@article{uneatlantico517,
           pages = {131272},
           title = {Strawberry (Fragaria {$\times$} ananassa cv. Romina) methanolic extract attenuates Alzheimer?s beta amyloid production and oxidative stress by SKN-1/NRF and DAF-16/FOXO mediated mechanisms in C. elegans},
          volume = {372},
          author = {Mar{\'i}a D. Navarro-Hortal and Jose M. Romero-M{\'a}rquez and Adelaida Esteban-Mu{\~n}oz and Cristina S{\'a}nchez-Gonz{\'a}lez and Lorenzo Rivas-Garc{\'i}a and Juan Llopis and Danila Cianciosi and Francesca Giampieri and Sandra Sumalla Cano and Maurizio Battino and Jos{\'e} L. Quiles},
         journal = {Food Chemistry},
            year = {2022},
           month = {Marzo},
        abstract = {Bioactive compounds from strawberries have been associated with multiple healthy benefits. The present study
aimed to assess chemical characterization of a methanolic extract of the Romina strawberry variety in terms of
antioxidant capacity, polyphenols profile and chemical elements content. Additionally, potential toxicity, the
effect on amyloid-{\ensuremath{\beta}} production and oxidative stress of the extract was in vivo evaluated in the experimental model
Caenorhabditis elegans. Results revealed an important content in phenolic compounds (mainly ellagic acid and
pelargonidin-3-glucoside) and minerals (K, Mg, P and Ca). The treatment with 100, 500 or 1000 {\ensuremath{\mu}}g/mL of
strawberry extract did not show toxicity. On the contrary, the extract was able to delay amyloid {\ensuremath{\beta}}-protein
induced paralysis, reduced amyloid-{\ensuremath{\beta}} aggregation and prevented oxidative stress. The potential molecular
mechanisms present behind the observed results explored by RNAi technology revealed that DAF-16/FOXO and
SKN-1/NRF2 signaling pathways were, at least partially, involved.},
             url = {http://repositorio.uneatlantico.es/id/eprint/517/},
        keywords = {Berries; Antioxidant; Anthocyanins; Minerals; RNAi; ROS}
}