
SKN-1/NRF2 signaling pathways were, at least partially, involved.
Y1  - 2022/03//
ER  -