%0 Journal Article
%@ 03088146
%A Navarro-Hortal, María D.
%A Romero-Márquez, Jose M.
%A Esteban-Muñoz, Adelaida
%A Sánchez-González, Cristina
%A Rivas-García, Lorenzo
%A Llopis, Juan
%A Cianciosi, Danila
%A Giampieri, Francesca
%A Sumalla Cano, Sandra
%A Battino, Maurizio
%A Quiles, José L.
%D 2022
%F uneatlantico:517
%J Food Chemistry
%K Berries; Antioxidant; Anthocyanins; Minerals; RNAi; ROS
%P 131272
%T Strawberry (Fragaria × ananassa cv. Romina) methanolic extract attenuates Alzheimer’s beta amyloid production and oxidative stress by SKN-1/NRF and DAF-16/FOXO mediated mechanisms in C. elegans
%U http://repositorio.uneatlantico.es/id/eprint/517/
%V 372
%X Bioactive compounds from strawberries have been associated with multiple healthy benefits. The present study aimed to assess chemical characterization of a methanolic extract of the Romina strawberry variety in terms of antioxidant capacity, polyphenols profile and chemical elements content. Additionally, potential toxicity, the effect on amyloid-β production and oxidative stress of the extract was in vivo evaluated in the experimental model Caenorhabditis elegans. Results revealed an important content in phenolic compounds (mainly ellagic acid and pelargonidin-3-glucoside) and minerals (K, Mg, P and Ca). The treatment with 100, 500 or 1000 μg/mL of strawberry extract did not show toxicity. On the contrary, the extract was able to delay amyloid β-protein induced paralysis, reduced amyloid-β aggregation and prevented oxidative stress. The potential molecular mechanisms present behind the observed results explored by RNAi technology revealed that DAF-16/FOXO and SKN-1/NRF2 signaling pathways were, at least partially, involved.